LeishMANIAdb
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Peroxisomal biogenesis factor 11 (PEX11), putative

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Peroxisomal biogenesis factor 11 (PEX11), putative
Gene product:
Peroxisomal biogenesis factor 11 (PEX11), putative
Species:
Leishmania donovani
UniProt:
A0A3S7X9W6_LEIDO
TriTrypDb:
LdBPK_353740.1 * , LdCL_350042400 , LDHU3_35.4900
Length:
253

Annotations

LeishMANIAdb annotations

Publication identifier(s): 11260462
A known glcosomal (peroxisomal) kinetoplastid protein. Known to be a dimeric, essential component of glycosomes (PMID: 11260462). Localization: Peroxisomal (experimental)

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 4
Forrest at al. (procyclic) no yes: 4
Silverman et al. no yes: 0
Pissara et al. no yes: 15
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 5
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 10
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 20
NetGPI no yes: 0, no: 20
Cellular components
Term Name Level Count
GO:0016020 membrane 2 2
GO:0110165 cellular anatomical entity 1 3
GO:0005777 peroxisome 6 1
GO:0020015 glycosome 7 1
GO:0042579 microbody 5 1
GO:0043226 organelle 2 1
GO:0043227 membrane-bounded organelle 3 1
GO:0043229 intracellular organelle 3 1
GO:0043231 intracellular membrane-bounded organelle 4 1

Expansion

Sequence features

A0A3S7X9W6
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7X9W6

Function

Biological processes
Term Name Level Count
GO:0006996 organelle organization 4 18
GO:0009987 cellular process 1 18
GO:0016043 cellular component organization 3 18
GO:0016559 peroxisome fission 6 18
GO:0048285 organelle fission 5 18
GO:0071840 cellular component organization or biogenesis 2 18
Could not find GO molecular_function term for this entry.

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_NRD_NRD_1 177 179 PF00675 0.281
CLV_PCSK_KEX2_1 177 179 PF00082 0.276
CLV_PCSK_SKI1_1 137 141 PF00082 0.421
CLV_PCSK_SKI1_1 178 182 PF00082 0.262
CLV_PCSK_SKI1_1 64 68 PF00082 0.447
DEG_SPOP_SBC_1 230 234 PF00917 0.351
DOC_CDC14_PxL_1 73 81 PF14671 0.345
DOC_CYCLIN_yCln2_LP_2 224 230 PF00134 0.402
DOC_CYCLIN_yCln2_LP_2 37 43 PF00134 0.276
DOC_MAPK_gen_1 174 183 PF00069 0.451
DOC_MAPK_gen_1 23 32 PF00069 0.468
DOC_PP1_RVXF_1 133 139 PF00149 0.345
DOC_PP2B_LxvP_1 224 227 PF13499 0.532
DOC_PP2B_LxvP_1 37 40 PF13499 0.231
DOC_USP7_MATH_1 2 6 PF00917 0.679
DOC_USP7_MATH_1 211 215 PF00917 0.453
DOC_WW_Pin1_4 231 236 PF00397 0.453
DOC_WW_Pin1_4 77 82 PF00397 0.264
LIG_14-3-3_CanoR_1 25 30 PF00244 0.546
LIG_14-3-3_CanoR_1 68 75 PF00244 0.255
LIG_14-3-3_CanoR_1 9 17 PF00244 0.434
LIG_Actin_WH2_2 142 159 PF00022 0.377
LIG_Actin_WH2_2 184 200 PF00022 0.360
LIG_BRCT_BRCA1_1 102 106 PF00533 0.278
LIG_BRCT_BRCA1_1 49 53 PF00533 0.202
LIG_FHA_1 106 112 PF00498 0.296
LIG_FHA_1 5 11 PF00498 0.573
LIG_LIR_Gen_1 104 112 PF02991 0.345
LIG_LIR_Gen_1 158 166 PF02991 0.544
LIG_LIR_Gen_1 50 61 PF02991 0.314
LIG_LIR_Gen_1 70 79 PF02991 0.224
LIG_LIR_LC3C_4 70 75 PF02991 0.347
LIG_LIR_Nem_3 103 109 PF02991 0.370
LIG_LIR_Nem_3 11 16 PF02991 0.479
LIG_LIR_Nem_3 158 164 PF02991 0.544
LIG_LIR_Nem_3 50 56 PF02991 0.274
LIG_LIR_Nem_3 70 75 PF02991 0.238
LIG_MYND_1 77 81 PF01753 0.333
LIG_PDZ_Class_1 248 253 PF00595 0.494
LIG_Pex14_2 106 110 PF04695 0.288
LIG_Pex14_2 129 133 PF04695 0.334
LIG_Pex14_2 138 142 PF04695 0.369
LIG_SH2_CRK 161 165 PF00017 0.440
LIG_SH2_CRK 194 198 PF00017 0.600
LIG_SH2_CRK 63 67 PF00017 0.260
LIG_SH2_STAT5 153 156 PF00017 0.487
LIG_SH2_STAT5 16 19 PF00017 0.477
LIG_SH2_STAT5 194 197 PF00017 0.570
LIG_SH2_STAT5 207 210 PF00017 0.459
LIG_SH3_3 199 205 PF00018 0.468
LIG_SH3_3 71 77 PF00018 0.360
MOD_CK2_1 164 170 PF00069 0.521
MOD_GlcNHglycan 199 202 PF01048 0.703
MOD_GlcNHglycan 208 211 PF01048 0.673
MOD_GlcNHglycan 213 216 PF01048 0.659
MOD_GlcNHglycan 48 52 PF01048 0.511
MOD_GlcNHglycan 81 84 PF01048 0.517
MOD_GSK3_1 101 108 PF00069 0.357
MOD_GSK3_1 192 199 PF00069 0.602
MOD_GSK3_1 4 11 PF00069 0.655
MOD_GSK3_1 79 86 PF00069 0.293
MOD_LATS_1 62 68 PF00433 0.240
MOD_N-GLC_1 18 23 PF02516 0.286
MOD_N-GLC_1 2 7 PF02516 0.498
MOD_NEK2_1 141 146 PF00069 0.411
MOD_NEK2_1 155 160 PF00069 0.499
MOD_NEK2_1 192 197 PF00069 0.280
MOD_NEK2_1 229 234 PF00069 0.394
MOD_NEK2_1 241 246 PF00069 0.411
MOD_NEK2_1 248 253 PF00069 0.422
MOD_NEK2_2 105 110 PF00069 0.345
MOD_PIKK_1 164 170 PF00454 0.529
MOD_PIKK_1 4 10 PF00454 0.567
MOD_PIKK_1 67 73 PF00454 0.358
MOD_PK_1 25 31 PF00069 0.545
MOD_PKA_2 67 73 PF00069 0.255
MOD_PKA_2 8 14 PF00069 0.408
MOD_PKB_1 23 31 PF00069 0.545
MOD_Plk_1 2 8 PF00069 0.676
MOD_Plk_4 187 193 PF00069 0.316
MOD_Plk_4 25 31 PF00069 0.533
MOD_Plk_4 33 39 PF00069 0.199
MOD_Plk_4 52 58 PF00069 0.311
MOD_Plk_4 83 89 PF00069 0.281
MOD_ProDKin_1 231 237 PF00069 0.451
MOD_ProDKin_1 77 83 PF00069 0.264
MOD_SUMO_rev_2 166 173 PF00179 0.476
TRG_ENDOCYTIC_2 153 156 PF00928 0.488
TRG_ENDOCYTIC_2 161 164 PF00928 0.468
TRG_ENDOCYTIC_2 194 197 PF00928 0.567
TRG_ENDOCYTIC_2 63 66 PF00928 0.260
TRG_ER_diArg_1 135 138 PF00400 0.348

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N0P4J0 Leptomonas seymouri 72% 100%
A0A0N1IJQ7 Leptomonas seymouri 25% 100%
A0A1X0P585 Trypanosomatidae 28% 100%
A0A1X0P5I2 Trypanosomatidae 27% 100%
A0A3Q8IVG4 Leishmania donovani 26% 94%
A0A3R7K892 Trypanosoma rangeli 25% 100%
A0A3R7MWK0 Trypanosoma rangeli 26% 100%
A4HN40 Leishmania braziliensis 83% 100%
A4HN41 Leishmania braziliensis 25% 96%
A4IBQ8 Leishmania infantum 99% 100%
A4IBQ9 Leishmania infantum 26% 94%
C9ZYW5 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 29% 100%
C9ZYW6 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 29% 100%
C9ZYW7 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 24% 100%
E9AFJ3 Leishmania major 93% 100%
E9AFJ4 Leishmania major 26% 95%
E9B6P7 Leishmania mexicana (strain MHOM/GT/2001/U1103) 92% 100%
E9B6P8 Leishmania mexicana (strain MHOM/GT/2001/U1103) 25% 94%
V5BTC6 Trypanosoma cruzi 29% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2024 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS