Hypothetical_protein_conserved

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

conserved hypothetical protein

Species:

Leishmania donovani

UniProt:

A0A3S7X9W4_LEIDO

TriTrypDb:

LdBPK_354190.1 , LdCL_350047000 , LDHU3_35.5410

Length:

585

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S7X9W4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7X9W4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	152	156	PF00656	0.617
CLV_C14_Caspase3-7	518	522	PF00656	0.564
CLV_NRD_NRD_1	172	174	PF00675	0.633
CLV_NRD_NRD_1	204	206	PF00675	0.685
CLV_NRD_NRD_1	240	242	PF00675	0.704
CLV_NRD_NRD_1	273	275	PF00675	0.578
CLV_NRD_NRD_1	429	431	PF00675	0.658
CLV_NRD_NRD_1	433	435	PF00675	0.674
CLV_NRD_NRD_1	66	68	PF00675	0.729
CLV_PCSK_KEX2_1	172	174	PF00082	0.693
CLV_PCSK_KEX2_1	204	206	PF00082	0.685
CLV_PCSK_KEX2_1	240	242	PF00082	0.704
CLV_PCSK_KEX2_1	273	275	PF00082	0.578
CLV_PCSK_KEX2_1	290	292	PF00082	0.609
CLV_PCSK_KEX2_1	487	489	PF00082	0.675
CLV_PCSK_KEX2_1	66	68	PF00082	0.736
CLV_PCSK_PC1ET2_1	290	292	PF00082	0.609
CLV_PCSK_PC1ET2_1	487	489	PF00082	0.659
CLV_PCSK_SKI1_1	193	197	PF00082	0.587
CLV_PCSK_SKI1_1	205	209	PF00082	0.697
CLV_PCSK_SKI1_1	340	344	PF00082	0.592
CLV_PCSK_SKI1_1	430	434	PF00082	0.604
DEG_SCF_FBW7_2	43	50	PF00400	0.667
DEG_SPOP_SBC_1	104	108	PF00917	0.646
DEG_SPOP_SBC_1	299	303	PF00917	0.630
DOC_CKS1_1	139	144	PF01111	0.663
DOC_CKS1_1	197	202	PF01111	0.633
DOC_PP2B_LxvP_1	330	333	PF13499	0.716
DOC_PP4_FxxP_1	524	527	PF00568	0.623
DOC_USP7_MATH_1	180	184	PF00917	0.626
DOC_USP7_MATH_1	214	218	PF00917	0.633
DOC_USP7_MATH_1	248	252	PF00917	0.768
DOC_USP7_MATH_1	28	32	PF00917	0.632
DOC_USP7_MATH_1	333	337	PF00917	0.601
DOC_USP7_MATH_1	424	428	PF00917	0.622
DOC_USP7_MATH_1	492	496	PF00917	0.633
DOC_USP7_MATH_1	501	505	PF00917	0.647
DOC_USP7_MATH_1	509	513	PF00917	0.583
DOC_USP7_MATH_1	60	64	PF00917	0.660
DOC_USP7_UBL2_3	431	435	PF12436	0.691
DOC_WW_Pin1_4	138	143	PF00397	0.679
DOC_WW_Pin1_4	196	201	PF00397	0.686
DOC_WW_Pin1_4	224	229	PF00397	0.675
DOC_WW_Pin1_4	235	240	PF00397	0.724
DOC_WW_Pin1_4	301	306	PF00397	0.756
DOC_WW_Pin1_4	322	327	PF00397	0.688
DOC_WW_Pin1_4	347	352	PF00397	0.671
DOC_WW_Pin1_4	41	46	PF00397	0.758
DOC_WW_Pin1_4	481	486	PF00397	0.598
DOC_WW_Pin1_4	523	528	PF00397	0.676
DOC_WW_Pin1_4	533	538	PF00397	0.616
DOC_WW_Pin1_4	56	61	PF00397	0.606
DOC_WW_Pin1_4	564	569	PF00397	0.634
LIG_14-3-3_CanoR_1	12	17	PF00244	0.660
LIG_14-3-3_CanoR_1	193	198	PF00244	0.598
LIG_14-3-3_CanoR_1	204	214	PF00244	0.642
LIG_14-3-3_CanoR_1	247	253	PF00244	0.695
LIG_14-3-3_CanoR_1	256	261	PF00244	0.606
LIG_14-3-3_CanoR_1	278	288	PF00244	0.697
LIG_14-3-3_CanoR_1	37	45	PF00244	0.683
LIG_14-3-3_CanoR_1	488	494	PF00244	0.777
LIG_14-3-3_CanoR_1	54	60	PF00244	0.631
LIG_14-3-3_CanoR_1	561	567	PF00244	0.647
LIG_14-3-3_CanoR_1	580	584	PF00244	0.648
LIG_14-3-3_CanoR_1	79	85	PF00244	0.619
LIG_Actin_WH2_2	190	206	PF00022	0.577
LIG_BIR_II_1	1	5	PF00653	0.643
LIG_EVH1_2	449	453	PF00568	0.685
LIG_FHA_1	105	111	PF00498	0.691
LIG_FHA_1	118	124	PF00498	0.518
LIG_FHA_1	337	343	PF00498	0.676
LIG_FHA_1	431	437	PF00498	0.691
LIG_FHA_1	572	578	PF00498	0.655
LIG_FHA_2	568	574	PF00498	0.598
LIG_LIR_Apic_2	521	527	PF02991	0.590
LIG_LIR_Gen_1	127	138	PF02991	0.545
LIG_LIR_Gen_1	192	202	PF02991	0.577
LIG_LIR_Gen_1	311	319	PF02991	0.627
LIG_LIR_Gen_1	46	56	PF02991	0.665
LIG_LIR_Gen_1	570	577	PF02991	0.603
LIG_LIR_Nem_3	127	133	PF02991	0.562
LIG_LIR_Nem_3	311	316	PF02991	0.631
LIG_LIR_Nem_3	46	51	PF02991	0.706
LIG_LIR_Nem_3	570	575	PF02991	0.704
LIG_PDZ_Class_2	580	585	PF00595	0.649
LIG_Pex14_2	524	528	PF04695	0.587
LIG_PTAP_UEV_1	306	311	PF05743	0.620
LIG_SH2_CRK	313	317	PF00017	0.632
LIG_SH2_NCK_1	249	253	PF00017	0.698
LIG_SH2_NCK_1	313	317	PF00017	0.632
LIG_SH2_STAP1	313	317	PF00017	0.632
LIG_SH3_2	236	241	PF14604	0.625
LIG_SH3_2	482	487	PF14604	0.609
LIG_SH3_3	111	117	PF00018	0.718
LIG_SH3_3	174	180	PF00018	0.772
LIG_SH3_3	233	239	PF00018	0.635
LIG_SH3_3	269	275	PF00018	0.760
LIG_SH3_3	304	310	PF00018	0.606
LIG_SH3_3	446	452	PF00018	0.648
LIG_SH3_3	476	482	PF00018	0.594
LIG_SH3_3	547	553	PF00018	0.625
LIG_SUMO_SIM_par_1	441	446	PF11976	0.555
LIG_SUMO_SIM_par_1	573	578	PF11976	0.612
LIG_WRC_WIRS_1	463	468	PF05994	0.592
MOD_CDC14_SPxK_1	238	241	PF00782	0.703
MOD_CDC14_SPxK_1	484	487	PF00782	0.607
MOD_CDK_SPK_2	235	240	PF00069	0.701
MOD_CDK_SPK_2	347	352	PF00069	0.704
MOD_CDK_SPK_2	564	569	PF00069	0.617
MOD_CDK_SPxK_1	235	241	PF00069	0.701
MOD_CDK_SPxK_1	481	487	PF00069	0.606
MOD_CDK_SPxxK_3	481	488	PF00069	0.606
MOD_CDK_SPxxK_3	523	530	PF00069	0.617
MOD_CK1_1	102	108	PF00069	0.637
MOD_CK1_1	124	130	PF00069	0.692
MOD_CK1_1	149	155	PF00069	0.660
MOD_CK1_1	15	21	PF00069	0.614
MOD_CK1_1	156	162	PF00069	0.612
MOD_CK1_1	183	189	PF00069	0.618
MOD_CK1_1	255	261	PF00069	0.632
MOD_CK1_1	294	300	PF00069	0.657
MOD_CK1_1	301	307	PF00069	0.654
MOD_CK1_1	31	37	PF00069	0.820
MOD_CK1_1	336	342	PF00069	0.694
MOD_CK1_1	346	352	PF00069	0.682
MOD_CK1_1	465	471	PF00069	0.559
MOD_CK1_1	473	479	PF00069	0.566
MOD_CK1_1	535	541	PF00069	0.623
MOD_CK1_1	567	573	PF00069	0.619
MOD_CK1_1	62	68	PF00069	0.649
MOD_CK2_1	226	232	PF00069	0.621
MOD_GlcNHglycan	1	4	PF01048	0.595
MOD_GlcNHglycan	125	129	PF01048	0.616
MOD_GlcNHglycan	134	137	PF01048	0.670
MOD_GlcNHglycan	149	152	PF01048	0.585
MOD_GlcNHglycan	168	171	PF01048	0.607
MOD_GlcNHglycan	216	219	PF01048	0.677
MOD_GlcNHglycan	244	247	PF01048	0.653
MOD_GlcNHglycan	250	253	PF01048	0.597
MOD_GlcNHglycan	293	296	PF01048	0.659
MOD_GlcNHglycan	352	355	PF01048	0.746
MOD_GlcNHglycan	380	383	PF01048	0.729
MOD_GlcNHglycan	393	396	PF01048	0.613
MOD_GlcNHglycan	418	421	PF01048	0.629
MOD_GlcNHglycan	472	475	PF01048	0.654
MOD_GlcNHglycan	494	497	PF01048	0.575
MOD_GlcNHglycan	503	506	PF01048	0.612
MOD_GlcNHglycan	577	580	PF01048	0.584
MOD_GlcNHglycan	93	96	PF01048	0.701
MOD_GSK3_1	117	124	PF00069	0.619
MOD_GSK3_1	12	19	PF00069	0.657
MOD_GSK3_1	149	156	PF00069	0.623
MOD_GSK3_1	157	164	PF00069	0.663
MOD_GSK3_1	180	187	PF00069	0.639
MOD_GSK3_1	189	196	PF00069	0.560
MOD_GSK3_1	214	221	PF00069	0.572
MOD_GSK3_1	222	229	PF00069	0.622
MOD_GSK3_1	248	255	PF00069	0.654
MOD_GSK3_1	290	297	PF00069	0.711
MOD_GSK3_1	299	306	PF00069	0.672
MOD_GSK3_1	31	38	PF00069	0.664
MOD_GSK3_1	342	349	PF00069	0.685
MOD_GSK3_1	389	396	PF00069	0.674
MOD_GSK3_1	397	404	PF00069	0.603
MOD_GSK3_1	426	433	PF00069	0.712
MOD_GSK3_1	488	495	PF00069	0.638
MOD_GSK3_1	544	551	PF00069	0.626
MOD_GSK3_1	55	62	PF00069	0.769
MOD_GSK3_1	560	567	PF00069	0.621
MOD_GSK3_1	571	578	PF00069	0.615
MOD_GSK3_1	98	105	PF00069	0.712
MOD_LATS_1	414	420	PF00433	0.565
MOD_N-GLC_1	147	152	PF02516	0.690
MOD_N-GLC_1	16	21	PF02516	0.624
MOD_N-GLC_1	389	394	PF02516	0.632
MOD_NEK2_1	146	151	PF00069	0.644
MOD_NEK2_1	203	208	PF00069	0.682
MOD_NEK2_1	279	284	PF00069	0.746
MOD_NEK2_1	342	347	PF00069	0.701
MOD_NEK2_1	393	398	PF00069	0.616
MOD_NEK2_1	453	458	PF00069	0.597
MOD_NEK2_1	575	580	PF00069	0.584
MOD_PIKK_1	16	22	PF00454	0.653
MOD_PIKK_1	180	186	PF00454	0.625
MOD_PIKK_1	218	224	PF00454	0.691
MOD_PIKK_1	366	372	PF00454	0.643
MOD_PIKK_1	73	79	PF00454	0.670
MOD_PK_1	12	18	PF00069	0.598
MOD_PK_1	256	262	PF00069	0.605
MOD_PK_1	515	521	PF00069	0.605
MOD_PKA_1	290	296	PF00069	0.604
MOD_PKA_1	430	436	PF00069	0.689
MOD_PKA_1	487	493	PF00069	0.611
MOD_PKA_2	161	167	PF00069	0.698
MOD_PKA_2	180	186	PF00069	0.625
MOD_PKA_2	203	209	PF00069	0.627
MOD_PKA_2	255	261	PF00069	0.622
MOD_PKA_2	290	296	PF00069	0.644
MOD_PKA_2	31	37	PF00069	0.662
MOD_PKA_2	38	44	PF00069	0.660
MOD_PKA_2	400	406	PF00069	0.656
MOD_PKA_2	487	493	PF00069	0.780
MOD_PKA_2	509	515	PF00069	0.616
MOD_PKA_2	560	566	PF00069	0.648
MOD_PKA_2	579	585	PF00069	0.574
MOD_PKA_2	65	71	PF00069	0.719
MOD_Plk_1	389	395	PF00069	0.634
MOD_Plk_4	80	86	PF00069	0.644
MOD_ProDKin_1	138	144	PF00069	0.680
MOD_ProDKin_1	196	202	PF00069	0.682
MOD_ProDKin_1	224	230	PF00069	0.674
MOD_ProDKin_1	235	241	PF00069	0.724
MOD_ProDKin_1	301	307	PF00069	0.755
MOD_ProDKin_1	322	328	PF00069	0.693
MOD_ProDKin_1	347	353	PF00069	0.670
MOD_ProDKin_1	41	47	PF00069	0.755
MOD_ProDKin_1	481	487	PF00069	0.600
MOD_ProDKin_1	523	529	PF00069	0.676
MOD_ProDKin_1	533	539	PF00069	0.619
MOD_ProDKin_1	56	62	PF00069	0.605
MOD_ProDKin_1	564	570	PF00069	0.631
TRG_DiLeu_BaLyEn_6	114	119	PF01217	0.623
TRG_DiLeu_BaLyEn_6	338	343	PF01217	0.594
TRG_DiLeu_BaLyEn_6	459	464	PF01217	0.601
TRG_ENDOCYTIC_2	130	133	PF00928	0.683
TRG_ENDOCYTIC_2	313	316	PF00928	0.635
TRG_ER_diArg_1	11	14	PF00400	0.612
TRG_ER_diArg_1	172	175	PF00400	0.598
TRG_ER_diArg_1	203	205	PF00400	0.685
TRG_ER_diArg_1	239	241	PF00400	0.759
TRG_ER_diArg_1	272	274	PF00400	0.583
TRG_ER_diArg_1	360	363	PF00400	0.704
TRG_Pf-PMV_PEXEL_1	434	439	PF00026	0.609

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I3V4	Leptomonas seymouri	37%	100%
A4HN84	Leishmania braziliensis	64%	100%
A4IBV2	Leishmania infantum	100%	100%
E9AFN9	Leishmania major	89%	100%
E9B6U2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	100%