ATP-dependent_RNA_helicase_putative/GeneDB:LmjF.3 5.4030

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

ATP-dependent RNA helicase, putative

Species:

Leishmania donovani

UniProt:

A0A3S7X9W0_LEIDO

TriTrypDb:

LdBPK_354080.1 , LdCL_350045900 , LDHU3_35.5300

Length:

690

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005730	nucleolus	5	1
GO:0043226	organelle	2	1
GO:0043228	non-membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043232	intracellular non-membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	2
GO:0016020	membrane	2	1

Expansion

Sequence features

A0A3S7X9W0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7X9W0

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	12
GO:0003676	nucleic acid binding	3	12
GO:0003723	RNA binding	4	11
GO:0003824	catalytic activity	1	12
GO:0004386	helicase activity	2	12
GO:0005488	binding	1	12
GO:0005524	ATP binding	5	12
GO:0016787	hydrolase activity	2	12
GO:0017076	purine nucleotide binding	4	12
GO:0030554	adenyl nucleotide binding	5	12
GO:0032553	ribonucleotide binding	3	12
GO:0032555	purine ribonucleotide binding	4	12
GO:0032559	adenyl ribonucleotide binding	5	12
GO:0035639	purine ribonucleoside triphosphate binding	4	12
GO:0036094	small molecule binding	2	12
GO:0043167	ion binding	2	12
GO:0043168	anion binding	3	12
GO:0097159	organic cyclic compound binding	2	12
GO:0097367	carbohydrate derivative binding	2	12
GO:0140640	catalytic activity, acting on a nucleic acid	2	12
GO:0140657	ATP-dependent activity	1	12
GO:1901265	nucleoside phosphate binding	3	12
GO:1901363	heterocyclic compound binding	2	12

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	304	308	PF00656	0.510
CLV_C14_Caspase3-7	412	416	PF00656	0.439
CLV_C14_Caspase3-7	601	605	PF00656	0.757
CLV_NRD_NRD_1	202	204	PF00675	0.255
CLV_NRD_NRD_1	427	429	PF00675	0.565
CLV_NRD_NRD_1	438	440	PF00675	0.455
CLV_NRD_NRD_1	453	455	PF00675	0.533
CLV_NRD_NRD_1	456	458	PF00675	0.523
CLV_NRD_NRD_1	477	479	PF00675	0.589
CLV_NRD_NRD_1	495	497	PF00675	0.401
CLV_NRD_NRD_1	652	654	PF00675	0.659
CLV_NRD_NRD_1	679	681	PF00675	0.565
CLV_NRD_NRD_1	686	688	PF00675	0.544
CLV_PCSK_FUR_1	454	458	PF00082	0.644
CLV_PCSK_FUR_1	579	583	PF00082	0.568
CLV_PCSK_KEX2_1	196	198	PF00082	0.249
CLV_PCSK_KEX2_1	202	204	PF00082	0.249
CLV_PCSK_KEX2_1	320	322	PF00082	0.260
CLV_PCSK_KEX2_1	330	332	PF00082	0.260
CLV_PCSK_KEX2_1	427	429	PF00082	0.533
CLV_PCSK_KEX2_1	438	440	PF00082	0.512
CLV_PCSK_KEX2_1	453	455	PF00082	0.525
CLV_PCSK_KEX2_1	456	458	PF00082	0.489
CLV_PCSK_KEX2_1	477	479	PF00082	0.641
CLV_PCSK_KEX2_1	495	497	PF00082	0.363
CLV_PCSK_KEX2_1	554	556	PF00082	0.587
CLV_PCSK_KEX2_1	581	583	PF00082	0.517
CLV_PCSK_KEX2_1	606	608	PF00082	0.653
CLV_PCSK_KEX2_1	652	654	PF00082	0.604
CLV_PCSK_KEX2_1	98	100	PF00082	0.333
CLV_PCSK_PC1ET2_1	196	198	PF00082	0.260
CLV_PCSK_PC1ET2_1	320	322	PF00082	0.260
CLV_PCSK_PC1ET2_1	330	332	PF00082	0.260
CLV_PCSK_PC1ET2_1	438	440	PF00082	0.527
CLV_PCSK_PC1ET2_1	477	479	PF00082	0.648
CLV_PCSK_PC1ET2_1	554	556	PF00082	0.587
CLV_PCSK_PC1ET2_1	581	583	PF00082	0.556
CLV_PCSK_PC1ET2_1	606	608	PF00082	0.653
CLV_PCSK_PC1ET2_1	98	100	PF00082	0.333
CLV_PCSK_PC7_1	326	332	PF00082	0.307
CLV_PCSK_SKI1_1	129	133	PF00082	0.257
CLV_PCSK_SKI1_1	2	6	PF00082	0.455
CLV_PCSK_SKI1_1	213	217	PF00082	0.307
CLV_PCSK_SKI1_1	326	330	PF00082	0.260
CLV_PCSK_SKI1_1	333	337	PF00082	0.260
CLV_PCSK_SKI1_1	428	432	PF00082	0.621
CLV_PCSK_SKI1_1	474	478	PF00082	0.620
CLV_PCSK_SKI1_1	479	483	PF00082	0.537
CLV_PCSK_SKI1_1	525	529	PF00082	0.301
CLV_PCSK_SKI1_1	603	607	PF00082	0.657
CLV_PCSK_SKI1_1	620	624	PF00082	0.593
CLV_PCSK_SKI1_1	98	102	PF00082	0.260
DEG_APCC_DBOX_1	187	195	PF00400	0.535
DEG_Nend_UBRbox_1	1	4	PF02207	0.542
DOC_CKS1_1	147	152	PF01111	0.449
DOC_CYCLIN_RxL_1	422	434	PF00134	0.633
DOC_CYCLIN_RxL_1	96	107	PF00134	0.490
DOC_MAPK_DCC_7	344	353	PF00069	0.460
DOC_MAPK_gen_1	276	284	PF00069	0.445
DOC_MAPK_gen_1	330	337	PF00069	0.470
DOC_MAPK_gen_1	375	385	PF00069	0.524
DOC_MAPK_gen_1	554	563	PF00069	0.491
DOC_MAPK_gen_1	612	621	PF00069	0.558
DOC_MAPK_HePTP_8	341	353	PF00069	0.460
DOC_MAPK_MEF2A_6	224	233	PF00069	0.429
DOC_MAPK_MEF2A_6	276	284	PF00069	0.435
DOC_MAPK_MEF2A_6	344	353	PF00069	0.460
DOC_MAPK_MEF2A_6	5	13	PF00069	0.435
DOC_MAPK_MEF2A_6	554	563	PF00069	0.434
DOC_PP1_RVXF_1	179	186	PF00149	0.449
DOC_PP1_RVXF_1	265	272	PF00149	0.474
DOC_PP1_RVXF_1	379	386	PF00149	0.439
DOC_PP1_RVXF_1	97	104	PF00149	0.470
DOC_PP2B_LxvP_1	346	349	PF13499	0.449
DOC_PP2B_LxvP_1	559	562	PF13499	0.406
DOC_PP2B_LxvP_1	82	85	PF13499	0.554
DOC_PP4_FxxP_1	385	388	PF00568	0.337
DOC_PP4_FxxP_1	545	548	PF00568	0.301
DOC_USP7_MATH_1	487	491	PF00917	0.485
DOC_USP7_MATH_1	511	515	PF00917	0.313
DOC_USP7_UBL2_3	196	200	PF12436	0.430
DOC_USP7_UBL2_3	664	668	PF12436	0.424
DOC_WW_Pin1_4	109	114	PF00397	0.554
DOC_WW_Pin1_4	146	151	PF00397	0.449
DOC_WW_Pin1_4	485	490	PF00397	0.390
LIG_14-3-3_CanoR_1	224	230	PF00244	0.415
LIG_14-3-3_CanoR_1	232	237	PF00244	0.527
LIG_14-3-3_CanoR_1	260	268	PF00244	0.298
LIG_14-3-3_CanoR_1	378	384	PF00244	0.503
LIG_14-3-3_CanoR_1	427	431	PF00244	0.585
LIG_14-3-3_CanoR_1	510	516	PF00244	0.301
LIG_14-3-3_CanoR_1	607	616	PF00244	0.591
LIG_BRCT_BRCA1_1	252	256	PF00533	0.394
LIG_BRCT_BRCA1_1	381	385	PF00533	0.376
LIG_Clathr_ClatBox_1	173	177	PF01394	0.460
LIG_FHA_1	210	216	PF00498	0.460
LIG_FHA_1	228	234	PF00498	0.465
LIG_FHA_1	28	34	PF00498	0.449
LIG_FHA_2	34	40	PF00498	0.535
LIG_LIR_Apic_2	382	388	PF02991	0.342
LIG_LIR_Apic_2	51	57	PF02991	0.449
LIG_LIR_Gen_1	169	179	PF02991	0.458
LIG_LIR_Gen_1	291	301	PF02991	0.490
LIG_LIR_Gen_1	36	45	PF02991	0.535
LIG_LIR_Gen_1	390	399	PF02991	0.388
LIG_LIR_Gen_1	539	548	PF02991	0.295
LIG_LIR_Gen_1	644	651	PF02991	0.638
LIG_LIR_Nem_3	121	125	PF02991	0.533
LIG_LIR_Nem_3	169	174	PF02991	0.458
LIG_LIR_Nem_3	253	258	PF02991	0.473
LIG_LIR_Nem_3	291	297	PF02991	0.490
LIG_LIR_Nem_3	36	41	PF02991	0.535
LIG_LIR_Nem_3	390	396	PF02991	0.361
LIG_LIR_Nem_3	539	545	PF02991	0.303
LIG_LIR_Nem_3	565	570	PF02991	0.490
LIG_MLH1_MIPbox_1	252	256	PF16413	0.394
LIG_NRBOX	152	158	PF00104	0.460
LIG_NRBOX	190	196	PF00104	0.526
LIG_NRBOX	58	64	PF00104	0.510
LIG_NRBOX	637	643	PF00104	0.627
LIG_NRP_CendR_1	687	690	PF00754	0.599
LIG_PCNA_yPIPBox_3	629	642	PF02747	0.531
LIG_PTB_Apo_2	73	80	PF02174	0.526
LIG_Rb_LxCxE_1	51	73	PF01857	0.474
LIG_SH2_CRK	357	361	PF00017	0.460
LIG_SH2_CRK	38	42	PF00017	0.514
LIG_SH2_GRB2like	393	396	PF00017	0.469
LIG_SH2_SRC	357	360	PF00017	0.449
LIG_SH2_SRC	54	57	PF00017	0.510
LIG_SH2_STAP1	154	158	PF00017	0.449
LIG_SH2_STAP1	38	42	PF00017	0.472
LIG_SH2_STAT3	120	123	PF00017	0.449
LIG_SH2_STAT3	526	529	PF00017	0.317
LIG_SH2_STAT5	125	128	PF00017	0.461
LIG_SH2_STAT5	283	286	PF00017	0.446
LIG_SH2_STAT5	393	396	PF00017	0.360
LIG_SH2_STAT5	526	529	PF00017	0.317
LIG_SH2_STAT5	54	57	PF00017	0.449
LIG_SH2_STAT5	647	650	PF00017	0.487
LIG_SH3_1	357	363	PF00018	0.460
LIG_SH3_3	144	150	PF00018	0.510
LIG_SH3_3	243	249	PF00018	0.470
LIG_SH3_3	357	363	PF00018	0.460
LIG_SUMO_SIM_anti_2	172	178	PF11976	0.460
LIG_SUMO_SIM_par_1	172	178	PF11976	0.460
LIG_SUMO_SIM_par_1	225	230	PF11976	0.446
LIG_SUMO_SIM_par_1	531	537	PF11976	0.317
LIG_SUMO_SIM_par_1	80	86	PF11976	0.474
LIG_TRAF2_1	585	588	PF00917	0.615
LIG_TRAF2_2	403	408	PF00917	0.477
LIG_TYR_ITSM	34	41	PF00017	0.422
LIG_UBA3_1	173	181	PF00899	0.336
LIG_UBA3_1	194	200	PF00899	0.271
LIG_UBA3_1	621	626	PF00899	0.667
LIG_WRC_WIRS_1	512	517	PF05994	0.301
MOD_CDK_SPxK_1	146	152	PF00069	0.301
MOD_CK1_1	235	241	PF00069	0.517
MOD_CK1_1	379	385	PF00069	0.465
MOD_CK1_1	48	54	PF00069	0.301
MOD_CK1_1	627	633	PF00069	0.662
MOD_CK1_1	673	679	PF00069	0.605
MOD_CK1_1	7	13	PF00069	0.420
MOD_CK2_1	166	172	PF00069	0.336
MOD_CK2_1	449	455	PF00069	0.583
MOD_CK2_1	622	628	PF00069	0.515
MOD_CK2_1	673	679	PF00069	0.500
MOD_GlcNHglycan	207	210	PF01048	0.301
MOD_GlcNHglycan	237	240	PF01048	0.544
MOD_GlcNHglycan	297	300	PF01048	0.371
MOD_GlcNHglycan	378	381	PF01048	0.522
MOD_GlcNHglycan	47	50	PF01048	0.301
MOD_GlcNHglycan	587	592	PF01048	0.581
MOD_GlcNHglycan	675	678	PF01048	0.590
MOD_GSK3_1	201	208	PF00069	0.301
MOD_GSK3_1	209	216	PF00069	0.301
MOD_GSK3_1	426	433	PF00069	0.533
MOD_GSK3_1	583	590	PF00069	0.656
MOD_N-GLC_1	109	114	PF02516	0.408
MOD_NEK2_1	156	161	PF00069	0.332
MOD_NEK2_1	166	171	PF00069	0.301
MOD_NEK2_1	18	23	PF00069	0.491
MOD_NEK2_1	207	212	PF00069	0.301
MOD_NEK2_1	256	261	PF00069	0.399
MOD_NEK2_1	271	276	PF00069	0.288
MOD_NEK2_1	33	38	PF00069	0.386
MOD_NEK2_1	376	381	PF00069	0.576
MOD_NEK2_1	622	627	PF00069	0.585
MOD_NEK2_1	642	647	PF00069	0.312
MOD_PIKK_1	166	172	PF00454	0.448
MOD_PIKK_1	207	213	PF00454	0.301
MOD_PIKK_1	259	265	PF00454	0.340
MOD_PIKK_1	469	475	PF00454	0.638
MOD_PKA_2	201	207	PF00069	0.301
MOD_PKA_2	259	265	PF00069	0.354
MOD_PKA_2	410	416	PF00069	0.473
MOD_PKA_2	426	432	PF00069	0.519
MOD_PKA_2	583	589	PF00069	0.534
MOD_Plk_1	670	676	PF00069	0.592
MOD_Plk_2-3	410	416	PF00069	0.523
MOD_Plk_4	362	368	PF00069	0.301
MOD_Plk_4	379	385	PF00069	0.375
MOD_Plk_4	487	493	PF00069	0.395
MOD_Plk_4	511	517	PF00069	0.301
MOD_Plk_4	642	648	PF00069	0.507
MOD_Plk_4	670	676	PF00069	0.574
MOD_ProDKin_1	109	115	PF00069	0.448
MOD_ProDKin_1	146	152	PF00069	0.301
MOD_ProDKin_1	485	491	PF00069	0.384
MOD_SUMO_for_1	316	319	PF00179	0.317
MOD_SUMO_for_1	648	651	PF00179	0.492
MOD_SUMO_rev_2	274	281	PF00179	0.307
MOD_SUMO_rev_2	673	683	PF00179	0.519
MOD_SUMO_rev_2	69	77	PF00179	0.321
TRG_DiLeu_BaEn_1	178	183	PF01217	0.301
TRG_DiLeu_BaEn_1	617	622	PF01217	0.636
TRG_DiLeu_BaEn_1	637	642	PF01217	0.325
TRG_DiLeu_BaEn_2	391	397	PF01217	0.403
TRG_DiLeu_BaEn_2	565	571	PF01217	0.510
TRG_ENDOCYTIC_2	154	157	PF00928	0.301
TRG_ENDOCYTIC_2	294	297	PF00928	0.358
TRG_ENDOCYTIC_2	38	41	PF00928	0.353
TRG_ENDOCYTIC_2	393	396	PF00928	0.360
TRG_ENDOCYTIC_2	647	650	PF00928	0.633
TRG_ER_diArg_1	494	496	PF00400	0.425
TRG_ER_diArg_1	555	558	PF00400	0.612
TRG_ER_diArg_1	63	66	PF00400	0.422
TRG_ER_FFAT_2	671	679	PF00635	0.544
TRG_NES_CRM1_1	390	400	PF08389	0.391
TRG_NES_CRM1_1	552	565	PF08389	0.424
TRG_NES_CRM1_1	614	628	PF08389	0.664
TRG_NLS_Bipartite_1	320	334	PF00514	0.340
TRG_NLS_MonoExtC_3	605	611	PF00514	0.594
TRG_NLS_MonoExtN_4	603	610	PF00514	0.641
TRG_Pf-PMV_PEXEL_1	213	217	PF00026	0.301
TRG_Pf-PMV_PEXEL_1	525	529	PF00026	0.301
TRG_Pf-PMV_PEXEL_1	87	91	PF00026	0.301

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P4X4	Leptomonas seymouri	84%	99%
A0A0S4IX79	Bodo saltans	56%	95%
A0A1X0P5E1	Trypanosomatidae	65%	97%
A0A1X0P9U0	Trypanosomatidae	27%	83%
A0A3Q8ID91	Leishmania donovani	30%	100%
A0A3R7M1K3	Trypanosoma rangeli	30%	96%
A0A3R7NR45	Trypanosoma rangeli	28%	84%
A0A3S5IQZ7	Trypanosoma rangeli	27%	87%
A0A3S7XAT8	Leishmania donovani	34%	100%
A0A422NKE3	Trypanosoma rangeli	65%	95%
A3LX02	Scheffersomyces stipitis (strain ATCC 58785 / CBS 6054 / NBRC 10063 / NRRL Y-11545)	31%	100%
A4HGR1	Leishmania braziliensis	31%	100%
A4HK38	Leishmania braziliensis	27%	100%
A4HN73	Leishmania braziliensis	91%	100%
A4HP49	Leishmania braziliensis	33%	100%
A4HT33	Leishmania infantum	31%	100%
A4HUC1	Leishmania infantum	27%	88%
A4HZF8	Leishmania infantum	26%	100%
A4I3T6	Leishmania infantum	30%	100%
A4IBU1	Leishmania infantum	100%	100%
A4IDF6	Leishmania infantum	34%	100%
A5DAR2	Meyerozyma guilliermondii (strain ATCC 6260 / CBS 566 / DSM 6381 / JCM 1539 / NBRC 10279 / NRRL Y-324)	27%	92%
A6R918	Ajellomyces capsulatus (strain NAm1 / WU24)	35%	100%
A6RMZ2	Botryotinia fuckeliana (strain B05.10)	36%	100%
A7F2S3	Sclerotinia sclerotiorum (strain ATCC 18683 / 1980 / Ss-1)	36%	100%
C9ZYS3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	68%	89%
E9AFM8	Leishmania major	95%	100%
E9AJG4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	29%	100%
E9ASV7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	34%	100%
E9B028	Leishmania mexicana (strain MHOM/GT/2001/U1103)	30%	100%
E9B6T1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	96%	100%
P0CR08	Cryptococcus neoformans var. neoformans serotype D (strain JEC21 / ATCC MYA-565)	32%	92%
P0CR09	Cryptococcus neoformans var. neoformans serotype D (strain B-3501A)	32%	92%
Q1EB38	Coccidioides immitis (strain RS)	30%	74%
Q4Q1N9	Leishmania major	34%	100%
Q4Q858	Leishmania major	30%	100%
Q4QHK6	Leishmania major	26%	93%
Q59S50	Candida albicans (strain SC5314 / ATCC MYA-2876)	27%	95%
Q6NZQ2	Mus musculus	29%	100%
V5DUK0	Trypanosoma cruzi	64%	90%