Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S7X9V8_LEIDO

TriTrypDb:

LdBPK_354310.1 , LdCL_350048200 , LDHU3_35.5700

Length:

298

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S7X9V8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7X9V8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	189	193	PF00656	0.723
CLV_NRD_NRD_1	267	269	PF00675	0.459
CLV_PCSK_KEX2_1	267	269	PF00082	0.459
CLV_PCSK_KEX2_1	286	288	PF00082	0.306
CLV_PCSK_PC1ET2_1	286	288	PF00082	0.559
CLV_PCSK_SKI1_1	133	137	PF00082	0.403
CLV_PCSK_SKI1_1	177	181	PF00082	0.757
CLV_PCSK_SKI1_1	257	261	PF00082	0.520
CLV_Separin_Metazoa	238	242	PF03568	0.579
DEG_APCC_DBOX_1	60	68	PF00400	0.487
DEG_SCF_FBW7_2	231	238	PF00400	0.551
DOC_CKS1_1	232	237	PF01111	0.547
DOC_CYCLIN_yCln2_LP_2	114	120	PF00134	0.630
DOC_MAPK_MEF2A_6	206	214	PF00069	0.467
DOC_PP2B_LxvP_1	210	213	PF13499	0.446
DOC_PP4_FxxP_1	5	8	PF00568	0.647
DOC_USP7_MATH_1	175	179	PF00917	0.731
DOC_USP7_MATH_1	201	205	PF00917	0.715
DOC_USP7_MATH_1	290	294	PF00917	0.553
DOC_USP7_MATH_1	8	12	PF00917	0.643
DOC_WW_Pin1_4	138	143	PF00397	0.460
DOC_WW_Pin1_4	168	173	PF00397	0.741
DOC_WW_Pin1_4	231	236	PF00397	0.396
LIG_14-3-3_CanoR_1	160	164	PF00244	0.595
LIG_14-3-3_CanoR_1	226	232	PF00244	0.445
LIG_14-3-3_CanoR_1	29	35	PF00244	0.561
LIG_14-3-3_CanoR_1	36	40	PF00244	0.530
LIG_14-3-3_CanoR_1	7	13	PF00244	0.688
LIG_CSL_BTD_1	42	45	PF09270	0.356
LIG_deltaCOP1_diTrp_1	40	46	PF00928	0.475
LIG_FHA_1	149	155	PF00498	0.702
LIG_FHA_1	192	198	PF00498	0.774
LIG_FHA_1	207	213	PF00498	0.458
LIG_FHA_1	277	283	PF00498	0.502
LIG_FHA_1	73	79	PF00498	0.397
LIG_FHA_1	83	89	PF00498	0.389
LIG_FHA_2	214	220	PF00498	0.497
LIG_FHA_2	240	246	PF00498	0.564
LIG_LIR_Gen_1	89	99	PF02991	0.340
LIG_LIR_Nem_3	124	129	PF02991	0.525
LIG_LIR_Nem_3	40	46	PF02991	0.440
LIG_LIR_Nem_3	89	95	PF02991	0.353
LIG_LIR_Nem_3	97	102	PF02991	0.368
LIG_PCNA_yPIPBox_3	224	233	PF02747	0.266
LIG_SH2_SRC	217	220	PF00017	0.518
LIG_SH2_STAT5	123	126	PF00017	0.433
LIG_SH2_STAT5	127	130	PF00017	0.367
LIG_SH2_STAT5	217	220	PF00017	0.483
LIG_SH3_1	241	247	PF00018	0.509
LIG_SH3_3	241	247	PF00018	0.581
MOD_CK1_1	141	147	PF00069	0.534
MOD_CK1_1	205	211	PF00069	0.521
MOD_CK1_1	225	231	PF00069	0.435
MOD_CK2_1	18	24	PF00069	0.643
MOD_CK2_1	213	219	PF00069	0.487
MOD_CK2_1	239	245	PF00069	0.568
MOD_GlcNHglycan	12	15	PF01048	0.671
MOD_GlcNHglycan	151	154	PF01048	0.576
MOD_GlcNHglycan	177	180	PF01048	0.706
MOD_GlcNHglycan	282	285	PF01048	0.472
MOD_GlcNHglycan	292	295	PF01048	0.461
MOD_GlcNHglycan	96	99	PF01048	0.464
MOD_GSK3_1	102	109	PF00069	0.505
MOD_GSK3_1	141	148	PF00069	0.562
MOD_GSK3_1	154	161	PF00069	0.671
MOD_GSK3_1	171	178	PF00069	0.535
MOD_GSK3_1	201	208	PF00069	0.605
MOD_GSK3_1	276	283	PF00069	0.537
MOD_N-GLC_1	121	126	PF02516	0.500
MOD_N-GLC_2	183	185	PF02516	0.536
MOD_NEK2_1	129	134	PF00069	0.417
MOD_NEK2_1	145	150	PF00069	0.658
MOD_NEK2_1	239	244	PF00069	0.579
MOD_NEK2_1	282	287	PF00069	0.486
MOD_NEK2_1	82	87	PF00069	0.473
MOD_NEK2_1	91	96	PF00069	0.340
MOD_NEK2_2	155	160	PF00069	0.564
MOD_OFUCOSY	69	76	PF10250	0.560
MOD_PIKK_1	44	50	PF00454	0.557
MOD_PKA_2	145	151	PF00069	0.619
MOD_PKA_2	159	165	PF00069	0.455
MOD_PKA_2	225	231	PF00069	0.486
MOD_PKA_2	28	34	PF00069	0.574
MOD_PKA_2	35	41	PF00069	0.516
MOD_Plk_1	222	228	PF00069	0.561
MOD_Plk_4	206	212	PF00069	0.527
MOD_Plk_4	213	219	PF00069	0.480
MOD_Plk_4	277	283	PF00069	0.469
MOD_Plk_4	91	97	PF00069	0.469
MOD_ProDKin_1	138	144	PF00069	0.458
MOD_ProDKin_1	168	174	PF00069	0.742
MOD_ProDKin_1	231	237	PF00069	0.397
MOD_SUMO_for_1	271	274	PF00179	0.534
TRG_ENDOCYTIC_2	126	129	PF00928	0.486
TRG_ENDOCYTIC_2	20	23	PF00928	0.620
TRG_ER_diArg_1	240	243	PF00400	0.508
TRG_ER_diArg_1	266	268	PF00400	0.446
TRG_Pf-PMV_PEXEL_1	86	90	PF00026	0.437

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HY73	Leptomonas seymouri	52%	100%
A0A0S4JF57	Bodo saltans	31%	100%
A0A1X0P581	Trypanosomatidae	35%	100%
A0A3R7NNI3	Trypanosoma rangeli	36%	100%
A4HN94	Leishmania braziliensis	72%	100%
A4IBW4	Leishmania infantum	99%	100%
C9ZYP7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	43%	100%
E9AFQ1	Leishmania major	92%	100%
E9B6V4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%
V5BCR5	Trypanosoma cruzi	32%	100%