Mitochondrial phosphate transporter, putative

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

mitochondrial phosphate transporter, putative (fragment)

Species:

Leishmania donovani

UniProt:

A0A3S7X9V4_LEIDO

TriTrypDb:

LdBPK_354490.1 , LdCL_350050100 , LDHU3_35.5930

Length:

317

Annotations

LeishMANIAdb annotations

Forms a well-defined channel with 6 helices. Some paralogs tend to have an additional hydrophobic segment that might be a transit or signal peptide. It is unclear if the N-peptide is a signal or transit peptide. Localization: Mitochondrial (by homology)

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 3
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 7

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	yes	yes: 14

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 15
NetGPI	no	yes: 0, no: 15

Cellular components
Term	Name	Level	Count
GO:0005743	mitochondrial inner membrane	5	14
GO:0016020	membrane	2	14
GO:0019866	organelle inner membrane	4	14
GO:0031090	organelle membrane	3	14
GO:0031966	mitochondrial membrane	4	14
GO:0110165	cellular anatomical entity	1	16
GO:0005737	cytoplasm	2	2
GO:0005739	mitochondrion	5	2
GO:0020023	kinetoplast	2	2
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043231	intracellular membrane-bounded organelle	4	2

Expansion

Sequence features

A0A3S7X9V4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7X9V4

Function

Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	16
GO:0006811	monoatomic ion transport	4	16
GO:0006817	phosphate ion transport	7	16
GO:0006820	monoatomic anion transport	5	16
GO:0009987	cellular process	1	16
GO:0015698	inorganic anion transport	6	16
GO:0034220	monoatomic ion transmembrane transport	3	16
GO:0035435	phosphate ion transmembrane transport	6	16
GO:0051179	localization	1	16
GO:0051234	establishment of localization	2	16
GO:0055085	transmembrane transport	2	16
GO:0098656	monoatomic anion transmembrane transport	4	16
GO:0098660	inorganic ion transmembrane transport	4	16
GO:0098661	inorganic anion transmembrane transport	5	16
GO:1990542	mitochondrial transmembrane transport	3	16
GO:1990547	mitochondrial phosphate ion transmembrane transport	4	16

Molecular functions
Term	Name	Level	Count
GO:0005215	transporter activity	1	16
GO:0005315	inorganic phosphate transmembrane transporter activity	4	16
GO:0015291	secondary active transmembrane transporter activity	4	16
GO:0015318	inorganic molecular entity transmembrane transporter activity	3	16
GO:0022804	active transmembrane transporter activity	3	16
GO:0022857	transmembrane transporter activity	2	16

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_PCSK_SKI1_1	197	201	PF00082	0.380
CLV_PCSK_SKI1_1	303	307	PF00082	0.467
DOC_AGCK_PIF_2	99	104	PF00069	0.438
DOC_MAPK_gen_1	119	127	PF00069	0.516
DOC_MAPK_MEF2A_6	222	230	PF00069	0.388
DOC_PP4_FxxP_1	213	216	PF00568	0.427
DOC_USP7_MATH_1	166	170	PF00917	0.385
DOC_USP7_MATH_1	172	176	PF00917	0.332
DOC_USP7_MATH_1	179	183	PF00917	0.235
DOC_USP7_MATH_1	241	245	PF00917	0.387
DOC_USP7_MATH_1	260	264	PF00917	0.547
DOC_WW_Pin1_4	151	156	PF00397	0.312
DOC_WW_Pin1_4	52	57	PF00397	0.324
LIG_14-3-3_CanoR_1	58	63	PF00244	0.474
LIG_BIR_II_1	1	5	PF00653	0.490
LIG_BRCT_BRCA1_1	131	135	PF00533	0.332
LIG_BRCT_BRCA1_1	174	178	PF00533	0.438
LIG_BRCT_BRCA1_1	226	230	PF00533	0.400
LIG_DLG_GKlike_1	58	66	PF00625	0.458
LIG_FHA_1	159	165	PF00498	0.426
LIG_FHA_1	281	287	PF00498	0.423
LIG_LIR_Apic_2	9	15	PF02991	0.444
LIG_LIR_Gen_1	107	113	PF02991	0.332
LIG_LIR_Gen_1	134	144	PF02991	0.316
LIG_LIR_Gen_1	270	281	PF02991	0.433
LIG_LIR_Nem_3	103	108	PF02991	0.343
LIG_LIR_Nem_3	263	267	PF02991	0.442
LIG_LIR_Nem_3	270	276	PF02991	0.388
LIG_LIR_Nem_3	57	62	PF02991	0.316
LIG_PCNA_yPIPBox_3	71	85	PF02747	0.390
LIG_Pex14_1	8	12	PF04695	0.431
LIG_REV1ctd_RIR_1	197	207	PF16727	0.319
LIG_SH2_CRK	180	184	PF00017	0.409
LIG_SH2_CRK	209	213	PF00017	0.312
LIG_SH2_CRK	264	268	PF00017	0.412
LIG_SH2_GRB2like	109	112	PF00017	0.332
LIG_SH2_GRB2like	12	15	PF00017	0.477
LIG_SH2_GRB2like	273	276	PF00017	0.454
LIG_SH2_NCK_1	220	224	PF00017	0.464
LIG_SH2_PTP2	12	15	PF00017	0.550
LIG_SH2_PTP2	273	276	PF00017	0.477
LIG_SH2_SRC	12	15	PF00017	0.477
LIG_SH2_SRC	209	212	PF00017	0.396
LIG_SH2_SRC	273	276	PF00017	0.346
LIG_SH2_STAP1	109	113	PF00017	0.332
LIG_SH2_STAT3	91	94	PF00017	0.316
LIG_SH2_STAT5	104	107	PF00017	0.474
LIG_SH2_STAT5	12	15	PF00017	0.481
LIG_SH2_STAT5	193	196	PF00017	0.316
LIG_SH2_STAT5	211	214	PF00017	0.425
LIG_SH2_STAT5	234	237	PF00017	0.361
LIG_SH2_STAT5	273	276	PF00017	0.361
LIG_SH3_1	12	18	PF00018	0.455
LIG_SH3_3	12	18	PF00018	0.455
LIG_SH3_3	240	246	PF00018	0.384
LIG_SH3_4	215	222	PF00018	0.546
LIG_SUMO_SIM_par_1	283	290	PF11976	0.387
MOD_CDC14_SPxK_1	55	58	PF00782	0.331
MOD_CDK_SPK_2	151	156	PF00069	0.399
MOD_CDK_SPxK_1	52	58	PF00069	0.331
MOD_GlcNHglycan	129	132	PF01048	0.316
MOD_GlcNHglycan	175	178	PF01048	0.352
MOD_GlcNHglycan	231	234	PF01048	0.355
MOD_GlcNHglycan	251	254	PF01048	0.456
MOD_GlcNHglycan	310	313	PF01048	0.412
MOD_GlcNHglycan	91	94	PF01048	0.432
MOD_GSK3_1	151	158	PF00069	0.319
MOD_N-GLC_2	275	277	PF02516	0.437
MOD_NEK2_1	1	6	PF00069	0.576
MOD_NEK2_1	127	132	PF00069	0.312
MOD_NEK2_1	144	149	PF00069	0.449
MOD_NEK2_1	226	231	PF00069	0.451
MOD_NEK2_1	287	292	PF00069	0.353
MOD_NEK2_1	308	313	PF00069	0.418
MOD_NEK2_2	166	171	PF00069	0.419
MOD_PIKK_1	221	227	PF00454	0.407
MOD_Plk_1	19	25	PF00069	0.558
MOD_Plk_4	179	185	PF00069	0.296
MOD_Plk_4	19	25	PF00069	0.428
MOD_Plk_4	246	252	PF00069	0.444
MOD_ProDKin_1	151	157	PF00069	0.312
MOD_ProDKin_1	52	58	PF00069	0.324
MOD_SUMO_for_1	70	73	PF00179	0.417
TRG_ENDOCYTIC_2	102	105	PF00928	0.312
TRG_ENDOCYTIC_2	109	112	PF00928	0.316
TRG_ENDOCYTIC_2	121	124	PF00928	0.398
TRG_ENDOCYTIC_2	180	183	PF00928	0.458
TRG_ENDOCYTIC_2	209	212	PF00928	0.316
TRG_ENDOCYTIC_2	264	267	PF00928	0.427
TRG_ENDOCYTIC_2	273	276	PF00928	0.396

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I993	Leptomonas seymouri	84%	100%
A0A0S4JBC4	Bodo saltans	39%	82%
A0A0S4JNX4	Bodo saltans	72%	94%
A0A0S4KJX8	Bodo saltans	26%	91%
A0A1X0P0K9	Trypanosomatidae	39%	100%
A0A1X0P561	Trypanosomatidae	76%	99%
A0A3S5IRV4	Trypanosoma rangeli	77%	100%
A0A3S7X9Y0	Leishmania donovani	98%	100%
A0A422NF39	Trypanosoma rangeli	25%	100%
A4HNB1	Leishmania braziliensis	94%	100%
A4HNB2	Leishmania braziliensis	93%	100%
A4IBY2	Leishmania infantum	93%	100%
A4IBY3	Leishmania infantum	100%	100%
B0G143	Dictyostelium discoideum	25%	100%
C9ZYM2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	77%	100%
D0A4I3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	35%	83%
E9AFR9	Leishmania major	97%	100%
E9AFS0	Leishmania major	99%	100%
E9B6X2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	96%	100%
O04619	Arabidopsis thaliana	25%	90%
O61703	Choristoneura fumiferana	51%	91%
P12234	Bos taurus	51%	88%
P16036	Rattus norvegicus	50%	89%
P16260	Homo sapiens	25%	95%
P23641	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	38%	100%
P40035	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	44%	100%
P40614	Caenorhabditis elegans	56%	93%
Q00325	Homo sapiens	50%	88%
Q01888	Bos taurus	27%	96%
Q03829	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	25%	86%
Q54BF6	Dictyostelium discoideum	40%	100%
Q5R7W2	Pongo abelii	51%	88%
Q7DNC3	Arabidopsis thaliana	41%	100%
Q8C0K5	Mus musculus	25%	95%
Q8VEM8	Mus musculus	51%	89%
Q9FMU6	Arabidopsis thaliana	51%	85%
Q9M2Z8	Arabidopsis thaliana	49%	87%
Q9P7V8	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	46%	100%
V5BT68	Trypanosoma cruzi	76%	100%