TAX-1

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

TAX-1

Gene product:

TAX-1

Species:

Leishmania donovani

UniProt:

A0A3S7X9V3_LEIDO

TriTrypDb:

LdBPK_354460.1 , LdCL_350049700 , LDHU3_35.5890

Length:

411

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0005930	axoneme	2	1
GO:0032838	plasma membrane bounded cell projection cytoplasm	4	1
GO:0097014	ciliary plasm	5	1
GO:0099568	cytoplasmic region	3	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A0A3S7X9V3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7X9V3

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	1
GO:0004427	inorganic diphosphate phosphatase activity	6	1
GO:0016462	pyrophosphatase activity	5	1
GO:0016787	hydrolase activity	2	1
GO:0016817	hydrolase activity, acting on acid anhydrides	3	1
GO:0016818	hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	4	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	262	264	PF00675	0.466
CLV_PCSK_KEX2_1	147	149	PF00082	0.506
CLV_PCSK_KEX2_1	262	264	PF00082	0.434
CLV_PCSK_KEX2_1	313	315	PF00082	0.576
CLV_PCSK_PC1ET2_1	147	149	PF00082	0.506
CLV_PCSK_PC1ET2_1	313	315	PF00082	0.576
CLV_PCSK_PC7_1	309	315	PF00082	0.558
CLV_PCSK_SKI1_1	143	147	PF00082	0.465
CLV_PCSK_SKI1_1	213	217	PF00082	0.479
CLV_PCSK_SKI1_1	99	103	PF00082	0.400
DOC_CKS1_1	63	68	PF01111	0.542
DOC_CYCLIN_yCln2_LP_2	132	138	PF00134	0.323
DOC_MAPK_gen_1	123	132	PF00069	0.481
DOC_MAPK_gen_1	262	270	PF00069	0.442
DOC_MAPK_HePTP_8	162	174	PF00069	0.494
DOC_MAPK_MEF2A_6	112	120	PF00069	0.501
DOC_MAPK_MEF2A_6	165	174	PF00069	0.451
DOC_MAPK_MEF2A_6	262	270	PF00069	0.548
DOC_MAPK_MEF2A_6	324	333	PF00069	0.340
DOC_PP4_FxxP_1	124	127	PF00568	0.475
DOC_PP4_FxxP_1	356	359	PF00568	0.529
DOC_USP7_MATH_1	187	191	PF00917	0.492
DOC_USP7_MATH_1	28	32	PF00917	0.636
DOC_USP7_MATH_1	298	302	PF00917	0.394
DOC_USP7_MATH_1	318	322	PF00917	0.207
DOC_USP7_UBL2_3	143	147	PF12436	0.499
DOC_WW_Pin1_4	273	278	PF00397	0.532
DOC_WW_Pin1_4	5	10	PF00397	0.651
DOC_WW_Pin1_4	62	67	PF00397	0.527
LIG_14-3-3_CanoR_1	201	205	PF00244	0.449
LIG_14-3-3_CanoR_1	213	222	PF00244	0.329
LIG_14-3-3_CanoR_1	314	323	PF00244	0.439
LIG_14-3-3_CanoR_1	350	359	PF00244	0.444
LIG_BIR_II_1	1	5	PF00653	0.665
LIG_BRCT_BRCA1_1	352	356	PF00533	0.446
LIG_deltaCOP1_diTrp_1	368	374	PF00928	0.391
LIG_FHA_1	201	207	PF00498	0.316
LIG_FHA_2	334	340	PF00498	0.512
LIG_FHA_2	379	385	PF00498	0.656
LIG_FHA_2	397	403	PF00498	0.662
LIG_LIR_Apic_2	122	127	PF02991	0.478
LIG_LIR_Apic_2	353	359	PF02991	0.534
LIG_LIR_Gen_1	203	212	PF02991	0.339
LIG_LIR_Gen_1	217	227	PF02991	0.364
LIG_LIR_Gen_1	246	257	PF02991	0.452
LIG_LIR_Gen_1	53	63	PF02991	0.384
LIG_LIR_Nem_3	203	208	PF02991	0.334
LIG_LIR_Nem_3	217	222	PF02991	0.359
LIG_LIR_Nem_3	246	252	PF02991	0.421
LIG_LIR_Nem_3	48	52	PF02991	0.421
LIG_LIR_Nem_3	53	59	PF02991	0.356
LIG_Pex14_1	370	374	PF04695	0.387
LIG_SH2_CRK	241	245	PF00017	0.329
LIG_SH2_GRB2like	378	381	PF00017	0.530
LIG_SH2_PTP2	161	164	PF00017	0.478
LIG_SH2_STAP1	249	253	PF00017	0.500
LIG_SH2_STAP1	3	7	PF00017	0.603
LIG_SH2_STAT5	136	139	PF00017	0.339
LIG_SH2_STAT5	161	164	PF00017	0.470
LIG_SH2_STAT5	205	208	PF00017	0.340
LIG_SH2_STAT5	221	224	PF00017	0.295
LIG_SH3_3	356	362	PF00018	0.546
LIG_SUMO_SIM_anti_2	57	65	PF11976	0.538
LIG_TRAF2_1	277	280	PF00917	0.591
LIG_TRAF2_1	94	97	PF00917	0.469
LIG_TYR_ITIM	247	252	PF00017	0.416
LIG_WRC_WIRS_1	216	221	PF05994	0.339
MOD_CK1_1	2	8	PF00069	0.722
MOD_CK1_1	200	206	PF00069	0.457
MOD_CK1_1	230	236	PF00069	0.464
MOD_CK1_1	273	279	PF00069	0.491
MOD_CK2_1	187	193	PF00069	0.485
MOD_CK2_1	333	339	PF00069	0.459
MOD_CK2_1	378	384	PF00069	0.605
MOD_GlcNHglycan	235	238	PF01048	0.424
MOD_GlcNHglycan	316	319	PF01048	0.507
MOD_GlcNHglycan	390	394	PF01048	0.593
MOD_GlcNHglycan	84	87	PF01048	0.445
MOD_GSK3_1	1	8	PF00069	0.719
MOD_GSK3_1	14	21	PF00069	0.673
MOD_GSK3_1	200	207	PF00069	0.333
MOD_GSK3_1	314	321	PF00069	0.428
MOD_GSK3_1	374	381	PF00069	0.495
MOD_GSK3_1	389	396	PF00069	0.613
MOD_GSK3_1	71	78	PF00069	0.561
MOD_N-GLC_1	45	50	PF02516	0.569
MOD_NEK2_1	1	6	PF00069	0.704
MOD_NEK2_1	137	142	PF00069	0.335
MOD_NEK2_1	227	232	PF00069	0.315
MOD_PIKK_1	350	356	PF00454	0.421
MOD_PIKK_1	37	43	PF00454	0.541
MOD_PKA_2	200	206	PF00069	0.418
MOD_PKA_2	75	81	PF00069	0.546
MOD_PKB_1	80	88	PF00069	0.532
MOD_Plk_1	168	174	PF00069	0.444
MOD_Plk_1	37	43	PF00069	0.603
MOD_Plk_1	374	380	PF00069	0.533
MOD_Plk_1	389	395	PF00069	0.635
MOD_Plk_1	45	51	PF00069	0.434
MOD_Plk_4	200	206	PF00069	0.320
MOD_ProDKin_1	273	279	PF00069	0.529
MOD_ProDKin_1	5	11	PF00069	0.652
MOD_ProDKin_1	62	68	PF00069	0.536
TRG_DiLeu_BaEn_1	58	63	PF01217	0.384
TRG_DiLeu_BaEn_1	97	102	PF01217	0.414
TRG_ENDOCYTIC_2	136	139	PF00928	0.339
TRG_ENDOCYTIC_2	161	164	PF00928	0.478
TRG_ENDOCYTIC_2	205	208	PF00928	0.347
TRG_ENDOCYTIC_2	221	224	PF00928	0.333
TRG_ENDOCYTIC_2	241	244	PF00928	0.150
TRG_ENDOCYTIC_2	249	252	PF00928	0.428
TRG_ER_diArg_1	118	121	PF00400	0.464
TRG_ER_diArg_1	80	83	PF00400	0.510
TRG_Pf-PMV_PEXEL_1	99	104	PF00026	0.423

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P968	Leptomonas seymouri	73%	100%
A0A0S4JSR6	Bodo saltans	44%	70%
A0A1X0P6F9	Trypanosomatidae	56%	100%
A0A3R7KSW5	Trypanosoma rangeli	52%	100%
A4HNA8	Leishmania braziliensis	81%	100%
A4IBX9	Leishmania infantum	100%	100%
C9ZYM8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	54%	100%
E9AFR6	Leishmania major	94%	100%
E9B6W9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%
Q9H0C1	Homo sapiens	27%	100%
V5BXU3	Trypanosoma cruzi	54%	100%