Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania donovani

UniProt:

A0A3S7X9U4_LEIDO

TriTrypDb:

LdBPK_354360.1 , LdCL_350048700 , LDHU3_35.5770

Length:

325

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	6
GO:0110165	cellular anatomical entity	1	6

Expansion

Sequence features

A0A3S7X9U4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7X9U4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	60	62	PF00675	0.450
CLV_NRD_NRD_1	73	75	PF00675	0.455
CLV_PCSK_FUR_1	57	61	PF00082	0.475
CLV_PCSK_KEX2_1	129	131	PF00082	0.590
CLV_PCSK_KEX2_1	272	274	PF00082	0.453
CLV_PCSK_KEX2_1	284	286	PF00082	0.441
CLV_PCSK_KEX2_1	59	61	PF00082	0.428
CLV_PCSK_KEX2_1	72	74	PF00082	0.373
CLV_PCSK_PC1ET2_1	129	131	PF00082	0.500
CLV_PCSK_PC1ET2_1	272	274	PF00082	0.453
CLV_PCSK_PC1ET2_1	284	286	PF00082	0.441
CLV_PCSK_PC7_1	68	74	PF00082	0.480
CLV_PCSK_SKI1_1	12	16	PF00082	0.700
CLV_PCSK_SKI1_1	162	166	PF00082	0.617
CLV_PCSK_SKI1_1	284	288	PF00082	0.447
CLV_PCSK_SKI1_1	77	81	PF00082	0.465
DEG_Nend_UBRbox_2	1	3	PF02207	0.572
DEG_SCF_FBW7_1	8	13	PF00400	0.408
DEG_SPOP_SBC_1	95	99	PF00917	0.775
DOC_CYCLIN_RxL_1	282	292	PF00134	0.728
DOC_CYCLIN_yClb1_LxF_4	221	226	PF00134	0.741
DOC_CYCLIN_yCln2_LP_2	139	145	PF00134	0.764
DOC_MAPK_gen_1	129	137	PF00069	0.666
DOC_MAPK_JIP1_4	185	191	PF00069	0.672
DOC_MAPK_MEF2A_6	185	193	PF00069	0.821
DOC_PP1_RVXF_1	221	227	PF00149	0.743
DOC_PP2B_LxvP_1	139	142	PF13499	0.733
DOC_PP2B_LxvP_1	189	192	PF13499	0.771
DOC_PP4_FxxP_1	226	229	PF00568	0.751
DOC_USP7_MATH_1	10	14	PF00917	0.539
DOC_USP7_MATH_1	192	196	PF00917	0.740
DOC_USP7_MATH_1	210	214	PF00917	0.813
DOC_USP7_MATH_1	294	298	PF00917	0.721
DOC_USP7_MATH_1	302	306	PF00917	0.667
DOC_USP7_MATH_1	46	50	PF00917	0.690
DOC_USP7_MATH_2	103	109	PF00917	0.761
DOC_USP7_UBL2_3	129	133	PF12436	0.641
DOC_WW_Pin1_4	149	154	PF00397	0.747
DOC_WW_Pin1_4	200	205	PF00397	0.765
DOC_WW_Pin1_4	225	230	PF00397	0.728
DOC_WW_Pin1_4	6	11	PF00397	0.443
LIG_14-3-3_CanoR_1	185	190	PF00244	0.673
LIG_14-3-3_CanoR_1	260	268	PF00244	0.678
LIG_14-3-3_CanoR_1	77	86	PF00244	0.651
LIG_CSL_BTD_1	135	138	PF09270	0.744
LIG_FHA_1	154	160	PF00498	0.694
LIG_FHA_1	174	180	PF00498	0.850
LIG_FHA_1	215	221	PF00498	0.673
LIG_FHA_1	288	294	PF00498	0.746
LIG_FHA_1	319	325	PF00498	0.807
LIG_FHA_1	81	87	PF00498	0.646
LIG_FHA_1	9	15	PF00498	0.432
LIG_FHA_2	195	201	PF00498	0.800
LIG_FHA_2	305	311	PF00498	0.585
LIG_FHA_2	88	94	PF00498	0.716
LIG_LIR_Gen_1	13	20	PF02991	0.481
LIG_LIR_Nem_3	13	18	PF02991	0.482
LIG_MYND_1	138	142	PF01753	0.747
LIG_NRBOX	23	29	PF00104	0.415
LIG_PALB2_WD40_1	132	140	PF16756	0.740
LIG_PCNA_yPIPBox_3	267	281	PF02747	0.719
LIG_Rb_LxCxE_1	49	63	PF01857	0.653
LIG_SH2_GRB2like	20	23	PF00017	0.398
LIG_SH2_GRB2like	244	247	PF00017	0.705
LIG_SH2_STAP1	122	126	PF00017	0.653
LIG_SH2_STAT5	126	129	PF00017	0.711
LIG_SH3_3	139	145	PF00018	0.720
LIG_SH3_3	148	154	PF00018	0.665
LIG_SUMO_SIM_anti_2	25	31	PF11976	0.419
LIG_TYR_ITIM	29	34	PF00017	0.513
MOD_CDC14_SPxK_1	152	155	PF00782	0.711
MOD_CDK_SPxK_1	149	155	PF00069	0.713
MOD_CDK_SPxK_1	6	12	PF00069	0.547
MOD_CK1_1	107	113	PF00069	0.676
MOD_CK1_1	195	201	PF00069	0.705
MOD_CK1_1	202	208	PF00069	0.711
MOD_CK1_1	215	221	PF00069	0.712
MOD_CK1_1	242	248	PF00069	0.660
MOD_CK1_1	252	258	PF00069	0.491
MOD_CK1_1	304	310	PF00069	0.559
MOD_CK1_1	6	12	PF00069	0.722
MOD_CK1_1	87	93	PF00069	0.742
MOD_CK1_1	97	103	PF00069	0.570
MOD_CK2_1	125	131	PF00069	0.763
MOD_CK2_1	175	181	PF00069	0.687
MOD_CK2_1	259	265	PF00069	0.527
MOD_CK2_1	304	310	PF00069	0.458
MOD_CK2_1	87	93	PF00069	0.626
MOD_GlcNHglycan	194	197	PF01048	0.710
MOD_GlcNHglycan	214	217	PF01048	0.757
MOD_GlcNHglycan	5	8	PF01048	0.706
MOD_GlcNHglycan	80	83	PF01048	0.609
MOD_GSK3_1	149	156	PF00069	0.713
MOD_GSK3_1	181	188	PF00069	0.706
MOD_GSK3_1	192	199	PF00069	0.704
MOD_GSK3_1	202	209	PF00069	0.725
MOD_GSK3_1	210	217	PF00069	0.751
MOD_GSK3_1	225	232	PF00069	0.499
MOD_GSK3_1	244	251	PF00069	0.654
MOD_GSK3_1	318	325	PF00069	0.776
MOD_GSK3_1	6	13	PF00069	0.689
MOD_GSK3_1	80	87	PF00069	0.644
MOD_GSK3_1	97	104	PF00069	0.746
MOD_N-GLC_1	167	172	PF02516	0.736
MOD_N-GLC_1	181	186	PF02516	0.775
MOD_N-GLC_1	245	250	PF02516	0.737
MOD_N-GLC_1	3	8	PF02516	0.677
MOD_N-GLC_2	148	150	PF02516	0.575
MOD_N-GLC_2	256	258	PF02516	0.644
MOD_NEK2_1	239	244	PF00069	0.679
MOD_NEK2_1	289	294	PF00069	0.668
MOD_NEK2_2	10	15	PF00069	0.533
MOD_PIKK_1	229	235	PF00454	0.645
MOD_PKA_2	242	248	PF00069	0.674
MOD_PKA_2	252	258	PF00069	0.476
MOD_PKA_2	259	265	PF00069	0.572
MOD_Plk_1	239	245	PF00069	0.712
MOD_Plk_1	3	9	PF00069	0.630
MOD_Plk_4	185	191	PF00069	0.763
MOD_Plk_4	46	52	PF00069	0.492
MOD_ProDKin_1	149	155	PF00069	0.692
MOD_ProDKin_1	200	206	PF00069	0.716
MOD_ProDKin_1	225	231	PF00069	0.666
MOD_ProDKin_1	6	12	PF00069	0.547
MOD_SUMO_rev_2	125	135	PF00179	0.586
TRG_DiLeu_BaEn_1	25	30	PF01217	0.513
TRG_DiLeu_BaLyEn_6	135	140	PF01217	0.694
TRG_DiLeu_BaLyEn_6	216	221	PF01217	0.566
TRG_DiLeu_BaLyEn_6	264	269	PF01217	0.656
TRG_ENDOCYTIC_2	31	34	PF00928	0.513
TRG_ER_diArg_1	59	61	PF00400	0.553
TRG_ER_diArg_1	72	74	PF00400	0.560
TRG_Pf-PMV_PEXEL_1	12	16	PF00026	0.626

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IK89	Leptomonas seymouri	34%	100%
A4HN98	Leishmania braziliensis	63%	100%
A4IBW9	Leishmania infantum	100%	100%
E9AFQ6	Leishmania major	85%	100%
E9B6V9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	82%	100%