Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S7X9S4_LEIDO

TriTrypDb:

LdBPK_354160.1 , LdCL_350046700 , LDHU3_35.5380

Length:

422

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S7X9S4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7X9S4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	131	135	PF00656	0.617
CLV_NRD_NRD_1	218	220	PF00675	0.653
CLV_NRD_NRD_1	222	224	PF00675	0.598
CLV_NRD_NRD_1	311	313	PF00675	0.476
CLV_NRD_NRD_1	330	332	PF00675	0.490
CLV_PCSK_FUR_1	309	313	PF00082	0.512
CLV_PCSK_KEX2_1	109	111	PF00082	0.444
CLV_PCSK_KEX2_1	218	220	PF00082	0.618
CLV_PCSK_KEX2_1	222	224	PF00082	0.589
CLV_PCSK_KEX2_1	262	264	PF00082	0.449
CLV_PCSK_KEX2_1	311	313	PF00082	0.452
CLV_PCSK_PC1ET2_1	109	111	PF00082	0.522
CLV_PCSK_PC1ET2_1	218	220	PF00082	0.578
CLV_PCSK_PC1ET2_1	262	264	PF00082	0.501
CLV_PCSK_PC7_1	307	313	PF00082	0.433
CLV_PCSK_SKI1_1	201	205	PF00082	0.370
CLV_PCSK_SKI1_1	311	315	PF00082	0.515
CLV_PCSK_SKI1_1	335	339	PF00082	0.381
CLV_PCSK_SKI1_1	53	57	PF00082	0.465
DEG_APCC_DBOX_1	52	60	PF00400	0.468
DEG_Nend_UBRbox_1	1	4	PF02207	0.550
DEG_SCF_FBW7_1	224	231	PF00400	0.518
DEG_SPOP_SBC_1	36	40	PF00917	0.481
DOC_CYCLIN_yCln2_LP_2	163	169	PF00134	0.467
DOC_MAPK_gen_1	109	117	PF00069	0.488
DOC_MAPK_gen_1	48	56	PF00069	0.592
DOC_MAPK_MEF2A_6	109	116	PF00069	0.409
DOC_MAPK_MEF2A_6	48	56	PF00069	0.592
DOC_MAPK_MEF2A_6	68	76	PF00069	0.314
DOC_MAPK_MEF2A_6	95	103	PF00069	0.496
DOC_PP4_FxxP_1	148	151	PF00568	0.457
DOC_PP4_FxxP_1	402	405	PF00568	0.595
DOC_USP7_MATH_1	183	187	PF00917	0.496
DOC_USP7_MATH_1	228	232	PF00917	0.603
DOC_USP7_MATH_1	333	337	PF00917	0.431
DOC_USP7_MATH_1	87	91	PF00917	0.497
DOC_USP7_UBL2_3	258	262	PF12436	0.536
DOC_USP7_UBL2_3	44	48	PF12436	0.478
DOC_WW_Pin1_4	224	229	PF00397	0.650
DOC_WW_Pin1_4	325	330	PF00397	0.451
LIG_14-3-3_CanoR_1	386	392	PF00244	0.426
LIG_14-3-3_CanoR_1	417	422	PF00244	0.596
LIG_14-3-3_CanoR_1	77	85	PF00244	0.446
LIG_Actin_WH2_2	39	55	PF00022	0.608
LIG_APCC_ABBA_1	291	296	PF00400	0.372
LIG_BRCT_BRCA1_1	144	148	PF00533	0.497
LIG_BRCT_BRCA1_1	198	202	PF00533	0.431
LIG_BRCT_BRCA1_1	89	93	PF00533	0.552
LIG_BRCT_BRCA1_2	89	95	PF00533	0.614
LIG_deltaCOP1_diTrp_1	67	75	PF00928	0.452
LIG_FHA_1	168	174	PF00498	0.485
LIG_FHA_1	179	185	PF00498	0.369
LIG_FHA_1	254	260	PF00498	0.442
LIG_FHA_1	5	11	PF00498	0.630
LIG_FHA_1	81	87	PF00498	0.517
LIG_FHA_2	126	132	PF00498	0.484
LIG_FHA_2	153	159	PF00498	0.495
LIG_FHA_2	202	208	PF00498	0.371
LIG_FHA_2	228	234	PF00498	0.745
LIG_FHA_2	319	325	PF00498	0.361
LIG_FHA_2	393	399	PF00498	0.693
LIG_LIR_Apic_2	145	151	PF02991	0.485
LIG_LIR_Gen_1	155	165	PF02991	0.457
LIG_LIR_Gen_1	369	380	PF02991	0.504
LIG_LIR_Gen_1	67	76	PF02991	0.467
LIG_LIR_Nem_3	144	150	PF02991	0.541
LIG_LIR_Nem_3	155	160	PF02991	0.444
LIG_LIR_Nem_3	199	205	PF02991	0.484
LIG_LIR_Nem_3	336	341	PF02991	0.381
LIG_LIR_Nem_3	369	375	PF02991	0.581
LIG_LIR_Nem_3	416	421	PF02991	0.666
LIG_LIR_Nem_3	67	72	PF02991	0.449
LIG_LYPXL_yS_3	205	208	PF13949	0.385
LIG_NRBOX	286	292	PF00104	0.323
LIG_PCNA_yPIPBox_3	29	37	PF02747	0.483
LIG_PDZ_Class_1	417	422	PF00595	0.560
LIG_Pex14_1	69	73	PF04695	0.427
LIG_Pex14_2	346	350	PF04695	0.400
LIG_SH2_GRB2like	376	379	PF00017	0.401
LIG_SH2_NCK_1	294	298	PF00017	0.314
LIG_SH2_SRC	294	297	PF00017	0.468
LIG_SH2_STAP1	143	147	PF00017	0.661
LIG_SH2_STAP1	376	380	PF00017	0.489
LIG_SH2_STAP1	415	419	PF00017	0.656
LIG_SH2_STAT5	136	139	PF00017	0.484
LIG_SH2_STAT5	23	26	PF00017	0.530
LIG_SH2_STAT5	301	304	PF00017	0.457
LIG_SH2_STAT5	418	421	PF00017	0.691
LIG_SH2_STAT5	73	76	PF00017	0.448
LIG_SH3_2	330	335	PF14604	0.414
LIG_SH3_3	119	125	PF00018	0.424
LIG_SH3_3	274	280	PF00018	0.404
LIG_SH3_3	302	308	PF00018	0.403
LIG_SH3_3	323	329	PF00018	0.503
LIG_SUMO_SIM_anti_2	321	328	PF11976	0.357
LIG_SUMO_SIM_par_1	180	186	PF11976	0.439
LIG_SUMO_SIM_par_1	207	212	PF11976	0.547
LIG_TRAF2_1	128	131	PF00917	0.454
LIG_TRAF2_1	240	243	PF00917	0.542
LIG_TRAF2_1	363	366	PF00917	0.502
LIG_UBA3_1	384	392	PF00899	0.388
LIG_WRC_WIRS_1	251	256	PF05994	0.546
LIG_WRC_WIRS_1	388	393	PF05994	0.459
LIG_WRC_WIRS_1	5	10	PF05994	0.561
LIG_WW_3	328	332	PF00397	0.432
MOD_CDC14_SPxK_1	328	331	PF00782	0.435
MOD_CDK_SPxK_1	325	331	PF00069	0.396
MOD_CDK_SPxxK_3	325	332	PF00069	0.399
MOD_CK1_1	135	141	PF00069	0.643
MOD_CK1_1	368	374	PF00069	0.662
MOD_CK1_1	387	393	PF00069	0.320
MOD_CK2_1	125	131	PF00069	0.425
MOD_CK2_1	13	19	PF00069	0.661
MOD_CK2_1	152	158	PF00069	0.451
MOD_CK2_1	201	207	PF00069	0.365
MOD_CK2_1	227	233	PF00069	0.672
MOD_Cter_Amidation	95	98	PF01082	0.553
MOD_GlcNHglycan	15	18	PF01048	0.591
MOD_GlcNHglycan	152	155	PF01048	0.512
MOD_GlcNHglycan	230	233	PF01048	0.634
MOD_GSK3_1	174	181	PF00069	0.457
MOD_GSK3_1	197	204	PF00069	0.374
MOD_GSK3_1	224	231	PF00069	0.697
MOD_GSK3_1	314	321	PF00069	0.463
MOD_GSK3_1	76	83	PF00069	0.536
MOD_N-GLC_1	13	18	PF02516	0.561
MOD_N-GLC_1	87	92	PF02516	0.615
MOD_NEK2_1	137	142	PF00069	0.535
MOD_NEK2_1	197	202	PF00069	0.567
MOD_NEK2_1	37	42	PF00069	0.630
MOD_NEK2_1	384	389	PF00069	0.363
MOD_NEK2_2	333	338	PF00069	0.394
MOD_PIKK_1	152	158	PF00454	0.528
MOD_PIKK_1	209	215	PF00454	0.531
MOD_PIKK_1	318	324	PF00454	0.390
MOD_PIKK_1	37	43	PF00454	0.631
MOD_PKA_2	197	203	PF00069	0.391
MOD_PKA_2	76	82	PF00069	0.432
MOD_Plk_1	333	339	PF00069	0.567
MOD_Plk_4	132	138	PF00069	0.516
MOD_Plk_4	333	339	PF00069	0.537
MOD_Plk_4	368	374	PF00069	0.528
MOD_ProDKin_1	224	230	PF00069	0.654
MOD_ProDKin_1	325	331	PF00069	0.458
MOD_SUMO_rev_2	102	111	PF00179	0.542
MOD_SUMO_rev_2	377	385	PF00179	0.388
TRG_DiLeu_BaEn_1	286	291	PF01217	0.379
TRG_DiLeu_BaEn_2	70	76	PF01217	0.445
TRG_DiLeu_BaEn_4	158	164	PF01217	0.475
TRG_ENDOCYTIC_2	205	208	PF00928	0.422
TRG_ENDOCYTIC_2	294	297	PF00928	0.372
TRG_ENDOCYTIC_2	73	76	PF00928	0.439
TRG_ER_diArg_1	222	224	PF00400	0.682
TRG_ER_diArg_1	29	32	PF00400	0.550
TRG_ER_diArg_1	307	310	PF00400	0.478
TRG_ER_diArg_1	311	313	PF00400	0.478
TRG_ER_diArg_1	51	54	PF00400	0.592
TRG_NLS_MonoExtC_3	217	222	PF00514	0.578
TRG_NLS_MonoExtN_4	215	222	PF00514	0.613
TRG_Pf-PMV_PEXEL_1	394	398	PF00026	0.653

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PBR9	Leptomonas seymouri	69%	90%
A0A0S4J059	Bodo saltans	44%	94%
A0A1X0P5E2	Trypanosomatidae	55%	93%
A4HN81	Leishmania braziliensis	86%	100%
A4IBU9	Leishmania infantum	100%	100%
C9ZYR2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	56%	92%
E9AFN6	Leishmania major	95%	100%
E9B6T9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	95%	100%
V5BCS7	Trypanosoma cruzi	55%	93%