4E-interacting protein, putative

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

4E-interacting protein, putative

Species:

Leishmania donovani

UniProt:

A0A3S7X9R7_LEIDO

TriTrypDb:

LdBPK_354030.1 , LdCL_350045400 , LDHU3_35.5230

Length:

791

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A0A3S7X9R7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7X9R7

PDB structure(s): 5wb5_B

Function

Biological processes
Term	Name	Level	Count
GO:0006417	regulation of translation	6	1
GO:0009889	regulation of biosynthetic process	4	1
GO:0010468	regulation of gene expression	5	1
GO:0010556	regulation of macromolecule biosynthetic process	5	1
GO:0010608	post-transcriptional regulation of gene expression	6	1
GO:0019222	regulation of metabolic process	3	1
GO:0031323	regulation of cellular metabolic process	4	1
GO:0031326	regulation of cellular biosynthetic process	5	1
GO:0034248	regulation of amide metabolic process	5	1
GO:0050789	regulation of biological process	2	1
GO:0050794	regulation of cellular process	3	1
GO:0051171	regulation of nitrogen compound metabolic process	4	1
GO:0051246	regulation of protein metabolic process	5	1
GO:0060255	regulation of macromolecule metabolic process	4	1
GO:0065007	biological regulation	1	1
GO:0080090	regulation of primary metabolic process	4	1
GO:2000112	obsolete regulation of cellular macromolecule biosynthetic process	6	1

Molecular functions
Term	Name	Level	Count
GO:0045182	translation regulator activity	1	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	205	209	PF00656	0.579
CLV_NRD_NRD_1	120	122	PF00675	0.629
CLV_NRD_NRD_1	189	191	PF00675	0.503
CLV_NRD_NRD_1	30	32	PF00675	0.574
CLV_NRD_NRD_1	47	49	PF00675	0.628
CLV_NRD_NRD_1	745	747	PF00675	0.542
CLV_PCSK_KEX2_1	120	122	PF00082	0.619
CLV_PCSK_KEX2_1	179	181	PF00082	0.482
CLV_PCSK_KEX2_1	46	48	PF00082	0.640
CLV_PCSK_KEX2_1	745	747	PF00082	0.542
CLV_PCSK_PC1ET2_1	179	181	PF00082	0.482
CLV_PCSK_PC1ET2_1	46	48	PF00082	0.639
CLV_PCSK_SKI1_1	15	19	PF00082	0.512
CLV_PCSK_SKI1_1	196	200	PF00082	0.486
CLV_PCSK_SKI1_1	501	505	PF00082	0.596
CLV_PCSK_SKI1_1	546	550	PF00082	0.617
CLV_Separin_Metazoa	12	16	PF03568	0.526
CLV_Separin_Metazoa	28	32	PF03568	0.429
DEG_APCC_DBOX_1	9	17	PF00400	0.477
DEG_COP1_1	479	489	PF00400	0.657
DEG_SCF_FBW7_1	294	301	PF00400	0.618
DEG_SCF_FBW7_1	449	456	PF00400	0.624
DEG_SIAH_1	289	297	PF03145	0.632
DEG_SPOP_SBC_1	283	287	PF00917	0.558
DEG_SPOP_SBC_1	366	370	PF00917	0.637
DOC_CKS1_1	295	300	PF01111	0.618
DOC_CKS1_1	450	455	PF01111	0.657
DOC_CYCLIN_yClb3_PxF_3	557	563	PF00134	0.672
DOC_CYCLIN_yClb5_NLxxxL_5	191	199	PF00134	0.506
DOC_CYCLIN_yCln2_LP_2	713	719	PF00134	0.552
DOC_MAPK_gen_1	31	38	PF00069	0.611
DOC_PP2B_LxvP_1	627	630	PF13499	0.639
DOC_PP2B_LxvP_1	713	716	PF13499	0.559
DOC_PP4_FxxP_1	146	149	PF00568	0.559
DOC_PP4_FxxP_1	275	278	PF00568	0.616
DOC_PP4_FxxP_1	399	402	PF00568	0.620
DOC_PP4_FxxP_1	563	566	PF00568	0.678
DOC_PP4_FxxP_1	576	579	PF00568	0.573
DOC_PP4_FxxP_1	726	729	PF00568	0.493
DOC_PP4_FxxP_1	744	747	PF00568	0.414
DOC_USP7_MATH_1	267	271	PF00917	0.658
DOC_USP7_MATH_1	278	282	PF00917	0.578
DOC_USP7_MATH_1	290	294	PF00917	0.735
DOC_USP7_MATH_1	298	302	PF00917	0.542
DOC_USP7_MATH_1	310	314	PF00917	0.587
DOC_USP7_MATH_1	344	348	PF00917	0.778
DOC_USP7_MATH_1	367	371	PF00917	0.672
DOC_USP7_MATH_1	381	385	PF00917	0.578
DOC_USP7_MATH_1	412	416	PF00917	0.660
DOC_USP7_MATH_1	439	443	PF00917	0.583
DOC_USP7_MATH_1	477	481	PF00917	0.558
DOC_USP7_MATH_1	577	581	PF00917	0.747
DOC_USP7_MATH_1	586	590	PF00917	0.633
DOC_USP7_MATH_1	639	643	PF00917	0.649
DOC_WW_Pin1_4	103	108	PF00397	0.630
DOC_WW_Pin1_4	260	265	PF00397	0.673
DOC_WW_Pin1_4	294	299	PF00397	0.594
DOC_WW_Pin1_4	342	347	PF00397	0.674
DOC_WW_Pin1_4	405	410	PF00397	0.618
DOC_WW_Pin1_4	449	454	PF00397	0.650
DOC_WW_Pin1_4	515	520	PF00397	0.598
DOC_WW_Pin1_4	556	561	PF00397	0.669
DOC_WW_Pin1_4	579	584	PF00397	0.668
DOC_WW_Pin1_4	595	600	PF00397	0.545
DOC_WW_Pin1_4	684	689	PF00397	0.683
LIG_14-3-3_CanoR_1	15	20	PF00244	0.552
LIG_14-3-3_CanoR_1	242	249	PF00244	0.633
LIG_BIR_III_2	343	347	PF00653	0.648
LIG_BRCT_BRCA1_1	240	244	PF00533	0.560
LIG_EH_1	774	778	PF12763	0.627
LIG_eIF4E_1	8	14	PF01652	0.475
LIG_EVH1_1	627	631	PF00568	0.638
LIG_FHA_1	216	222	PF00498	0.520
LIG_FHA_1	524	530	PF00498	0.646
LIG_FHA_1	690	696	PF00498	0.681
LIG_FHA_2	160	166	PF00498	0.559
LIG_FHA_2	205	211	PF00498	0.509
LIG_FHA_2	227	233	PF00498	0.602
LIG_FHA_2	250	256	PF00498	0.631
LIG_FHA_2	528	534	PF00498	0.601
LIG_FHA_2	7	13	PF00498	0.484
LIG_LIR_Apic_2	144	149	PF02991	0.564
LIG_LIR_Apic_2	272	278	PF02991	0.626
LIG_LIR_Apic_2	398	402	PF02991	0.618
LIG_LIR_Gen_1	141	149	PF02991	0.624
LIG_LIR_Nem_3	141	146	PF02991	0.741
LIG_MLH1_MIPbox_1	240	244	PF16413	0.560
LIG_MYND_1	693	697	PF01753	0.676
LIG_NRBOX	494	500	PF00104	0.516
LIG_NRP_CendR_1	790	791	PF00754	0.640
LIG_SH2_STAP1	143	147	PF00017	0.567
LIG_SH2_STAT5	725	728	PF00017	0.521
LIG_SH2_STAT5	8	11	PF00017	0.481
LIG_SH3_3	259	265	PF00018	0.662
LIG_SH3_3	349	355	PF00018	0.667
LIG_SH3_3	35	41	PF00018	0.590
LIG_SH3_3	398	404	PF00018	0.674
LIG_SH3_3	406	412	PF00018	0.595
LIG_SH3_3	414	420	PF00018	0.552
LIG_SH3_3	447	453	PF00018	0.652
LIG_SH3_3	461	467	PF00018	0.650
LIG_SH3_3	507	513	PF00018	0.628
LIG_SH3_3	554	560	PF00018	0.668
LIG_SH3_3	563	569	PF00018	0.596
LIG_SH3_3	580	586	PF00018	0.531
LIG_SH3_3	614	620	PF00018	0.676
LIG_SH3_3	623	629	PF00018	0.594
LIG_SH3_3	630	636	PF00018	0.523
LIG_SH3_3	668	674	PF00018	0.673
LIG_SH3_3	691	697	PF00018	0.679
LIG_SH3_3	704	710	PF00018	0.557
LIG_SH3_3	770	776	PF00018	0.638
LIG_SUMO_SIM_anti_2	494	499	PF11976	0.527
LIG_SUMO_SIM_par_1	34	40	PF11976	0.582
LIG_TRAF2_1	162	165	PF00917	0.562
LIG_TRAF2_1	9	12	PF00917	0.528
MOD_CK1_1	103	109	PF00069	0.617
MOD_CK1_1	281	287	PF00069	0.573
MOD_CK1_1	313	319	PF00069	0.768
MOD_CK1_1	326	332	PF00069	0.491
MOD_CK1_1	357	363	PF00069	0.729
MOD_CK1_1	384	390	PF00069	0.689
MOD_CK1_1	462	468	PF00069	0.615
MOD_CK1_1	479	485	PF00069	0.646
MOD_CK1_1	515	521	PF00069	0.630
MOD_CK1_1	57	63	PF00069	0.682
MOD_CK1_1	589	595	PF00069	0.647
MOD_CK1_1	64	70	PF00069	0.609
MOD_CK1_1	95	101	PF00069	0.619
MOD_CK2_1	159	165	PF00069	0.567
MOD_CK2_1	204	210	PF00069	0.503
MOD_CK2_1	249	255	PF00069	0.632
MOD_CK2_1	527	533	PF00069	0.611
MOD_CK2_1	6	12	PF00069	0.567
MOD_GlcNHglycan	140	143	PF01048	0.605
MOD_GlcNHglycan	173	176	PF01048	0.448
MOD_GlcNHglycan	20	23	PF01048	0.523
MOD_GlcNHglycan	244	247	PF01048	0.585
MOD_GlcNHglycan	252	255	PF01048	0.634
MOD_GlcNHglycan	300	303	PF01048	0.618
MOD_GlcNHglycan	328	331	PF01048	0.583
MOD_GlcNHglycan	346	349	PF01048	0.633
MOD_GlcNHglycan	383	386	PF01048	0.716
MOD_GlcNHglycan	393	396	PF01048	0.610
MOD_GlcNHglycan	441	444	PF01048	0.664
MOD_GlcNHglycan	479	482	PF01048	0.647
MOD_GlcNHglycan	490	493	PF01048	0.623
MOD_GlcNHglycan	507	510	PF01048	0.547
MOD_GlcNHglycan	592	595	PF01048	0.649
MOD_GlcNHglycan	71	74	PF01048	0.675
MOD_GlcNHglycan	79	82	PF01048	0.799
MOD_GlcNHglycan	87	90	PF01048	0.678
MOD_GSK3_1	130	137	PF00069	0.653
MOD_GSK3_1	238	245	PF00069	0.611
MOD_GSK3_1	256	263	PF00069	0.769
MOD_GSK3_1	267	274	PF00069	0.672
MOD_GSK3_1	277	284	PF00069	0.579
MOD_GSK3_1	290	297	PF00069	0.647
MOD_GSK3_1	309	316	PF00069	0.608
MOD_GSK3_1	319	326	PF00069	0.654
MOD_GSK3_1	331	338	PF00069	0.608
MOD_GSK3_1	357	364	PF00069	0.685
MOD_GSK3_1	377	384	PF00069	0.521
MOD_GSK3_1	391	398	PF00069	0.564
MOD_GSK3_1	424	431	PF00069	0.738
MOD_GSK3_1	434	441	PF00069	0.602
MOD_GSK3_1	449	456	PF00069	0.592
MOD_GSK3_1	476	483	PF00069	0.676
MOD_GSK3_1	484	491	PF00069	0.727
MOD_GSK3_1	501	508	PF00069	0.596
MOD_GSK3_1	515	522	PF00069	0.569
MOD_GSK3_1	523	530	PF00069	0.772
MOD_GSK3_1	552	559	PF00069	0.666
MOD_GSK3_1	57	64	PF00069	0.732
MOD_GSK3_1	585	592	PF00069	0.644
MOD_GSK3_1	639	646	PF00069	0.671
MOD_GSK3_1	65	72	PF00069	0.625
MOD_GSK3_1	94	101	PF00069	0.657
MOD_N-GLC_1	381	386	PF02516	0.606
MOD_N-GLC_1	61	66	PF02516	0.608
MOD_N-GLC_1	684	689	PF02516	0.683
MOD_N-GLC_1	98	103	PF02516	0.713
MOD_NEK2_1	171	176	PF00069	0.493
MOD_NEK2_1	320	325	PF00069	0.591
MOD_NEK2_1	331	336	PF00069	0.599
MOD_NEK2_1	505	510	PF00069	0.636
MOD_NEK2_1	54	59	PF00069	0.745
MOD_NEK2_1	63	68	PF00069	0.596
MOD_NEK2_2	3	8	PF00069	0.541
MOD_NEK2_2	310	315	PF00069	0.642
MOD_NEK2_2	747	752	PF00069	0.562
MOD_PIKK_1	300	306	PF00454	0.632
MOD_PIKK_1	354	360	PF00454	0.747
MOD_PIKK_1	410	416	PF00454	0.569
MOD_PIKK_1	443	449	PF00454	0.588
MOD_PIKK_1	457	463	PF00454	0.706
MOD_PIKK_1	523	529	PF00454	0.709
MOD_PIKK_1	639	645	PF00454	0.649
MOD_PKA_2	171	177	PF00069	0.472
MOD_PKA_2	477	483	PF00069	0.656
MOD_PKB_1	240	248	PF00069	0.575
MOD_Plk_2-3	215	221	PF00069	0.581
MOD_Plk_4	290	296	PF00069	0.670
MOD_Plk_4	413	419	PF00069	0.688
MOD_Plk_4	501	507	PF00069	0.606
MOD_Plk_4	533	539	PF00069	0.525
MOD_Plk_4	54	60	PF00069	0.690
MOD_Plk_4	747	753	PF00069	0.566
MOD_ProDKin_1	103	109	PF00069	0.633
MOD_ProDKin_1	260	266	PF00069	0.670
MOD_ProDKin_1	294	300	PF00069	0.596
MOD_ProDKin_1	342	348	PF00069	0.674
MOD_ProDKin_1	405	411	PF00069	0.618
MOD_ProDKin_1	449	455	PF00069	0.657
MOD_ProDKin_1	515	521	PF00069	0.599
MOD_ProDKin_1	556	562	PF00069	0.672
MOD_ProDKin_1	579	585	PF00069	0.670
MOD_ProDKin_1	595	601	PF00069	0.546
MOD_ProDKin_1	684	690	PF00069	0.684
MOD_SUMO_for_1	202	205	PF00179	0.580
TRG_DiLeu_BaEn_1	220	225	PF01217	0.556
TRG_DiLeu_BaLyEn_6	570	575	PF01217	0.624
TRG_DiLeu_LyEn_5	220	225	PF01217	0.556
TRG_ENDOCYTIC_2	143	146	PF00928	0.632
TRG_ER_diArg_1	239	242	PF00400	0.562
TRG_ER_diArg_1	744	746	PF00400	0.512
TRG_NES_CRM1_1	24	37	PF08389	0.580
TRG_NLS_MonoExtC_3	177	183	PF00514	0.480

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HU08	Leptomonas seymouri	42%	100%
A4HN68	Leishmania braziliensis	73%	100%
A4IBT6	Leishmania infantum	99%	100%
E9AFM3	Leishmania major	90%	100%
E9B6S6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%