Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania donovani

UniProt:

A0A3S7X9Q8_LEIDO

TriTrypDb:

LdBPK_353580.1 , LdCL_350040800 , LDHU3_35.4700

Length:

426

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S7X9Q8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7X9Q8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	195	199	PF00656	0.754
CLV_C14_Caspase3-7	389	393	PF00656	0.635
CLV_C14_Caspase3-7	394	398	PF00656	0.569
CLV_PCSK_SKI1_1	173	177	PF00082	0.656
DOC_CYCLIN_yCln2_LP_2	413	419	PF00134	0.709
DOC_MAPK_gen_1	214	223	PF00069	0.572
DOC_MAPK_MEF2A_6	203	212	PF00069	0.615
DOC_MAPK_MEF2A_6	214	223	PF00069	0.599
DOC_PP1_RVXF_1	185	191	PF00149	0.767
DOC_PP1_SILK_1	297	302	PF00149	0.697
DOC_PP4_FxxP_1	94	97	PF00568	0.604
DOC_USP7_MATH_1	136	140	PF00917	0.715
DOC_USP7_MATH_1	257	261	PF00917	0.693
DOC_USP7_MATH_1	266	270	PF00917	0.479
DOC_USP7_MATH_1	97	101	PF00917	0.603
DOC_USP7_UBL2_3	108	112	PF12436	0.781
DOC_WW_Pin1_4	262	267	PF00397	0.702
LIG_14-3-3_CanoR_1	388	396	PF00244	0.641
LIG_14-3-3_CanoR_1	50	59	PF00244	0.564
LIG_Actin_WH2_2	174	191	PF00022	0.642
LIG_Actin_WH2_2	288	303	PF00022	0.705
LIG_APCC_ABBA_1	167	172	PF00400	0.700
LIG_BIR_II_1	1	5	PF00653	0.655
LIG_BIR_III_4	122	126	PF00653	0.804
LIG_CaM_NSCaTE_8	296	303	PF13499	0.693
LIG_deltaCOP1_diTrp_1	143	152	PF00928	0.671
LIG_deltaCOP1_diTrp_1	376	380	PF00928	0.712
LIG_eIF4E_1	278	284	PF01652	0.704
LIG_FHA_1	22	28	PF00498	0.700
LIG_FHA_1	313	319	PF00498	0.641
LIG_FHA_1	47	53	PF00498	0.657
LIG_FHA_1	81	87	PF00498	0.641
LIG_FHA_2	135	141	PF00498	0.760
LIG_FHA_2	152	158	PF00498	0.546
LIG_FHA_2	270	276	PF00498	0.664
LIG_FHA_2	347	353	PF00498	0.674
LIG_FHA_2	387	393	PF00498	0.727
LIG_GBD_Chelix_1	180	188	PF00786	0.663
LIG_LIR_Apic_2	68	74	PF02991	0.707
LIG_LIR_Apic_2	92	97	PF02991	0.562
LIG_LIR_Gen_1	243	254	PF02991	0.621
LIG_LIR_Gen_1	293	303	PF02991	0.641
LIG_LIR_Gen_1	377	386	PF02991	0.710
LIG_LIR_Gen_1	407	417	PF02991	0.607
LIG_LIR_Nem_3	100	106	PF02991	0.633
LIG_LIR_Nem_3	243	249	PF02991	0.711
LIG_LIR_Nem_3	275	281	PF02991	0.605
LIG_LIR_Nem_3	293	299	PF02991	0.643
LIG_LIR_Nem_3	377	383	PF02991	0.657
LIG_LIR_Nem_3	407	413	PF02991	0.583
LIG_LIR_Nem_3	418	424	PF02991	0.527
LIG_NRBOX	86	92	PF00104	0.534
LIG_Rb_LxCxE_1	330	352	PF01857	0.748
LIG_Rb_pABgroove_1	240	248	PF01858	0.620
LIG_SH2_CRK	103	107	PF00017	0.568
LIG_SH2_PTP2	71	74	PF00017	0.582
LIG_SH2_SRC	356	359	PF00017	0.655
LIG_SH2_SRC	71	74	PF00017	0.711
LIG_SH2_STAP1	356	360	PF00017	0.652
LIG_SH2_STAP1	417	421	PF00017	0.612
LIG_SH2_STAT5	287	290	PF00017	0.640
LIG_SH2_STAT5	35	38	PF00017	0.603
LIG_SH2_STAT5	417	420	PF00017	0.611
LIG_SH2_STAT5	71	74	PF00017	0.582
LIG_SH3_3	216	222	PF00018	0.597
LIG_SH3_3	247	253	PF00018	0.644
LIG_SH3_3	260	266	PF00018	0.459
LIG_SH3_3	313	319	PF00018	0.679
LIG_SUMO_SIM_anti_2	381	387	PF11976	0.716
LIG_TRAF2_1	272	275	PF00917	0.608
LIG_UBA3_1	245	251	PF00899	0.717
LIG_WRC_WIRS_1	328	333	PF05994	0.597
LIG_WRC_WIRS_1	91	96	PF05994	0.740
MOD_CK1_1	107	113	PF00069	0.760
MOD_CK1_1	183	189	PF00069	0.601
MOD_CK1_1	261	267	PF00069	0.789
MOD_CK1_1	269	275	PF00069	0.500
MOD_CK1_1	312	318	PF00069	0.557
MOD_CK1_1	362	368	PF00069	0.682
MOD_CK1_1	80	86	PF00069	0.630
MOD_CK1_1	99	105	PF00069	0.704
MOD_CK2_1	269	275	PF00069	0.677
MOD_CK2_1	333	339	PF00069	0.642
MOD_CK2_1	346	352	PF00069	0.558
MOD_CK2_1	50	56	PF00069	0.648
MOD_GlcNHglycan	126	130	PF01048	0.708
MOD_GlcNHglycan	19	22	PF01048	0.595
MOD_GlcNHglycan	24	27	PF01048	0.541
MOD_GlcNHglycan	266	269	PF01048	0.653
MOD_GlcNHglycan	339	342	PF01048	0.675
MOD_GlcNHglycan	364	367	PF01048	0.525
MOD_GlcNHglycan	389	392	PF01048	0.639
MOD_GlcNHglycan	79	82	PF01048	0.621
MOD_GlcNHglycan	99	102	PF01048	0.679
MOD_GSK3_1	104	111	PF00069	0.538
MOD_GSK3_1	17	24	PF00069	0.611
MOD_GSK3_1	225	232	PF00069	0.684
MOD_GSK3_1	257	264	PF00069	0.772
MOD_GSK3_1	291	298	PF00069	0.711
MOD_GSK3_1	333	340	PF00069	0.569
MOD_GSK3_1	387	394	PF00069	0.582
MOD_GSK3_1	40	47	PF00069	0.699
MOD_GSK3_1	77	84	PF00069	0.711
MOD_GSK3_1	95	102	PF00069	0.638
MOD_LATS_1	38	44	PF00433	0.521
MOD_N-GLC_1	4	9	PF02516	0.647
MOD_N-GLC_2	142	144	PF02516	0.687
MOD_NEK2_1	180	185	PF00069	0.633
MOD_NEK2_1	28	33	PF00069	0.557
MOD_NEK2_1	327	332	PF00069	0.593
MOD_NEK2_1	386	391	PF00069	0.727
MOD_NEK2_1	90	95	PF00069	0.658
MOD_PK_1	40	46	PF00069	0.517
MOD_PKA_2	225	231	PF00069	0.633
MOD_PKA_2	387	393	PF00069	0.635
MOD_PKB_1	372	380	PF00069	0.630
MOD_Plk_1	171	177	PF00069	0.614
MOD_Plk_1	391	397	PF00069	0.656
MOD_Plk_1	81	87	PF00069	0.656
MOD_Plk_4	114	120	PF00069	0.706
MOD_Plk_4	291	297	PF00069	0.669
MOD_Plk_4	391	397	PF00069	0.588
MOD_Plk_4	40	46	PF00069	0.709
MOD_Plk_4	81	87	PF00069	0.551
MOD_Plk_4	90	96	PF00069	0.637
MOD_ProDKin_1	262	268	PF00069	0.700
TRG_DiLeu_BaLyEn_6	219	224	PF01217	0.594
TRG_ENDOCYTIC_2	103	106	PF00928	0.698
TRG_ENDOCYTIC_2	278	281	PF00928	0.616
TRG_ENDOCYTIC_2	356	359	PF00928	0.713
TRG_ENDOCYTIC_2	409	412	PF00928	0.656
TRG_ENDOCYTIC_2	417	420	PF00928	0.568
TRG_ER_diArg_1	187	190	PF00400	0.768
TRG_Pf-PMV_PEXEL_1	50	54	PF00026	0.556

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P2P5	Leptomonas seymouri	37%	90%
A4HN22	Leishmania braziliensis	73%	100%
A4IBP6	Leishmania infantum	100%	100%
E9AFH7	Leishmania major	90%	100%
E9B6N2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	100%