U5_snRNA-associated_splicing_factor/GeneDB:LmjF.3 5.3950

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

PRP8 protein homologue, putative

Species:

Leishmania donovani

UniProt:

A0A3S7X9Q5_LEIDO

TriTrypDb:

LdBPK_354000.1 , LdCL_350045100 , LDHU3_35.5170

Length:

2427

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	yes	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

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Cellular components
Term	Name	Level	Count
GO:0005654	nucleoplasm	2	1
GO:0005681	spliceosomal complex	3	12
GO:0005682	U5 snRNP	5	1
GO:0030532	small nuclear ribonucleoprotein complex	3	1
GO:0032991	protein-containing complex	1	12
GO:0071013	catalytic step 2 spliceosome	3	1
GO:0097525	spliceosomal snRNP complex	4	1
GO:0110165	cellular anatomical entity	1	1
GO:0120114	Sm-like protein family complex	2	1
GO:0140513	nuclear protein-containing complex	2	12

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Expansion

Sequence features

A0A3S7X9Q5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

No structure information available for this entry

Related structures:

Function

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Biological processes
Term	Name	Level	Count
GO:0000244	spliceosomal tri-snRNP complex assembly	8	1
GO:0000375	RNA splicing, via transesterification reactions	8	11
GO:0000377	RNA splicing, via transesterification reactions with bulged adenosine as nucleophile	9	11
GO:0000387	spliceosomal snRNP assembly	7	1
GO:0000398	mRNA splicing, via spliceosome	8	11
GO:0006139	nucleobase-containing compound metabolic process	3	11
GO:0006396	RNA processing	6	11
GO:0006397	mRNA processing	7	11
GO:0006725	cellular aromatic compound metabolic process	3	11
GO:0006807	nitrogen compound metabolic process	2	11

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Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	12
GO:0003723	RNA binding	4	12
GO:0003824	catalytic activity	1	12
GO:0005488	binding	1	12
GO:0008233	peptidase activity	3	12
GO:0008237	metallopeptidase activity	4	12
GO:0016740	transferase activity	2	1
GO:0016787	hydrolase activity	2	12
GO:0017069	snRNA binding	5	12
GO:0017070	U6 snRNA binding	6	12

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Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	1240	1244	PF00656	0.370
CLV_C14_Caspase3-7	2155	2159	PF00656	0.397
CLV_C14_Caspase3-7	2310	2314	PF00656	0.288
CLV_C14_Caspase3-7	340	344	PF00656	0.333
CLV_C14_Caspase3-7	962	966	PF00656	0.400
CLV_MEL_PAP_1	1491	1497	PF00089	0.428
CLV_NRD_NRD_1	1179	1181	PF00675	0.436
CLV_NRD_NRD_1	1317	1319	PF00675	0.226
CLV_NRD_NRD_1	171	173	PF00675	0.253
CLV_NRD_NRD_1	1756	1758	PF00675	0.283

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I297	Leptomonas seymouri	91%	100%
A0A0S4JNS5	Bodo saltans	53%	100%
A0A1X0P548	Trypanosomatidae	73%	100%
A0A422N464	Trypanosoma rangeli	73%	100%
A4HN66	Leishmania braziliensis	95%	100%
A4IBT3	Leishmania infantum	100%	100%
C9ZYT5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	72%	100%
E9AFM0	Leishmania major	99%	100%
E9B6S3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	99%	100%
O14187	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	41%	100%

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