tRNA N(3)-methylcytidine methyltransferase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

methyltransferase domain containing protein, putative

Species:

Leishmania donovani

UniProt:

A0A3S7X9Q3_LEIDO

TriTrypDb:

LdBPK_353650.1 , LdCL_350041500 , LDHU3_35.4790

Length:

387

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S7X9Q3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7X9Q3

Function

Biological processes
Term	Name	Level	Count
GO:0001510	RNA methylation	4	12
GO:0006139	nucleobase-containing compound metabolic process	3	12
GO:0006725	cellular aromatic compound metabolic process	3	12
GO:0006807	nitrogen compound metabolic process	2	12
GO:0008152	metabolic process	1	12
GO:0009451	RNA modification	5	12
GO:0009987	cellular process	1	12
GO:0016070	RNA metabolic process	5	12
GO:0032259	methylation	2	12
GO:0034641	cellular nitrogen compound metabolic process	3	12
GO:0043170	macromolecule metabolic process	3	12
GO:0043412	macromolecule modification	4	12
GO:0043414	macromolecule methylation	3	12
GO:0044237	cellular metabolic process	2	12
GO:0044238	primary metabolic process	2	12
GO:0044260	obsolete cellular macromolecule metabolic process	3	12
GO:0046483	heterocycle metabolic process	3	12
GO:0071704	organic substance metabolic process	2	12
GO:0090304	nucleic acid metabolic process	4	12
GO:1901360	organic cyclic compound metabolic process	3	12

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	12
GO:0008168	methyltransferase activity	4	12
GO:0016740	transferase activity	2	12
GO:0016741	transferase activity, transferring one-carbon groups	3	12

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	263	265	PF00675	0.279
CLV_NRD_NRD_1	28	30	PF00675	0.570
CLV_NRD_NRD_1	289	291	PF00675	0.354
CLV_NRD_NRD_1	298	300	PF00675	0.318
CLV_NRD_NRD_1	330	332	PF00675	0.188
CLV_NRD_NRD_1	353	355	PF00675	0.391
CLV_NRD_NRD_1	362	364	PF00675	0.302
CLV_NRD_NRD_1	380	382	PF00675	0.587
CLV_PCSK_KEX2_1	172	174	PF00082	0.380
CLV_PCSK_KEX2_1	263	265	PF00082	0.262
CLV_PCSK_KEX2_1	289	291	PF00082	0.254
CLV_PCSK_KEX2_1	297	299	PF00082	0.261
CLV_PCSK_KEX2_1	30	32	PF00082	0.534
CLV_PCSK_KEX2_1	362	364	PF00082	0.408
CLV_PCSK_KEX2_1	380	382	PF00082	0.646
CLV_PCSK_KEX2_1	65	67	PF00082	0.499
CLV_PCSK_PC1ET2_1	172	174	PF00082	0.380
CLV_PCSK_PC1ET2_1	30	32	PF00082	0.534
CLV_PCSK_PC1ET2_1	65	67	PF00082	0.518
CLV_PCSK_SKI1_1	154	158	PF00082	0.389
CLV_PCSK_SKI1_1	172	176	PF00082	0.389
CLV_PCSK_SKI1_1	331	335	PF00082	0.259
DEG_SPOP_SBC_1	209	213	PF00917	0.421
DOC_ANK_TNKS_1	296	303	PF00023	0.265
DOC_CKS1_1	201	206	PF01111	0.265
DOC_CYCLIN_RxL_1	149	160	PF00134	0.387
DOC_CYCLIN_yCln2_LP_2	175	178	PF00134	0.188
DOC_MAPK_gen_1	354	360	PF00069	0.436
DOC_MAPK_RevD_3	159	173	PF00069	0.303
DOC_MAPK_RevD_3	248	264	PF00069	0.279
DOC_MAPK_RevD_3	339	355	PF00069	0.349
DOC_PP2B_LxvP_1	175	178	PF13499	0.188
DOC_PP4_FxxP_1	201	204	PF00568	0.371
DOC_USP7_MATH_1	112	116	PF00917	0.394
DOC_USP7_MATH_1	123	127	PF00917	0.413
DOC_USP7_MATH_1	191	195	PF00917	0.355
DOC_USP7_MATH_1	197	201	PF00917	0.326
DOC_USP7_MATH_1	209	213	PF00917	0.244
DOC_USP7_MATH_1	254	258	PF00917	0.371
DOC_USP7_MATH_1	39	43	PF00917	0.613
DOC_USP7_MATH_1	4	8	PF00917	0.751
DOC_USP7_MATH_1	46	50	PF00917	0.596
DOC_WW_Pin1_4	119	124	PF00397	0.286
DOC_WW_Pin1_4	200	205	PF00397	0.349
DOC_WW_Pin1_4	232	237	PF00397	0.199
DOC_WW_Pin1_4	31	36	PF00397	0.596
LIG_14-3-3_CanoR_1	15	20	PF00244	0.732
LIG_14-3-3_CanoR_1	354	359	PF00244	0.513
LIG_14-3-3_CanoR_1	45	52	PF00244	0.542
LIG_14-3-3_CanoR_1	73	78	PF00244	0.419
LIG_BIR_II_1	1	5	PF00653	0.696
LIG_BRCT_BRCA1_1	244	248	PF00533	0.255
LIG_BRCT_BRCA1_1	321	325	PF00533	0.244
LIG_BRCT_BRCA1_1	356	360	PF00533	0.491
LIG_Clathr_ClatBox_1	156	160	PF01394	0.303
LIG_FHA_1	227	233	PF00498	0.308
LIG_Integrin_RGD_1	299	301	PF01839	0.308
LIG_LIR_Apic_2	198	204	PF02991	0.315
LIG_LIR_Gen_1	126	132	PF02991	0.303
LIG_LIR_Gen_1	242	250	PF02991	0.260
LIG_LIR_Nem_3	242	246	PF02991	0.387
LIG_LIR_Nem_3	322	327	PF02991	0.244
LIG_LIR_Nem_3	34	40	PF02991	0.515
LIG_LIR_Nem_3	42	47	PF02991	0.451
LIG_LIR_Nem_3	89	93	PF02991	0.250
LIG_MLH1_MIPbox_1	321	325	PF16413	0.244
LIG_OCRL_FandH_1	79	91	PF00620	0.362
LIG_PCNA_yPIPBox_3	316	325	PF02747	0.244
LIG_Pex14_1	68	72	PF04695	0.329
LIG_Pex14_2	360	364	PF04695	0.468
LIG_SH2_STAT5	277	280	PF00017	0.259
LIG_SH2_STAT5	85	88	PF00017	0.244
LIG_SH3_1	33	39	PF00018	0.572
LIG_SH3_2	10	15	PF14604	0.533
LIG_SH3_3	185	191	PF00018	0.241
LIG_SH3_3	32	38	PF00018	0.572
LIG_SH3_3	7	13	PF00018	0.623
LIG_SUMO_SIM_anti_2	242	248	PF11976	0.389
LIG_SUMO_SIM_par_1	340	345	PF11976	0.304
LIG_TRAF2_1	326	329	PF00917	0.308
LIG_WRPW_2	44	47	PF00400	0.467
MOD_CK1_1	117	123	PF00069	0.394
MOD_CK1_1	200	206	PF00069	0.302
MOD_CK1_1	212	218	PF00069	0.427
MOD_CK2_1	125	131	PF00069	0.349
MOD_CK2_1	323	329	PF00069	0.251
MOD_Cter_Amidation	27	30	PF01082	0.544
MOD_DYRK1A_RPxSP_1	31	35	PF00069	0.472
MOD_GlcNHglycan	106	109	PF01048	0.418
MOD_GlcNHglycan	116	119	PF01048	0.427
MOD_GlcNHglycan	214	217	PF01048	0.363
MOD_GlcNHglycan	372	375	PF01048	0.512
MOD_GlcNHglycan	384	387	PF01048	0.718
MOD_GlcNHglycan	48	51	PF01048	0.676
MOD_GSK3_1	100	107	PF00069	0.364
MOD_GSK3_1	119	126	PF00069	0.405
MOD_GSK3_1	15	22	PF00069	0.558
MOD_GSK3_1	207	214	PF00069	0.351
MOD_GSK3_1	249	256	PF00069	0.308
MOD_GSK3_1	310	317	PF00069	0.249
MOD_GSK3_1	319	326	PF00069	0.255
MOD_GSK3_1	370	377	PF00069	0.523
MOD_GSK3_1	380	387	PF00069	0.675
MOD_GSK3_1	4	11	PF00069	0.702
MOD_N-GLC_1	317	322	PF02516	0.238
MOD_N-GLC_1	73	78	PF02516	0.393
MOD_NEK2_1	159	164	PF00069	0.223
MOD_NEK2_1	291	296	PF00069	0.380
MOD_NEK2_2	197	202	PF00069	0.188
MOD_PIKK_1	8	14	PF00454	0.661
MOD_PK_1	354	360	PF00069	0.507
MOD_PKA_1	354	360	PF00069	0.449
MOD_PKA_1	380	386	PF00069	0.553
MOD_PKA_2	353	359	PF00069	0.506
MOD_PKA_2	380	386	PF00069	0.676
MOD_PKB_1	368	376	PF00069	0.373
MOD_Plk_1	159	165	PF00069	0.228
MOD_Plk_1	197	203	PF00069	0.225
MOD_Plk_1	73	79	PF00069	0.391
MOD_Plk_4	197	203	PF00069	0.308
MOD_Plk_4	242	248	PF00069	0.251
MOD_ProDKin_1	119	125	PF00069	0.286
MOD_ProDKin_1	200	206	PF00069	0.349
MOD_ProDKin_1	232	238	PF00069	0.199
MOD_ProDKin_1	31	37	PF00069	0.596
TRG_DiLeu_BaEn_1	171	176	PF01217	0.210
TRG_DiLeu_BaEn_1	242	247	PF01217	0.355
TRG_DiLeu_BaEn_2	238	244	PF01217	0.308
TRG_ENDOCYTIC_2	147	150	PF00928	0.272
TRG_ENDOCYTIC_2	37	40	PF00928	0.538
TRG_ER_diArg_1	262	264	PF00400	0.279
TRG_ER_diArg_1	289	291	PF00400	0.353
TRG_ER_diArg_1	296	299	PF00400	0.318
TRG_ER_diArg_1	362	364	PF00400	0.400
TRG_ER_diArg_1	369	372	PF00400	0.414
TRG_NLS_MonoExtC_3	28	33	PF00514	0.557
TRG_NLS_MonoExtN_4	29	34	PF00514	0.666
TRG_Pf-PMV_PEXEL_1	331	335	PF00026	0.303

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P4J3	Leptomonas seymouri	66%	100%
A0A0N1I1R8	Leptomonas seymouri	27%	100%
A0A0S4ISJ6	Bodo saltans	26%	88%
A0A0S4KFU5	Bodo saltans	35%	100%
A0A1X0NXB7	Trypanosomatidae	26%	100%
A0A1X0P5J2	Trypanosomatidae	44%	100%
A0A3Q8IDT0	Leishmania donovani	24%	100%
A0A3R7M2M3	Trypanosoma rangeli	45%	100%
A0A422MZQ7	Trypanosoma rangeli	27%	100%
A4HBJ6	Leishmania braziliensis	27%	100%
A4HN30	Leishmania braziliensis	77%	100%
A4HZL8	Leishmania infantum	25%	100%
A4IBP9	Leishmania infantum	100%	100%
A8KBL7	Danio rerio	24%	100%
C9ZYX5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	45%	100%
D0A1J3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	25%	100%
E9AFI4	Leishmania major	93%	100%
E9AUW5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	26%	100%
E9B6N9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%
Q0P5B2	Bos taurus	25%	100%
Q4QCL7	Leishmania major	24%	100%
Q5RDV8	Pongo abelii	27%	100%
Q5ZHP8	Gallus gallus	23%	100%
Q6AXU8	Rattus norvegicus	28%	100%
Q6P1Q9	Homo sapiens	23%	100%
Q86BS6	Drosophila melanogaster	25%	100%
Q8BVH9	Mus musculus	27%	100%
Q8TCB7	Homo sapiens	27%	100%
Q96IZ6	Homo sapiens	23%	100%
V5BCV4	Trypanosoma cruzi	46%	100%
V5DGW7	Trypanosoma cruzi	27%	100%