LeishMANIAdb
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Uncharacterized protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
Uncharacterized protein
Gene product:
hypothetical protein, conserved
Species:
Leishmania donovani
UniProt:
A0A3S7X9P9_LEIDO
TriTrypDb:
LdBPK_353050.1 * , LdCL_350035400 , LDHU3_35.3950
Length:
460

Annotations

LeishMANIAdb annotations

Possesses a conserved Fe2+ binding catalytic pocket. Might be involved in some unknown metabolic pathway.. Most similar to Chlamydomonas proteins A0A2K3DQH2 and A0A835WMM9.

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 9
NetGPI no yes: 0, no: 9
Cellular components
Term Name Level Count
GO:0016020 membrane 2 9
GO:0110165 cellular anatomical entity 1 9

Expansion

Sequence features

A0A3S7X9P9
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7X9P9

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_MEL_PAP_1 284 290 PF00089 0.416
CLV_NRD_NRD_1 139 141 PF00675 0.383
CLV_NRD_NRD_1 24 26 PF00675 0.378
CLV_NRD_NRD_1 270 272 PF00675 0.324
CLV_NRD_NRD_1 56 58 PF00675 0.508
CLV_PCSK_KEX2_1 26 28 PF00082 0.382
CLV_PCSK_KEX2_1 270 272 PF00082 0.324
CLV_PCSK_KEX2_1 56 58 PF00082 0.506
CLV_PCSK_PC1ET2_1 26 28 PF00082 0.382
CLV_PCSK_SKI1_1 119 123 PF00082 0.355
CLV_PCSK_SKI1_1 155 159 PF00082 0.479
CLV_PCSK_SKI1_1 407 411 PF00082 0.392
DEG_APCC_DBOX_1 208 216 PF00400 0.531
DEG_APCC_DBOX_1 450 458 PF00400 0.624
DEG_APCC_KENBOX_2 101 105 PF00400 0.598
DEG_COP1_1 6 16 PF00400 0.297
DEG_Nend_Nbox_1 1 3 PF02207 0.381
DEG_SPOP_SBC_1 173 177 PF00917 0.665
DEG_SPOP_SBC_1 400 404 PF00917 0.609
DOC_CKS1_1 82 87 PF01111 0.660
DOC_CYCLIN_RxL_1 401 414 PF00134 0.591
DOC_MAPK_MEF2A_6 102 109 PF00069 0.540
DOC_MAPK_RevD_3 11 26 PF00069 0.300
DOC_PP2B_LxvP_1 11 14 PF13499 0.307
DOC_PP2B_LxvP_1 379 382 PF13499 0.670
DOC_PP2B_PxIxI_1 13 19 PF00149 0.372
DOC_USP7_MATH_1 157 161 PF00917 0.643
DOC_USP7_MATH_1 165 169 PF00917 0.718
DOC_USP7_MATH_1 173 177 PF00917 0.705
DOC_USP7_MATH_1 203 207 PF00917 0.547
DOC_USP7_MATH_1 382 386 PF00917 0.667
DOC_USP7_MATH_1 400 404 PF00917 0.592
DOC_WW_Pin1_4 174 179 PF00397 0.743
DOC_WW_Pin1_4 241 246 PF00397 0.481
DOC_WW_Pin1_4 278 283 PF00397 0.517
DOC_WW_Pin1_4 340 345 PF00397 0.658
DOC_WW_Pin1_4 81 86 PF00397 0.712
LIG_14-3-3_CanoR_1 128 134 PF00244 0.560
LIG_14-3-3_CanoR_1 225 231 PF00244 0.551
LIG_14-3-3_CanoR_1 285 295 PF00244 0.554
LIG_14-3-3_CanoR_1 401 409 PF00244 0.702
LIG_APCC_ABBA_1 393 398 PF00400 0.483
LIG_BIR_III_4 438 442 PF00653 0.593
LIG_CtBP_PxDLS_1 115 119 PF00389 0.576
LIG_DCNL_PONY_1 1 4 PF03556 0.427
LIG_deltaCOP1_diTrp_1 323 326 PF00928 0.477
LIG_deltaCOP1_diTrp_1 414 418 PF00928 0.655
LIG_FHA_1 13 19 PF00498 0.297
LIG_FHA_1 185 191 PF00498 0.583
LIG_FHA_2 175 181 PF00498 0.682
LIG_FHA_2 298 304 PF00498 0.509
LIG_FHA_2 427 433 PF00498 0.708
LIG_FHA_2 44 50 PF00498 0.606
LIG_FHA_2 98 104 PF00498 0.648
LIG_LIR_Gen_1 263 269 PF02991 0.479
LIG_LIR_Gen_1 450 459 PF02991 0.599
LIG_LIR_Gen_1 6 16 PF02991 0.393
LIG_LIR_LC3C_4 389 394 PF02991 0.468
LIG_LIR_Nem_3 180 184 PF02991 0.646
LIG_LIR_Nem_3 229 233 PF02991 0.570
LIG_LIR_Nem_3 263 267 PF02991 0.494
LIG_LIR_Nem_3 53 58 PF02991 0.655
LIG_LIR_Nem_3 6 11 PF02991 0.276
LIG_LYPXL_yS_3 44 47 PF13949 0.589
LIG_REV1ctd_RIR_1 52 59 PF16727 0.641
LIG_SH2_CRK 250 254 PF00017 0.600
LIG_SH2_CRK 8 12 PF00017 0.393
LIG_SH2_PTP2 264 267 PF00017 0.477
LIG_SH2_STAP1 8 12 PF00017 0.393
LIG_SH2_STAT5 221 224 PF00017 0.637
LIG_SH2_STAT5 240 243 PF00017 0.456
LIG_SH2_STAT5 264 267 PF00017 0.477
LIG_SH2_STAT5 369 372 PF00017 0.604
LIG_SH2_STAT5 453 456 PF00017 0.572
LIG_SH2_STAT5 8 11 PF00017 0.393
LIG_SH3_1 250 256 PF00018 0.608
LIG_SH3_1 338 344 PF00018 0.655
LIG_SH3_2 341 346 PF14604 0.660
LIG_SH3_3 110 116 PF00018 0.595
LIG_SH3_3 250 256 PF00018 0.563
LIG_SH3_3 262 268 PF00018 0.449
LIG_SH3_3 303 309 PF00018 0.565
LIG_SH3_3 338 344 PF00018 0.695
LIG_SH3_3 67 73 PF00018 0.707
LIG_SUMO_SIM_anti_2 303 308 PF11976 0.555
LIG_SUMO_SIM_par_1 455 460 PF11976 0.666
LIG_WRC_WIRS_1 415 420 PF05994 0.476
LIG_WRC_WIRS_1 424 429 PF05994 0.544
MOD_CDC14_SPxK_1 343 346 PF00782 0.546
MOD_CDK_SPxK_1 340 346 PF00069 0.532
MOD_CDK_SPxxK_3 241 248 PF00069 0.291
MOD_CDK_SPxxK_3 278 285 PF00069 0.408
MOD_CK1_1 169 175 PF00069 0.681
MOD_CK1_1 286 292 PF00069 0.432
MOD_CK1_1 385 391 PF00069 0.542
MOD_CK1_1 423 429 PF00069 0.620
MOD_CK1_1 6 12 PF00069 0.393
MOD_CK2_1 426 432 PF00069 0.721
MOD_CK2_1 43 49 PF00069 0.417
MOD_CK2_1 97 103 PF00069 0.593
MOD_GlcNHglycan 159 162 PF01048 0.681
MOD_GlcNHglycan 171 174 PF01048 0.636
MOD_GlcNHglycan 205 208 PF01048 0.435
MOD_GlcNHglycan 309 312 PF01048 0.457
MOD_GlcNHglycan 384 387 PF01048 0.601
MOD_GlcNHglycan 61 64 PF01048 0.642
MOD_GSK3_1 129 136 PF00069 0.555
MOD_GSK3_1 165 172 PF00069 0.650
MOD_GSK3_1 330 337 PF00069 0.580
MOD_GSK3_1 39 46 PF00069 0.557
MOD_GSK3_1 401 408 PF00069 0.653
MOD_NEK2_1 184 189 PF00069 0.475
MOD_NEK2_1 21 26 PF00069 0.530
MOD_PIKK_1 127 133 PF00454 0.455
MOD_PK_1 420 426 PF00069 0.596
MOD_PKA_2 127 133 PF00069 0.530
MOD_PKA_2 165 171 PF00069 0.665
MOD_PKA_2 226 232 PF00069 0.381
MOD_PKA_2 286 292 PF00069 0.524
MOD_PKA_2 400 406 PF00069 0.588
MOD_PKA_2 433 439 PF00069 0.501
MOD_Plk_1 145 151 PF00069 0.421
MOD_Plk_2-3 428 434 PF00069 0.684
MOD_Plk_4 12 18 PF00069 0.322
MOD_Plk_4 273 279 PF00069 0.393
MOD_Plk_4 3 9 PF00069 0.272
MOD_Plk_4 330 336 PF00069 0.646
MOD_ProDKin_1 174 180 PF00069 0.691
MOD_ProDKin_1 241 247 PF00069 0.333
MOD_ProDKin_1 278 284 PF00069 0.400
MOD_ProDKin_1 340 346 PF00069 0.584
MOD_ProDKin_1 81 87 PF00069 0.656
TRG_DiLeu_BaEn_1 195 200 PF01217 0.468
TRG_ENDOCYTIC_2 264 267 PF00928 0.326
TRG_ENDOCYTIC_2 369 372 PF00928 0.503
TRG_ENDOCYTIC_2 44 47 PF00928 0.482
TRG_ENDOCYTIC_2 453 456 PF00928 0.435
TRG_ENDOCYTIC_2 8 11 PF00928 0.393
TRG_ER_diArg_1 209 212 PF00400 0.484
TRG_ER_diArg_1 25 28 PF00400 0.471
TRG_ER_diArg_1 269 271 PF00400 0.365
TRG_ER_diArg_1 284 287 PF00400 0.498
TRG_ER_diArg_1 360 363 PF00400 0.406
TRG_ER_diArg_1 55 57 PF00400 0.591
TRG_NES_CRM1_1 231 242 PF08389 0.464
TRG_NLS_MonoExtN_4 139 144 PF00514 0.415
TRG_Pf-PMV_PEXEL_1 188 192 PF00026 0.463
TRG_Pf-PMV_PEXEL_1 220 224 PF00026 0.474
TRG_Pf-PMV_PEXEL_1 407 412 PF00026 0.538

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1I3G4 Leptomonas seymouri 62% 95%
A0A1X0P5E8 Trypanosomatidae 50% 100%
A4HMW7 Leishmania braziliensis 82% 100%
A4IBI8 Leishmania infantum 99% 100%
C9ZZ52 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 46% 100%
E9AFC4 Leishmania major 94% 100%
E9B6H9 Leishmania mexicana (strain MHOM/GT/2001/U1103) 89% 100%
V5DUR9 Trypanosoma cruzi 47% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2024 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS