Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S7X9N6_LEIDO

TriTrypDb:

LdBPK_353760.1 , LdCL_350042600 , LDHU3_35.4920

Length:

341

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	10
GO:0110165	cellular anatomical entity	1	10

Expansion

Sequence features

A0A3S7X9N6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7X9N6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	56	60	PF00656	0.487
CLV_NRD_NRD_1	129	131	PF00675	0.572
CLV_NRD_NRD_1	77	79	PF00675	0.677
CLV_PCSK_FUR_1	75	79	PF00082	0.613
CLV_PCSK_KEX2_1	129	131	PF00082	0.568
CLV_PCSK_KEX2_1	77	79	PF00082	0.714
CLV_PCSK_SKI1_1	117	121	PF00082	0.663
CLV_PCSK_SKI1_1	274	278	PF00082	0.568
CLV_PCSK_SKI1_1	282	286	PF00082	0.355
DEG_MDM2_SWIB_1	235	243	PF02201	0.575
DEG_SCF_TRCP1_1	59	65	PF00400	0.499
DOC_ANK_TNKS_1	76	83	PF00023	0.464
DOC_CKS1_1	275	280	PF01111	0.358
DOC_MAPK_gen_1	139	147	PF00069	0.394
DOC_PP1_RVXF_1	144	150	PF00149	0.348
DOC_USP7_MATH_1	115	119	PF00917	0.433
DOC_USP7_MATH_1	21	25	PF00917	0.549
DOC_USP7_MATH_1	322	326	PF00917	0.702
DOC_USP7_MATH_1	331	335	PF00917	0.555
DOC_USP7_UBL2_3	189	193	PF12436	0.526
DOC_WW_Pin1_4	17	22	PF00397	0.531
DOC_WW_Pin1_4	242	247	PF00397	0.577
DOC_WW_Pin1_4	274	279	PF00397	0.342
LIG_14-3-3_CanoR_1	166	175	PF00244	0.292
LIG_14-3-3_CanoR_1	282	288	PF00244	0.493
LIG_14-3-3_CanoR_1	83	88	PF00244	0.484
LIG_BIR_III_2	330	334	PF00653	0.605
LIG_BRCT_BRCA1_1	200	204	PF00533	0.522
LIG_deltaCOP1_diTrp_1	317	323	PF00928	0.550
LIG_FHA_1	178	184	PF00498	0.571
LIG_FHA_1	206	212	PF00498	0.621
LIG_FHA_1	310	316	PF00498	0.588
LIG_FHA_1	84	90	PF00498	0.430
LIG_FHA_2	49	55	PF00498	0.520
LIG_LIR_Apic_2	317	322	PF02991	0.538
LIG_LIR_Gen_1	188	199	PF02991	0.531
LIG_LIR_Gen_1	201	212	PF02991	0.494
LIG_LIR_Gen_1	232	243	PF02991	0.611
LIG_LIR_Gen_1	249	258	PF02991	0.375
LIG_LIR_Gen_1	43	50	PF02991	0.430
LIG_LIR_Gen_1	65	73	PF02991	0.443
LIG_LIR_Nem_3	188	194	PF02991	0.533
LIG_LIR_Nem_3	201	207	PF02991	0.499
LIG_LIR_Nem_3	232	238	PF02991	0.585
LIG_LIR_Nem_3	249	254	PF02991	0.412
LIG_LIR_Nem_3	3	7	PF02991	0.572
LIG_LIR_Nem_3	43	49	PF02991	0.537
LIG_NRBOX	233	239	PF00104	0.528
LIG_Pex14_2	235	239	PF04695	0.566
LIG_Pex14_2	99	103	PF04695	0.466
LIG_SH2_CRK	191	195	PF00017	0.561
LIG_SH2_CRK	273	277	PF00017	0.359
LIG_SH2_GRB2like	125	128	PF00017	0.394
LIG_SH2_SRC	123	126	PF00017	0.458
LIG_SH2_STAT3	307	310	PF00017	0.558
LIG_SH2_STAT5	163	166	PF00017	0.272
LIG_SH2_STAT5	182	185	PF00017	0.525
LIG_SH2_STAT5	268	271	PF00017	0.406
LIG_SH2_STAT5	298	301	PF00017	0.403
LIG_SH3_3	240	246	PF00018	0.542
LIG_SUMO_SIM_par_1	283	289	PF11976	0.341
LIG_WRPW_2	304	307	PF00400	0.537
LIG_WRPW_2	320	323	PF00400	0.547
MOD_CDC14_SPxK_1	245	248	PF00782	0.563
MOD_CDK_SPxK_1	242	248	PF00069	0.570
MOD_CK1_1	22	28	PF00069	0.527
MOD_CK1_1	257	263	PF00069	0.341
MOD_CK1_1	286	292	PF00069	0.370
MOD_CK2_1	94	100	PF00069	0.363
MOD_CMANNOS	149	152	PF00535	0.514
MOD_CMANNOS	320	323	PF00535	0.366
MOD_GlcNHglycan	12	15	PF01048	0.735
MOD_GlcNHglycan	239	242	PF01048	0.377
MOD_GlcNHglycan	259	262	PF01048	0.199
MOD_GlcNHglycan	290	293	PF01048	0.483
MOD_GlcNHglycan	59	62	PF01048	0.732
MOD_GSK3_1	17	24	PF00069	0.536
MOD_GSK3_1	183	190	PF00069	0.620
MOD_GSK3_1	237	244	PF00069	0.558
MOD_GSK3_1	253	260	PF00069	0.406
MOD_GSK3_1	36	43	PF00069	0.406
MOD_N-GLC_1	254	259	PF02516	0.341
MOD_NEK2_1	187	192	PF00069	0.574
MOD_NEK2_1	219	224	PF00069	0.595
MOD_NEK2_1	254	259	PF00069	0.434
MOD_NEK2_1	285	290	PF00069	0.393
MOD_NEK2_1	36	41	PF00069	0.556
MOD_NEK2_1	94	99	PF00069	0.524
MOD_PIKK_1	62	68	PF00454	0.486
MOD_PKA_2	10	16	PF00069	0.536
MOD_PKA_2	82	88	PF00069	0.507
MOD_Plk_1	187	193	PF00069	0.599
MOD_Plk_1	254	260	PF00069	0.342
MOD_Plk_2-3	42	48	PF00069	0.491
MOD_Plk_2-3	88	94	PF00069	0.445
MOD_ProDKin_1	17	23	PF00069	0.528
MOD_ProDKin_1	242	248	PF00069	0.570
MOD_ProDKin_1	274	280	PF00069	0.337
MOD_SUMO_rev_2	25	35	PF00179	0.490
TRG_ENDOCYTIC_2	184	187	PF00928	0.501
TRG_ENDOCYTIC_2	191	194	PF00928	0.529
TRG_ENDOCYTIC_2	268	271	PF00928	0.406
TRG_ENDOCYTIC_2	273	276	PF00928	0.407
TRG_ENDOCYTIC_2	64	67	PF00928	0.473
TRG_ER_diArg_1	129	131	PF00400	0.385
TRG_ER_diArg_1	75	78	PF00400	0.508
TRG_Pf-PMV_PEXEL_1	38	42	PF00026	0.724

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PB50	Leptomonas seymouri	58%	99%
A0A1X0P6A1	Trypanosomatidae	41%	100%
A0A422MTB0	Trypanosoma rangeli	40%	100%
A4HN42	Leishmania braziliensis	86%	100%
A4IBR0	Leishmania infantum	99%	100%
C9ZYW4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	39%	100%
E9AFJ5	Leishmania major	99%	100%
E9B6P9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	94%	100%
V5C2T1	Trypanosoma cruzi	42%	100%