NifU-like N terminal domain family protein

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

iron-sulfur cluster assembly protein, putative

Species:

Leishmania donovani

UniProt:

A0A3S7X9M5_LEIDO

TriTrypDb:

LdBPK_353670.1 , LdCL_350041700 , LDHU3_35.4820

Length:

161

Annotations

Annotations by Jardim et al.

Metal Binding, iron-sulfur cluster assembly

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0005739	mitochondrion	5	1
GO:0005759	mitochondrial matrix	5	1
GO:0031974	membrane-enclosed lumen	2	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0043233	organelle lumen	3	1
GO:0070013	intracellular organelle lumen	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A0A3S7X9M5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7X9M5

Function

Biological processes
Term	Name	Level	Count
GO:0006790	sulfur compound metabolic process	3	12
GO:0008152	metabolic process	1	12
GO:0009987	cellular process	1	12
GO:0016043	cellular component organization	3	12
GO:0016226	iron-sulfur cluster assembly	4	12
GO:0022607	cellular component assembly	4	12
GO:0031163	metallo-sulfur cluster assembly	5	12
GO:0044237	cellular metabolic process	2	12
GO:0071840	cellular component organization or biogenesis	2	12
GO:0006873	intracellular monoatomic ion homeostasis	4	1
GO:0006875	obsolete intracellular metal ion homeostasis	6	1
GO:0006879	intracellular iron ion homeostasis	8	1
GO:0019725	cellular homeostasis	2	1
GO:0030003	intracellular monoatomic cation homeostasis	5	1
GO:0042592	homeostatic process	3	1
GO:0046916	obsolete intracellular transition metal ion homeostasis	7	1
GO:0048878	chemical homeostasis	4	1
GO:0050801	monoatomic ion homeostasis	5	1
GO:0055065	obsolete metal ion homeostasis	7	1
GO:0055072	obsolete iron ion homeostasis	9	1
GO:0055076	obsolete transition metal ion homeostasis	8	1
GO:0055080	monoatomic cation homeostasis	6	1
GO:0055082	intracellular chemical homeostasis	3	1
GO:0065007	biological regulation	1	1
GO:0065008	regulation of biological quality	2	1
GO:0098771	inorganic ion homeostasis	6	1

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	12
GO:0005506	iron ion binding	6	12
GO:0043167	ion binding	2	12
GO:0043169	cation binding	3	12
GO:0046872	metal ion binding	4	12
GO:0046914	transition metal ion binding	5	12
GO:0051536	iron-sulfur cluster binding	3	12
GO:0051540	metal cluster binding	2	12
GO:0008198	ferrous iron binding	7	1
GO:0016530	metallochaperone activity	2	1
GO:0051537	2 iron, 2 sulfur cluster binding	4	1
GO:0140104	molecular carrier activity	1	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	99	103	PF00656	0.506
CLV_NRD_NRD_1	152	154	PF00675	0.646
CLV_PCSK_KEX2_1	152	154	PF00082	0.624
CLV_PCSK_PC1ET2_1	152	154	PF00082	0.624
DOC_PP2B_LxvP_1	115	118	PF13499	0.445
DOC_USP7_MATH_1	86	90	PF00917	0.439
DOC_USP7_UBL2_3	105	109	PF12436	0.486
LIG_14-3-3_CanoR_1	96	101	PF00244	0.445
LIG_BIR_II_1	1	5	PF00653	0.512
LIG_FHA_1	66	72	PF00498	0.444
LIG_FHA_2	105	111	PF00498	0.506
LIG_FHA_2	97	103	PF00498	0.428
LIG_LIR_Apic_2	26	31	PF02991	0.447
LIG_LIR_Nem_3	73	79	PF02991	0.454
LIG_SH2_CRK	28	32	PF00017	0.501
LIG_SH2_STAP1	20	24	PF00017	0.486
LIG_SH2_STAP1	90	94	PF00017	0.456
LIG_SH2_STAT3	90	93	PF00017	0.456
LIG_SH2_STAT5	139	142	PF00017	0.445
LIG_SUMO_SIM_par_1	67	73	PF11976	0.550
MOD_CK1_1	148	154	PF00069	0.482
MOD_CK1_1	89	95	PF00069	0.439
MOD_CK2_1	104	110	PF00069	0.489
MOD_GlcNHglycan	82	85	PF01048	0.243
MOD_GSK3_1	138	145	PF00069	0.447
MOD_GSK3_1	85	92	PF00069	0.456
MOD_NEK2_1	104	109	PF00069	0.437
MOD_NEK2_1	122	127	PF00069	0.445
MOD_NEK2_2	128	133	PF00069	0.506
MOD_NEK2_2	15	20	PF00069	0.540
MOD_PIKK_1	55	61	PF00454	0.456
MOD_PIKK_1	89	95	PF00454	0.445
MOD_Plk_1	113	119	PF00069	0.456
MOD_Plk_1	128	134	PF00069	0.486
MOD_Plk_1	55	61	PF00069	0.443
MOD_Plk_4	122	128	PF00069	0.441
MOD_Plk_4	65	71	PF00069	0.471
MOD_SUMO_for_1	158	161	PF00179	0.686
MOD_SUMO_rev_2	67	76	PF00179	0.456
TRG_DiLeu_BaLyEn_6	2	7	PF01217	0.429
TRG_Pf-PMV_PEXEL_1	17	22	PF00026	0.578

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PCH5	Leptomonas seymouri	91%	95%
A0A0S4KK43	Bodo saltans	78%	100%
A0A1X0P6B0	Trypanosomatidae	87%	92%
A0A3R7KQV6	Trypanosoma rangeli	80%	98%
A4HN32	Leishmania braziliensis	96%	100%
A4IBQ1	Leishmania infantum	100%	100%
B0YLW7	Trachipleistophora hominis	59%	100%
C9ZYX3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	82%	89%
E9AFI6	Leishmania major	96%	100%
E9B6P1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	96%	100%
O31270	Azotobacter vinelandii	59%	100%
O32163	Bacillus subtilis (strain 168)	31%	100%
O49627	Arabidopsis thaliana	61%	96%
O51885	Buchnera aphidicola subsp. Schizaphis graminum (strain Sg)	55%	100%
O67045	Aquifex aeolicus (strain VF5)	54%	100%
O81433	Arabidopsis thaliana	57%	94%
P0ACD4	Escherichia coli (strain K12)	58%	100%
P0ACD5	Escherichia coli O6:H1 (strain CFT073 / ATCC 700928 / UPEC)	58%	100%
P0ACD6	Escherichia coli O157:H7	58%	100%
P0ACD7	Shigella flexneri	58%	100%
P0DMG1	Archaeoglobus fulgidus (strain ATCC 49558 / DSM 4304 / JCM 9628 / NBRC 100126 / VC-16)	44%	100%
P0DMG2	Archaeoglobus fulgidus (strain ATCC 49558 / DSM 4304 / JCM 9628 / NBRC 100126 / VC-16)	44%	100%
P57658	Buchnera aphidicola subsp. Acyrthosiphon pisum (strain APS)	54%	100%
Q03020	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	59%	98%
Q12056	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	59%	100%
Q57074	Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)	59%	100%
Q6BGU0	Debaryomyces hansenii (strain ATCC 36239 / CBS 767 / BCRC 21394 / JCM 1990 / NBRC 0083 / IGC 2968)	61%	90%
Q6CFQ0	Yarrowia lipolytica (strain CLIB 122 / E 150)	62%	89%
Q6CRQ9	Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)	61%	89%
Q6FJY3	Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65)	63%	76%
Q75C07	Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)	64%	100%
Q89A18	Buchnera aphidicola subsp. Baizongia pistaciae (strain Bp)	55%	100%
Q8LR34	Oryza sativa subsp. japonica	53%	94%
Q8SSM2	Encephalitozoon cuniculi (strain GB-M1)	57%	100%
Q9D7P6	Mus musculus	54%	96%
Q9H1K1	Homo sapiens	54%	96%
Q9MAB6	Arabidopsis thaliana	58%	99%
Q9UTC6	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	60%	84%
Q9ZD61	Rickettsia prowazekii (strain Madrid E)	62%	100%
V5BTL0	Trypanosoma cruzi	83%	99%