Hypothetical_protein_conserved

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S7X9M3_LEIDO

TriTrypDb:

LdBPK_352750.1 , LdCL_350032400 , LDHU3_35.3500

Length:

512

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S7X9M3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7X9M3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	310	314	PF00656	0.620
CLV_NRD_NRD_1	492	494	PF00675	0.554
CLV_NRD_NRD_1	7	9	PF00675	0.586
CLV_PCSK_KEX2_1	444	446	PF00082	0.736
CLV_PCSK_KEX2_1	491	493	PF00082	0.569
CLV_PCSK_PC1ET2_1	444	446	PF00082	0.736
CLV_PCSK_PC1ET2_1	491	493	PF00082	0.569
CLV_PCSK_SKI1_1	139	143	PF00082	0.561
CLV_PCSK_SKI1_1	221	225	PF00082	0.628
CLV_PCSK_SKI1_1	29	33	PF00082	0.513
CLV_PCSK_SKI1_1	294	298	PF00082	0.550
CLV_PCSK_SKI1_1	482	486	PF00082	0.534
CLV_PCSK_SKI1_1	8	12	PF00082	0.455
DEG_APCC_DBOX_1	293	301	PF00400	0.576
DEG_APCC_DBOX_1	349	357	PF00400	0.580
DEG_APCC_DBOX_1	7	15	PF00400	0.448
DEG_Nend_UBRbox_1	1	4	PF02207	0.645
DEG_SCF_FBW7_1	59	66	PF00400	0.638
DEG_SPOP_SBC_1	208	212	PF00917	0.686
DEG_SPOP_SBC_1	48	52	PF00917	0.783
DEG_SPOP_SBC_1	74	78	PF00917	0.705
DOC_CYCLIN_RxL_1	136	146	PF00134	0.550
DOC_MAPK_gen_1	137	144	PF00069	0.585
DOC_MAPK_RevD_3	479	493	PF00069	0.489
DOC_PP1_RVXF_1	137	144	PF00149	0.473
DOC_PP1_RVXF_1	346	352	PF00149	0.528
DOC_PP4_FxxP_1	427	430	PF00568	0.655
DOC_USP7_MATH_1	208	212	PF00917	0.729
DOC_USP7_MATH_1	223	227	PF00917	0.756
DOC_USP7_MATH_1	314	318	PF00917	0.537
DOC_USP7_MATH_1	358	362	PF00917	0.667
DOC_USP7_MATH_1	438	442	PF00917	0.747
DOC_USP7_MATH_1	461	465	PF00917	0.599
DOC_USP7_MATH_1	68	72	PF00917	0.831
DOC_USP7_MATH_1	74	78	PF00917	0.722
DOC_USP7_UBL2_3	12	16	PF12436	0.526
DOC_WW_Pin1_4	354	359	PF00397	0.567
DOC_WW_Pin1_4	451	456	PF00397	0.698
DOC_WW_Pin1_4	59	64	PF00397	0.729
DOC_WW_Pin1_4	70	75	PF00397	0.689
LIG_14-3-3_CanoR_1	150	159	PF00244	0.647
LIG_14-3-3_CanoR_1	29	35	PF00244	0.530
LIG_14-3-3_CanoR_1	348	354	PF00244	0.443
LIG_14-3-3_CanoR_1	465	470	PF00244	0.548
LIG_14-3-3_CanoR_1	93	101	PF00244	0.666
LIG_BRCT_BRCA1_1	463	467	PF00533	0.569
LIG_FHA_1	101	107	PF00498	0.547
LIG_FHA_1	154	160	PF00498	0.560
LIG_FHA_1	296	302	PF00498	0.500
LIG_FHA_2	281	287	PF00498	0.574
LIG_FHA_2	308	314	PF00498	0.571
LIG_FHA_2	328	334	PF00498	0.292
LIG_FHA_2	37	43	PF00498	0.741
LIG_FHA_2	438	444	PF00498	0.791
LIG_FHA_2	457	463	PF00498	0.557
LIG_FHA_2	64	70	PF00498	0.739
LIG_FHA_2	80	86	PF00498	0.497
LIG_IRF3_LxIS_1	160	167	PF10401	0.695
LIG_LIR_Apic_2	424	430	PF02991	0.635
LIG_LIR_Gen_1	373	383	PF02991	0.424
LIG_LIR_Gen_1	408	418	PF02991	0.686
LIG_LIR_LC3C_4	367	371	PF02991	0.550
LIG_LIR_Nem_3	373	378	PF02991	0.418
LIG_LIR_Nem_3	408	413	PF02991	0.628
LIG_LIR_Nem_3	464	470	PF02991	0.582
LIG_MLH1_MIPbox_1	467	471	PF16413	0.537
LIG_NRBOX	480	486	PF00104	0.521
LIG_PCNA_yPIPBox_3	139	152	PF02747	0.615
LIG_Pex14_2	275	279	PF04695	0.545
LIG_Pex14_2	30	34	PF04695	0.630
LIG_Pex14_2	347	351	PF04695	0.408
LIG_Pex14_2	467	471	PF04695	0.445
LIG_PTB_Apo_2	369	376	PF02174	0.443
LIG_SH2_CRK	138	142	PF00017	0.592
LIG_SH2_CRK	19	23	PF00017	0.488
LIG_SH2_CRK	7	11	PF00017	0.445
LIG_SH2_SRC	391	394	PF00017	0.533
LIG_SH2_STAP1	325	329	PF00017	0.627
LIG_SH2_STAT3	325	328	PF00017	0.557
LIG_SH2_STAT5	111	114	PF00017	0.537
LIG_SH2_STAT5	180	183	PF00017	0.672
LIG_SH2_STAT5	19	22	PF00017	0.634
LIG_SH2_STAT5	24	27	PF00017	0.558
LIG_SH2_STAT5	329	332	PF00017	0.567
LIG_SH2_STAT5	339	342	PF00017	0.545
LIG_SH2_STAT5	374	377	PF00017	0.393
LIG_SH2_STAT5	391	394	PF00017	0.533
LIG_SH2_STAT5	470	473	PF00017	0.505
LIG_SH3_3	352	358	PF00018	0.480
LIG_SH3_3	449	455	PF00018	0.566
LIG_SUMO_SIM_anti_2	364	370	PF11976	0.537
LIG_SUMO_SIM_par_1	367	373	PF11976	0.549
LIG_TRAF2_1	117	120	PF00917	0.447
LIG_TRFH_1	351	355	PF08558	0.447
LIG_TYR_ITIM	136	141	PF00017	0.588
LIG_TYR_ITIM	484	489	PF00017	0.535
MOD_CDK_SPK_2	70	75	PF00069	0.704
MOD_CK1_1	153	159	PF00069	0.530
MOD_CK1_1	194	200	PF00069	0.675
MOD_CK1_1	211	217	PF00069	0.809
MOD_CK1_1	41	47	PF00069	0.735
MOD_CK1_1	450	456	PF00069	0.743
MOD_CK1_1	53	59	PF00069	0.789
MOD_CK1_1	73	79	PF00069	0.510
MOD_CK2_1	280	286	PF00069	0.591
MOD_CK2_1	327	333	PF00069	0.595
MOD_CK2_1	358	364	PF00069	0.683
MOD_CK2_1	36	42	PF00069	0.697
MOD_CK2_1	443	449	PF00069	0.759
MOD_CK2_1	456	462	PF00069	0.363
MOD_Cter_Amidation	489	492	PF01082	0.536
MOD_GlcNHglycan	120	123	PF01048	0.629
MOD_GlcNHglycan	189	192	PF01048	0.727
MOD_GlcNHglycan	193	196	PF01048	0.712
MOD_GlcNHglycan	215	218	PF01048	0.796
MOD_GlcNHglycan	249	252	PF01048	0.608
MOD_GlcNHglycan	359	363	PF01048	0.577
MOD_GlcNHglycan	415	418	PF01048	0.625
MOD_GlcNHglycan	440	443	PF01048	0.658
MOD_GlcNHglycan	77	80	PF01048	0.729
MOD_GSK3_1	160	167	PF00069	0.697
MOD_GSK3_1	187	194	PF00069	0.730
MOD_GSK3_1	204	211	PF00069	0.755
MOD_GSK3_1	213	220	PF00069	0.756
MOD_GSK3_1	314	321	PF00069	0.442
MOD_GSK3_1	354	361	PF00069	0.646
MOD_GSK3_1	38	45	PF00069	0.670
MOD_GSK3_1	443	450	PF00069	0.773
MOD_GSK3_1	461	468	PF00069	0.549
MOD_GSK3_1	47	54	PF00069	0.683
MOD_GSK3_1	59	66	PF00069	0.738
MOD_GSK3_1	70	77	PF00069	0.656
MOD_N-GLC_1	187	192	PF02516	0.700
MOD_N-GLC_1	314	319	PF02516	0.537
MOD_N-GLC_1	472	477	PF02516	0.561
MOD_NEK2_1	159	164	PF00069	0.628
MOD_NEK2_1	193	198	PF00069	0.727
MOD_NEK2_1	30	35	PF00069	0.533
MOD_NEK2_1	36	41	PF00069	0.607
MOD_NEK2_1	413	418	PF00069	0.694
MOD_PIKK_1	153	159	PF00454	0.564
MOD_PIKK_1	182	188	PF00454	0.674
MOD_PIKK_1	196	202	PF00454	0.750
MOD_PIKK_1	295	301	PF00454	0.510
MOD_PKA_2	212	218	PF00069	0.739
MOD_PKA_2	265	271	PF00069	0.559
MOD_PKA_2	349	355	PF00069	0.535
MOD_PKA_2	92	98	PF00069	0.710
MOD_Plk_1	101	107	PF00069	0.612
MOD_Plk_1	314	320	PF00069	0.428
MOD_Plk_1	448	454	PF00069	0.770
MOD_Plk_4	102	108	PF00069	0.613
MOD_Plk_4	370	376	PF00069	0.437
MOD_ProDKin_1	354	360	PF00069	0.570
MOD_ProDKin_1	451	457	PF00069	0.690
MOD_ProDKin_1	59	65	PF00069	0.731
MOD_ProDKin_1	70	76	PF00069	0.688
MOD_SUMO_rev_2	178	185	PF00179	0.658
TRG_DiLeu_BaEn_1	381	386	PF01217	0.541
TRG_DiLeu_BaEn_4	387	393	PF01217	0.578
TRG_ENDOCYTIC_2	111	114	PF00928	0.582
TRG_ENDOCYTIC_2	138	141	PF00928	0.559
TRG_ENDOCYTIC_2	486	489	PF00928	0.424
TRG_ENDOCYTIC_2	7	10	PF00928	0.453
TRG_ER_diArg_1	263	266	PF00400	0.546
TRG_ER_diArg_1	347	350	PF00400	0.553
TRG_NLS_MonoExtN_4	488	495	PF00514	0.518
TRG_Pf-PMV_PEXEL_1	399	403	PF00026	0.630

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IBR0	Leptomonas seymouri	51%	97%
A0A1X0P6J4	Trypanosomatidae	24%	100%
A0A422P2R2	Trypanosoma rangeli	27%	100%
A4HMT7	Leishmania braziliensis	75%	100%
A4IBD8	Leishmania infantum	99%	100%
C9ZZ79	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	27%	100%
E9AF94	Leishmania major	93%	100%
E9B6E9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	93%	100%
V5BTJ6	Trypanosoma cruzi	30%	100%