Kinase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Kinase

Gene product:

inositol polyphosphate kinase, putative

Species:

Leishmania donovani

UniProt:

A0A3S7X9M0_LEIDO

TriTrypDb:

LdBPK_353190.1 , LdCL_350036800 , LDHU3_35.4180

Length:

376

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	1
GO:0005737	cytoplasm	2	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A0A3S7X9M0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7X9M0

Function

Biological processes
Term	Name	Level	Count
GO:0006066	alcohol metabolic process	3	11
GO:0006793	phosphorus metabolic process	3	11
GO:0006796	phosphate-containing compound metabolic process	4	11
GO:0008152	metabolic process	1	11
GO:0009058	biosynthetic process	2	11
GO:0009987	cellular process	1	11
GO:0016310	phosphorylation	5	11
GO:0019637	organophosphate metabolic process	3	11
GO:0019751	polyol metabolic process	4	11
GO:0032958	inositol phosphate biosynthetic process	5	11
GO:0043647	inositol phosphate metabolic process	4	11
GO:0044237	cellular metabolic process	2	11
GO:0044281	small molecule metabolic process	2	11
GO:0044283	small molecule biosynthetic process	3	11
GO:0046165	alcohol biosynthetic process	4	11
GO:0046173	polyol biosynthetic process	5	11
GO:0071704	organic substance metabolic process	2	11
GO:0090407	organophosphate biosynthetic process	4	11
GO:1901576	organic substance biosynthetic process	3	11
GO:1901615	organic hydroxy compound metabolic process	3	11
GO:1901617	organic hydroxy compound biosynthetic process	4	11

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	11
GO:0016301	kinase activity	4	11
GO:0016740	transferase activity	2	11
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	11
GO:0008440	inositol-1,4,5-trisphosphate 3-kinase activity	6	1
GO:0016773	phosphotransferase activity, alcohol group as acceptor	4	1
GO:0051765	inositol tetrakisphosphate kinase activity	5	1
GO:0051766	inositol trisphosphate kinase activity	5	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	212	214	PF00675	0.480
CLV_NRD_NRD_1	33	35	PF00675	0.505
CLV_NRD_NRD_1	351	353	PF00675	0.334
CLV_PCSK_KEX2_1	212	214	PF00082	0.468
CLV_PCSK_SKI1_1	252	256	PF00082	0.341
CLV_PCSK_SKI1_1	300	304	PF00082	0.378
CLV_PCSK_SKI1_1	318	322	PF00082	0.271
DEG_SPOP_SBC_1	279	283	PF00917	0.266
DOC_CKS1_1	182	187	PF01111	0.355
DOC_CYCLIN_yClb5_NLxxxL_5	368	374	PF00134	0.480
DOC_MAPK_MEF2A_6	167	175	PF00069	0.434
DOC_PP1_RVXF_1	172	178	PF00149	0.408
DOC_USP7_MATH_1	122	126	PF00917	0.482
DOC_USP7_MATH_1	224	228	PF00917	0.402
DOC_USP7_MATH_1	279	283	PF00917	0.491
DOC_USP7_MATH_1	320	324	PF00917	0.335
DOC_USP7_MATH_1	83	87	PF00917	0.449
DOC_USP7_UBL2_3	96	100	PF12436	0.584
DOC_WW_Pin1_4	178	183	PF00397	0.335
DOC_WW_Pin1_4	3	8	PF00397	0.726
DOC_WW_Pin1_4	306	311	PF00397	0.421
DOC_WW_Pin1_4	332	337	PF00397	0.466
LIG_14-3-3_CanoR_1	225	233	PF00244	0.447
LIG_14-3-3_CanoR_1	34	44	PF00244	0.445
LIG_14-3-3_CanoR_1	348	352	PF00244	0.360
LIG_APCC_ABBA_1	104	109	PF00400	0.544
LIG_BIR_II_1	1	5	PF00653	0.734
LIG_BIR_III_4	11	15	PF00653	0.566
LIG_BRCT_BRCA1_1	17	21	PF00533	0.619
LIG_BRCT_BRCA1_1	85	89	PF00533	0.512
LIG_FHA_1	188	194	PF00498	0.266
LIG_FHA_1	336	342	PF00498	0.407
LIG_FHA_1	60	66	PF00498	0.665
LIG_FHA_2	182	188	PF00498	0.335
LIG_FHA_2	262	268	PF00498	0.405
LIG_FHA_2	279	285	PF00498	0.448
LIG_FHA_2	36	42	PF00498	0.391
LIG_Integrin_RGD_1	66	68	PF01839	0.525
LIG_LIR_Gen_1	111	122	PF02991	0.434
LIG_LIR_Gen_1	37	48	PF02991	0.370
LIG_LIR_Gen_1	371	376	PF02991	0.454
LIG_LIR_Nem_3	111	117	PF02991	0.410
LIG_LIR_Nem_3	349	354	PF02991	0.378
LIG_LIR_Nem_3	371	376	PF02991	0.454
LIG_PDZ_Class_2	371	376	PF00595	0.449
LIG_Pex14_1	40	44	PF04695	0.463
LIG_Pex14_2	132	136	PF04695	0.487
LIG_Pex14_2	89	93	PF04695	0.475
LIG_PTB_Apo_2	130	137	PF02174	0.428
LIG_Rb_pABgroove_1	324	332	PF01858	0.408
LIG_SH2_CRK	330	334	PF00017	0.289
LIG_SH2_NCK_1	330	334	PF00017	0.355
LIG_SH2_SRC	214	217	PF00017	0.424
LIG_SH2_STAP1	330	334	PF00017	0.434
LIG_SH2_STAT5	214	217	PF00017	0.367
LIG_SH2_STAT5	373	376	PF00017	0.544
LIG_SH2_STAT5	45	48	PF00017	0.349
LIG_SH3_1	179	185	PF00018	0.355
LIG_SH3_3	124	130	PF00018	0.532
LIG_SH3_3	179	185	PF00018	0.338
LIG_SH3_3	330	336	PF00018	0.188
LIG_SUMO_SIM_anti_2	325	331	PF11976	0.342
LIG_SUMO_SIM_par_1	325	331	PF11976	0.342
LIG_TYR_ITIM	328	333	PF00017	0.237
LIG_UBA3_1	88	96	PF00899	0.497
MOD_CDK_SPxxK_3	181	188	PF00069	0.355
MOD_CK1_1	181	187	PF00069	0.335
MOD_CK1_1	335	341	PF00069	0.347
MOD_CK2_1	278	284	PF00069	0.447
MOD_CK2_1	35	41	PF00069	0.397
MOD_GlcNHglycan	1	4	PF01048	0.719
MOD_GlcNHglycan	100	103	PF01048	0.546
MOD_GlcNHglycan	124	127	PF01048	0.522
MOD_GlcNHglycan	160	165	PF01048	0.471
MOD_GlcNHglycan	322	325	PF01048	0.432
MOD_GSK3_1	279	286	PF00069	0.423
MOD_GSK3_1	83	90	PF00069	0.517
MOD_LATS_1	243	249	PF00433	0.266
MOD_NEK2_1	253	258	PF00069	0.287
MOD_NEK2_1	346	351	PF00069	0.441
MOD_NEK2_1	356	361	PF00069	0.441
MOD_NEK2_1	84	89	PF00069	0.496
MOD_NEK2_1	98	103	PF00069	0.504
MOD_NEK2_2	29	34	PF00069	0.541
MOD_PKA_1	34	40	PF00069	0.385
MOD_PKA_2	201	207	PF00069	0.410
MOD_PKA_2	224	230	PF00069	0.404
MOD_PKA_2	29	35	PF00069	0.508
MOD_PKA_2	347	353	PF00069	0.378
MOD_PKA_2	60	66	PF00069	0.498
MOD_Plk_1	283	289	PF00069	0.490
MOD_Plk_1	356	362	PF00069	0.396
MOD_Plk_2-3	298	304	PF00069	0.363
MOD_Plk_4	16	22	PF00069	0.608
MOD_Plk_4	298	304	PF00069	0.454
MOD_Plk_4	322	328	PF00069	0.295
MOD_Plk_4	84	90	PF00069	0.372
MOD_ProDKin_1	178	184	PF00069	0.335
MOD_ProDKin_1	3	9	PF00069	0.717
MOD_ProDKin_1	306	312	PF00069	0.421
MOD_ProDKin_1	332	338	PF00069	0.466
MOD_SUMO_rev_2	181	190	PF00179	0.408
TRG_DiLeu_BaEn_1	298	303	PF01217	0.441
TRG_ENDOCYTIC_2	330	333	PF00928	0.237
TRG_ENDOCYTIC_2	373	376	PF00928	0.533
TRG_ENDOCYTIC_2	45	48	PF00928	0.349
TRG_ER_diArg_1	212	214	PF00400	0.480
TRG_ER_diArg_1	285	288	PF00400	0.382
TRG_NES_CRM1_1	317	331	PF08389	0.447

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IKC0	Leptomonas seymouri	58%	100%
A0A1X0NEH0	Trypanosomatidae	31%	100%
A0A422N9V2	Trypanosoma rangeli	31%	100%
A4HMY1	Leishmania braziliensis	75%	100%
A4IBK5	Leishmania infantum	99%	100%
C9ZZ39	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	30%	100%
E9AFD8	Leishmania major	90%	100%
E9B6J3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	87%	100%
V5BTG0	Trypanosoma cruzi	33%	100%