Cap-specific mRNA (nucleoside-2'-O-)-methyltransferase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

poly A polymerase regulatory subunit, putative

Species:

Leishmania donovani

UniProt:

A0A3S7X9K6_LEIDO

TriTrypDb:

LdBPK_353430.1 , LdCL_350039300 , LDHU3_35.4510

Length:

547

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S7X9K6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7X9K6

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	12
GO:0006370	7-methylguanosine mRNA capping	8	12
GO:0006396	RNA processing	6	12
GO:0006397	mRNA processing	7	12
GO:0006725	cellular aromatic compound metabolic process	3	12
GO:0006807	nitrogen compound metabolic process	2	12
GO:0008152	metabolic process	1	12
GO:0009452	7-methylguanosine RNA capping	8	12
GO:0009987	cellular process	1	12
GO:0016070	RNA metabolic process	5	12
GO:0016071	mRNA metabolic process	6	12
GO:0034641	cellular nitrogen compound metabolic process	3	12
GO:0036260	RNA capping	7	12
GO:0043170	macromolecule metabolic process	3	12
GO:0044237	cellular metabolic process	2	12
GO:0044238	primary metabolic process	2	12
GO:0046483	heterocycle metabolic process	3	12
GO:0071704	organic substance metabolic process	2	12
GO:0090304	nucleic acid metabolic process	4	12
GO:1901360	organic cyclic compound metabolic process	3	12

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	11
GO:0003746	translation elongation factor activity	4	11
GO:0003824	catalytic activity	1	12
GO:0004483	mRNA (nucleoside-2'-O-)-methyltransferase activity	6	12
GO:0005488	binding	1	11
GO:0008135	translation factor activity, RNA binding	3	11
GO:0008168	methyltransferase activity	4	12
GO:0008171	O-methyltransferase activity	5	12
GO:0008173	RNA methyltransferase activity	4	12
GO:0008174	mRNA methyltransferase activity	5	12
GO:0008757	S-adenosylmethionine-dependent methyltransferase activity	5	12
GO:0016740	transferase activity	2	12
GO:0016741	transferase activity, transferring one-carbon groups	3	12
GO:0045182	translation regulator activity	1	11
GO:0090079	translation regulator activity, nucleic acid binding	2	11
GO:0097159	organic cyclic compound binding	2	11
GO:0140098	catalytic activity, acting on RNA	3	12
GO:0140640	catalytic activity, acting on a nucleic acid	2	12
GO:1901363	heterocyclic compound binding	2	11

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	164	166	PF00675	0.378
CLV_NRD_NRD_1	409	411	PF00675	0.508
CLV_NRD_NRD_1	434	436	PF00675	0.420
CLV_NRD_NRD_1	7	9	PF00675	0.643
CLV_NRD_NRD_1	80	82	PF00675	0.344
CLV_PCSK_KEX2_1	164	166	PF00082	0.378
CLV_PCSK_KEX2_1	433	435	PF00082	0.459
CLV_PCSK_KEX2_1	7	9	PF00082	0.570
CLV_PCSK_PC1ET2_1	7	9	PF00082	0.570
CLV_PCSK_SKI1_1	137	141	PF00082	0.329
CLV_PCSK_SKI1_1	164	168	PF00082	0.503
CLV_PCSK_SKI1_1	238	242	PF00082	0.371
CLV_PCSK_SKI1_1	37	41	PF00082	0.613
CLV_PCSK_SKI1_1	402	406	PF00082	0.538
CLV_PCSK_SKI1_1	411	415	PF00082	0.416
CLV_PCSK_SKI1_1	435	439	PF00082	0.491
CLV_PCSK_SKI1_1	70	74	PF00082	0.459
CLV_PCSK_SKI1_1	81	85	PF00082	0.344
CLV_Separin_Metazoa	412	416	PF03568	0.518
DEG_SPOP_SBC_1	22	26	PF00917	0.629
DOC_CYCLIN_RxL_1	221	230	PF00134	0.484
DOC_CYCLIN_RxL_1	235	245	PF00134	0.372
DOC_CYCLIN_RxL_1	77	87	PF00134	0.363
DOC_CYCLIN_yCln2_LP_2	50	56	PF00134	0.422
DOC_MAPK_DCC_7	165	175	PF00069	0.464
DOC_MAPK_gen_1	236	243	PF00069	0.393
DOC_MAPK_gen_1	360	367	PF00069	0.368
DOC_MAPK_gen_1	410	416	PF00069	0.533
DOC_MAPK_gen_1	433	440	PF00069	0.449
DOC_MAPK_MEF2A_6	236	243	PF00069	0.444
DOC_MAPK_MEF2A_6	316	323	PF00069	0.412
DOC_MAPK_NFAT4_5	316	324	PF00069	0.433
DOC_PP1_RVXF_1	236	243	PF00149	0.377
DOC_PP2B_LxvP_1	220	223	PF13499	0.470
DOC_PP2B_LxvP_1	319	322	PF13499	0.414
DOC_PP2B_LxvP_1	334	337	PF13499	0.352
DOC_PP4_FxxP_1	283	286	PF00568	0.389
DOC_PP4_FxxP_1	396	399	PF00568	0.426
DOC_USP7_MATH_1	181	185	PF00917	0.451
DOC_USP7_MATH_1	22	26	PF00917	0.585
DOC_USP7_MATH_1	286	290	PF00917	0.499
DOC_USP7_MATH_1	443	447	PF00917	0.606
DOC_USP7_MATH_1	64	68	PF00917	0.486
DOC_USP7_UBL2_3	445	449	PF12436	0.629
LIG_14-3-3_CanoR_1	124	128	PF00244	0.366
LIG_14-3-3_CanoR_1	164	173	PF00244	0.475
LIG_14-3-3_CanoR_1	284	294	PF00244	0.458
LIG_14-3-3_CanoR_1	326	336	PF00244	0.384
LIG_14-3-3_CanoR_1	518	523	PF00244	0.516
LIG_Actin_WH2_2	387	404	PF00022	0.470
LIG_BIR_III_4	457	461	PF00653	0.643
LIG_BRCT_BRCA1_1	24	28	PF00533	0.654
LIG_BRCT_BRCA1_1	290	294	PF00533	0.607
LIG_BRCT_BRCA1_1	48	52	PF00533	0.522
LIG_CaM_IQ_9	182	197	PF13499	0.636
LIG_eIF4E_1	314	320	PF01652	0.470
LIG_FHA_1	124	130	PF00498	0.333
LIG_FHA_1	165	171	PF00498	0.510
LIG_FHA_1	200	206	PF00498	0.496
LIG_FHA_1	207	213	PF00498	0.486
LIG_FHA_1	269	275	PF00498	0.473
LIG_FHA_1	301	307	PF00498	0.597
LIG_FHA_1	38	44	PF00498	0.561
LIG_FHA_1	404	410	PF00498	0.532
LIG_FHA_1	419	425	PF00498	0.287
LIG_FHA_1	493	499	PF00498	0.634
LIG_FHA_1	504	510	PF00498	0.459
LIG_FHA_1	533	539	PF00498	0.552
LIG_FHA_2	28	34	PF00498	0.496
LIG_FHA_2	326	332	PF00498	0.399
LIG_FHA_2	425	431	PF00498	0.470
LIG_GBD_Chelix_1	416	424	PF00786	0.546
LIG_HCF-1_HBM_1	378	381	PF13415	0.413
LIG_Integrin_RGD_1	316	318	PF01839	0.459
LIG_IRF3_LxIS_1	239	244	PF10401	0.479
LIG_LIR_Apic_2	42	47	PF02991	0.433
LIG_LIR_Apic_2	92	97	PF02991	0.396
LIG_LIR_Gen_1	126	135	PF02991	0.328
LIG_LIR_Gen_1	18	28	PF02991	0.650
LIG_LIR_Gen_1	268	274	PF02991	0.395
LIG_LIR_Gen_1	33	43	PF02991	0.346
LIG_LIR_Gen_1	392	401	PF02991	0.441
LIG_LIR_Gen_1	98	109	PF02991	0.364
LIG_LIR_LC3C_4	331	336	PF02991	0.380
LIG_LIR_Nem_3	126	130	PF02991	0.323
LIG_LIR_Nem_3	18	23	PF02991	0.652
LIG_LIR_Nem_3	268	273	PF02991	0.400
LIG_LIR_Nem_3	33	38	PF02991	0.523
LIG_LIR_Nem_3	351	357	PF02991	0.375
LIG_LIR_Nem_3	392	396	PF02991	0.427
LIG_LIR_Nem_3	49	55	PF02991	0.297
LIG_LIR_Nem_3	98	104	PF02991	0.344
LIG_PCNA_PIPBox_1	13	22	PF02747	0.632
LIG_PCNA_yPIPBox_3	7	20	PF02747	0.647
LIG_PTB_Apo_2	14	21	PF02174	0.632
LIG_PTB_Apo_2	147	154	PF02174	0.328
LIG_PTB_Phospho_1	14	20	PF10480	0.631
LIG_REV1ctd_RIR_1	354	364	PF16727	0.362
LIG_SH2_CRK	101	105	PF00017	0.379
LIG_SH2_CRK	20	24	PF00017	0.670
LIG_SH2_CRK	44	48	PF00017	0.460
LIG_SH2_GRB2like	177	180	PF00017	0.424
LIG_SH2_NCK_1	381	385	PF00017	0.396
LIG_SH2_SRC	177	180	PF00017	0.470
LIG_SH2_STAP1	381	385	PF00017	0.396
LIG_SH2_STAT5	287	290	PF00017	0.453
LIG_SH2_STAT5	314	317	PF00017	0.390
LIG_SH2_STAT5	393	396	PF00017	0.393
LIG_SH2_STAT5	5	8	PF00017	0.680
LIG_SH2_STAT5	94	97	PF00017	0.387
LIG_SH3_2	61	66	PF14604	0.537
LIG_SH3_3	136	142	PF00018	0.386
LIG_SH3_3	248	254	PF00018	0.480
LIG_SH3_3	58	64	PF00018	0.535
LIG_SUMO_SIM_par_1	52	59	PF11976	0.471
LIG_TYR_ITIM	99	104	PF00017	0.385
MOD_CK1_1	184	190	PF00069	0.473
MOD_CK1_1	21	27	PF00069	0.561
MOD_CK1_1	289	295	PF00069	0.572
MOD_CK1_1	471	477	PF00069	0.716
MOD_CK1_1	480	486	PF00069	0.755
MOD_CK1_1	521	527	PF00069	0.602
MOD_CK1_1	533	539	PF00069	0.613
MOD_CK2_1	325	331	PF00069	0.385
MOD_CK2_1	498	504	PF00069	0.541
MOD_GlcNHglycan	2	5	PF01048	0.715
MOD_GlcNHglycan	20	23	PF01048	0.411
MOD_GlcNHglycan	247	250	PF01048	0.412
MOD_GlcNHglycan	470	473	PF01048	0.738
MOD_GlcNHglycan	482	485	PF01048	0.591
MOD_GlcNHglycan	535	538	PF01048	0.528
MOD_GlcNHglycan	73	76	PF01048	0.437
MOD_GSK3_1	119	126	PF00069	0.425
MOD_GSK3_1	18	25	PF00069	0.552
MOD_GSK3_1	241	248	PF00069	0.373
MOD_GSK3_1	285	292	PF00069	0.515
MOD_GSK3_1	322	329	PF00069	0.390
MOD_GSK3_1	33	40	PF00069	0.502
MOD_N-GLC_1	154	159	PF02516	0.374
MOD_N-GLC_1	480	485	PF02516	0.728
MOD_N-GLC_1	518	523	PF02516	0.523
MOD_NEK2_1	23	28	PF00069	0.651
MOD_NEK2_1	356	361	PF00069	0.479
MOD_NEK2_1	538	543	PF00069	0.593
MOD_PIKK_1	227	233	PF00454	0.339
MOD_PIKK_1	443	449	PF00454	0.603
MOD_PK_1	247	253	PF00069	0.445
MOD_PK_1	518	524	PF00069	0.444
MOD_PKA_1	164	170	PF00069	0.467
MOD_PKA_2	123	129	PF00069	0.363
MOD_PKA_2	164	170	PF00069	0.439
MOD_PKA_2	206	212	PF00069	0.522
MOD_PKA_2	300	306	PF00069	0.643
MOD_PKA_2	325	331	PF00069	0.385
MOD_PKA_2	511	517	PF00069	0.540
MOD_Plk_1	154	160	PF00069	0.374
MOD_Plk_1	276	282	PF00069	0.450
MOD_Plk_1	518	524	PF00069	0.515
MOD_Plk_1	97	103	PF00069	0.364
MOD_Plk_4	276	282	PF00069	0.450
MOD_Plk_4	389	395	PF00069	0.420
MOD_Plk_4	89	95	PF00069	0.389
MOD_SUMO_rev_2	183	192	PF00179	0.617
MOD_SUMO_rev_2	462	472	PF00179	0.677
MOD_SUMO_rev_2	67	75	PF00179	0.363
TRG_DiLeu_BaEn_1	386	391	PF01217	0.440
TRG_DiLeu_BaLyEn_6	236	241	PF01217	0.468
TRG_DiLeu_BaLyEn_6	301	306	PF01217	0.596
TRG_ENDOCYTIC_2	101	104	PF00928	0.344
TRG_ENDOCYTIC_2	20	23	PF00928	0.660
TRG_ENDOCYTIC_2	393	396	PF00928	0.402
TRG_ER_diArg_1	146	149	PF00400	0.464
TRG_ER_diArg_1	164	166	PF00400	0.281
TRG_ER_diArg_1	432	435	PF00400	0.432
TRG_ER_diArg_1	65	68	PF00400	0.363
TRG_ER_FFAT_2	14	25	PF00635	0.661
TRG_NLS_MonoCore_2	6	11	PF00514	0.634
TRG_NLS_MonoExtC_3	7	12	PF00514	0.579
TRG_NLS_MonoExtN_4	7	13	PF00514	0.622
TRG_Pf-PMV_PEXEL_1	164	168	PF00026	0.439
TRG_Pf-PMV_PEXEL_1	304	308	PF00026	0.583

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PB31	Leptomonas seymouri	74%	100%
A0A0S4IHM6	Bodo saltans	53%	100%
A0A0S4JS06	Bodo saltans	45%	100%
A0A1X0P597	Trypanosomatidae	63%	100%
A0A422NR92	Trypanosoma rangeli	58%	100%
A4HN05	Leishmania braziliensis	87%	99%
A4IBM8	Leishmania infantum	99%	100%
C9ZZ04	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	59%	100%
E9AFG2	Leishmania major	97%	100%
E9B6L7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	95%	100%