Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Present in the outer mitochondrial membrane proteome 7

Species:

Leishmania donovani

UniProt:

A0A3S7X9K3_LEIDO

TriTrypDb:

LdBPK_353160.1 , LdCL_350036500 , LDHU3_35.4130

Length:

598

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0005741	mitochondrial outer membrane	5	1
GO:0016020	membrane	2	4
GO:0019867	outer membrane	3	1
GO:0031090	organelle membrane	3	1
GO:0031966	mitochondrial membrane	4	1
GO:0031968	organelle outer membrane	4	1
GO:0098588	bounding membrane of organelle	4	1
GO:0110165	cellular anatomical entity	1	4

Expansion

Sequence features

A0A3S7X9K3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7X9K3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	264	268	PF00656	0.651
CLV_C14_Caspase3-7	35	39	PF00656	0.712
CLV_NRD_NRD_1	190	192	PF00675	0.602
CLV_NRD_NRD_1	249	251	PF00675	0.624
CLV_NRD_NRD_1	28	30	PF00675	0.449
CLV_NRD_NRD_1	33	35	PF00675	0.396
CLV_NRD_NRD_1	347	349	PF00675	0.564
CLV_NRD_NRD_1	550	552	PF00675	0.417
CLV_NRD_NRD_1	8	10	PF00675	0.558
CLV_PCSK_KEX2_1	190	192	PF00082	0.602
CLV_PCSK_KEX2_1	248	250	PF00082	0.624
CLV_PCSK_KEX2_1	27	29	PF00082	0.454
CLV_PCSK_KEX2_1	33	35	PF00082	0.413
CLV_PCSK_KEX2_1	550	552	PF00082	0.417
CLV_PCSK_KEX2_1	8	10	PF00082	0.508
CLV_PCSK_PC7_1	29	35	PF00082	0.532
CLV_PCSK_SKI1_1	559	563	PF00082	0.441
DEG_Nend_UBRbox_2	1	3	PF02207	0.582
DEG_SPOP_SBC_1	527	531	PF00917	0.635
DOC_ANK_TNKS_1	237	244	PF00023	0.728
DOC_MAPK_DCC_7	49	57	PF00069	0.666
DOC_MAPK_gen_1	313	322	PF00069	0.743
DOC_MAPK_HePTP_8	310	322	PF00069	0.748
DOC_MAPK_MEF2A_6	313	322	PF00069	0.748
DOC_MAPK_MEF2A_6	361	369	PF00069	0.729
DOC_MAPK_MEF2A_6	49	57	PF00069	0.625
DOC_PP2B_LxvP_1	320	323	PF13499	0.705
DOC_PP2B_LxvP_1	83	86	PF13499	0.655
DOC_PP4_FxxP_1	293	296	PF00568	0.641
DOC_PP4_FxxP_1	73	76	PF00568	0.630
DOC_USP7_MATH_1	102	106	PF00917	0.742
DOC_USP7_MATH_1	174	178	PF00917	0.660
DOC_USP7_MATH_1	237	241	PF00917	0.722
DOC_USP7_MATH_1	296	300	PF00917	0.654
DOC_USP7_MATH_1	347	351	PF00917	0.612
DOC_USP7_MATH_1	430	434	PF00917	0.760
DOC_WW_Pin1_4	164	169	PF00397	0.741
DOC_WW_Pin1_4	252	257	PF00397	0.771
DOC_WW_Pin1_4	336	341	PF00397	0.759
DOC_WW_Pin1_4	367	372	PF00397	0.643
DOC_WW_Pin1_4	484	489	PF00397	0.650
LIG_14-3-3_CanoR_1	100	107	PF00244	0.773
LIG_14-3-3_CanoR_1	190	196	PF00244	0.766
LIG_14-3-3_CanoR_1	197	204	PF00244	0.578
LIG_14-3-3_CanoR_1	33	40	PF00244	0.689
LIG_14-3-3_CanoR_1	348	352	PF00244	0.683
LIG_14-3-3_CanoR_1	550	556	PF00244	0.613
LIG_14-3-3_CanoR_1	559	564	PF00244	0.630
LIG_14-3-3_CanoR_1	9	18	PF00244	0.408
LIG_APCC_ABBAyCdc20_2	539	545	PF00400	0.583
LIG_deltaCOP1_diTrp_1	573	582	PF00928	0.638
LIG_FHA_1	11	17	PF00498	0.414
LIG_FHA_1	118	124	PF00498	0.688
LIG_FHA_1	144	150	PF00498	0.657
LIG_FHA_1	21	27	PF00498	0.353
LIG_FHA_1	274	280	PF00498	0.650
LIG_FHA_1	435	441	PF00498	0.734
LIG_FHA_1	499	505	PF00498	0.669
LIG_FHA_1	552	558	PF00498	0.572
LIG_FHA_1	560	566	PF00498	0.500
LIG_FHA_1	586	592	PF00498	0.620
LIG_FHA_2	135	141	PF00498	0.719
LIG_FHA_2	256	262	PF00498	0.773
LIG_FHA_2	33	39	PF00498	0.753
LIG_FHA_2	351	357	PF00498	0.745
LIG_FHA_2	519	525	PF00498	0.667
LIG_FHA_2	529	535	PF00498	0.642
LIG_FHA_2	568	574	PF00498	0.591
LIG_GBD_Chelix_1	44	52	PF00786	0.483
LIG_LIR_Apic_2	390	396	PF02991	0.673
LIG_LIR_Apic_2	441	447	PF02991	0.687
LIG_LIR_Apic_2	554	558	PF02991	0.551
LIG_LIR_Gen_1	198	204	PF02991	0.618
LIG_LIR_Gen_1	387	396	PF02991	0.700
LIG_LIR_Gen_1	501	506	PF02991	0.618
LIG_LIR_Nem_3	126	130	PF02991	0.680
LIG_LIR_Nem_3	198	202	PF02991	0.617
LIG_LIR_Nem_3	387	392	PF02991	0.674
LIG_LIR_Nem_3	472	478	PF02991	0.626
LIG_LIR_Nem_3	501	505	PF02991	0.617
LIG_Pex14_2	195	199	PF04695	0.694
LIG_Pex14_2	227	231	PF04695	0.689
LIG_Pex14_2	449	453	PF04695	0.643
LIG_PTB_Apo_2	512	519	PF02174	0.598
LIG_SH2_CRK	218	222	PF00017	0.603
LIG_SH2_CRK	307	311	PF00017	0.710
LIG_SH2_NCK_1	218	222	PF00017	0.603
LIG_SH2_NCK_1	393	397	PF00017	0.586
LIG_SH2_PTP2	444	447	PF00017	0.706
LIG_SH2_PTP2	555	558	PF00017	0.552
LIG_SH2_SRC	393	396	PF00017	0.584
LIG_SH2_STAP1	218	222	PF00017	0.603
LIG_SH2_STAT5	127	130	PF00017	0.659
LIG_SH2_STAT5	218	221	PF00017	0.551
LIG_SH2_STAT5	444	447	PF00017	0.666
LIG_SH2_STAT5	494	497	PF00017	0.657
LIG_SH2_STAT5	555	558	PF00017	0.535
LIG_SH2_STAT5	77	80	PF00017	0.632
LIG_SH3_2	343	348	PF14604	0.726
LIG_SH3_3	337	343	PF00018	0.766
LIG_SH3_3	409	415	PF00018	0.764
LIG_SH3_3	459	465	PF00018	0.655
LIG_SH3_3	493	499	PF00018	0.672
LIG_SH3_3	65	71	PF00018	0.648
LIG_SUMO_SIM_anti_2	219	226	PF11976	0.660
LIG_SUMO_SIM_anti_2	562	567	PF11976	0.574
LIG_SUMO_SIM_par_1	219	226	PF11976	0.544
LIG_SUMO_SIM_par_1	363	368	PF11976	0.696
LIG_TYR_ITIM	473	478	PF00017	0.583
MOD_CDK_SPK_2	484	489	PF00069	0.650
MOD_CK1_1	101	107	PF00069	0.745
MOD_CK1_1	336	342	PF00069	0.749
MOD_CK1_1	350	356	PF00069	0.779
MOD_CK1_1	373	379	PF00069	0.676
MOD_CK1_1	407	413	PF00069	0.761
MOD_CK2_1	255	261	PF00069	0.808
MOD_CK2_1	350	356	PF00069	0.800
MOD_CK2_1	518	524	PF00069	0.656
MOD_CK2_1	528	534	PF00069	0.653
MOD_CK2_1	567	573	PF00069	0.576
MOD_Cter_Amidation	188	191	PF01082	0.553
MOD_Cter_Amidation	246	249	PF01082	0.626
MOD_GlcNHglycan	100	103	PF01048	0.564
MOD_GlcNHglycan	13	16	PF01048	0.382
MOD_GlcNHglycan	171	174	PF01048	0.533
MOD_GlcNHglycan	239	242	PF01048	0.612
MOD_GlcNHglycan	244	248	PF01048	0.567
MOD_GlcNHglycan	252	255	PF01048	0.478
MOD_GlcNHglycan	287	290	PF01048	0.501
MOD_GlcNHglycan	384	387	PF01048	0.500
MOD_GlcNHglycan	389	392	PF01048	0.467
MOD_GlcNHglycan	406	409	PF01048	0.520
MOD_GlcNHglycan	458	461	PF01048	0.485
MOD_GlcNHglycan	521	524	PF01048	0.462
MOD_GlcNHglycan	534	538	PF01048	0.367
MOD_GlcNHglycan	95	99	PF01048	0.556
MOD_GSK3_1	16	23	PF00069	0.344
MOD_GSK3_1	175	182	PF00069	0.764
MOD_GSK3_1	191	198	PF00069	0.681
MOD_GSK3_1	233	240	PF00069	0.731
MOD_GSK3_1	248	255	PF00069	0.788
MOD_GSK3_1	332	339	PF00069	0.738
MOD_GSK3_1	363	370	PF00069	0.692
MOD_GSK3_1	430	437	PF00069	0.799
MOD_GSK3_1	465	472	PF00069	0.686
MOD_GSK3_1	484	491	PF00069	0.666
MOD_GSK3_1	526	533	PF00069	0.623
MOD_GSK3_1	567	574	PF00069	0.617
MOD_GSK3_1	94	101	PF00069	0.787
MOD_N-GLC_1	333	338	PF02516	0.520
MOD_NEK2_1	123	128	PF00069	0.654
MOD_NEK2_1	233	238	PF00069	0.733
MOD_NEK2_1	365	370	PF00069	0.675
MOD_NEK2_1	48	53	PF00069	0.707
MOD_NEK2_1	518	523	PF00069	0.601
MOD_NEK2_2	324	329	PF00069	0.703
MOD_OFUCOSY	332	337	PF10250	0.435
MOD_PKA_1	248	254	PF00069	0.804
MOD_PKA_2	237	243	PF00069	0.765
MOD_PKA_2	248	254	PF00069	0.596
MOD_PKA_2	32	38	PF00069	0.682
MOD_PKA_2	347	353	PF00069	0.678
MOD_PKA_2	488	494	PF00069	0.612
MOD_PKA_2	546	552	PF00069	0.625
MOD_PKA_2	93	99	PF00069	0.734
MOD_PKB_1	248	256	PF00069	0.802
MOD_Plk_1	324	330	PF00069	0.761
MOD_Plk_4	20	26	PF00069	0.310
MOD_Plk_4	216	222	PF00069	0.545
MOD_Plk_4	370	376	PF00069	0.717
MOD_Plk_4	399	405	PF00069	0.662
MOD_Plk_4	438	444	PF00069	0.668
MOD_Plk_4	469	475	PF00069	0.691
MOD_Plk_4	48	54	PF00069	0.668
MOD_Plk_4	559	565	PF00069	0.617
MOD_ProDKin_1	164	170	PF00069	0.745
MOD_ProDKin_1	252	258	PF00069	0.770
MOD_ProDKin_1	336	342	PF00069	0.757
MOD_ProDKin_1	367	373	PF00069	0.648
MOD_ProDKin_1	484	490	PF00069	0.644
MOD_SUMO_rev_2	177	183	PF00179	0.684
MOD_SUMO_rev_2	356	363	PF00179	0.690
TRG_ENDOCYTIC_2	218	221	PF00928	0.625
TRG_ENDOCYTIC_2	306	309	PF00928	0.716
TRG_ENDOCYTIC_2	475	478	PF00928	0.590
TRG_ER_diArg_1	248	250	PF00400	0.680
TRG_ER_diArg_1	26	29	PF00400	0.645
TRG_ER_diArg_1	550	553	PF00400	0.614
TRG_ER_diArg_1	8	10	PF00400	0.308

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HVZ7	Leptomonas seymouri	46%	94%
A0A3R7NG87	Trypanosoma rangeli	28%	100%
A4HMX8	Leishmania braziliensis	70%	100%
A4IBK2	Leishmania infantum	98%	100%
C9ZZ42	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	23%	100%
E9AFD5	Leishmania major	89%	100%
E9B6J0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	87%	100%
V5DUQ9	Trypanosoma cruzi	23%	100%