Tetrapyrrole_(Corrin/Porphyrin)_Methylases_putati ve/Pfam:PF00590

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Tetrapyrrole (Corrin/Porphyrin) Methylases, putative

Species:

Leishmania donovani

UniProt:

A0A3S7X9K0_LEIDO

TriTrypDb:

LdBPK_353400.1 , LdCL_350039000 , LDHU3_35.4470

Length:

462

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

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Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	12
GO:0016020	membrane	2	1
GO:0110165	cellular anatomical entity	1	12

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Expansion

Sequence features

A0A3S7X9K0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7X9K0

Function

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Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	12
GO:0006364	rRNA processing	8	12
GO:0006396	RNA processing	6	12
GO:0006725	cellular aromatic compound metabolic process	3	12
GO:0006807	nitrogen compound metabolic process	2	12
GO:0008152	metabolic process	1	12
GO:0009987	cellular process	1	12
GO:0016070	RNA metabolic process	5	12
GO:0016072	rRNA metabolic process	7	12
GO:0032259	methylation	2	12

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Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	12
GO:0008168	methyltransferase activity	4	12
GO:0016740	transferase activity	2	12
GO:0016741	transferase activity, transferring one-carbon groups	3	12

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Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	16	18	PF00675	0.616
CLV_NRD_NRD_1	284	286	PF00675	0.217
CLV_NRD_NRD_1	365	367	PF00675	0.456
CLV_NRD_NRD_1	368	370	PF00675	0.458
CLV_NRD_NRD_1	414	416	PF00675	0.515
CLV_NRD_NRD_1	417	419	PF00675	0.465
CLV_NRD_NRD_1	425	427	PF00675	0.404
CLV_NRD_NRD_1	429	431	PF00675	0.367
CLV_NRD_NRD_1	59	61	PF00675	0.708
CLV_NRD_NRD_1	67	69	PF00675	0.628

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P4G3	Leptomonas seymouri	67%	100%
A0A0S4IXW1	Bodo saltans	43%	100%
A0A1X0P5K8	Trypanosomatidae	56%	100%
A0A3R7N6Y9	Trypanosoma rangeli	55%	100%
A4HN02	Leishmania braziliensis	84%	100%
A4IBM5	Leishmania infantum	100%	100%
C9ZZ09	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	57%	100%
E9AFF9	Leishmania major	96%	100%
E9B6L4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%
V5BY28	Trypanosoma cruzi	57%	100%

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