Hypothetical_protein_conserved

Quick info Annotations Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Leucine Rich repeats (2 copies), putative

Species:

Leishmania donovani

UniProt:

A0A3S7X9J5_LEIDO

TriTrypDb:

LdBPK_353360.1 , LdCL_350038600 , LDHU3_35.4410

Length:

303

Annotations

Annotations by Jardim et al.

Uncharacterized Protein, Uncharacterized

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	yes	yes: 6
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 12
NetGPI	no	yes: 0, no: 12

Cellular components
Term	Name	Level	Count
GO:0005929	cilium	4	13
GO:0042995	cell projection	2	13
GO:0043226	organelle	2	13
GO:0043227	membrane-bounded organelle	3	13
GO:0110165	cellular anatomical entity	1	13
GO:0120025	plasma membrane bounded cell projection	3	13

Expansion

Sequence features

A0A3S7X9J5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7X9J5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	108	110	PF00675	0.381
CLV_NRD_NRD_1	194	196	PF00675	0.797
CLV_NRD_NRD_1	20	22	PF00675	0.536
CLV_NRD_NRD_1	294	296	PF00675	0.573
CLV_NRD_NRD_1	64	66	PF00675	0.370
CLV_NRD_NRD_1	71	73	PF00675	0.355
CLV_PCSK_KEX2_1	108	110	PF00082	0.391
CLV_PCSK_KEX2_1	20	22	PF00082	0.644
CLV_PCSK_KEX2_1	294	296	PF00082	0.573
CLV_PCSK_KEX2_1	64	66	PF00082	0.380
CLV_PCSK_SKI1_1	124	128	PF00082	0.441
CLV_PCSK_SKI1_1	195	199	PF00082	0.799
DOC_CDC14_PxL_1	85	93	PF14671	0.589
DOC_MAPK_gen_1	20	27	PF00069	0.629
DOC_MAPK_gen_1	64	71	PF00069	0.606
DOC_MAPK_MEF2A_6	39	46	PF00069	0.611
DOC_PP4_FxxP_1	144	147	PF00568	0.703
DOC_SPAK_OSR1_1	109	113	PF12202	0.591
DOC_USP7_MATH_1	114	118	PF00917	0.591
DOC_USP7_MATH_1	177	181	PF00917	0.804
DOC_USP7_MATH_1	197	201	PF00917	0.693
DOC_USP7_MATH_1	244	248	PF00917	0.837
DOC_WW_Pin1_4	245	250	PF00397	0.829
DOC_WW_Pin1_4	283	288	PF00397	0.725
LIG_14-3-3_CanoR_1	13	22	PF00244	0.591
LIG_BIR_II_1	1	5	PF00653	0.544
LIG_FHA_1	14	20	PF00498	0.535
LIG_FHA_1	196	202	PF00498	0.738
LIG_FHA_1	4	10	PF00498	0.511
LIG_FHA_2	125	131	PF00498	0.662
LIG_FHA_2	160	166	PF00498	0.753
LIG_FHA_2	181	187	PF00498	0.819
LIG_Integrin_isoDGR_2	211	213	PF01839	0.866
LIG_LIR_Apic_2	143	147	PF02991	0.633
LIG_LIR_Apic_2	149	154	PF02991	0.606
LIG_LIR_Apic_2	231	236	PF02991	0.651
LIG_LIR_Gen_1	258	266	PF02991	0.786
LIG_LIR_Nem_3	104	110	PF02991	0.600
LIG_LIR_Nem_3	258	262	PF02991	0.871
LIG_LRP6_Inhibitor_1	71	77	PF00058	0.477
LIG_MAD2	279	287	PF02301	0.711
LIG_MYND_3	88	92	PF01753	0.622
LIG_Rb_LxCxE_1	86	104	PF01857	0.622
LIG_SH2_CRK	151	155	PF00017	0.768
LIG_SH2_CRK	259	263	PF00017	0.866
LIG_SH2_SRC	233	236	PF00017	0.787
LIG_SH3_3	263	269	PF00018	0.795
LIG_SH3_3	94	100	PF00018	0.594
LIG_TRAF2_1	127	130	PF00917	0.662
LIG_TRAF2_1	162	165	PF00917	0.775
LIG_TRAF2_1	269	272	PF00917	0.726
LIG_WRC_WIRS_1	141	146	PF05994	0.736
MOD_CDK_SPxxK_3	245	252	PF00069	0.832
MOD_CK1_1	180	186	PF00069	0.903
MOD_CK1_1	216	222	PF00069	0.750
MOD_CK1_1	261	267	PF00069	0.798
MOD_CK1_1	283	289	PF00069	0.627
MOD_CK2_1	124	130	PF00069	0.491
MOD_CK2_1	159	165	PF00069	0.755
MOD_CK2_1	180	186	PF00069	0.817
MOD_GlcNHglycan	179	182	PF01048	0.862
MOD_GlcNHglycan	201	204	PF01048	0.799
MOD_GlcNHglycan	215	218	PF01048	0.776
MOD_GlcNHglycan	266	269	PF01048	0.752
MOD_GlcNHglycan	300	303	PF01048	0.741
MOD_GSK3_1	171	178	PF00069	0.764
MOD_GSK3_1	195	202	PF00069	0.787
MOD_GSK3_1	216	223	PF00069	0.757
MOD_GSK3_1	260	267	PF00069	0.831
MOD_LATS_1	193	199	PF00433	0.793
MOD_N-GLC_1	172	177	PF02516	0.762
MOD_N-GLC_2	237	239	PF02516	0.653
MOD_N-GLC_2	26	28	PF02516	0.503
MOD_NEK2_1	11	16	PF00069	0.517
MOD_NEK2_1	296	301	PF00069	0.714
MOD_NEK2_1	47	52	PF00069	0.475
MOD_NEK2_1	83	88	PF00069	0.490
MOD_PIKK_1	27	33	PF00454	0.644
MOD_PKA_1	195	201	PF00069	0.799
MOD_Plk_4	228	234	PF00069	0.655
MOD_ProDKin_1	245	251	PF00069	0.831
MOD_ProDKin_1	283	289	PF00069	0.721
TRG_DiLeu_BaEn_1	92	97	PF01217	0.455
TRG_ENDOCYTIC_2	107	110	PF00928	0.461
TRG_ENDOCYTIC_2	259	262	PF00928	0.870
TRG_ER_diArg_1	107	109	PF00400	0.452
TRG_ER_diArg_1	19	21	PF00400	0.646
TRG_ER_diArg_1	293	295	PF00400	0.584
TRG_ER_diArg_1	64	66	PF00400	0.435
TRG_NES_CRM1_1	17	31	PF08389	0.526
TRG_NES_CRM1_1	33	45	PF08389	0.492
TRG_Pf-PMV_PEXEL_1	124	128	PF00026	0.533
TRG_Pf-PMV_PEXEL_1	64	68	PF00026	0.456
TRG_Pf-PMV_PEXEL_1	77	81	PF00026	0.497

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IJM3	Leptomonas seymouri	63%	99%
A0A0S4JGU9	Bodo saltans	40%	96%
A0A1X0P674	Trypanosomatidae	48%	96%
A0A422N788	Trypanosoma rangeli	49%	100%
A4HMZ8	Leishmania braziliensis	80%	100%
A4IBM1	Leishmania infantum	100%	100%
C9ZZ14	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	48%	100%
D0A2P1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	25%	100%
E9AFF5	Leishmania major	95%	100%
E9B6L0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	100%
V5DUQ3	Trypanosoma cruzi	48%	100%