Hypothetical_protein_conserved

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S7X9J2_LEIDO

TriTrypDb:

LdBPK_353320.1 , LdCL_350038200 , LDHU3_35.4370

Length:

188

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S7X9J2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7X9J2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	9	13	PF00656	0.524
CLV_NRD_NRD_1	163	165	PF00675	0.507
CLV_NRD_NRD_1	167	169	PF00675	0.519
CLV_NRD_NRD_1	180	182	PF00675	0.561
CLV_NRD_NRD_1	183	185	PF00675	0.436
CLV_NRD_NRD_1	32	34	PF00675	0.521
CLV_NRD_NRD_1	52	54	PF00675	0.438
CLV_NRD_NRD_1	66	68	PF00675	0.534
CLV_PCSK_KEX2_1	180	182	PF00082	0.561
CLV_PCSK_KEX2_1	32	34	PF00082	0.521
CLV_PCSK_KEX2_1	52	54	PF00082	0.438
CLV_PCSK_KEX2_1	65	67	PF00082	0.435
CLV_PCSK_PC7_1	176	182	PF00082	0.554
CLV_PCSK_SKI1_1	180	184	PF00082	0.544
CLV_PCSK_SKI1_1	66	70	PF00082	0.444
CLV_PCSK_SKI1_1	86	90	PF00082	0.458
DOC_USP7_MATH_1	144	148	PF00917	0.662
DOC_USP7_UBL2_3	153	157	PF12436	0.532
DOC_USP7_UBL2_3	161	165	PF12436	0.548
DOC_USP7_UBL2_3	169	173	PF12436	0.442
DOC_USP7_UBL2_3	89	93	PF12436	0.531
DOC_WW_Pin1_4	126	131	PF00397	0.591
LIG_14-3-3_CanoR_1	65	73	PF00244	0.463
LIG_14-3-3_CanoR_1	75	81	PF00244	0.507
LIG_BIR_II_1	1	5	PF00653	0.650
LIG_deltaCOP1_diTrp_1	7	17	PF00928	0.516
LIG_FHA_1	1	7	PF00498	0.669
LIG_FHA_1	67	73	PF00498	0.442
LIG_FHA_2	75	81	PF00498	0.553
LIG_LIR_Gen_1	15	25	PF02991	0.483
LIG_LIR_Nem_3	147	151	PF02991	0.499
LIG_LIR_Nem_3	15	21	PF02991	0.505
LIG_NRP_CendR_1	185	188	PF00754	0.581
LIG_PCNA_PIPBox_1	11	20	PF02747	0.523
LIG_Pex14_2	17	21	PF04695	0.475
LIG_SH2_CRK	148	152	PF00017	0.483
LIG_SH2_CRK	179	183	PF00017	0.561
LIG_TRAF2_1	60	63	PF00917	0.584
LIG_TYR_ITIM	177	182	PF00017	0.557
MOD_CDK_SPxxK_3	126	133	PF00069	0.593
MOD_CK1_1	111	117	PF00069	0.628
MOD_CK1_1	74	80	PF00069	0.482
MOD_CK2_1	111	117	PF00069	0.637
MOD_CK2_1	57	63	PF00069	0.518
MOD_CK2_1	74	80	PF00069	0.482
MOD_GlcNHglycan	59	62	PF01048	0.518
MOD_GSK3_1	109	116	PF00069	0.535
MOD_GSK3_1	120	127	PF00069	0.602
MOD_GSK3_1	19	26	PF00069	0.507
MOD_GSK3_1	39	46	PF00069	0.381
MOD_GSK3_1	98	105	PF00069	0.646
MOD_NEK2_1	108	113	PF00069	0.591
MOD_NEK2_2	102	107	PF00069	0.590
MOD_PIKK_1	43	49	PF00454	0.674
MOD_PKA_1	66	72	PF00069	0.444
MOD_PKA_2	163	169	PF00069	0.557
MOD_PKA_2	66	72	PF00069	0.466
MOD_PKA_2	74	80	PF00069	0.501
MOD_Plk_1	19	25	PF00069	0.557
MOD_ProDKin_1	126	132	PF00069	0.591
TRG_ENDOCYTIC_2	148	151	PF00928	0.493
TRG_ENDOCYTIC_2	179	182	PF00928	0.562
TRG_ER_diArg_1	179	181	PF00400	0.566
TRG_ER_diArg_1	65	67	PF00400	0.488
TRG_NLS_Bipartite_1	168	188	PF00514	0.486
TRG_NLS_MonoExtC_3	183	188	PF00514	0.509
TRG_NLS_MonoExtN_4	181	188	PF00514	0.505
TRG_Pf-PMV_PEXEL_1	181	186	PF00026	0.546

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PDT8	Leptomonas seymouri	52%	100%
A4HMZ4	Leishmania braziliensis	67%	100%
A4IBL8	Leishmania infantum	99%	100%
E9AFF1	Leishmania major	92%	100%
E9B6K6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	86%	99%