Hypothetical_protein_conserved

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S7X9I9_LEIDO

TriTrypDb:

LdBPK_353270.1 , LdCL_350037700 , LDHU3_35.4300

Length:

170

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0005930	axoneme	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A0A3S7X9I9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7X9I9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	12	14	PF00675	0.631
CLV_PCSK_KEX2_1	10	12	PF00082	0.539
CLV_PCSK_PC1ET2_1	10	12	PF00082	0.546
CLV_PCSK_SKI1_1	36	40	PF00082	0.488
CLV_PCSK_SKI1_1	72	76	PF00082	0.496
DOC_PP2B_LxvP_1	20	23	PF13499	0.549
DOC_USP7_MATH_1	88	92	PF00917	0.472
DOC_USP7_MATH_1	9	13	PF00917	0.645
DOC_USP7_UBL2_3	10	14	PF12436	0.598
DOC_WW_Pin1_4	48	53	PF00397	0.408
LIG_14-3-3_CanoR_1	67	76	PF00244	0.544
LIG_BIR_II_1	1	5	PF00653	0.693
LIG_FHA_1	56	62	PF00498	0.497
LIG_FHA_1	88	94	PF00498	0.465
LIG_FHA_2	28	34	PF00498	0.417
LIG_FHA_2	58	64	PF00498	0.489
LIG_FHA_2	87	93	PF00498	0.472
LIG_LIR_LC3C_4	44	49	PF02991	0.434
LIG_LIR_Nem_3	107	113	PF02991	0.423
LIG_MYND_1	18	22	PF01753	0.490
LIG_RPA_C_Fungi	153	165	PF08784	0.408
LIG_SH2_CRK	85	89	PF00017	0.428
LIG_SH2_NCK_1	85	89	PF00017	0.428
LIG_SH2_SRC	108	111	PF00017	0.434
LIG_SH3_1	15	21	PF00018	0.570
LIG_SH3_3	15	21	PF00018	0.580
LIG_SH3_3	46	52	PF00018	0.389
LIG_SUMO_SIM_anti_2	44	51	PF11976	0.549
LIG_SUMO_SIM_par_1	44	51	PF11976	0.383
LIG_TRAF2_1	144	147	PF00917	0.555
LIG_WW_2	18	21	PF00397	0.494
MOD_CK1_1	4	10	PF00069	0.609
MOD_CK1_1	70	76	PF00069	0.582
MOD_CK2_1	57	63	PF00069	0.488
MOD_GlcNHglycan	43	46	PF01048	0.441
MOD_GlcNHglycan	7	10	PF01048	0.652
MOD_GlcNHglycan	72	75	PF01048	0.510
MOD_GSK3_1	1	8	PF00069	0.688
MOD_GSK3_1	37	44	PF00069	0.409
MOD_GSK3_1	70	77	PF00069	0.605
MOD_GSK3_1	93	100	PF00069	0.479
MOD_N-GLC_1	68	73	PF02516	0.500
MOD_NEK2_1	1	6	PF00069	0.691
MOD_NEK2_1	104	109	PF00069	0.307
MOD_NEK2_1	131	136	PF00069	0.481
MOD_NEK2_1	68	73	PF00069	0.546
MOD_NEK2_1	97	102	PF00069	0.403
MOD_PIKK_1	131	137	PF00454	0.482
MOD_PKA_2	4	10	PF00069	0.613
MOD_Plk_4	57	63	PF00069	0.415
MOD_ProDKin_1	48	54	PF00069	0.414
TRG_DiLeu_BaEn_1	123	128	PF01217	0.455
TRG_ENDOCYTIC_2	110	113	PF00928	0.422
TRG_NLS_MonoExtC_3	9	14	PF00514	0.672
TRG_NLS_MonoExtN_4	10	17	PF00514	0.598
TRG_Pf-PMV_PEXEL_1	29	33	PF00026	0.370

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PCS8	Leptomonas seymouri	54%	97%
A0A1X0P5D6	Trypanosomatidae	42%	100%
A4HMY9	Leishmania braziliensis	79%	100%
A4IBL3	Leishmania infantum	99%	100%
C9ZZ27	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	34%	99%
E9AFE6	Leishmania major	95%	100%
E9B6K1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	93%	100%