LeishMANIAdb
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Riboflavin kinase

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Riboflavin kinase
Gene product:
riboflavin kinase/fmn adenylyltransferase-like protein
Species:
Leishmania donovani
UniProt:
A0A3S7X9I7_LEIDO
TriTrypDb:
LdBPK_353210.1 , LdCL_350037100 , LDHU3_35.4210
Length:
183

Annotations

Annotations by Jardim et al.

Coenzyme/cofactor biosynthesis, Riboflavin kinase/fmn adenylyltransferase-like

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 5
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. yes yes: 16
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 11
NetGPI no yes: 0, no: 11
Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S7X9I7
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7X9I7

Function

Biological processes
Term Name Level Count
GO:0006139 nucleobase-containing compound metabolic process 3 12
GO:0006725 cellular aromatic compound metabolic process 3 12
GO:0006753 nucleoside phosphate metabolic process 4 12
GO:0006766 vitamin metabolic process 3 12
GO:0006767 water-soluble vitamin metabolic process 4 12
GO:0006771 riboflavin metabolic process 5 12
GO:0006793 phosphorus metabolic process 3 12
GO:0006796 phosphate-containing compound metabolic process 4 12
GO:0006807 nitrogen compound metabolic process 2 12
GO:0008152 metabolic process 1 12
GO:0009058 biosynthetic process 2 12
GO:0009110 vitamin biosynthetic process 4 12
GO:0009117 nucleotide metabolic process 5 12
GO:0009123 nucleoside monophosphate metabolic process 5 12
GO:0009124 nucleoside monophosphate biosynthetic process 6 12
GO:0009156 ribonucleoside monophosphate biosynthetic process 7 12
GO:0009161 ribonucleoside monophosphate metabolic process 6 12
GO:0009165 nucleotide biosynthetic process 6 12
GO:0009231 riboflavin biosynthetic process 6 12
GO:0009259 ribonucleotide metabolic process 5 12
GO:0009260 ribonucleotide biosynthetic process 6 12
GO:0009398 FMN biosynthetic process 6 12
GO:0009987 cellular process 1 12
GO:0016310 phosphorylation 5 12
GO:0018130 heterocycle biosynthetic process 4 12
GO:0019438 aromatic compound biosynthetic process 4 12
GO:0019637 organophosphate metabolic process 3 12
GO:0019693 ribose phosphate metabolic process 4 12
GO:0034641 cellular nitrogen compound metabolic process 3 12
GO:0034654 nucleobase-containing compound biosynthetic process 4 12
GO:0042364 water-soluble vitamin biosynthetic process 5 12
GO:0042726 flavin-containing compound metabolic process 4 12
GO:0042727 flavin-containing compound biosynthetic process 5 12
GO:0044237 cellular metabolic process 2 12
GO:0044238 primary metabolic process 2 12
GO:0044249 cellular biosynthetic process 3 12
GO:0044271 cellular nitrogen compound biosynthetic process 4 12
GO:0044281 small molecule metabolic process 2 12
GO:0044283 small molecule biosynthetic process 3 12
GO:0046390 ribose phosphate biosynthetic process 5 12
GO:0046444 FMN metabolic process 5 12
GO:0046483 heterocycle metabolic process 3 12
GO:0055086 nucleobase-containing small molecule metabolic process 3 12
GO:0071704 organic substance metabolic process 2 12
GO:0090407 organophosphate biosynthetic process 4 12
GO:1901135 carbohydrate derivative metabolic process 3 12
GO:1901137 carbohydrate derivative biosynthetic process 4 12
GO:1901293 nucleoside phosphate biosynthetic process 5 12
GO:1901360 organic cyclic compound metabolic process 3 12
GO:1901362 organic cyclic compound biosynthetic process 4 12
GO:1901564 organonitrogen compound metabolic process 3 12
GO:1901566 organonitrogen compound biosynthetic process 4 12
GO:1901576 organic substance biosynthetic process 3 12
Molecular functions
Term Name Level Count
GO:0000166 nucleotide binding 3 12
GO:0003824 catalytic activity 1 12
GO:0005488 binding 1 12
GO:0005524 ATP binding 5 12
GO:0008531 riboflavin kinase activity 5 12
GO:0016301 kinase activity 4 12
GO:0016740 transferase activity 2 12
GO:0016772 transferase activity, transferring phosphorus-containing groups 3 12
GO:0016773 phosphotransferase activity, alcohol group as acceptor 4 12
GO:0016779 nucleotidyltransferase activity 4 7
GO:0017076 purine nucleotide binding 4 12
GO:0030554 adenyl nucleotide binding 5 12
GO:0032553 ribonucleotide binding 3 12
GO:0032555 purine ribonucleotide binding 4 12
GO:0032559 adenyl ribonucleotide binding 5 12
GO:0035639 purine ribonucleoside triphosphate binding 4 12
GO:0036094 small molecule binding 2 12
GO:0043167 ion binding 2 12
GO:0043168 anion binding 3 12
GO:0097159 organic cyclic compound binding 2 12
GO:0097367 carbohydrate derivative binding 2 12
GO:1901265 nucleoside phosphate binding 3 12
GO:1901363 heterocyclic compound binding 2 12

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_PCSK_SKI1_1 112 116 PF00082 0.392
DOC_PP2B_LxvP_1 146 149 PF13499 0.544
DOC_PP4_FxxP_1 37 40 PF00568 0.417
DOC_WW_Pin1_4 65 70 PF00397 0.428
LIG_14-3-3_CanoR_1 112 117 PF00244 0.364
LIG_14-3-3_CanoR_1 118 125 PF00244 0.352
LIG_BIR_III_2 66 70 PF00653 0.274
LIG_BRCT_BRCA1_1 176 180 PF00533 0.455
LIG_FHA_1 23 29 PF00498 0.295
LIG_FHA_2 124 130 PF00498 0.371
LIG_LIR_Apic_2 36 40 PF02991 0.417
LIG_LIR_Gen_1 105 114 PF02991 0.366
LIG_LIR_Gen_1 123 132 PF02991 0.401
LIG_LIR_Gen_1 177 183 PF02991 0.521
LIG_LIR_Nem_3 105 110 PF02991 0.323
LIG_LIR_Nem_3 123 128 PF02991 0.202
LIG_LIR_Nem_3 150 154 PF02991 0.440
LIG_LIR_Nem_3 177 183 PF02991 0.498
LIG_PDZ_Class_2 178 183 PF00595 0.507
LIG_Pex14_2 98 102 PF04695 0.328
LIG_PTB_Apo_2 81 88 PF02174 0.317
LIG_SH2_CRK 41 45 PF00017 0.271
LIG_SH2_GRB2like 41 44 PF00017 0.417
LIG_SH2_STAP1 107 111 PF00017 0.235
LIG_SH2_STAP1 41 45 PF00017 0.417
LIG_SH3_3 68 74 PF00018 0.465
LIG_SUMO_SIM_par_1 112 117 PF11976 0.336
LIG_TRAF2_1 127 130 PF00917 0.449
LIG_WRC_WIRS_1 175 180 PF05994 0.461
MOD_CK1_1 123 129 PF00069 0.390
MOD_CK2_1 123 129 PF00069 0.371
MOD_GlcNHglycan 122 125 PF01048 0.405
MOD_GlcNHglycan 91 95 PF01048 0.388
MOD_GSK3_1 120 127 PF00069 0.422
MOD_NEK2_1 77 82 PF00069 0.317
MOD_PIKK_1 118 124 PF00454 0.449
MOD_PIKK_1 16 22 PF00454 0.317
MOD_PKB_1 118 126 PF00069 0.371
MOD_Plk_2-3 56 62 PF00069 0.332
MOD_ProDKin_1 65 71 PF00069 0.428
TRG_ENDOCYTIC_2 107 110 PF00928 0.316
TRG_ENDOCYTIC_2 41 44 PF00928 0.314
TRG_ER_diArg_1 6 9 PF00400 0.371

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N0P5K3 Leptomonas seymouri 64% 98%
A0A0S4JJJ4 Bodo saltans 43% 98%
A0A1X0P5M5 Trypanosomatidae 44% 100%
A0A3R7RGI7 Trypanosoma rangeli 48% 100%
A1C603 Aspergillus clavatus (strain ATCC 1007 / CBS 513.65 / DSM 816 / NCTC 3887 / NRRL 1 / QM 1276 / 107) 30% 86%
A1DG00 Neosartorya fischeri (strain ATCC 1020 / DSM 3700 / CBS 544.65 / FGSC A1164 / JCM 1740 / NRRL 181 / WB 181) 29% 84%
A2QFH1 Aspergillus niger (strain CBS 513.88 / FGSC A1513) 30% 86%
A3M0C9 Scheffersomyces stipitis (strain ATCC 58785 / CBS 6054 / NBRC 10063 / NRRL Y-11545) 33% 100%
A4HMY3 Leishmania braziliensis 85% 100%
A4IBK7 Leishmania infantum 100% 100%
A4QQ05 Magnaporthe oryzae (strain 70-15 / ATCC MYA-4617 / FGSC 8958) 38% 92%
A5DAH9 Meyerozyma guilliermondii (strain ATCC 6260 / CBS 566 / DSM 6381 / JCM 1539 / NBRC 10279 / NRRL Y-324) 32% 100%
A5E1A0 Lodderomyces elongisporus (strain ATCC 11503 / CBS 2605 / JCM 1781 / NBRC 1676 / NRRL YB-4239) 30% 100%
C9ZZ35 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 43% 100%
E9AFE0 Leishmania major 95% 100%
E9B6J5 Leishmania mexicana (strain MHOM/GT/2001/U1103) 94% 100%
O74866 Schizosaccharomyces pombe (strain 972 / ATCC 24843) 36% 100%
O76206 Drosophila melanogaster 33% 100%
P0C5D9 Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970) 34% 78%
Q03778 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 28% 84%
Q0CHR1 Aspergillus terreus (strain NIH 2624 / FGSC A1156) 31% 89%
Q2UMM4 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 30% 92%
Q4WHD2 Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100) 30% 86%
Q5AW61 Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) 30% 87%
Q6CG11 Yarrowia lipolytica (strain CLIB 122 / E 150) 30% 95%
Q6CT57 Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37) 32% 99%
Q6FM49 Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65) 27% 97%
Q6M923 Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987) 30% 77%
Q75DY2 Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056) 32% 98%
Q8CFV9 Mus musculus 37% 100%
Q969G6 Homo sapiens 36% 100%
V5DUW4 Trypanosoma cruzi 47% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS