LeishMANIAdb
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Dynein_light_chain_putative/GeneDB:LmjF.35.2910

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Dynein_light_chain_putative/GeneDB:LmjF.35.2910
Gene product:
dynein light chain, putative
Species:
Leishmania donovani
UniProt:
A0A3S7X9I4_LEIDO
TriTrypDb:
LdBPK_352960.1 , LdCL_350034500 , LDHU3_35.3800
Length:
123

Annotations

Annotations by Jardim et al.

Structural Proteins, dynein light chain, putative

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. yes yes: 20
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 11
NetGPI no yes: 0, no: 11
Cellular components
Term Name Level Count
GO:0005737 cytoplasm 2 1
GO:0005868 cytoplasmic dynein complex 4 1
GO:0005875 microtubule associated complex 2 1
GO:0030286 dynein complex 3 1
GO:0032991 protein-containing complex 1 1
GO:0110165 cellular anatomical entity 1 1
GO:1902494 catalytic complex 2 1

Expansion

Sequence features

A0A3S7X9I4
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7X9I4

Function

Biological processes
Term Name Level Count
GO:0007017 microtubule-based process 2 1
GO:0007018 microtubule-based movement 3 1
GO:0009987 cellular process 1 1
Molecular functions
Term Name Level Count
GO:0005488 binding 1 1
GO:0005515 protein binding 2 1
GO:0045505 dynein intermediate chain binding 3 1

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 96 100 PF00656 0.405
CLV_PCSK_SKI1_1 109 113 PF00082 0.405
CLV_PCSK_SKI1_1 30 34 PF00082 0.376
DEG_Nend_UBRbox_3 1 3 PF02207 0.646
DOC_CYCLIN_RxL_1 106 116 PF00134 0.405
DOC_USP7_UBL2_3 26 30 PF12436 0.348
DOC_USP7_UBL2_3 61 65 PF12436 0.506
LIG_eIF4E_1 106 112 PF01652 0.316
LIG_FHA_1 112 118 PF00498 0.389
LIG_FHA_1 7 13 PF00498 0.547
LIG_FHA_2 55 61 PF00498 0.329
LIG_LIR_Gen_1 99 107 PF02991 0.329
LIG_LIR_Nem_3 116 121 PF02991 0.306
LIG_LIR_Nem_3 68 73 PF02991 0.462
LIG_LIR_Nem_3 99 105 PF02991 0.327
LIG_SH2_CRK 70 74 PF00017 0.462
LIG_SH2_STAT5 101 104 PF00017 0.319
LIG_SH2_STAT5 106 109 PF00017 0.312
LIG_SH3_4 26 33 PF00018 0.348
LIG_TRFH_1 10 14 PF08558 0.496
MOD_CK2_1 28 34 PF00069 0.317
MOD_GSK3_1 28 35 PF00069 0.340
MOD_NEK2_1 111 116 PF00069 0.297
MOD_NEK2_2 113 118 PF00069 0.329
MOD_Plk_1 5 11 PF00069 0.684
MOD_Plk_4 113 119 PF00069 0.316
MOD_Plk_4 28 34 PF00069 0.334
TRG_ENDOCYTIC_2 70 73 PF00928 0.316

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1I3B2 Leptomonas seymouri 85% 100%
A0A0N1PFP4 Leptomonas seymouri 33% 98%
A0A0S4IQE7 Bodo saltans 26% 100%
A0A0S4JDH6 Bodo saltans 72% 88%
A0A1X0NYC6 Trypanosomatidae 28% 98%
A0A1X0P6I3 Trypanosomatidae 70% 99%
A0A3R7LJS7 Trypanosoma rangeli 25% 98%
A0A3S5H7J0 Leishmania donovani 32% 100%
A0A422P2R8 Trypanosoma rangeli 77% 99%
A2VDD2 Xenopus laevis 31% 70%
A4HGD9 Leishmania braziliensis 30% 100%
A4HMV8 Leishmania braziliensis 96% 100%
A4I3H2 Leishmania infantum 32% 100%
A4IBH9 Leishmania infantum 100% 100%
C9ZZ62 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 77% 99%
E9AFB5 Leishmania major 99% 100%
E9AZR1 Leishmania mexicana (strain MHOM/GT/2001/U1103) 32% 100%
E9B6H0 Leishmania mexicana (strain MHOM/GT/2001/U1103) 98% 100%
F1QMY1 Danio rerio 38% 82%
P63171 Bos taurus 26% 100%
P63172 Homo sapiens 26% 100%
Q32P71 Bos taurus 37% 81%
Q3B8D7 Xenopus laevis 30% 69%
Q4Q8H2 Leishmania major 31% 100%
Q54PG1 Dictyostelium discoideum 28% 100%
Q66IC8 Danio rerio 32% 71%
Q8N7M0 Homo sapiens 28% 69%
Q8WW35 Homo sapiens 38% 87%
Q94524 Drosophila melanogaster 24% 100%
Q9CQ66 Mus musculus 39% 85%
Q9D5I4 Mus musculus 20% 71%
Q9Z336 Rattus norvegicus 24% 100%
V5BTL3 Trypanosoma cruzi 73% 99%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS