Protein-S-isoprenylcysteine O-methyltransferase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

prenyl protein specific carboxyl methyltransferase, putative

Species:

Leishmania donovani

UniProt:

A0A3S7X9G8_LEIDO

TriTrypDb:

LdBPK_353080.1 , LdCL_350035700 , LDHU3_35.3990

Length:

266

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	yes	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005789	endoplasmic reticulum membrane	4	12
GO:0016020	membrane	2	12
GO:0031090	organelle membrane	3	12
GO:0110165	cellular anatomical entity	1	12
GO:0005783	endoplasmic reticulum	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1

Expansion

Sequence features

A0A3S7X9G8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7X9G8

Function

Biological processes
Term	Name	Level	Count
GO:0006479	protein methylation	4	1
GO:0006481	C-terminal protein methylation	5	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	1
GO:0008213	protein alkylation	5	1
GO:0009987	cellular process	1	1
GO:0018410	C-terminal protein amino acid modification	6	1
GO:0019538	protein metabolic process	3	1
GO:0032259	methylation	2	1
GO:0036211	protein modification process	4	1
GO:0043170	macromolecule metabolic process	3	1
GO:0043412	macromolecule modification	4	1
GO:0043414	macromolecule methylation	3	1
GO:0043687	post-translational protein modification	5	1
GO:0044237	cellular metabolic process	2	1
GO:0044238	primary metabolic process	2	1
GO:0044260	obsolete cellular macromolecule metabolic process	3	1
GO:0071704	organic substance metabolic process	2	1
GO:1901564	organonitrogen compound metabolic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	12
GO:0003880	protein C-terminal carboxyl O-methyltransferase activity	5	12
GO:0004671	protein C-terminal S-isoprenylcysteine carboxyl O-methyltransferase activity	6	12
GO:0008168	methyltransferase activity	4	12
GO:0008171	O-methyltransferase activity	5	12
GO:0008276	protein methyltransferase activity	3	12
GO:0008757	S-adenosylmethionine-dependent methyltransferase activity	5	12
GO:0010340	carboxyl-O-methyltransferase activity	6	12
GO:0016740	transferase activity	2	12
GO:0016741	transferase activity, transferring one-carbon groups	3	12
GO:0051998	protein carboxyl O-methyltransferase activity	4	12
GO:0140096	catalytic activity, acting on a protein	2	12

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	56	60	PF00656	0.364
CLV_C14_Caspase3-7	91	95	PF00656	0.548
CLV_NRD_NRD_1	18	20	PF00675	0.413
CLV_PCSK_KEX2_1	18	20	PF00082	0.397
CLV_PCSK_KEX2_1	253	255	PF00082	0.390
CLV_PCSK_PC1ET2_1	253	255	PF00082	0.266
DOC_CDC14_PxL_1	99	107	PF14671	0.525
DOC_CYCLIN_RxL_1	22	32	PF00134	0.592
DOC_CYCLIN_yCln2_LP_2	195	201	PF00134	0.257
DOC_CYCLIN_yCln2_LP_2	214	220	PF00134	0.299
DOC_MAPK_gen_1	253	263	PF00069	0.481
DOC_MAPK_MEF2A_6	256	265	PF00069	0.494
DOC_PP4_FxxP_1	85	88	PF00568	0.607
LIG_14-3-3_CanoR_1	132	136	PF00244	0.578
LIG_14-3-3_CanoR_1	141	150	PF00244	0.296
LIG_14-3-3_CanoR_1	161	166	PF00244	0.355
LIG_BIR_II_1	1	5	PF00653	0.707
LIG_EH1_1	254	262	PF00400	0.506
LIG_eIF4E_1	144	150	PF01652	0.380
LIG_FHA_1	108	114	PF00498	0.554
LIG_FHA_1	143	149	PF00498	0.351
LIG_FHA_1	186	192	PF00498	0.287
LIG_FHA_1	30	36	PF00498	0.366
LIG_FHA_2	54	60	PF00498	0.398
LIG_FHA_2	89	95	PF00498	0.526
LIG_LIR_Apic_2	118	123	PF02991	0.550
LIG_LIR_Gen_1	151	160	PF02991	0.317
LIG_LIR_Gen_1	170	176	PF02991	0.295
LIG_LIR_Gen_1	94	104	PF02991	0.545
LIG_LIR_Nem_3	151	155	PF02991	0.294
LIG_LIR_Nem_3	227	233	PF02991	0.477
LIG_LIR_Nem_3	250	255	PF02991	0.485
LIG_LIR_Nem_3	94	99	PF02991	0.510
LIG_Pex14_2	201	205	PF04695	0.246
LIG_REV1ctd_RIR_1	136	145	PF16727	0.532
LIG_REV1ctd_RIR_1	228	238	PF16727	0.446
LIG_SH2_CRK	192	196	PF00017	0.257
LIG_SH2_NCK_1	120	124	PF00017	0.630
LIG_SH2_NCK_1	237	241	PF00017	0.482
LIG_SH2_SRC	104	107	PF00017	0.529
LIG_SH2_SRC	120	123	PF00017	0.437
LIG_SH2_SRC	237	240	PF00017	0.461
LIG_SH2_STAP1	144	148	PF00017	0.368
LIG_SH2_STAT5	104	107	PF00017	0.502
LIG_SH2_STAT5	144	147	PF00017	0.310
LIG_SH2_STAT5	194	197	PF00017	0.260
LIG_SH2_STAT5	200	203	PF00017	0.230
LIG_SH2_STAT5	229	232	PF00017	0.508
LIG_SH2_STAT5	247	250	PF00017	0.346
LIG_SH2_STAT5	67	70	PF00017	0.342
LIG_SH3_3	258	264	PF00018	0.501
LIG_SUMO_SIM_anti_2	151	157	PF11976	0.377
LIG_TRAF2_1	236	239	PF00917	0.451
LIG_WRC_WIRS_1	149	154	PF05994	0.360
MOD_CK1_1	170	176	PF00069	0.294
MOD_CK1_1	2	8	PF00069	0.719
MOD_GlcNHglycan	107	110	PF01048	0.320
MOD_GlcNHglycan	145	148	PF01048	0.404
MOD_GlcNHglycan	181	184	PF01048	0.532
MOD_GlcNHglycan	218	221	PF01048	0.446
MOD_GlcNHglycan	4	7	PF01048	0.460
MOD_GSK3_1	53	60	PF00069	0.282
MOD_N-GLC_1	142	147	PF02516	0.287
MOD_N-GLC_1	170	175	PF02516	0.446
MOD_N-GLC_1	57	62	PF02516	0.523
MOD_NEK2_1	1	6	PF00069	0.722
MOD_NEK2_1	105	110	PF00069	0.514
MOD_NEK2_1	148	153	PF00069	0.349
MOD_NEK2_1	204	209	PF00069	0.269
MOD_PKA_2	131	137	PF00069	0.545
MOD_PKA_2	179	185	PF00069	0.271
MOD_Plk_1	170	176	PF00069	0.246
MOD_Plk_1	238	244	PF00069	0.493
MOD_Plk_1	57	63	PF00069	0.333
MOD_Plk_4	131	137	PF00069	0.607
MOD_Plk_4	161	167	PF00069	0.340
MOD_Plk_4	224	230	PF00069	0.373
MOD_Plk_4	57	63	PF00069	0.290
TRG_ENDOCYTIC_2	192	195	PF00928	0.257
TRG_ER_diArg_1	17	19	PF00400	0.643
TRG_Pf-PMV_PEXEL_1	26	31	PF00026	0.307

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P511	Leptomonas seymouri	66%	100%
A0A0S4JHW1	Bodo saltans	46%	100%
A0A1X0P5F1	Trypanosomatidae	52%	100%
A0A422P2Y4	Trypanosoma rangeli	51%	100%
A2XX73	Oryza sativa subsp. indica	33%	100%
A4HMX0	Leishmania braziliensis	83%	100%
A4IBJ1	Leishmania infantum	100%	100%
C9ZZ50	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	46%	100%
D6WJ77	Tribolium castaneum	35%	95%
E9AFC7	Leishmania major	93%	100%
E9B6I2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%
O12947	Xenopus laevis	33%	92%
O60725	Homo sapiens	34%	94%
P32584	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	30%	100%
P87014	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	35%	100%
Q558K8	Dictyostelium discoideum	34%	100%
Q7XSR9	Oryza sativa subsp. japonica	33%	100%
Q9EQK7	Mus musculus	33%	94%
Q9WVM4	Rattus norvegicus	33%	94%
V5C2X9	Trypanosoma cruzi	49%	100%