TPR_REGION domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S7X9G6_LEIDO

TriTrypDb:

LdBPK_353020.1 , LdCL_350035100 , LDHU3_35.3890

Length:

381

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S7X9G6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7X9G6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	132	136	PF00656	0.573
CLV_PCSK_SKI1_1	354	358	PF00082	0.516
CLV_PCSK_SKI1_1	55	59	PF00082	0.495
CLV_PCSK_SKI1_1	93	97	PF00082	0.456
DEG_Nend_Nbox_1	1	3	PF02207	0.662
DEG_SPOP_SBC_1	361	365	PF00917	0.667
DOC_CYCLIN_RxL_1	90	97	PF00134	0.514
DOC_MAPK_gen_1	321	331	PF00069	0.494
DOC_PP2B_LxvP_1	358	361	PF13499	0.640
DOC_SPAK_OSR1_1	16	20	PF12202	0.456
DOC_USP7_MATH_1	115	119	PF00917	0.591
DOC_USP7_MATH_1	168	172	PF00917	0.741
DOC_USP7_MATH_1	179	183	PF00917	0.665
DOC_USP7_MATH_1	206	210	PF00917	0.717
DOC_USP7_MATH_1	361	365	PF00917	0.689
DOC_USP7_MATH_1	83	87	PF00917	0.415
DOC_WW_Pin1_4	202	207	PF00397	0.785
DOC_WW_Pin1_4	210	215	PF00397	0.633
DOC_WW_Pin1_4	79	84	PF00397	0.465
LIG_14-3-3_CanoR_1	107	112	PF00244	0.395
LIG_14-3-3_CanoR_1	146	155	PF00244	0.542
LIG_Actin_WH2_2	342	359	PF00022	0.517
LIG_AP2alpha_1	133	137	PF02296	0.474
LIG_BRCT_BRCA1_1	13	17	PF00533	0.645
LIG_FHA_1	178	184	PF00498	0.783
LIG_FHA_1	234	240	PF00498	0.379
LIG_FHA_1	82	88	PF00498	0.432
LIG_FHA_2	203	209	PF00498	0.769
LIG_FHA_2	32	38	PF00498	0.549
LIG_FHA_2	341	347	PF00498	0.584
LIG_FHA_2	60	66	PF00498	0.428
LIG_LIR_Apic_2	26	32	PF02991	0.535
LIG_LIR_Gen_1	22	32	PF02991	0.582
LIG_LIR_Gen_1	236	246	PF02991	0.379
LIG_LIR_Nem_3	110	114	PF02991	0.424
LIG_LIR_Nem_3	22	28	PF02991	0.571
LIG_LIR_Nem_3	236	241	PF02991	0.404
LIG_NRBOX	274	280	PF00104	0.446
LIG_NRBOX	90	96	PF00104	0.521
LIG_Pex14_2	133	137	PF04695	0.433
LIG_Pex14_2	25	29	PF04695	0.528
LIG_SH2_SRC	312	315	PF00017	0.433
LIG_SH2_STAT5	111	114	PF00017	0.395
LIG_SH2_STAT5	312	315	PF00017	0.392
LIG_SH2_STAT5	42	45	PF00017	0.525
LIG_SH3_3	160	166	PF00018	0.731
LIG_SH3_3	195	201	PF00018	0.619
LIG_SUMO_SIM_anti_2	326	333	PF11976	0.523
LIG_TRAF2_1	192	195	PF00917	0.763
LIG_TRAF2_1	373	376	PF00917	0.763
LIG_TRFH_1	111	115	PF08558	0.415
LIG_UBA3_1	278	282	PF00899	0.414
LIG_UBA3_1	66	73	PF00899	0.457
LIG_UBA3_1	74	81	PF00899	0.447
MOD_CK1_1	118	124	PF00069	0.623
MOD_CK1_1	150	156	PF00069	0.586
MOD_CK1_1	209	215	PF00069	0.718
MOD_CK1_1	27	33	PF00069	0.588
MOD_CK1_1	363	369	PF00069	0.677
MOD_CK2_1	118	124	PF00069	0.650
MOD_CK2_1	189	195	PF00069	0.783
MOD_CK2_1	223	229	PF00069	0.595
MOD_CK2_1	31	37	PF00069	0.567
MOD_CK2_1	340	346	PF00069	0.566
MOD_GlcNHglycan	117	120	PF01048	0.567
MOD_GlcNHglycan	149	152	PF01048	0.545
MOD_GlcNHglycan	157	160	PF01048	0.673
MOD_GlcNHglycan	189	192	PF01048	0.762
MOD_GlcNHglycan	304	308	PF01048	0.430
MOD_GlcNHglycan	367	370	PF01048	0.670
MOD_GlcNHglycan	4	7	PF01048	0.657
MOD_GSK3_1	114	121	PF00069	0.584
MOD_GSK3_1	19	26	PF00069	0.571
MOD_GSK3_1	202	209	PF00069	0.679
MOD_GSK3_1	27	34	PF00069	0.591
MOD_GSK3_1	360	367	PF00069	0.636
MOD_GSK3_1	77	84	PF00069	0.441
MOD_LATS_1	268	274	PF00433	0.495
MOD_N-GLC_1	115	120	PF02516	0.592
MOD_N-GLC_1	19	24	PF02516	0.624
MOD_N-GLC_2	147	149	PF02516	0.544
MOD_NEK2_1	129	134	PF00069	0.576
MOD_NEK2_1	2	7	PF00069	0.558
MOD_NEK2_1	233	238	PF00069	0.411
MOD_NEK2_1	24	29	PF00069	0.497
MOD_NEK2_1	58	63	PF00069	0.507
MOD_PIKK_1	212	218	PF00454	0.707
MOD_PIKK_1	340	346	PF00454	0.501
MOD_Plk_1	115	121	PF00069	0.620
MOD_Plk_1	233	239	PF00069	0.392
MOD_Plk_1	270	276	PF00069	0.460
MOD_Plk_1	47	53	PF00069	0.529
MOD_Plk_4	107	113	PF00069	0.410
MOD_Plk_4	24	30	PF00069	0.500
MOD_ProDKin_1	202	208	PF00069	0.787
MOD_ProDKin_1	210	216	PF00069	0.629
MOD_ProDKin_1	79	85	PF00069	0.466
MOD_SUMO_rev_2	350	359	PF00179	0.495
MOD_SUMO_rev_2	77	83	PF00179	0.468
TRG_DiLeu_BaEn_1	327	332	PF01217	0.444
TRG_ENDOCYTIC_2	230	233	PF00928	0.542
TRG_Pf-PMV_PEXEL_1	73	77	PF00026	0.425
TRG_Pf-PMV_PEXEL_1	93	97	PF00026	0.441

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PBE1	Leptomonas seymouri	67%	100%
A0A0S4JHH3	Bodo saltans	47%	100%
A0A1X0P5G2	Trypanosomatidae	56%	100%
A0A422P2T5	Trypanosoma rangeli	56%	100%
A4HMW4	Leishmania braziliensis	81%	100%
A4IBI5	Leishmania infantum	98%	100%
C9ZZ56	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	53%	100%
E9AFC1	Leishmania major	91%	100%
E9B6H6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	100%
V5BD06	Trypanosoma cruzi	59%	100%