LeishMANIAdb
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SNARE domain family protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
SNARE domain family protein
Gene product:
QA-SNARE protein putative
Species:
Leishmania donovani
UniProt:
A0A3S7X9G5_LEIDO
TriTrypDb:
LdBPK_352760.1 * , LdCL_350032500 , LDHU3_35.3510
Length:
302

Annotations

Annotations by Jardim et al.

Vesicle mediated transport, QA-SNARE

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. yes yes: 18
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 14
NetGPI no yes: 0, no: 14
Cellular components
Term Name Level Count
GO:0016020 membrane 2 12
GO:0031201 SNARE complex 3 15
GO:0032991 protein-containing complex 1 15
GO:0098796 membrane protein complex 2 15
GO:0110165 cellular anatomical entity 1 12
GO:0012505 endomembrane system 2 2

Expansion

Sequence features

A0A3S7X9G5
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7X9G5

Function

Biological processes
Term Name Level Count
GO:0006810 transport 3 15
GO:0006886 intracellular protein transport 4 15
GO:0008104 protein localization 4 15
GO:0009987 cellular process 1 15
GO:0015031 protein transport 4 15
GO:0016192 vesicle-mediated transport 4 13
GO:0033036 macromolecule localization 2 15
GO:0045184 establishment of protein localization 3 15
GO:0046907 intracellular transport 3 15
GO:0051179 localization 1 15
GO:0051234 establishment of localization 2 15
GO:0051641 cellular localization 2 15
GO:0051649 establishment of localization in cell 3 15
GO:0070727 cellular macromolecule localization 3 15
GO:0071702 organic substance transport 4 15
GO:0071705 nitrogen compound transport 4 15
GO:0006906 vesicle fusion 6 2
GO:0006996 organelle organization 4 2
GO:0016043 cellular component organization 3 2
GO:0016050 vesicle organization 5 2
GO:0022406 membrane docking 2 2
GO:0048278 vesicle docking 4 2
GO:0048284 organelle fusion 5 2
GO:0051640 organelle localization 2 2
GO:0061024 membrane organization 4 2
GO:0061025 membrane fusion 5 2
GO:0071840 cellular component organization or biogenesis 2 2
GO:0090174 organelle membrane fusion 6 2
GO:0140056 organelle localization by membrane tethering 3 2
Molecular functions
Term Name Level Count
GO:0000149 SNARE binding 3 2
GO:0005484 SNAP receptor activity 3 2
GO:0005488 binding 1 2
GO:0005515 protein binding 2 2
GO:0030674 protein-macromolecule adaptor activity 2 2
GO:0060090 molecular adaptor activity 1 2

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 116 120 PF00656 0.571
CLV_NRD_NRD_1 152 154 PF00675 0.321
CLV_NRD_NRD_1 19 21 PF00675 0.445
CLV_NRD_NRD_1 50 52 PF00675 0.349
CLV_NRD_NRD_1 67 69 PF00675 0.281
CLV_PCSK_FUR_1 17 21 PF00082 0.472
CLV_PCSK_KEX2_1 152 154 PF00082 0.324
CLV_PCSK_KEX2_1 19 21 PF00082 0.424
CLV_PCSK_KEX2_1 50 52 PF00082 0.388
CLV_PCSK_KEX2_1 67 69 PF00082 0.274
CLV_PCSK_PC7_1 148 154 PF00082 0.304
CLV_PCSK_SKI1_1 104 108 PF00082 0.315
CLV_PCSK_SKI1_1 130 134 PF00082 0.322
CLV_PCSK_SKI1_1 193 197 PF00082 0.366
CLV_PCSK_SKI1_1 97 101 PF00082 0.353
DOC_ANK_TNKS_1 114 121 PF00023 0.646
DOC_CKS1_1 37 42 PF01111 0.547
DOC_MAPK_DCC_7 35 43 PF00069 0.633
DOC_MAPK_gen_1 152 158 PF00069 0.537
DOC_MAPK_gen_1 65 75 PF00069 0.573
DOC_MAPK_MEF2A_6 67 75 PF00069 0.544
DOC_PP1_RVXF_1 70 76 PF00149 0.571
DOC_PP1_SILK_1 126 131 PF00149 0.524
DOC_USP7_UBL2_3 100 104 PF12436 0.512
DOC_WW_Pin1_4 36 41 PF00397 0.548
LIG_14-3-3_CanoR_1 219 227 PF00244 0.532
LIG_BIR_II_1 1 5 PF00653 0.577
LIG_EH1_1 283 291 PF00400 0.298
LIG_FHA_1 112 118 PF00498 0.635
LIG_FHA_1 200 206 PF00498 0.601
LIG_FHA_1 21 27 PF00498 0.656
LIG_FHA_1 234 240 PF00498 0.540
LIG_FHA_1 275 281 PF00498 0.481
LIG_FHA_2 120 126 PF00498 0.567
LIG_FHA_2 76 82 PF00498 0.660
LIG_IRF3_LxIS_1 106 112 PF10401 0.465
LIG_LIR_Gen_1 216 224 PF02991 0.496
LIG_LIR_Nem_3 216 220 PF02991 0.494
LIG_LIR_Nem_3 7 13 PF02991 0.520
LIG_PCNA_PIPBox_1 92 101 PF02747 0.532
LIG_PCNA_yPIPBox_3 92 104 PF02747 0.542
LIG_REV1ctd_RIR_1 295 302 PF16727 0.391
LIG_SH2_CRK 13 17 PF00017 0.592
LIG_SH2_CRK 221 225 PF00017 0.502
LIG_SH2_PTP2 37 40 PF00017 0.574
LIG_SH2_STAP1 113 117 PF00017 0.621
LIG_SH2_STAT5 113 116 PF00017 0.637
LIG_SH2_STAT5 190 193 PF00017 0.546
LIG_SH2_STAT5 37 40 PF00017 0.574
LIG_SH3_3 15 21 PF00018 0.578
LIG_SUMO_SIM_anti_2 125 130 PF11976 0.527
LIG_SUMO_SIM_par_1 235 240 PF11976 0.564
LIG_TRAF2_1 28 31 PF00917 0.670
LIG_TYR_ITIM 11 16 PF00017 0.567
LIG_UBA3_1 292 299 PF00899 0.277
MOD_CK1_1 223 229 PF00069 0.500
MOD_CK1_1 274 280 PF00069 0.502
MOD_CK2_1 119 125 PF00069 0.575
MOD_CK2_1 223 229 PF00069 0.503
MOD_CK2_1 75 81 PF00069 0.617
MOD_GlcNHglycan 273 276 PF01048 0.286
MOD_GSK3_1 219 226 PF00069 0.533
MOD_N-GLC_1 141 146 PF02516 0.325
MOD_NEK2_1 109 114 PF00069 0.582
MOD_NEK2_1 252 257 PF00069 0.478
MOD_PIKK_1 147 153 PF00454 0.602
MOD_PIKK_1 162 168 PF00454 0.628
MOD_PIKK_1 193 199 PF00454 0.555
MOD_PKA_2 147 153 PF00069 0.548
MOD_Plk_1 109 115 PF00069 0.602
MOD_Plk_1 124 130 PF00069 0.450
MOD_Plk_1 29 35 PF00069 0.626
MOD_Plk_2-3 119 125 PF00069 0.549
MOD_Plk_4 124 130 PF00069 0.528
MOD_Plk_4 199 205 PF00069 0.591
MOD_Plk_4 233 239 PF00069 0.522
MOD_ProDKin_1 36 42 PF00069 0.542
MOD_SUMO_for_1 71 74 PF00179 0.556
TRG_DiLeu_BaEn_1 182 187 PF01217 0.647
TRG_DiLeu_BaEn_1 22 27 PF01217 0.672
TRG_DiLeu_BaEn_1 240 245 PF01217 0.604
TRG_ENDOCYTIC_2 13 16 PF00928 0.590
TRG_ENDOCYTIC_2 221 224 PF00928 0.494
TRG_ER_diArg_1 152 154 PF00400 0.511
TRG_ER_diArg_1 16 19 PF00400 0.593
TRG_ER_diArg_1 49 51 PF00400 0.617
TRG_ER_diArg_1 66 68 PF00400 0.513
TRG_NES_CRM1_1 229 240 PF08389 0.504
TRG_Pf-PMV_PEXEL_1 115 119 PF00026 0.366
TRG_Pf-PMV_PEXEL_1 225 229 PF00026 0.315

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1I246 Leptomonas seymouri 27% 100%
A0A0N1IMN0 Leptomonas seymouri 93% 100%
A0A0S4J7F1 Bodo saltans 28% 100%
A0A0S4JKJ1 Bodo saltans 54% 100%
A0A1X0P0Y0 Trypanosomatidae 30% 100%
A0A1X0P5S4 Trypanosomatidae 73% 100%
A0A3Q8IK46 Leishmania donovani 26% 96%
A0A3R7MIN3 Trypanosoma rangeli 28% 100%
A0A422P2Q8 Trypanosoma rangeli 75% 100%
A4HLJ5 Leishmania braziliensis 25% 95%
A4HMT8 Leishmania braziliensis 94% 100%
A4HN16 Leishmania braziliensis 24% 100%
A4I905 Leishmania infantum 26% 96%
A4IBD9 Leishmania infantum 100% 100%
C9ZZ78 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 62% 99%
D0A501 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 25% 100%
E9AF95 Leishmania major 97% 100%
E9B3X0 Leishmania mexicana (strain MHOM/GT/2001/U1103) 27% 95%
E9B6F0 Leishmania mexicana (strain MHOM/GT/2001/U1103) 98% 100%
O14662 Homo sapiens 28% 93%
O65359 Arabidopsis thaliana 26% 94%
P32856 Homo sapiens 25% 100%
P50279 Rattus norvegicus 25% 100%
P61264 Mus musculus 25% 100%
P61265 Rattus norvegicus 25% 100%
P61266 Homo sapiens 25% 100%
P61267 Bos taurus 25% 100%
P61268 Ovis aries 25% 100%
Q00262 Mus musculus 25% 100%
Q08144 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 26% 76%
Q4Q454 Leishmania major 28% 95%
Q5RBW6 Pongo abelii 24% 100%
Q86Y82 Homo sapiens 24% 100%
Q8BVI5 Mus musculus 27% 93%
Q9P6P1 Schizosaccharomyces pombe (strain 972 / ATCC 24843) 25% 100%
Q9SUJ1 Arabidopsis thaliana 26% 91%
Q9SWH4 Arabidopsis thaliana 25% 93%
V5BLU5 Trypanosoma cruzi 27% 100%
V5C306 Trypanosoma cruzi 75% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2024 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS