TFIIF-stimulated CTD phosphatase, putative

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

TFIIF-stimulated CTD phosphatase, putative

Species:

Leishmania donovani

UniProt:

A0A3S7X9F4_LEIDO

TriTrypDb:

LdBPK_352660.1 , LdCL_350031500 , LDHU3_35.3410

Length:

401

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 13
NetGPI	no	yes: 0, no: 13

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S7X9F4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7X9F4

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	1
GO:0004721	phosphoprotein phosphatase activity	3	1
GO:0016787	hydrolase activity	2	1
GO:0016788	hydrolase activity, acting on ester bonds	3	1
GO:0016791	phosphatase activity	5	1
GO:0042578	phosphoric ester hydrolase activity	4	1
GO:0140096	catalytic activity, acting on a protein	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	209	213	PF00656	0.739
CLV_C14_Caspase3-7	283	287	PF00656	0.444
CLV_NRD_NRD_1	243	245	PF00675	0.654
CLV_NRD_NRD_1	300	302	PF00675	0.601
CLV_NRD_NRD_1	307	309	PF00675	0.698
CLV_NRD_NRD_1	37	39	PF00675	0.490
CLV_PCSK_FUR_1	241	245	PF00082	0.609
CLV_PCSK_FUR_1	298	302	PF00082	0.540
CLV_PCSK_KEX2_1	241	243	PF00082	0.606
CLV_PCSK_KEX2_1	298	300	PF00082	0.542
CLV_PCSK_KEX2_1	36	38	PF00082	0.503
CLV_PCSK_KEX2_1	58	60	PF00082	0.475
CLV_PCSK_PC1ET2_1	36	38	PF00082	0.598
CLV_PCSK_PC1ET2_1	58	60	PF00082	0.509
CLV_PCSK_SKI1_1	109	113	PF00082	0.325
CLV_PCSK_SKI1_1	225	229	PF00082	0.727
CLV_PCSK_SKI1_1	248	252	PF00082	0.431
CLV_PCSK_SKI1_1	254	258	PF00082	0.434
CLV_PCSK_SKI1_1	85	89	PF00082	0.307
DEG_APCC_DBOX_1	253	261	PF00400	0.465
DEG_APCC_DBOX_1	80	88	PF00400	0.291
DEG_SCF_FBW7_1	187	194	PF00400	0.736
DOC_CKS1_1	188	193	PF01111	0.746
DOC_CYCLIN_RxL_1	248	259	PF00134	0.431
DOC_CYCLIN_yCln2_LP_2	368	371	PF00134	0.515
DOC_MAPK_gen_1	36	44	PF00069	0.514
DOC_MAPK_gen_1	58	64	PF00069	0.280
DOC_MAPK_gen_1	89	99	PF00069	0.280
DOC_PP2B_LxvP_1	368	371	PF13499	0.661
DOC_PP2B_LxvP_1	49	52	PF13499	0.421
DOC_PP2B_LxvP_1	8	11	PF13499	0.525
DOC_USP7_MATH_1	12	16	PF00917	0.605
DOC_USP7_MATH_1	210	214	PF00917	0.748
DOC_USP7_MATH_1	216	220	PF00917	0.768
DOC_USP7_MATH_1	227	231	PF00917	0.762
DOC_USP7_MATH_1	320	324	PF00917	0.668
DOC_USP7_MATH_1	336	340	PF00917	0.690
DOC_USP7_MATH_1	357	361	PF00917	0.785
DOC_WW_Pin1_4	1	6	PF00397	0.643
DOC_WW_Pin1_4	154	159	PF00397	0.300
DOC_WW_Pin1_4	187	192	PF00397	0.678
DOC_WW_Pin1_4	212	217	PF00397	0.776
DOC_WW_Pin1_4	235	240	PF00397	0.740
LIG_14-3-3_CanoR_1	241	251	PF00244	0.511
LIG_14-3-3_CanoR_1	269	277	PF00244	0.494
LIG_14-3-3_CanoR_1	279	283	PF00244	0.481
LIG_14-3-3_CanoR_1	59	63	PF00244	0.355
LIG_APCC_ABBAyCdc20_2	19	25	PF00400	0.587
LIG_EH1_1	118	126	PF00400	0.351
LIG_FHA_1	136	142	PF00498	0.312
LIG_FHA_1	149	155	PF00498	0.426
LIG_FHA_1	247	253	PF00498	0.455
LIG_FHA_1	39	45	PF00498	0.606
LIG_FHA_2	178	184	PF00498	0.644
LIG_FHA_2	204	210	PF00498	0.726
LIG_FHA_2	25	31	PF00498	0.638
LIG_FHA_2	281	287	PF00498	0.523
LIG_FHA_2	99	105	PF00498	0.286
LIG_LIR_Gen_1	147	158	PF02991	0.296
LIG_LIR_Gen_1	172	178	PF02991	0.426
LIG_LIR_Gen_1	57	66	PF02991	0.356
LIG_LIR_Gen_1	93	102	PF02991	0.308
LIG_LIR_Nem_3	172	177	PF02991	0.408
LIG_LIR_Nem_3	57	63	PF02991	0.356
LIG_LIR_Nem_3	93	98	PF02991	0.291
LIG_MYND_1	367	371	PF01753	0.575
LIG_MYND_1	6	10	PF01753	0.638
LIG_NRBOX	252	258	PF00104	0.423
LIG_SH2_CRK	60	64	PF00017	0.291
LIG_SH2_NCK_1	60	64	PF00017	0.426
LIG_SH2_NCK_1	79	83	PF00017	0.278
LIG_SH2_STAP1	107	111	PF00017	0.296
LIG_SH2_STAP1	137	141	PF00017	0.291
LIG_SH2_STAP1	150	154	PF00017	0.444
LIG_SH2_STAP1	60	64	PF00017	0.291
LIG_SH2_STAP1	79	83	PF00017	0.307
LIG_SH2_STAT5	137	140	PF00017	0.291
LIG_SH2_STAT5	150	153	PF00017	0.332
LIG_SH2_STAT5	60	63	PF00017	0.332
LIG_SH2_STAT5	83	86	PF00017	0.300
LIG_SH3_3	185	191	PF00018	0.689
LIG_SH3_3	324	330	PF00018	0.733
LIG_SH3_3	364	370	PF00018	0.791
LIG_SUMO_SIM_par_1	150	155	PF11976	0.270
LIG_TRAF2_1	180	183	PF00917	0.629
LIG_TRAF2_2	375	380	PF00917	0.609
LIG_UBA3_1	256	262	PF00899	0.484
LIG_UBA3_1	87	92	PF00899	0.291
MOD_CDC14_SPxK_1	238	241	PF00782	0.733
MOD_CDC14_SPxK_1	4	7	PF00782	0.599
MOD_CDK_SPxK_1	1	7	PF00069	0.627
MOD_CDK_SPxK_1	235	241	PF00069	0.738
MOD_CDK_SPxxK_3	235	242	PF00069	0.660
MOD_CK1_1	235	241	PF00069	0.769
MOD_CK1_1	263	269	PF00069	0.418
MOD_CK1_1	278	284	PF00069	0.443
MOD_CK1_1	332	338	PF00069	0.682
MOD_CK1_1	359	365	PF00069	0.725
MOD_CK1_1	54	60	PF00069	0.464
MOD_CK2_1	177	183	PF00069	0.624
MOD_CK2_1	203	209	PF00069	0.674
MOD_CK2_1	320	326	PF00069	0.613
MOD_CK2_1	336	342	PF00069	0.708
MOD_CK2_1	98	104	PF00069	0.286
MOD_Cter_Amidation	45	48	PF01082	0.552
MOD_GlcNHglycan	14	17	PF01048	0.567
MOD_GlcNHglycan	212	215	PF01048	0.636
MOD_GlcNHglycan	229	232	PF01048	0.782
MOD_GlcNHglycan	333	337	PF01048	0.660
MOD_GlcNHglycan	345	348	PF01048	0.647
MOD_GlcNHglycan	359	362	PF01048	0.788
MOD_GSK3_1	183	190	PF00069	0.698
MOD_GSK3_1	212	219	PF00069	0.783
MOD_GSK3_1	242	249	PF00069	0.565
MOD_GSK3_1	256	263	PF00069	0.502
MOD_GSK3_1	278	285	PF00069	0.514
MOD_GSK3_1	332	339	PF00069	0.707
MOD_GSK3_1	356	363	PF00069	0.621
MOD_GSK3_1	54	61	PF00069	0.510
MOD_N-GLC_1	148	153	PF02516	0.426
MOD_N-GLC_1	343	348	PF02516	0.726
MOD_NEK2_1	148	153	PF00069	0.426
MOD_NEK2_1	256	261	PF00069	0.453
MOD_NEK2_1	66	71	PF00069	0.285
MOD_PIKK_1	233	239	PF00454	0.757
MOD_PKA_1	242	248	PF00069	0.631
MOD_PKA_1	58	64	PF00069	0.291
MOD_PKA_2	242	248	PF00069	0.631
MOD_PKA_2	263	269	PF00069	0.349
MOD_PKA_2	278	284	PF00069	0.467
MOD_PKA_2	58	64	PF00069	0.421
MOD_PKB_1	241	249	PF00069	0.543
MOD_Plk_1	148	154	PF00069	0.426
MOD_Plk_1	246	252	PF00069	0.386
MOD_Plk_1	336	342	PF00069	0.695
MOD_Plk_1	66	72	PF00069	0.267
MOD_Plk_2-3	24	30	PF00069	0.528
MOD_Plk_4	148	154	PF00069	0.419
MOD_Plk_4	256	262	PF00069	0.470
MOD_Plk_4	38	44	PF00069	0.494
MOD_Plk_4	58	64	PF00069	0.285
MOD_Plk_4	66	72	PF00069	0.255
MOD_ProDKin_1	1	7	PF00069	0.634
MOD_ProDKin_1	154	160	PF00069	0.300
MOD_ProDKin_1	187	193	PF00069	0.678
MOD_ProDKin_1	212	218	PF00069	0.777
MOD_ProDKin_1	235	241	PF00069	0.738
MOD_SUMO_rev_2	20	27	PF00179	0.478
TRG_DiLeu_BaEn_1	39	44	PF01217	0.480
TRG_DiLeu_BaLyEn_6	364	369	PF01217	0.525
TRG_ENDOCYTIC_2	150	153	PF00928	0.291
TRG_ENDOCYTIC_2	60	63	PF00928	0.291
TRG_ER_diArg_1	240	243	PF00400	0.732
TRG_ER_diArg_1	298	301	PF00400	0.532
TRG_ER_diLys_1	396	401	PF00400	0.580
TRG_NES_CRM1_1	143	155	PF08389	0.343
TRG_Pf-PMV_PEXEL_1	142	147	PF00026	0.426
TRG_Pf-PMV_PEXEL_1	254	258	PF00026	0.485

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I1T4	Leptomonas seymouri	70%	96%
A0A0S4IUQ9	Bodo saltans	47%	100%
A0A1X0NJT2	Trypanosomatidae	33%	100%
A0A1X0P5T3	Trypanosomatidae	53%	100%
A0A3R7P338	Trypanosoma rangeli	55%	100%
A4HMT1	Leishmania braziliensis	80%	100%
A4IBC9	Leishmania infantum	100%	100%
C9ZZ90	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	50%	100%
E9AF85	Leishmania major	95%	100%
E9B6E0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	95%	99%
V5BSW0	Trypanosoma cruzi	32%	100%
V5BY89	Trypanosoma cruzi	54%	100%