Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S7X9F3_LEIDO

TriTrypDb:

LdBPK_352970.1 , LdCL_350034600 , LDHU3_35.3820

Length:

996

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S7X9F3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7X9F3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	237	241	PF00656	0.465
CLV_C14_Caspase3-7	297	301	PF00656	0.556
CLV_C14_Caspase3-7	303	307	PF00656	0.517
CLV_C14_Caspase3-7	325	329	PF00656	0.618
CLV_C14_Caspase3-7	54	58	PF00656	0.709
CLV_NRD_NRD_1	132	134	PF00675	0.594
CLV_NRD_NRD_1	184	186	PF00675	0.472
CLV_NRD_NRD_1	254	256	PF00675	0.531
CLV_NRD_NRD_1	280	282	PF00675	0.648
CLV_NRD_NRD_1	49	51	PF00675	0.574
CLV_NRD_NRD_1	540	542	PF00675	0.572
CLV_NRD_NRD_1	764	766	PF00675	0.481
CLV_NRD_NRD_1	88	90	PF00675	0.467
CLV_NRD_NRD_1	932	934	PF00675	0.512
CLV_NRD_NRD_1	958	960	PF00675	0.582
CLV_NRD_NRD_1	973	975	PF00675	0.434
CLV_PCSK_FUR_1	130	134	PF00082	0.525
CLV_PCSK_KEX2_1	132	134	PF00082	0.564
CLV_PCSK_KEX2_1	254	256	PF00082	0.531
CLV_PCSK_KEX2_1	280	282	PF00082	0.648
CLV_PCSK_KEX2_1	49	51	PF00082	0.574
CLV_PCSK_KEX2_1	499	501	PF00082	0.656
CLV_PCSK_KEX2_1	540	542	PF00082	0.697
CLV_PCSK_KEX2_1	764	766	PF00082	0.481
CLV_PCSK_KEX2_1	88	90	PF00082	0.531
CLV_PCSK_KEX2_1	958	960	PF00082	0.582
CLV_PCSK_KEX2_1	973	975	PF00082	0.434
CLV_PCSK_PC1ET2_1	499	501	PF00082	0.630
CLV_PCSK_SKI1_1	201	205	PF00082	0.487
CLV_PCSK_SKI1_1	221	225	PF00082	0.586
CLV_PCSK_SKI1_1	23	27	PF00082	0.613
CLV_PCSK_SKI1_1	346	350	PF00082	0.592
CLV_PCSK_SKI1_1	425	429	PF00082	0.676
CLV_PCSK_SKI1_1	480	484	PF00082	0.612
CLV_PCSK_SKI1_1	657	661	PF00082	0.647
CLV_PCSK_SKI1_1	709	713	PF00082	0.472
CLV_PCSK_SKI1_1	716	720	PF00082	0.413
CLV_PCSK_SKI1_1	770	774	PF00082	0.500
CLV_PCSK_SKI1_1	865	869	PF00082	0.492
CLV_PCSK_SKI1_1	88	92	PF00082	0.535
CLV_PCSK_SKI1_1	905	909	PF00082	0.476
CLV_PCSK_SKI1_1	933	937	PF00082	0.577
CLV_PCSK_SKI1_1	973	977	PF00082	0.516
DEG_APCC_DBOX_1	220	228	PF00400	0.483
DEG_APCC_DBOX_1	308	316	PF00400	0.685
DEG_APCC_DBOX_1	479	487	PF00400	0.667
DEG_Nend_UBRbox_3	1	3	PF02207	0.520
DEG_SPOP_SBC_1	465	469	PF00917	0.673
DEG_SPOP_SBC_1	680	684	PF00917	0.576
DEG_SPOP_SBC_1	99	103	PF00917	0.498
DOC_CKS1_1	247	252	PF01111	0.496
DOC_MAPK_gen_1	258	267	PF00069	0.452
DOC_MAPK_gen_1	955	964	PF00069	0.589
DOC_MAPK_HePTP_8	257	269	PF00069	0.437
DOC_MAPK_MEF2A_6	221	228	PF00069	0.432
DOC_MAPK_MEF2A_6	260	269	PF00069	0.382
DOC_MAPK_MEF2A_6	873	881	PF00069	0.553
DOC_PP2B_LxvP_1	455	458	PF13499	0.625
DOC_PP4_FxxP_1	523	526	PF00568	0.654
DOC_PP4_FxxP_1	830	833	PF00568	0.441
DOC_SPAK_OSR1_1	738	742	PF12202	0.507
DOC_USP7_MATH_1	383	387	PF00917	0.667
DOC_USP7_MATH_1	442	446	PF00917	0.642
DOC_USP7_MATH_1	458	462	PF00917	0.639
DOC_USP7_MATH_1	465	469	PF00917	0.814
DOC_USP7_MATH_1	475	479	PF00917	0.690
DOC_USP7_MATH_1	5	9	PF00917	0.613
DOC_USP7_MATH_1	61	65	PF00917	0.575
DOC_USP7_MATH_1	627	631	PF00917	0.683
DOC_USP7_MATH_1	632	636	PF00917	0.647
DOC_USP7_MATH_1	680	684	PF00917	0.578
DOC_USP7_MATH_1	714	718	PF00917	0.579
DOC_USP7_MATH_1	733	737	PF00917	0.317
DOC_USP7_MATH_1	893	897	PF00917	0.432
DOC_USP7_MATH_1	975	979	PF00917	0.444
DOC_USP7_MATH_1	989	993	PF00917	0.488
DOC_USP7_MATH_2	559	565	PF00917	0.581
DOC_WW_Pin1_4	246	251	PF00397	0.503
DOC_WW_Pin1_4	394	399	PF00397	0.690
DOC_WW_Pin1_4	420	425	PF00397	0.624
DOC_WW_Pin1_4	461	466	PF00397	0.812
DOC_WW_Pin1_4	695	700	PF00397	0.633
DOC_WW_Pin1_4	716	721	PF00397	0.427
DOC_WW_Pin1_4	829	834	PF00397	0.439
DOC_WW_Pin1_4	873	878	PF00397	0.556
LIG_14-3-3_CanoR_1	425	434	PF00244	0.709
LIG_14-3-3_CanoR_1	480	490	PF00244	0.647
LIG_14-3-3_CanoR_1	527	536	PF00244	0.661
LIG_14-3-3_CanoR_1	567	573	PF00244	0.580
LIG_14-3-3_CanoR_1	618	625	PF00244	0.514
LIG_14-3-3_CanoR_1	933	941	PF00244	0.553
LIG_14-3-3_CanoR_1	958	962	PF00244	0.577
LIG_14-3-3_CanoR_1	974	980	PF00244	0.466
LIG_Actin_WH2_2	181	199	PF00022	0.571
LIG_APCC_ABBA_1	656	661	PF00400	0.581
LIG_BRCT_BRCA1_1	519	523	PF00533	0.612
LIG_BRCT_BRCA1_1	564	568	PF00533	0.602
LIG_BRCT_BRCA1_1	735	739	PF00533	0.482
LIG_BRCT_BRCA1_1	990	994	PF00533	0.493
LIG_Clathr_ClatBox_1	16	20	PF01394	0.593
LIG_Clathr_ClatBox_1	878	882	PF01394	0.480
LIG_CtBP_PxDLS_1	311	315	PF00389	0.681
LIG_deltaCOP1_diTrp_1	704	712	PF00928	0.474
LIG_eIF4E_1	793	799	PF01652	0.374
LIG_FHA_1	167	173	PF00498	0.421
LIG_FHA_1	209	215	PF00498	0.549
LIG_FHA_1	376	382	PF00498	0.651
LIG_FHA_1	395	401	PF00498	0.560
LIG_FHA_1	450	456	PF00498	0.665
LIG_FHA_1	5	11	PF00498	0.609
LIG_FHA_1	517	523	PF00498	0.525
LIG_FHA_1	569	575	PF00498	0.591
LIG_FHA_1	602	608	PF00498	0.583
LIG_FHA_1	854	860	PF00498	0.589
LIG_FHA_1	93	99	PF00498	0.569
LIG_FHA_1	934	940	PF00498	0.552
LIG_FHA_2	100	106	PF00498	0.548
LIG_FHA_2	295	301	PF00498	0.544
LIG_FHA_2	574	580	PF00498	0.630
LIG_FHA_2	724	730	PF00498	0.468
LIG_FHA_2	800	806	PF00498	0.404
LIG_FHA_2	864	870	PF00498	0.404
LIG_GBD_Chelix_1	799	807	PF00786	0.380
LIG_GBD_Chelix_1	961	969	PF00786	0.568
LIG_LIR_Apic_2	520	526	PF02991	0.634
LIG_LIR_Apic_2	790	796	PF02991	0.381
LIG_LIR_Apic_2	847	851	PF02991	0.485
LIG_LIR_Gen_1	327	335	PF02991	0.547
LIG_LIR_Gen_1	603	614	PF02991	0.506
LIG_LIR_Gen_1	688	699	PF02991	0.570
LIG_LIR_Gen_1	737	747	PF02991	0.511
LIG_LIR_Gen_1	802	812	PF02991	0.363
LIG_LIR_Gen_1	866	875	PF02991	0.485
LIG_LIR_Gen_1	900	909	PF02991	0.445
LIG_LIR_Gen_1	942	949	PF02991	0.481
LIG_LIR_Nem_3	198	203	PF02991	0.474
LIG_LIR_Nem_3	276	282	PF02991	0.439
LIG_LIR_Nem_3	327	333	PF02991	0.548
LIG_LIR_Nem_3	603	609	PF02991	0.497
LIG_LIR_Nem_3	688	694	PF02991	0.584
LIG_LIR_Nem_3	704	708	PF02991	0.399
LIG_LIR_Nem_3	802	807	PF02991	0.343
LIG_LIR_Nem_3	840	844	PF02991	0.451
LIG_LIR_Nem_3	866	871	PF02991	0.472
LIG_LIR_Nem_3	884	890	PF02991	0.481
LIG_LIR_Nem_3	938	944	PF02991	0.487
LIG_LYPXL_yS_3	795	798	PF13949	0.382
LIG_NRBOX	223	229	PF00104	0.503
LIG_PDZ_Class_2	991	996	PF00595	0.566
LIG_PDZ_Wminus1_1	994	996	PF00595	0.572
LIG_Pex14_1	990	994	PF04695	0.493
LIG_Rb_pABgroove_1	329	337	PF01858	0.624
LIG_REV1ctd_RIR_1	737	746	PF16727	0.513
LIG_REV1ctd_RIR_1	769	777	PF16727	0.458
LIG_SH2_CRK	200	204	PF00017	0.518
LIG_SH2_CRK	279	283	PF00017	0.520
LIG_SH2_CRK	708	712	PF00017	0.439
LIG_SH2_CRK	715	719	PF00017	0.415
LIG_SH2_GRB2like	242	245	PF00017	0.490
LIG_SH2_NCK_1	611	615	PF00017	0.608
LIG_SH2_NCK_1	890	894	PF00017	0.505
LIG_SH2_PTP2	591	594	PF00017	0.582
LIG_SH2_SRC	591	594	PF00017	0.582
LIG_SH2_SRC	611	614	PF00017	0.381
LIG_SH2_SRC	809	812	PF00017	0.471
LIG_SH2_SRC	823	826	PF00017	0.300
LIG_SH2_STAP1	124	128	PF00017	0.462
LIG_SH2_STAP1	242	246	PF00017	0.461
LIG_SH2_STAP1	747	751	PF00017	0.501
LIG_SH2_STAP1	944	948	PF00017	0.521
LIG_SH2_STAT5	246	249	PF00017	0.481
LIG_SH2_STAT5	591	594	PF00017	0.582
LIG_SH2_STAT5	776	779	PF00017	0.441
LIG_SH2_STAT5	80	83	PF00017	0.476
LIG_SH2_STAT5	809	812	PF00017	0.516
LIG_SH2_STAT5	823	826	PF00017	0.313
LIG_SH2_STAT5	848	851	PF00017	0.454
LIG_SH2_STAT5	870	873	PF00017	0.512
LIG_SH2_STAT5	930	933	PF00017	0.493
LIG_SH3_1	444	450	PF00018	0.558
LIG_SH3_1	693	699	PF00018	0.558
LIG_SH3_2	696	701	PF14604	0.532
LIG_SH3_3	244	250	PF00018	0.493
LIG_SH3_3	377	383	PF00018	0.675
LIG_SH3_3	444	450	PF00018	0.765
LIG_SH3_3	469	475	PF00018	0.706
LIG_SH3_3	484	490	PF00018	0.655
LIG_SH3_3	693	699	PF00018	0.558
LIG_SUMO_SIM_anti_2	105	111	PF11976	0.544
LIG_SUMO_SIM_anti_2	219	226	PF11976	0.429
LIG_SUMO_SIM_anti_2	263	271	PF11976	0.486
LIG_SUMO_SIM_anti_2	452	458	PF11976	0.515
LIG_SUMO_SIM_anti_2	534	539	PF11976	0.598
LIG_SUMO_SIM_anti_2	876	882	PF11976	0.508
LIG_SUMO_SIM_anti_2	916	923	PF11976	0.549
LIG_SUMO_SIM_par_1	263	271	PF11976	0.496
LIG_SUMO_SIM_par_1	570	576	PF11976	0.546
LIG_SUMO_SIM_par_1	721	727	PF11976	0.459
LIG_SUMO_SIM_par_1	854	860	PF11976	0.403
LIG_SUMO_SIM_par_1	876	882	PF11976	0.571
LIG_TRAF2_1	559	562	PF00917	0.742
LIG_TRFH_1	246	250	PF08558	0.466
LIG_TYR_ITIM	706	711	PF00017	0.486
LIG_UBA3_1	181	186	PF00899	0.548
LIG_UBA3_1	658	665	PF00899	0.586
LIG_WW_2	447	450	PF00397	0.518
MOD_CDC14_SPxK_1	698	701	PF00782	0.513
MOD_CDK_SPK_2	420	425	PF00069	0.624
MOD_CDK_SPK_2	716	721	PF00069	0.427
MOD_CDK_SPxK_1	695	701	PF00069	0.538
MOD_CK1_1	103	109	PF00069	0.528
MOD_CK1_1	294	300	PF00069	0.695
MOD_CK1_1	360	366	PF00069	0.632
MOD_CK1_1	38	44	PF00069	0.659
MOD_CK1_1	461	467	PF00069	0.593
MOD_CK1_1	517	523	PF00069	0.611
MOD_CK1_1	630	636	PF00069	0.699
MOD_CK1_1	682	688	PF00069	0.615
MOD_CK1_1	988	994	PF00069	0.434
MOD_CK2_1	412	418	PF00069	0.695
MOD_CK2_1	567	573	PF00069	0.580
MOD_CK2_1	632	638	PF00069	0.689
MOD_CK2_1	663	669	PF00069	0.625
MOD_CK2_1	799	805	PF00069	0.345
MOD_CK2_1	857	863	PF00069	0.386
MOD_CK2_1	99	105	PF00069	0.553
MOD_DYRK1A_RPxSP_1	716	720	PF00069	0.471
MOD_GlcNHglycan	102	105	PF01048	0.655
MOD_GlcNHglycan	363	366	PF01048	0.625
MOD_GlcNHglycan	375	378	PF01048	0.632
MOD_GlcNHglycan	384	388	PF01048	0.576
MOD_GlcNHglycan	43	46	PF01048	0.712
MOD_GlcNHglycan	516	519	PF01048	0.598
MOD_GlcNHglycan	620	623	PF01048	0.592
MOD_GlcNHglycan	634	637	PF01048	0.632
MOD_GlcNHglycan	646	649	PF01048	0.649
MOD_GlcNHglycan	67	70	PF01048	0.755
MOD_GlcNHglycan	851	854	PF01048	0.516
MOD_GlcNHglycan	859	862	PF01048	0.477
MOD_GlcNHglycan	895	898	PF01048	0.518
MOD_GlcNHglycan	909	912	PF01048	0.413
MOD_GlcNHglycan	966	969	PF01048	0.525
MOD_GlcNHglycan	987	990	PF01048	0.522
MOD_GSK3_1	357	364	PF00069	0.624
MOD_GSK3_1	369	376	PF00069	0.639
MOD_GSK3_1	457	464	PF00069	0.690
MOD_GSK3_1	466	473	PF00069	0.720
MOD_GSK3_1	517	524	PF00069	0.623
MOD_GSK3_1	61	68	PF00069	0.596
MOD_GSK3_1	630	637	PF00069	0.715
MOD_GSK3_1	680	687	PF00069	0.585
MOD_GSK3_1	849	856	PF00069	0.508
MOD_GSK3_1	893	900	PF00069	0.500
MOD_GSK3_1	933	940	PF00069	0.589
MOD_GSK3_1	985	992	PF00069	0.471
MOD_GSK3_1	99	106	PF00069	0.530
MOD_N-GLC_1	360	365	PF02516	0.592
MOD_N-GLC_1	5	10	PF02516	0.586
MOD_N-GLC_1	61	66	PF02516	0.591
MOD_N-GLC_1	74	79	PF02516	0.525
MOD_N-GLC_1	873	878	PF02516	0.556
MOD_NEK2_1	203	208	PF00069	0.543
MOD_NEK2_1	21	26	PF00069	0.634
MOD_NEK2_1	261	266	PF00069	0.450
MOD_NEK2_1	274	279	PF00069	0.545
MOD_NEK2_1	466	471	PF00069	0.611
MOD_NEK2_1	498	503	PF00069	0.511
MOD_NEK2_1	907	912	PF00069	0.489
MOD_NEK2_1	93	98	PF00069	0.571
MOD_NEK2_1	964	969	PF00069	0.521
MOD_NEK2_1	985	990	PF00069	0.512
MOD_PIKK_1	208	214	PF00454	0.547
MOD_PIKK_1	389	395	PF00454	0.812
MOD_PIKK_1	630	636	PF00454	0.678
MOD_PIKK_1	831	837	PF00454	0.457
MOD_PIKK_1	928	934	PF00454	0.557
MOD_PK_1	292	298	PF00069	0.567
MOD_PKA_1	292	298	PF00069	0.567
MOD_PKA_1	499	505	PF00069	0.517
MOD_PKA_1	933	939	PF00069	0.509
MOD_PKA_2	499	505	PF00069	0.582
MOD_PKA_2	627	633	PF00069	0.677
MOD_PKA_2	957	963	PF00069	0.583
MOD_PKB_1	410	418	PF00069	0.670
MOD_Plk_1	38	44	PF00069	0.622
MOD_Plk_1	5	11	PF00069	0.584
MOD_Plk_1	52	58	PF00069	0.539
MOD_Plk_1	723	729	PF00069	0.384
MOD_Plk_1	937	943	PF00069	0.563
MOD_Plk_2-3	136	142	PF00069	0.657
MOD_Plk_2-3	724	730	PF00069	0.468
MOD_Plk_2-3	863	869	PF00069	0.402
MOD_Plk_2-3	937	943	PF00069	0.563
MOD_Plk_4	103	109	PF00069	0.641
MOD_Plk_4	210	216	PF00069	0.481
MOD_Plk_4	261	267	PF00069	0.593
MOD_Plk_4	430	436	PF00069	0.621
MOD_Plk_4	5	11	PF00069	0.699
MOD_Plk_4	517	523	PF00069	0.583
MOD_Plk_4	663	669	PF00069	0.549
MOD_Plk_4	799	805	PF00069	0.511
MOD_Plk_4	815	821	PF00069	0.405
MOD_Plk_4	837	843	PF00069	0.481
MOD_Plk_4	897	903	PF00069	0.505
MOD_Plk_4	980	986	PF00069	0.471
MOD_ProDKin_1	246	252	PF00069	0.511
MOD_ProDKin_1	394	400	PF00069	0.688
MOD_ProDKin_1	420	426	PF00069	0.618
MOD_ProDKin_1	461	467	PF00069	0.814
MOD_ProDKin_1	695	701	PF00069	0.628
MOD_ProDKin_1	716	722	PF00069	0.431
MOD_ProDKin_1	829	835	PF00069	0.438
MOD_ProDKin_1	873	879	PF00069	0.552
MOD_SUMO_for_1	954	957	PF00179	0.613
TRG_DiLeu_BaEn_1	105	110	PF01217	0.545
TRG_DiLeu_BaEn_1	220	225	PF01217	0.485
TRG_DiLeu_BaEn_1	916	921	PF01217	0.531
TRG_DiLeu_BaEn_1	957	962	PF01217	0.557
TRG_DiLeu_BaEn_2	325	331	PF01217	0.642
TRG_DiLeu_BaEn_4	82	88	PF01217	0.457
TRG_DiLeu_BaLyEn_6	493	498	PF01217	0.618
TRG_DiLeu_BaLyEn_6	874	879	PF01217	0.488
TRG_DiLeu_BaLyEn_6	915	920	PF01217	0.525
TRG_ENDOCYTIC_2	200	203	PF00928	0.457
TRG_ENDOCYTIC_2	279	282	PF00928	0.457
TRG_ENDOCYTIC_2	340	343	PF00928	0.546
TRG_ENDOCYTIC_2	356	359	PF00928	0.538
TRG_ENDOCYTIC_2	708	711	PF00928	0.429
TRG_ENDOCYTIC_2	715	718	PF00928	0.435
TRG_ENDOCYTIC_2	795	798	PF00928	0.382
TRG_ENDOCYTIC_2	804	807	PF00928	0.345
TRG_ENDOCYTIC_2	823	826	PF00928	0.369
TRG_ENDOCYTIC_2	944	947	PF00928	0.467
TRG_ER_diArg_1	130	133	PF00400	0.543
TRG_ER_diArg_1	182	185	PF00400	0.552
TRG_ER_diArg_1	253	255	PF00400	0.488
TRG_ER_diArg_1	257	260	PF00400	0.412
TRG_ER_diArg_1	279	281	PF00400	0.647
TRG_ER_diArg_1	409	412	PF00400	0.711
TRG_ER_diArg_1	48	50	PF00400	0.574
TRG_ER_diArg_1	540	542	PF00400	0.579
TRG_ER_diArg_1	763	765	PF00400	0.480
TRG_ER_diArg_1	87	89	PF00400	0.500
TRG_NES_CRM1_1	162	176	PF08389	0.535
TRG_NES_CRM1_1	256	271	PF08389	0.495
TRG_NES_CRM1_1	766	780	PF08389	0.515
TRG_Pf-PMV_PEXEL_1	112	116	PF00026	0.455
TRG_Pf-PMV_PEXEL_1	161	166	PF00026	0.563
TRG_Pf-PMV_PEXEL_1	540	544	PF00026	0.571
TRG_Pf-PMV_PEXEL_1	665	669	PF00026	0.633
TRG_Pf-PMV_PEXEL_1	801	805	PF00026	0.404

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A422P2S7	Trypanosoma rangeli	32%	96%
A4HMV9	Leishmania braziliensis	76%	100%
A4IBI0	Leishmania infantum	99%	100%
C9ZZ60	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	30%	94%
E9AFB6	Leishmania major	92%	100%
E9B6H1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	100%