Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein

Species:

Leishmania donovani

UniProt:

A0A3S7X9F0_LEIDO

TriTrypDb:

LdCL_350033700 , LDHU3_35.3720

Length:

556

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S7X9F0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7X9F0

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	154	158	PF00656	0.503
CLV_C14_Caspase3-7	432	436	PF00656	0.674
CLV_NRD_NRD_1	138	140	PF00675	0.539
CLV_NRD_NRD_1	294	296	PF00675	0.650
CLV_NRD_NRD_1	399	401	PF00675	0.571
CLV_PCSK_FUR_1	397	401	PF00082	0.572
CLV_PCSK_KEX2_1	138	140	PF00082	0.539
CLV_PCSK_KEX2_1	294	296	PF00082	0.629
CLV_PCSK_KEX2_1	311	313	PF00082	0.559
CLV_PCSK_KEX2_1	382	384	PF00082	0.743
CLV_PCSK_KEX2_1	399	401	PF00082	0.464
CLV_PCSK_KEX2_1	91	93	PF00082	0.583
CLV_PCSK_PC1ET2_1	311	313	PF00082	0.621
CLV_PCSK_PC1ET2_1	382	384	PF00082	0.641
CLV_PCSK_PC1ET2_1	91	93	PF00082	0.512
CLV_PCSK_SKI1_1	138	142	PF00082	0.655
CLV_PCSK_SKI1_1	202	206	PF00082	0.538
CLV_PCSK_SKI1_1	312	316	PF00082	0.543
CLV_PCSK_SKI1_1	383	387	PF00082	0.622
CLV_PCSK_SKI1_1	499	503	PF00082	0.559
CLV_PCSK_SKI1_1	511	515	PF00082	0.514
CLV_PCSK_SKI1_1	61	65	PF00082	0.531
CLV_PCSK_SKI1_1	92	96	PF00082	0.583
DEG_SCF_FBW7_1	513	518	PF00400	0.594
DOC_ANK_TNKS_1	450	457	PF00023	0.674
DOC_CYCLIN_RxL_1	234	245	PF00134	0.574
DOC_CYCLIN_yClb1_LxF_4	332	337	PF00134	0.416
DOC_MAPK_gen_1	235	243	PF00069	0.572
DOC_MAPK_gen_1	397	407	PF00069	0.567
DOC_MAPK_JIP1_4	237	243	PF00069	0.567
DOC_MAPK_MEF2A_6	202	211	PF00069	0.550
DOC_MAPK_MEF2A_6	235	243	PF00069	0.503
DOC_MAPK_MEF2A_6	56	64	PF00069	0.454
DOC_PP1_RVXF_1	332	338	PF00149	0.416
DOC_PP2B_LxvP_1	447	450	PF13499	0.672
DOC_USP7_MATH_1	105	109	PF00917	0.567
DOC_USP7_MATH_1	226	230	PF00917	0.572
DOC_USP7_MATH_1	242	246	PF00917	0.455
DOC_USP7_MATH_1	324	328	PF00917	0.728
DOC_USP7_MATH_1	515	519	PF00917	0.578
DOC_USP7_MATH_1	550	554	PF00917	0.513
DOC_USP7_MATH_1	82	86	PF00917	0.466
DOC_WD40_RPTOR_TOS_1	37	43	PF00400	0.577
DOC_WW_Pin1_4	248	253	PF00397	0.595
DOC_WW_Pin1_4	266	271	PF00397	0.452
DOC_WW_Pin1_4	31	36	PF00397	0.636
DOC_WW_Pin1_4	318	323	PF00397	0.665
DOC_WW_Pin1_4	441	446	PF00397	0.638
DOC_WW_Pin1_4	511	516	PF00397	0.647
LIG_14-3-3_CanoR_1	168	178	PF00244	0.498
LIG_14-3-3_CanoR_1	282	286	PF00244	0.495
LIG_14-3-3_CanoR_1	334	338	PF00244	0.420
LIG_14-3-3_CanoR_1	352	358	PF00244	0.529
LIG_Actin_WH2_2	537	554	PF00022	0.507
LIG_APCC_ABBA_1	109	114	PF00400	0.482
LIG_BIR_II_1	1	5	PF00653	0.502
LIG_BIR_III_2	222	226	PF00653	0.631
LIG_BRCT_BRCA1_1	155	159	PF00533	0.494
LIG_BRCT_BRCA1_1	2	6	PF00533	0.541
LIG_BRCT_BRCA1_1	33	37	PF00533	0.683
LIG_deltaCOP1_diTrp_1	262	271	PF00928	0.452
LIG_eIF4E_1	136	142	PF01652	0.555
LIG_FHA_1	476	482	PF00498	0.548
LIG_FHA_2	124	130	PF00498	0.549
LIG_FHA_2	194	200	PF00498	0.559
LIG_FHA_2	421	427	PF00498	0.637
LIG_FHA_2	541	547	PF00498	0.515
LIG_FHA_2	91	97	PF00498	0.508
LIG_LIR_Gen_1	156	167	PF02991	0.506
LIG_LIR_Gen_1	269	278	PF02991	0.477
LIG_LIR_Gen_1	491	501	PF02991	0.598
LIG_LIR_Nem_3	156	162	PF02991	0.521
LIG_LIR_Nem_3	203	208	PF02991	0.479
LIG_LIR_Nem_3	269	274	PF02991	0.440
LIG_LIR_Nem_3	3	9	PF02991	0.566
LIG_LIR_Nem_3	491	497	PF02991	0.584
LIG_MYND_1	470	474	PF01753	0.632
LIG_NRBOX	403	409	PF00104	0.561
LIG_Pex14_1	264	268	PF04695	0.430
LIG_Pex14_2	46	50	PF04695	0.471
LIG_SH2_SRC	220	223	PF00017	0.552
LIG_SH2_STAP1	112	116	PF00017	0.525
LIG_SH2_STAP1	136	140	PF00017	0.539
LIG_SH2_STAP1	344	348	PF00017	0.523
LIG_SH2_STAP1	47	51	PF00017	0.503
LIG_SH2_STAT3	124	127	PF00017	0.622
LIG_SH2_STAT5	112	115	PF00017	0.516
LIG_SH2_STAT5	161	164	PF00017	0.503
LIG_SH2_STAT5	220	223	PF00017	0.595
LIG_SH2_STAT5	268	271	PF00017	0.461
LIG_SH3_3	129	135	PF00018	0.515
LIG_SH3_3	246	252	PF00018	0.529
LIG_SH3_3	439	445	PF00018	0.679
LIG_Sin3_3	205	212	PF02671	0.548
LIG_SUMO_SIM_anti_2	409	417	PF11976	0.584
LIG_SUMO_SIM_par_1	239	245	PF11976	0.489
LIG_SUMO_SIM_par_1	532	540	PF11976	0.505
LIG_TRAF2_1	126	129	PF00917	0.538
LIG_TRAF2_1	388	391	PF00917	0.711
LIG_TRAF2_1	71	74	PF00917	0.593
LIG_UBA3_1	404	411	PF00899	0.577
MOD_CDK_SPxxK_3	441	448	PF00069	0.672
MOD_CK1_1	110	116	PF00069	0.649
MOD_CK1_1	172	178	PF00069	0.459
MOD_CK1_1	189	195	PF00069	0.595
MOD_CK1_1	229	235	PF00069	0.622
MOD_CK1_1	307	313	PF00069	0.631
MOD_CK1_1	420	426	PF00069	0.627
MOD_CK1_1	438	444	PF00069	0.672
MOD_CK1_1	475	481	PF00069	0.699
MOD_CK1_1	540	546	PF00069	0.553
MOD_CK2_1	123	129	PF00069	0.544
MOD_CK2_1	250	256	PF00069	0.637
MOD_CK2_1	420	426	PF00069	0.603
MOD_CK2_1	68	74	PF00069	0.591
MOD_CK2_1	82	88	PF00069	0.484
MOD_CK2_1	90	96	PF00069	0.471
MOD_DYRK1A_RPxSP_1	552	556	PF00069	0.551
MOD_GlcNHglycan	163	166	PF01048	0.565
MOD_GlcNHglycan	228	231	PF01048	0.679
MOD_GlcNHglycan	306	309	PF01048	0.632
MOD_GlcNHglycan	312	315	PF01048	0.592
MOD_GlcNHglycan	326	329	PF01048	0.508
MOD_GlcNHglycan	432	435	PF01048	0.629
MOD_GlcNHglycan	517	520	PF01048	0.543
MOD_GlcNHglycan	70	73	PF01048	0.541
MOD_GlcNHglycan	84	87	PF01048	0.454
MOD_GSK3_1	189	196	PF00069	0.592
MOD_GSK3_1	31	38	PF00069	0.698
MOD_GSK3_1	353	360	PF00069	0.518
MOD_GSK3_1	391	398	PF00069	0.653
MOD_GSK3_1	413	420	PF00069	0.637
MOD_GSK3_1	511	518	PF00069	0.649
MOD_GSK3_1	536	543	PF00069	0.498
MOD_GSK3_1	90	97	PF00069	0.495
MOD_N-GLC_1	429	434	PF02516	0.575
MOD_N-GLC_2	529	531	PF02516	0.483
MOD_NEK2_1	123	128	PF00069	0.592
MOD_NEK2_1	169	174	PF00069	0.469
MOD_NEK2_1	286	291	PF00069	0.559
MOD_NEK2_1	333	338	PF00069	0.553
MOD_NEK2_1	365	370	PF00069	0.600
MOD_NEK2_1	429	434	PF00069	0.622
MOD_NEK2_1	90	95	PF00069	0.542
MOD_NEK2_2	107	112	PF00069	0.544
MOD_PIKK_1	123	129	PF00454	0.595
MOD_PIKK_1	229	235	PF00454	0.739
MOD_PIKK_1	339	345	PF00454	0.570
MOD_PIKK_1	9	15	PF00454	0.539
MOD_PKA_2	186	192	PF00069	0.662
MOD_PKA_2	281	287	PF00069	0.481
MOD_PKA_2	333	339	PF00069	0.459
MOD_PKA_2	420	426	PF00069	0.603
MOD_PKA_2	438	444	PF00069	0.740
MOD_Plk_1	105	111	PF00069	0.454
MOD_Plk_1	536	542	PF00069	0.579
MOD_Plk_1	95	101	PF00069	0.610
MOD_Plk_4	107	113	PF00069	0.485
MOD_Plk_4	281	287	PF00069	0.565
MOD_Plk_4	333	339	PF00069	0.497
MOD_Plk_4	502	508	PF00069	0.537
MOD_ProDKin_1	248	254	PF00069	0.601
MOD_ProDKin_1	266	272	PF00069	0.455
MOD_ProDKin_1	31	37	PF00069	0.636
MOD_ProDKin_1	318	324	PF00069	0.663
MOD_ProDKin_1	441	447	PF00069	0.637
MOD_ProDKin_1	511	517	PF00069	0.648
MOD_SUMO_rev_2	38	46	PF00179	0.609
TRG_DiLeu_BaLyEn_6	403	408	PF01217	0.563
TRG_ENDOCYTIC_2	268	271	PF00928	0.457
TRG_ENDOCYTIC_2	47	50	PF00928	0.502
TRG_ER_diArg_1	293	295	PF00400	0.622
TRG_ER_diArg_1	397	400	PF00400	0.574
TRG_ER_diArg_1	508	511	PF00400	0.480
TRG_NES_CRM1_1	114	129	PF08389	0.459
TRG_NES_CRM1_1	403	417	PF08389	0.583
TRG_Pf-PMV_PEXEL_1	139	144	PF00026	0.554
TRG_Pf-PMV_PEXEL_1	406	410	PF00026	0.626

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P8Q6	Leptomonas seymouri	40%	89%
A4HMV0	Leishmania braziliensis	71%	100%
A4IBH2	Leishmania infantum	100%	100%
E9AFA7	Leishmania major	87%	100%
E9B6G2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	82%	99%