Poly(A)-specific ribonuclease PARN, putative

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

ribonuclease, putative

Species:

Leishmania donovani

UniProt:

A0A3S7X9D8_LEIDO

TriTrypDb:

LdBPK_352390.1 , LdCL_350028800 , LDHU3_35.3050

Length:

677

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 14
NetGPI	no	yes: 0, no: 14

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	2
GO:0032838	plasma membrane bounded cell projection cytoplasm	4	1
GO:0097014	ciliary plasm	5	1
GO:0099568	cytoplasmic region	3	1
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

A0A3S7X9D8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7X9D8

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	15
GO:0005488	binding	1	15
GO:0097159	organic cyclic compound binding	2	15
GO:1901363	heterocyclic compound binding	2	15
GO:0000175	3'-5'-RNA exonuclease activity	7	2
GO:0003723	RNA binding	4	2
GO:0003824	catalytic activity	1	2
GO:0004518	nuclease activity	4	2
GO:0004527	exonuclease activity	5	2
GO:0004532	RNA exonuclease activity	5	2
GO:0004540	RNA nuclease activity	4	2
GO:0008408	3'-5' exonuclease activity	6	2
GO:0016787	hydrolase activity	2	2
GO:0016788	hydrolase activity, acting on ester bonds	3	2
GO:0016796	exonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters	6	2
GO:0016896	RNA exonuclease activity, producing 5'-phosphomonoesters	6	2
GO:0140098	catalytic activity, acting on RNA	3	2
GO:0140640	catalytic activity, acting on a nucleic acid	2	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	388	392	PF00656	0.461
CLV_NRD_NRD_1	111	113	PF00675	0.261
CLV_NRD_NRD_1	211	213	PF00675	0.347
CLV_NRD_NRD_1	315	317	PF00675	0.253
CLV_NRD_NRD_1	402	404	PF00675	0.318
CLV_NRD_NRD_1	442	444	PF00675	0.357
CLV_NRD_NRD_1	480	482	PF00675	0.270
CLV_NRD_NRD_1	54	56	PF00675	0.411
CLV_PCSK_KEX2_1	211	213	PF00082	0.414
CLV_PCSK_KEX2_1	480	482	PF00082	0.317
CLV_PCSK_SKI1_1	138	142	PF00082	0.215
CLV_PCSK_SKI1_1	155	159	PF00082	0.393
CLV_PCSK_SKI1_1	212	216	PF00082	0.385
CLV_PCSK_SKI1_1	268	272	PF00082	0.370
CLV_PCSK_SKI1_1	384	388	PF00082	0.408
CLV_PCSK_SKI1_1	537	541	PF00082	0.261
CLV_PCSK_SKI1_1	621	625	PF00082	0.408
CLV_PCSK_SKI1_1	659	663	PF00082	0.350
DEG_Nend_UBRbox_2	1	3	PF02207	0.434
DEG_SPOP_SBC_1	130	134	PF00917	0.447
DEG_SPOP_SBC_1	409	413	PF00917	0.461
DOC_CDC14_PxL_1	187	195	PF14671	0.426
DOC_CYCLIN_yClb3_PxF_3	469	475	PF00134	0.412
DOC_MAPK_gen_1	268	276	PF00069	0.546
DOC_MAPK_gen_1	316	324	PF00069	0.454
DOC_MAPK_gen_1	665	672	PF00069	0.474
DOC_MAPK_MEF2A_6	69	78	PF00069	0.523
DOC_PP1_RVXF_1	442	449	PF00149	0.604
DOC_PP2B_LxvP_1	101	104	PF13499	0.480
DOC_PP4_FxxP_1	222	225	PF00568	0.412
DOC_SPAK_OSR1_1	333	337	PF12202	0.461
DOC_USP7_MATH_1	172	176	PF00917	0.567
DOC_USP7_MATH_1	186	190	PF00917	0.446
DOC_USP7_MATH_1	206	210	PF00917	0.489
DOC_USP7_MATH_1	242	246	PF00917	0.426
DOC_USP7_MATH_1	409	413	PF00917	0.464
DOC_USP7_MATH_1	49	53	PF00917	0.489
DOC_USP7_MATH_1	523	527	PF00917	0.546
DOC_USP7_MATH_1	531	535	PF00917	0.405
DOC_USP7_MATH_1	569	573	PF00917	0.418
DOC_USP7_UBL2_3	400	404	PF12436	0.509
DOC_WW_Pin1_4	322	327	PF00397	0.461
DOC_WW_Pin1_4	42	47	PF00397	0.532
LIG_14-3-3_CanoR_1	126	130	PF00244	0.412
LIG_14-3-3_CanoR_1	178	186	PF00244	0.518
LIG_14-3-3_CanoR_1	205	211	PF00244	0.595
LIG_14-3-3_CanoR_1	360	366	PF00244	0.461
LIG_14-3-3_CanoR_1	417	423	PF00244	0.583
LIG_14-3-3_CanoR_1	490	498	PF00244	0.546
LIG_14-3-3_CanoR_1	665	673	PF00244	0.580
LIG_APCC_ABBA_1	78	83	PF00400	0.489
LIG_APCC_ABBAyCdc20_2	382	388	PF00400	0.461
LIG_BIR_III_4	88	92	PF00653	0.564
LIG_BRCT_BRCA1_1	401	405	PF00533	0.596
LIG_BRCT_BRCA1_1	525	529	PF00533	0.546
LIG_eIF4E_1	380	386	PF01652	0.461
LIG_FHA_1	130	136	PF00498	0.489
LIG_FHA_1	248	254	PF00498	0.509
LIG_FHA_1	265	271	PF00498	0.528
LIG_FHA_1	487	493	PF00498	0.491
LIG_FHA_1	503	509	PF00498	0.506
LIG_FHA_1	538	544	PF00498	0.564
LIG_FHA_1	553	559	PF00498	0.503
LIG_FHA_1	601	607	PF00498	0.605
LIG_FHA_1	628	634	PF00498	0.388
LIG_FHA_1	80	86	PF00498	0.433
LIG_FHA_2	126	132	PF00498	0.558
LIG_FHA_2	617	623	PF00498	0.518
LIG_LIR_Gen_1	233	242	PF02991	0.489
LIG_LIR_Gen_1	454	465	PF02991	0.607
LIG_LIR_Gen_1	582	591	PF02991	0.462
LIG_LIR_Gen_1	79	89	PF02991	0.587
LIG_LIR_Nem_3	151	157	PF02991	0.554
LIG_LIR_Nem_3	21	27	PF02991	0.509
LIG_LIR_Nem_3	233	237	PF02991	0.481
LIG_LIR_Nem_3	28	34	PF02991	0.508
LIG_LIR_Nem_3	454	460	PF02991	0.568
LIG_LIR_Nem_3	474	478	PF02991	0.371
LIG_LIR_Nem_3	526	532	PF02991	0.556
LIG_LIR_Nem_3	582	586	PF02991	0.447
LIG_LIR_Nem_3	79	84	PF02991	0.590
LIG_NRBOX	431	437	PF00104	0.489
LIG_PCNA_PIPBox_1	456	465	PF02747	0.461
LIG_PDZ_Class_2	672	677	PF00595	0.471
LIG_Pex14_2	150	154	PF04695	0.557
LIG_Pex14_2	483	487	PF04695	0.577
LIG_SH2_CRK	583	587	PF00017	0.446
LIG_SH2_CRK	71	75	PF00017	0.572
LIG_SH2_GRB2like	576	579	PF00017	0.441
LIG_SH2_NCK_1	71	75	PF00017	0.572
LIG_SH2_STAP1	437	441	PF00017	0.489
LIG_SH2_STAP1	452	456	PF00017	0.508
LIG_SH2_STAP1	576	580	PF00017	0.538
LIG_SH2_STAP1	583	587	PF00017	0.472
LIG_SH2_STAT3	463	466	PF00017	0.532
LIG_SH2_STAT3	640	643	PF00017	0.449
LIG_SH2_STAT5	14	17	PF00017	0.507
LIG_SH2_STAT5	156	159	PF00017	0.489
LIG_SH2_STAT5	355	358	PF00017	0.546
LIG_SH2_STAT5	380	383	PF00017	0.537
LIG_SH2_STAT5	452	455	PF00017	0.489
LIG_SH2_STAT5	583	586	PF00017	0.509
LIG_SH2_STAT5	608	611	PF00017	0.411
LIG_SH2_STAT5	640	643	PF00017	0.404
LIG_SH3_3	180	186	PF00018	0.450
LIG_SH3_3	320	326	PF00018	0.574
LIG_SH3_3	467	473	PF00018	0.412
LIG_SUMO_SIM_anti_2	167	172	PF11976	0.583
LIG_SUMO_SIM_par_1	334	340	PF11976	0.489
LIG_WRC_WIRS_1	231	236	PF05994	0.546
LIG_WRC_WIRS_1	362	367	PF05994	0.546
LIG_WRC_WIRS_1	472	477	PF05994	0.489
MOD_CK1_1	235	241	PF00069	0.596
MOD_CK1_1	378	384	PF00069	0.590
MOD_CK1_1	413	419	PF00069	0.546
MOD_CK1_1	421	427	PF00069	0.460
MOD_CK1_1	474	480	PF00069	0.616
MOD_CK1_1	516	522	PF00069	0.529
MOD_CK1_1	594	600	PF00069	0.472
MOD_CK1_1	638	644	PF00069	0.535
MOD_CK1_1	79	85	PF00069	0.512
MOD_CK2_1	125	131	PF00069	0.564
MOD_CK2_1	322	328	PF00069	0.532
MOD_CK2_1	616	622	PF00069	0.368
MOD_CK2_1	665	671	PF00069	0.522
MOD_Cter_Amidation	314	317	PF01082	0.254
MOD_GlcNHglycan	105	108	PF01048	0.291
MOD_GlcNHglycan	141	144	PF01048	0.398
MOD_GlcNHglycan	151	154	PF01048	0.230
MOD_GlcNHglycan	234	237	PF01048	0.333
MOD_GlcNHglycan	244	247	PF01048	0.346
MOD_GlcNHglycan	30	34	PF01048	0.334
MOD_GlcNHglycan	342	345	PF01048	0.226
MOD_GlcNHglycan	372	375	PF01048	0.355
MOD_GlcNHglycan	428	431	PF01048	0.287
MOD_GlcNHglycan	533	536	PF01048	0.320
MOD_GlcNHglycan	612	615	PF01048	0.496
MOD_GlcNHglycan	637	640	PF01048	0.412
MOD_GlcNHglycan	93	96	PF01048	0.334
MOD_GSK3_1	125	132	PF00069	0.592
MOD_GSK3_1	409	416	PF00069	0.496
MOD_GSK3_1	417	424	PF00069	0.500
MOD_GSK3_1	482	489	PF00069	0.512
MOD_GSK3_1	502	509	PF00069	0.517
MOD_GSK3_1	51	58	PF00069	0.456
MOD_GSK3_1	513	520	PF00069	0.509
MOD_GSK3_1	581	588	PF00069	0.427
MOD_GSK3_1	93	100	PF00069	0.508
MOD_N-GLC_1	124	129	PF02516	0.275
MOD_N-GLC_1	502	507	PF02516	0.380
MOD_N-GLC_1	569	574	PF02516	0.419
MOD_NEK2_1	1	6	PF00069	0.403
MOD_NEK2_1	139	144	PF00069	0.585
MOD_NEK2_1	264	269	PF00069	0.584
MOD_NEK2_1	29	34	PF00069	0.481
MOD_NEK2_1	431	436	PF00069	0.529
MOD_NEK2_1	486	491	PF00069	0.505
MOD_NEK2_1	579	584	PF00069	0.487
MOD_NEK2_2	569	574	PF00069	0.573
MOD_PIKK_1	537	543	PF00454	0.601
MOD_PIKK_1	665	671	PF00454	0.473
MOD_PK_1	507	513	PF00069	0.590
MOD_PK_1	517	523	PF00069	0.532
MOD_PKA_1	55	61	PF00069	0.616
MOD_PKA_2	125	131	PF00069	0.412
MOD_PKA_2	172	178	PF00069	0.521
MOD_PKA_2	635	641	PF00069	0.531
MOD_Plk_1	124	130	PF00069	0.483
MOD_Plk_1	20	26	PF00069	0.518
MOD_Plk_1	247	253	PF00069	0.483
MOD_Plk_1	264	270	PF00069	0.489
MOD_Plk_1	569	575	PF00069	0.422
MOD_Plk_2-3	131	137	PF00069	0.598
MOD_Plk_4	131	137	PF00069	0.535
MOD_Plk_4	14	20	PF00069	0.527
MOD_Plk_4	302	308	PF00069	0.521
MOD_Plk_4	375	381	PF00069	0.461
MOD_Plk_4	418	424	PF00069	0.504
MOD_Plk_4	431	437	PF00069	0.524
MOD_Plk_4	474	480	PF00069	0.569
MOD_Plk_4	482	488	PF00069	0.522
MOD_Plk_4	507	513	PF00069	0.529
MOD_Plk_4	523	529	PF00069	0.430
MOD_Plk_4	582	588	PF00069	0.468
MOD_Plk_4	594	600	PF00069	0.527
MOD_Plk_4	69	75	PF00069	0.599
MOD_ProDKin_1	322	328	PF00069	0.461
MOD_ProDKin_1	42	48	PF00069	0.532
MOD_SUMO_for_1	386	389	PF00179	0.461
MOD_SUMO_rev_2	289	294	PF00179	0.509
TRG_DiLeu_BaEn_2	113	119	PF01217	0.489
TRG_DiLeu_BaLyEn_6	358	363	PF01217	0.461
TRG_ENDOCYTIC_2	197	200	PF00928	0.516
TRG_ENDOCYTIC_2	452	455	PF00928	0.546
TRG_ENDOCYTIC_2	576	579	PF00928	0.410
TRG_ENDOCYTIC_2	583	586	PF00928	0.413
TRG_ENDOCYTIC_2	71	74	PF00928	0.546
TRG_ER_diArg_1	210	212	PF00400	0.551
TRG_ER_diArg_1	479	481	PF00400	0.461
TRG_NES_CRM1_1	312	328	PF08389	0.489
TRG_Pf-PMV_PEXEL_1	316	320	PF00026	0.312

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PGE9	Leptomonas seymouri	42%	96%
A0A0S4J225	Bodo saltans	22%	93%
A0A3Q8ICI3	Leishmania donovani	27%	100%
A0A3R7LZW8	Trypanosoma rangeli	25%	100%
A4HCS6	Leishmania braziliensis	26%	100%
A4HMQ8	Leishmania braziliensis	67%	100%
A4I0A0	Leishmania infantum	27%	100%
A4IBC6	Leishmania infantum	100%	100%
C9ZZC3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	25%	100%
E9AF58	Leishmania major	92%	100%
E9AW65	Leishmania mexicana (strain MHOM/GT/2001/U1103)	27%	100%
E9B6B4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	100%
Q4QBB3	Leishmania major	27%	100%