Ubiquitin hydrolase, putative

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

ubiquitin hydrolase, putative

Species:

Leishmania donovani

UniProt:

A0A3S7X9D2_LEIDO

TriTrypDb:

LdBPK_352460.1 , LdCL_350029500 , LDHU3_35.3150

Length:

923

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 4
NetGPI	no	yes: 0, no: 4

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	1
GO:0005829	cytosol	2	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A0A3S7X9D2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7X9D2

Function

Biological processes
Term	Name	Level	Count
GO:0006508	proteolysis	4	5
GO:0006511	ubiquitin-dependent protein catabolic process	7	5
GO:0006807	nitrogen compound metabolic process	2	5
GO:0008152	metabolic process	1	5
GO:0009056	catabolic process	2	5
GO:0009057	macromolecule catabolic process	4	5
GO:0009987	cellular process	1	5
GO:0016579	protein deubiquitination	6	5
GO:0019538	protein metabolic process	3	5
GO:0019941	modification-dependent protein catabolic process	6	5
GO:0036211	protein modification process	4	5
GO:0043170	macromolecule metabolic process	3	5
GO:0043412	macromolecule modification	4	5
GO:0043632	modification-dependent macromolecule catabolic process	5	5
GO:0044237	cellular metabolic process	2	5
GO:0044238	primary metabolic process	2	5
GO:0044248	cellular catabolic process	3	5
GO:0044260	obsolete cellular macromolecule metabolic process	3	5
GO:0044265	obsolete cellular macromolecule catabolic process	4	5
GO:0051603	proteolysis involved in protein catabolic process	5	5
GO:0070646	protein modification by small protein removal	5	5
GO:0070647	protein modification by small protein conjugation or removal	5	5
GO:0071704	organic substance metabolic process	2	5
GO:1901564	organonitrogen compound metabolic process	3	5
GO:1901575	organic substance catabolic process	3	5

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	5
GO:0004843	cysteine-type deubiquitinase activity	5	5
GO:0008233	peptidase activity	3	5
GO:0008234	cysteine-type peptidase activity	4	5
GO:0016787	hydrolase activity	2	5
GO:0019783	ubiquitin-like protein peptidase activity	4	5
GO:0101005	deubiquitinase activity	5	5
GO:0140096	catalytic activity, acting on a protein	2	5
GO:0004175	endopeptidase activity	4	1
GO:0004197	cysteine-type endopeptidase activity	5	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	389	393	PF00656	0.603
CLV_C14_Caspase3-7	46	50	PF00656	0.647
CLV_NRD_NRD_1	122	124	PF00675	0.592
CLV_NRD_NRD_1	194	196	PF00675	0.713
CLV_NRD_NRD_1	25	27	PF00675	0.655
CLV_NRD_NRD_1	42	44	PF00675	0.598
CLV_NRD_NRD_1	499	501	PF00675	0.339
CLV_NRD_NRD_1	504	506	PF00675	0.314
CLV_NRD_NRD_1	512	514	PF00675	0.306
CLV_NRD_NRD_1	66	68	PF00675	0.649
CLV_NRD_NRD_1	795	797	PF00675	0.604
CLV_NRD_NRD_1	829	831	PF00675	0.578
CLV_NRD_NRD_1	913	915	PF00675	0.444
CLV_PCSK_FUR_1	716	720	PF00082	0.311
CLV_PCSK_KEX2_1	122	124	PF00082	0.577
CLV_PCSK_KEX2_1	194	196	PF00082	0.713
CLV_PCSK_KEX2_1	24	26	PF00082	0.649
CLV_PCSK_KEX2_1	263	265	PF00082	0.568
CLV_PCSK_KEX2_1	498	500	PF00082	0.363
CLV_PCSK_KEX2_1	504	506	PF00082	0.334
CLV_PCSK_KEX2_1	512	514	PF00082	0.278
CLV_PCSK_KEX2_1	718	720	PF00082	0.341
CLV_PCSK_KEX2_1	736	738	PF00082	0.295
CLV_PCSK_KEX2_1	829	831	PF00082	0.578
CLV_PCSK_KEX2_1	913	915	PF00082	0.444
CLV_PCSK_PC1ET2_1	263	265	PF00082	0.568
CLV_PCSK_PC1ET2_1	504	506	PF00082	0.303
CLV_PCSK_PC1ET2_1	718	720	PF00082	0.320
CLV_PCSK_PC1ET2_1	736	738	PF00082	0.295
CLV_PCSK_PC7_1	500	506	PF00082	0.269
CLV_PCSK_SKI1_1	115	119	PF00082	0.579
CLV_PCSK_SKI1_1	343	347	PF00082	0.720
CLV_PCSK_SKI1_1	397	401	PF00082	0.541
CLV_PCSK_SKI1_1	690	694	PF00082	0.494
CLV_PCSK_SKI1_1	759	763	PF00082	0.339
CLV_PCSK_SKI1_1	877	881	PF00082	0.567
CLV_PCSK_SKI1_1	890	894	PF00082	0.352
CLV_Separin_Metazoa	687	691	PF03568	0.396
DEG_APCC_DBOX_1	122	130	PF00400	0.581
DEG_SPOP_SBC_1	29	33	PF00917	0.549
DEG_SPOP_SBC_1	425	429	PF00917	0.609
DEG_SPOP_SBC_1	521	525	PF00917	0.396
DOC_CDC14_PxL_1	345	353	PF14671	0.655
DOC_CKS1_1	475	480	PF01111	0.396
DOC_CYCLIN_RxL_1	340	350	PF00134	0.640
DOC_CYCLIN_yCln2_LP_2	701	707	PF00134	0.396
DOC_MAPK_gen_1	829	835	PF00069	0.514
DOC_MAPK_MEF2A_6	642	651	PF00069	0.396
DOC_MAPK_RevD_3	898	914	PF00069	0.437
DOC_PP1_RVXF_1	604	611	PF00149	0.384
DOC_PP2B_LxvP_1	346	349	PF13499	0.654
DOC_PP4_FxxP_1	808	811	PF00568	0.495
DOC_SPAK_OSR1_1	642	646	PF12202	0.339
DOC_USP7_MATH_1	209	213	PF00917	0.689
DOC_USP7_MATH_1	239	243	PF00917	0.550
DOC_USP7_MATH_1	29	33	PF00917	0.557
DOC_USP7_MATH_1	298	302	PF00917	0.611
DOC_USP7_MATH_1	372	376	PF00917	0.614
DOC_USP7_MATH_1	425	429	PF00917	0.662
DOC_USP7_MATH_1	431	435	PF00917	0.598
DOC_USP7_MATH_1	52	56	PF00917	0.677
DOC_USP7_MATH_1	521	525	PF00917	0.396
DOC_USP7_MATH_1	851	855	PF00917	0.616
DOC_USP7_UBL2_3	676	680	PF12436	0.317
DOC_WW_Pin1_4	131	136	PF00397	0.583
DOC_WW_Pin1_4	248	253	PF00397	0.635
DOC_WW_Pin1_4	267	272	PF00397	0.705
DOC_WW_Pin1_4	303	308	PF00397	0.640
DOC_WW_Pin1_4	349	354	PF00397	0.773
DOC_WW_Pin1_4	355	360	PF00397	0.719
DOC_WW_Pin1_4	370	375	PF00397	0.681
DOC_WW_Pin1_4	427	432	PF00397	0.555
DOC_WW_Pin1_4	474	479	PF00397	0.396
DOC_WW_Pin1_4	81	86	PF00397	0.694
DOC_WW_Pin1_4	820	825	PF00397	0.677
LIG_14-3-3_CanoR_1	28	38	PF00244	0.637
LIG_14-3-3_CanoR_1	330	334	PF00244	0.617
LIG_14-3-3_CanoR_1	363	367	PF00244	0.574
LIG_14-3-3_CanoR_1	433	443	PF00244	0.548
LIG_14-3-3_CanoR_1	606	611	PF00244	0.459
LIG_14-3-3_CanoR_1	719	725	PF00244	0.311
LIG_14-3-3_CanoR_1	772	780	PF00244	0.396
LIG_14-3-3_CanoR_1	852	858	PF00244	0.625
LIG_BIR_II_1	1	5	PF00653	0.641
LIG_BIR_III_4	78	82	PF00653	0.596
LIG_BRCT_BRCA1_1	178	182	PF00533	0.531
LIG_BRCT_BRCA1_1	639	643	PF00533	0.396
LIG_deltaCOP1_diTrp_1	494	501	PF00928	0.242
LIG_eIF4E_1	641	647	PF01652	0.339
LIG_eIF4E_1	726	732	PF01652	0.269
LIG_FHA_1	290	296	PF00498	0.644
LIG_FHA_1	386	392	PF00498	0.640
LIG_FHA_1	462	468	PF00498	0.396
LIG_FHA_1	475	481	PF00498	0.268
LIG_FHA_1	521	527	PF00498	0.452
LIG_FHA_1	745	751	PF00498	0.311
LIG_FHA_2	108	114	PF00498	0.607
LIG_FHA_2	140	146	PF00498	0.615
LIG_FHA_2	315	321	PF00498	0.581
LIG_FHA_2	330	336	PF00498	0.597
LIG_FHA_2	379	385	PF00498	0.653
LIG_FHA_2	589	595	PF00498	0.373
LIG_FHA_2	616	622	PF00498	0.396
LIG_FHA_2	814	820	PF00498	0.588
LIG_Integrin_isoDGR_2	863	865	PF01839	0.652
LIG_IRF3_LxIS_1	643	650	PF10401	0.396
LIG_LIR_Apic_2	723	729	PF02991	0.339
LIG_LIR_Apic_2	806	811	PF02991	0.497
LIG_LIR_Gen_1	617	626	PF02991	0.339
LIG_LIR_Gen_1	640	651	PF02991	0.339
LIG_LIR_Gen_1	781	790	PF02991	0.396
LIG_LIR_Gen_1	906	915	PF02991	0.418
LIG_LIR_Nem_3	179	185	PF02991	0.633
LIG_LIR_Nem_3	590	595	PF02991	0.396
LIG_LIR_Nem_3	617	623	PF02991	0.439
LIG_LIR_Nem_3	640	646	PF02991	0.402
LIG_LIR_Nem_3	725	730	PF02991	0.396
LIG_LIR_Nem_3	777	783	PF02991	0.354
LIG_LIR_Nem_3	906	911	PF02991	0.408
LIG_MYND_1	349	353	PF01753	0.676
LIG_NRBOX	569	575	PF00104	0.396
LIG_PCNA_yPIPBox_3	468	482	PF02747	0.368
LIG_Pex14_2	751	755	PF04695	0.396
LIG_REV1ctd_RIR_1	691	701	PF16727	0.396
LIG_SH2_CRK	783	787	PF00017	0.368
LIG_SH2_GRB2like	466	469	PF00017	0.396
LIG_SH2_SRC	466	469	PF00017	0.490
LIG_SH2_STAP1	240	244	PF00017	0.621
LIG_SH2_STAP1	604	608	PF00017	0.396
LIG_SH2_STAP1	722	726	PF00017	0.339
LIG_SH2_STAT5	466	469	PF00017	0.490
LIG_SH2_STAT5	753	756	PF00017	0.396
LIG_SH2_STAT5	760	763	PF00017	0.327
LIG_SH2_STAT5	780	783	PF00017	0.325
LIG_SH2_STAT5	785	788	PF00017	0.452
LIG_SH2_STAT5	885	888	PF00017	0.445
LIG_SH2_STAT5	908	911	PF00017	0.403
LIG_SH3_1	406	412	PF00018	0.614
LIG_SH3_2	186	191	PF14604	0.552
LIG_SH3_3	183	189	PF00018	0.602
LIG_SH3_3	272	278	PF00018	0.701
LIG_SH3_3	31	37	PF00018	0.560
LIG_SH3_3	330	336	PF00018	0.558
LIG_SH3_3	406	412	PF00018	0.768
LIG_SH3_3	56	62	PF00018	0.579
LIG_SH3_3	746	752	PF00018	0.396
LIG_SH3_3	892	898	PF00018	0.410
LIG_SH3_4	585	592	PF00018	0.311
LIG_SUMO_SIM_par_1	306	312	PF11976	0.555
LIG_SUMO_SIM_par_1	344	350	PF11976	0.585
LIG_SUMO_SIM_par_1	523	531	PF11976	0.396
LIG_TRAF2_1	374	377	PF00917	0.530
LIG_TRFH_1	185	189	PF08558	0.553
LIG_TYR_ITIM	910	915	PF00017	0.423
LIG_TYR_ITSM	779	786	PF00017	0.396
LIG_UBA3_1	543	548	PF00899	0.396
LIG_UBA3_1	570	579	PF00899	0.396
LIG_UBA3_1	730	736	PF00899	0.325
LIG_WRC_WIRS_1	105	110	PF05994	0.533
LIG_WRC_WIRS_1	391	396	PF05994	0.626
LIG_WW_3	252	256	PF00397	0.560
MOD_CDK_SPK_2	81	86	PF00069	0.653
MOD_CDK_SPxK_1	427	433	PF00069	0.555
MOD_CDK_SPxxK_3	248	255	PF00069	0.541
MOD_CDK_SPxxK_3	267	274	PF00069	0.621
MOD_CK1_1	107	113	PF00069	0.587
MOD_CK1_1	152	158	PF00069	0.613
MOD_CK1_1	163	169	PF00069	0.587
MOD_CK1_1	2	8	PF00069	0.681
MOD_CK1_1	201	207	PF00069	0.646
MOD_CK1_1	212	218	PF00069	0.597
MOD_CK1_1	262	268	PF00069	0.709
MOD_CK1_1	297	303	PF00069	0.567
MOD_CK1_1	314	320	PF00069	0.619
MOD_CK1_1	325	331	PF00069	0.612
MOD_CK1_1	354	360	PF00069	0.688
MOD_CK1_1	365	371	PF00069	0.645
MOD_CK1_1	387	393	PF00069	0.564
MOD_CK1_1	426	432	PF00069	0.690
MOD_CK1_1	434	440	PF00069	0.572
MOD_CK1_1	444	450	PF00069	0.403
MOD_CK1_1	654	660	PF00069	0.339
MOD_CK1_1	823	829	PF00069	0.613
MOD_CK2_1	107	113	PF00069	0.611
MOD_CK2_1	329	335	PF00069	0.635
MOD_CK2_1	378	384	PF00069	0.631
MOD_CK2_1	511	517	PF00069	0.396
MOD_CK2_1	631	637	PF00069	0.294
MOD_CMANNOS	607	610	PF00535	0.339
MOD_Cter_Amidation	22	25	PF01082	0.551
MOD_Cter_Amidation	496	499	PF01082	0.330
MOD_GlcNHglycan	135	138	PF01048	0.569
MOD_GlcNHglycan	200	203	PF01048	0.683
MOD_GlcNHglycan	205	208	PF01048	0.685
MOD_GlcNHglycan	296	299	PF01048	0.579
MOD_GlcNHglycan	327	330	PF01048	0.750
MOD_GlcNHglycan	367	370	PF01048	0.570
MOD_GlcNHglycan	416	419	PF01048	0.686
MOD_GlcNHglycan	434	437	PF01048	0.546
MOD_GlcNHglycan	443	446	PF01048	0.497
MOD_GlcNHglycan	45	48	PF01048	0.632
MOD_GlcNHglycan	70	73	PF01048	0.640
MOD_GlcNHglycan	776	779	PF01048	0.387
MOD_GlcNHglycan	873	876	PF01048	0.636
MOD_GlcNHglycan	894	898	PF01048	0.350
MOD_GSK3_1	1	8	PF00069	0.644
MOD_GSK3_1	104	111	PF00069	0.574
MOD_GSK3_1	113	120	PF00069	0.579
MOD_GSK3_1	129	136	PF00069	0.604
MOD_GSK3_1	139	146	PF00069	0.583
MOD_GSK3_1	160	167	PF00069	0.579
MOD_GSK3_1	239	246	PF00069	0.683
MOD_GSK3_1	262	269	PF00069	0.737
MOD_GSK3_1	285	292	PF00069	0.600
MOD_GSK3_1	294	301	PF00069	0.558
MOD_GSK3_1	303	310	PF00069	0.567
MOD_GSK3_1	325	332	PF00069	0.640
MOD_GSK3_1	351	358	PF00069	0.675
MOD_GSK3_1	39	46	PF00069	0.594
MOD_GSK3_1	410	417	PF00069	0.568
MOD_GSK3_1	420	427	PF00069	0.676
MOD_GSK3_1	431	438	PF00069	0.576
MOD_GSK3_1	48	55	PF00069	0.583
MOD_GSK3_1	627	634	PF00069	0.339
MOD_GSK3_1	647	654	PF00069	0.396
MOD_GSK3_1	774	781	PF00069	0.339
MOD_GSK3_1	809	816	PF00069	0.482
MOD_GSK3_1	852	859	PF00069	0.627
MOD_GSK3_1	871	878	PF00069	0.543
MOD_GSK3_1	94	101	PF00069	0.607
MOD_LATS_1	277	283	PF00433	0.540
MOD_N-GLC_1	108	113	PF02516	0.560
MOD_N-GLC_1	247	252	PF02516	0.550
MOD_N-GLC_1	279	284	PF02516	0.653
MOD_N-GLC_1	354	359	PF02516	0.655
MOD_N-GLC_1	614	619	PF02516	0.394
MOD_N-GLC_1	744	749	PF02516	0.298
MOD_N-GLC_1	81	86	PF02516	0.634
MOD_N-GLC_1	890	895	PF02516	0.438
MOD_NEK2_1	1	6	PF00069	0.644
MOD_NEK2_1	117	122	PF00069	0.575
MOD_NEK2_1	143	148	PF00069	0.545
MOD_NEK2_1	285	290	PF00069	0.676
MOD_NEK2_1	309	314	PF00069	0.606
MOD_NEK2_1	399	404	PF00069	0.531
MOD_NEK2_1	414	419	PF00069	0.564
MOD_NEK2_1	461	466	PF00069	0.327
MOD_NEK2_1	480	485	PF00069	0.269
MOD_NEK2_1	543	548	PF00069	0.410
MOD_NEK2_1	569	574	PF00069	0.396
MOD_NEK2_1	647	652	PF00069	0.396
MOD_NEK2_1	813	818	PF00069	0.579
MOD_NEK2_1	9	14	PF00069	0.589
MOD_NEK2_1	98	103	PF00069	0.564
MOD_NEK2_2	329	334	PF00069	0.568
MOD_NEK2_2	436	441	PF00069	0.507
MOD_OFUCOSY	629	636	PF10250	0.339
MOD_OFUCOSY	769	775	PF10250	0.311
MOD_PIKK_1	243	249	PF00454	0.747
MOD_PIKK_1	372	378	PF00454	0.654
MOD_PIKK_1	656	662	PF00454	0.345
MOD_PIKK_1	813	819	PF00454	0.512
MOD_PIKK_1	9	15	PF00454	0.637
MOD_PKA_1	385	391	PF00069	0.538
MOD_PKA_1	43	49	PF00069	0.632
MOD_PKA_2	259	265	PF00069	0.589
MOD_PKA_2	289	295	PF00069	0.614
MOD_PKA_2	314	320	PF00069	0.648
MOD_PKA_2	329	335	PF00069	0.617
MOD_PKA_2	362	368	PF00069	0.576
MOD_PKA_2	39	45	PF00069	0.643
MOD_PKA_2	432	438	PF00069	0.552
MOD_PKA_2	511	517	PF00069	0.317
MOD_PKA_2	771	777	PF00069	0.396
MOD_PKA_2	851	857	PF00069	0.631
MOD_PKB_1	26	34	PF00069	0.615
MOD_Plk_1	108	114	PF00069	0.576
MOD_Plk_1	143	149	PF00069	0.614
MOD_Plk_1	614	620	PF00069	0.394
MOD_Plk_1	636	642	PF00069	0.339
MOD_Plk_1	744	750	PF00069	0.368
MOD_Plk_4	16	22	PF00069	0.540
MOD_Plk_4	233	239	PF00069	0.558
MOD_Plk_4	362	368	PF00069	0.574
MOD_Plk_4	466	472	PF00069	0.462
MOD_Plk_4	5	11	PF00069	0.601
MOD_Plk_4	522	528	PF00069	0.396
MOD_Plk_4	606	612	PF00069	0.370
MOD_Plk_4	615	621	PF00069	0.332
MOD_Plk_4	781	787	PF00069	0.339
MOD_ProDKin_1	131	137	PF00069	0.583
MOD_ProDKin_1	248	254	PF00069	0.631
MOD_ProDKin_1	267	273	PF00069	0.705
MOD_ProDKin_1	303	309	PF00069	0.644
MOD_ProDKin_1	349	355	PF00069	0.777
MOD_ProDKin_1	370	376	PF00069	0.704
MOD_ProDKin_1	427	433	PF00069	0.555
MOD_ProDKin_1	474	480	PF00069	0.396
MOD_ProDKin_1	81	87	PF00069	0.693
MOD_ProDKin_1	820	826	PF00069	0.676
MOD_SUMO_for_1	743	746	PF00179	0.396
MOD_SUMO_rev_2	514	521	PF00179	0.398
MOD_SUMO_rev_2	594	601	PF00179	0.339
MOD_SUMO_rev_2	670	677	PF00179	0.371
MOD_SUMO_rev_2	788	794	PF00179	0.541
TRG_ENDOCYTIC_2	620	623	PF00928	0.396
TRG_ENDOCYTIC_2	783	786	PF00928	0.396
TRG_ENDOCYTIC_2	908	911	PF00928	0.403
TRG_ENDOCYTIC_2	912	915	PF00928	0.397
TRG_ER_diArg_1	193	195	PF00400	0.706
TRG_ER_diArg_1	24	26	PF00400	0.651
TRG_ER_diArg_1	254	257	PF00400	0.585
TRG_ER_diArg_1	488	491	PF00400	0.339
TRG_ER_diArg_1	498	500	PF00400	0.269
TRG_ER_diArg_1	655	658	PF00400	0.339
TRG_ER_diArg_1	828	830	PF00400	0.579
TRG_ER_diArg_1	912	914	PF00400	0.428
TRG_NLS_MonoExtC_3	795	800	PF00514	0.568
TRG_Pf-PMV_PEXEL_1	403	408	PF00026	0.653
TRG_Pf-PMV_PEXEL_1	482	487	PF00026	0.379

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A4HMR5	Leishmania braziliensis	49%	100%
E9AF65	Leishmania major	81%	100%
E9B6C1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	71%	100%