PHD-like zinc-binding domain family protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

PHD-like zinc-binding domain containing protein, putative

Species:

Leishmania donovani

UniProt:

A0A3S7X9C0_LEIDO

TriTrypDb:

LdBPK_352670.1 , LdCL_350031600 , LDHU3_35.3420

Length:

743

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	2
GO:0016020	membrane	2	1

Expansion

Sequence features

A0A3S7X9C0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7X9C0

Function

Biological processes
Term	Name	Level	Count
GO:0006355	regulation of DNA-templated transcription	6	1
GO:0006357	regulation of transcription by RNA polymerase II	7	1
GO:0009889	regulation of biosynthetic process	4	1
GO:0010468	regulation of gene expression	5	1
GO:0010556	regulation of macromolecule biosynthetic process	5	1
GO:0019219	regulation of nucleobase-containing compound metabolic process	5	1
GO:0019222	regulation of metabolic process	3	1
GO:0031323	regulation of cellular metabolic process	4	1
GO:0031326	regulation of cellular biosynthetic process	5	1
GO:0050789	regulation of biological process	2	1
GO:0050794	regulation of cellular process	3	1
GO:0051171	regulation of nitrogen compound metabolic process	4	1
GO:0051252	regulation of RNA metabolic process	5	1
GO:0060255	regulation of macromolecule metabolic process	4	1
GO:0065007	biological regulation	1	1
GO:0080090	regulation of primary metabolic process	4	1
GO:1903506	regulation of nucleic acid-templated transcription	7	1
GO:2001141	regulation of RNA biosynthetic process	6	1

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	292	296	PF00656	0.448
CLV_C14_Caspase3-7	738	742	PF00656	0.631
CLV_NRD_NRD_1	237	239	PF00675	0.567
CLV_NRD_NRD_1	324	326	PF00675	0.417
CLV_NRD_NRD_1	336	338	PF00675	0.422
CLV_NRD_NRD_1	446	448	PF00675	0.615
CLV_NRD_NRD_1	525	527	PF00675	0.521
CLV_NRD_NRD_1	531	533	PF00675	0.480
CLV_NRD_NRD_1	586	588	PF00675	0.514
CLV_NRD_NRD_1	88	90	PF00675	0.482
CLV_PCSK_KEX2_1	237	239	PF00082	0.545
CLV_PCSK_KEX2_1	324	326	PF00082	0.436
CLV_PCSK_KEX2_1	336	338	PF00082	0.488
CLV_PCSK_KEX2_1	446	448	PF00082	0.649
CLV_PCSK_KEX2_1	531	533	PF00082	0.499
CLV_PCSK_KEX2_1	579	581	PF00082	0.437
CLV_PCSK_KEX2_1	585	587	PF00082	0.504
CLV_PCSK_KEX2_1	703	705	PF00082	0.542
CLV_PCSK_KEX2_1	88	90	PF00082	0.479
CLV_PCSK_KEX2_1	98	100	PF00082	0.578
CLV_PCSK_PC1ET2_1	579	581	PF00082	0.491
CLV_PCSK_PC1ET2_1	703	705	PF00082	0.542
CLV_PCSK_PC1ET2_1	98	100	PF00082	0.650
CLV_PCSK_PC7_1	84	90	PF00082	0.475
CLV_PCSK_PC7_1	94	100	PF00082	0.651
CLV_PCSK_SKI1_1	11	15	PF00082	0.487
CLV_PCSK_SKI1_1	257	261	PF00082	0.500
CLV_PCSK_SKI1_1	325	329	PF00082	0.483
CLV_PCSK_SKI1_1	89	93	PF00082	0.515
CLV_Separin_Metazoa	363	367	PF03568	0.451
DEG_APCC_DBOX_1	198	206	PF00400	0.646
DEG_SCF_TRCP1_1	408	413	PF00400	0.562
DEG_SPOP_SBC_1	435	439	PF00917	0.700
DOC_ANK_TNKS_1	585	592	PF00023	0.579
DOC_CKS1_1	279	284	PF01111	0.401
DOC_CKS1_1	368	373	PF01111	0.478
DOC_MAPK_gen_1	22	30	PF00069	0.283
DOC_MAPK_gen_1	280	288	PF00069	0.437
DOC_MAPK_gen_1	3	12	PF00069	0.372
DOC_MAPK_gen_1	321	330	PF00069	0.412
DOC_MAPK_gen_1	336	343	PF00069	0.435
DOC_MAPK_gen_1	355	364	PF00069	0.270
DOC_MAPK_gen_1	479	486	PF00069	0.620
DOC_MAPK_MEF2A_6	280	288	PF00069	0.424
DOC_MAPK_MEF2A_6	3	12	PF00069	0.348
DOC_MAPK_NFAT4_5	5	13	PF00069	0.355
DOC_PP1_RVXF_1	46	52	PF00149	0.360
DOC_PP1_RVXF_1	7	13	PF00149	0.369
DOC_PP4_FxxP_1	118	121	PF00568	0.560
DOC_PP4_FxxP_1	279	282	PF00568	0.414
DOC_PP4_FxxP_1	30	33	PF00568	0.458
DOC_USP7_MATH_1	434	438	PF00917	0.642
DOC_USP7_MATH_1	624	628	PF00917	0.524
DOC_USP7_MATH_1	705	709	PF00917	0.747
DOC_USP7_MATH_1	723	727	PF00917	0.578
DOC_WW_Pin1_4	111	116	PF00397	0.729
DOC_WW_Pin1_4	187	192	PF00397	0.633
DOC_WW_Pin1_4	223	228	PF00397	0.647
DOC_WW_Pin1_4	278	283	PF00397	0.385
DOC_WW_Pin1_4	367	372	PF00397	0.477
LIG_14-3-3_CanoR_1	446	451	PF00244	0.634
LIG_14-3-3_CanoR_1	487	497	PF00244	0.495
LIG_14-3-3_CanoR_1	596	604	PF00244	0.441
LIG_14-3-3_CanoR_1	660	668	PF00244	0.458
LIG_14-3-3_CanoR_1	693	700	PF00244	0.530
LIG_AP2alpha_2	683	685	PF02296	0.563
LIG_Clathr_ClatBox_1	353	357	PF01394	0.393
LIG_FHA_1	298	304	PF00498	0.458
LIG_FHA_1	536	542	PF00498	0.380
LIG_FHA_1	593	599	PF00498	0.483
LIG_FHA_1	606	612	PF00498	0.360
LIG_FHA_1	693	699	PF00498	0.553
LIG_FHA_2	285	291	PF00498	0.452
LIG_FHA_2	380	386	PF00498	0.577
LIG_FHA_2	503	509	PF00498	0.507
LIG_FHA_2	99	105	PF00498	0.692
LIG_Integrin_RGD_1	321	323	PF01839	0.456
LIG_LIR_Apic_2	116	121	PF02991	0.550
LIG_LIR_Apic_2	29	33	PF02991	0.463
LIG_LIR_Apic_2	683	689	PF02991	0.500
LIG_LIR_Gen_1	307	316	PF02991	0.461
LIG_LIR_Gen_1	35	45	PF02991	0.369
LIG_LIR_Gen_1	57	64	PF02991	0.372
LIG_LIR_Gen_1	662	672	PF02991	0.357
LIG_LIR_Gen_1	673	684	PF02991	0.436
LIG_LIR_Gen_1	76	87	PF02991	0.426
LIG_LIR_Nem_3	21	27	PF02991	0.476
LIG_LIR_Nem_3	307	311	PF02991	0.470
LIG_LIR_Nem_3	35	41	PF02991	0.294
LIG_LIR_Nem_3	429	435	PF02991	0.635
LIG_LIR_Nem_3	57	62	PF02991	0.371
LIG_LIR_Nem_3	662	668	PF02991	0.358
LIG_LIR_Nem_3	673	679	PF02991	0.418
LIG_LIR_Nem_3	76	82	PF02991	0.448
LIG_LYPXL_yS_3	432	435	PF13949	0.600
LIG_PTB_Apo_2	117	124	PF02174	0.558
LIG_PTB_Phospho_1	117	123	PF10480	0.555
LIG_Rb_LxCxE_1	154	168	PF01857	0.442
LIG_SH2_GRB2like	676	679	PF00017	0.427
LIG_SH2_STAT5	269	272	PF00017	0.384
LIG_SH2_STAT5	334	337	PF00017	0.400
LIG_SH2_STAT5	676	679	PF00017	0.427
LIG_SH2_STAT5	78	81	PF00017	0.417
LIG_SH3_1	94	100	PF00018	0.579
LIG_SH3_3	10	16	PF00018	0.425
LIG_SH3_3	130	136	PF00018	0.531
LIG_SH3_3	493	499	PF00018	0.584
LIG_SH3_3	610	616	PF00018	0.451
LIG_SH3_3	681	687	PF00018	0.483
LIG_SH3_3	94	100	PF00018	0.579
LIG_SUMO_SIM_anti_2	695	701	PF11976	0.545
LIG_SUMO_SIM_par_1	379	385	PF11976	0.609
LIG_SUMO_SIM_par_1	695	701	PF11976	0.487
LIG_TRAF2_1	480	483	PF00917	0.536
LIG_UBA3_1	352	361	PF00899	0.464
LIG_WRC_WIRS_1	27	32	PF05994	0.435
MOD_CDC14_SPxK_1	226	229	PF00782	0.603
MOD_CDK_SPK_2	278	283	PF00069	0.385
MOD_CDK_SPxK_1	223	229	PF00069	0.600
MOD_CK1_1	138	144	PF00069	0.630
MOD_CK1_1	165	171	PF00069	0.610
MOD_CK1_1	182	188	PF00069	0.633
MOD_CK1_1	437	443	PF00069	0.646
MOD_CK1_1	456	462	PF00069	0.466
MOD_CK1_1	491	497	PF00069	0.575
MOD_CK1_1	548	554	PF00069	0.450
MOD_CK1_1	57	63	PF00069	0.401
MOD_CK2_1	26	32	PF00069	0.435
MOD_CK2_1	284	290	PF00069	0.405
MOD_CK2_1	304	310	PF00069	0.401
MOD_CK2_1	357	363	PF00069	0.384
MOD_CK2_1	379	385	PF00069	0.570
MOD_CK2_1	477	483	PF00069	0.623
MOD_CK2_1	624	630	PF00069	0.530
MOD_CK2_1	713	719	PF00069	0.549
MOD_CK2_1	98	104	PF00069	0.612
MOD_GlcNHglycan	128	131	PF01048	0.666
MOD_GlcNHglycan	184	187	PF01048	0.663
MOD_GlcNHglycan	215	218	PF01048	0.663
MOD_GlcNHglycan	221	224	PF01048	0.604
MOD_GlcNHglycan	376	379	PF01048	0.650
MOD_GlcNHglycan	388	391	PF01048	0.675
MOD_GlcNHglycan	408	411	PF01048	0.770
MOD_GlcNHglycan	412	415	PF01048	0.708
MOD_GlcNHglycan	424	427	PF01048	0.527
MOD_GlcNHglycan	428	431	PF01048	0.458
MOD_GlcNHglycan	442	445	PF01048	0.524
MOD_GlcNHglycan	455	458	PF01048	0.572
MOD_GlcNHglycan	461	464	PF01048	0.574
MOD_GlcNHglycan	490	493	PF01048	0.761
MOD_GlcNHglycan	549	553	PF01048	0.393
MOD_GlcNHglycan	605	608	PF01048	0.514
MOD_GlcNHglycan	622	625	PF01048	0.513
MOD_GlcNHglycan	626	629	PF01048	0.543
MOD_GlcNHglycan	672	675	PF01048	0.439
MOD_GlcNHglycan	79	82	PF01048	0.522
MOD_GSK3_1	131	138	PF00069	0.729
MOD_GSK3_1	219	226	PF00069	0.658
MOD_GSK3_1	297	304	PF00069	0.393
MOD_GSK3_1	406	413	PF00069	0.710
MOD_GSK3_1	422	429	PF00069	0.533
MOD_GSK3_1	434	441	PF00069	0.561
MOD_GSK3_1	448	455	PF00069	0.722
MOD_GSK3_1	599	606	PF00069	0.455
MOD_GSK3_1	620	627	PF00069	0.490
MOD_GSK3_1	73	80	PF00069	0.578
MOD_N-GLC_1	138	143	PF02516	0.607
MOD_N-GLC_2	642	644	PF02516	0.473
MOD_NEK2_1	163	168	PF00069	0.517
MOD_NEK2_1	180	185	PF00069	0.525
MOD_NEK2_1	213	218	PF00069	0.615
MOD_NEK2_1	356	361	PF00069	0.473
MOD_NEK2_1	452	457	PF00069	0.765
MOD_NEK2_1	52	57	PF00069	0.401
MOD_NEK2_1	561	566	PF00069	0.517
MOD_NEK2_1	597	602	PF00069	0.474
MOD_NEK2_1	603	608	PF00069	0.426
MOD_NEK2_2	379	384	PF00069	0.667
MOD_NEK2_2	607	612	PF00069	0.506
MOD_PIKK_1	297	303	PF00454	0.470
MOD_PIKK_1	535	541	PF00454	0.431
MOD_PIKK_1	692	698	PF00454	0.467
MOD_PKA_1	446	452	PF00069	0.717
MOD_PKA_1	98	104	PF00069	0.627
MOD_PKA_2	357	363	PF00069	0.419
MOD_PKA_2	445	451	PF00069	0.621
MOD_PKA_2	562	568	PF00069	0.518
MOD_PKA_2	659	665	PF00069	0.423
MOD_PKA_2	692	698	PF00069	0.501
MOD_PKA_2	98	104	PF00069	0.646
MOD_PKB_1	255	263	PF00069	0.399
MOD_PKB_1	404	412	PF00069	0.615
MOD_Plk_1	34	40	PF00069	0.413
MOD_Plk_1	57	63	PF00069	0.366
MOD_Plk_1	713	719	PF00069	0.551
MOD_Plk_2-3	26	32	PF00069	0.398
MOD_Plk_2-3	34	40	PF00069	0.413
MOD_Plk_4	599	605	PF00069	0.502
MOD_ProDKin_1	111	117	PF00069	0.721
MOD_ProDKin_1	187	193	PF00069	0.634
MOD_ProDKin_1	223	229	PF00069	0.650
MOD_ProDKin_1	278	284	PF00069	0.393
MOD_ProDKin_1	367	373	PF00069	0.479
MOD_SUMO_rev_2	40	49	PF00179	0.395
MOD_SUMO_rev_2	584	594	PF00179	0.579
TRG_DiLeu_BaLyEn_6	348	353	PF01217	0.384
TRG_ENDOCYTIC_2	38	41	PF00928	0.362
TRG_ENDOCYTIC_2	432	435	PF00928	0.600
TRG_ENDOCYTIC_2	676	679	PF00928	0.474
TRG_ER_diArg_1	2	5	PF00400	0.401
TRG_ER_diArg_1	236	238	PF00400	0.549
TRG_ER_diArg_1	254	257	PF00400	0.337
TRG_ER_diArg_1	335	337	PF00400	0.424
TRG_ER_diArg_1	445	447	PF00400	0.711
TRG_ER_diArg_1	478	481	PF00400	0.522
TRG_ER_diArg_1	530	532	PF00400	0.489
TRG_ER_diArg_1	585	587	PF00400	0.518
TRG_ER_diArg_1	8	11	PF00400	0.403
TRG_Pf-PMV_PEXEL_1	42	46	PF00026	0.461
TRG_Pf-PMV_PEXEL_1	580	584	PF00026	0.488

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PDF9	Leptomonas seymouri	70%	100%
A4HMT2	Leishmania braziliensis	81%	100%
A4IBD0	Leishmania infantum	100%	100%
C9ZZ89	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	43%	100%
E9AF86	Leishmania major	92%	100%
E9B6E1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%
V5DUV4	Trypanosoma cruzi	49%	100%