LeishMANIAdb
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Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
Uncharacterized protein
Gene product:
hypothetical protein, conserved
Species:
Leishmania donovani
UniProt:
A0A3S7X9B2_LEIDO
TriTrypDb:
LdBPK_352480.1 * , LdCL_350029700 , LDHU3_35.3190
Length:
783

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 5
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 2, no: 1
NetGPI no yes: 0, no: 3
Cellular components
Term Name Level Count
GO:0016020 membrane 2 2
GO:0110165 cellular anatomical entity 1 2

Expansion

Sequence features

A0A3S7X9B2
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7X9B2

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 133 137 PF00656 0.750
CLV_C14_Caspase3-7 387 391 PF00656 0.778
CLV_C14_Caspase3-7 44 48 PF00656 0.479
CLV_C14_Caspase3-7 542 546 PF00656 0.751
CLV_C14_Caspase3-7 638 642 PF00656 0.716
CLV_NRD_NRD_1 152 154 PF00675 0.531
CLV_NRD_NRD_1 225 227 PF00675 0.602
CLV_NRD_NRD_1 305 307 PF00675 0.571
CLV_NRD_NRD_1 411 413 PF00675 0.548
CLV_NRD_NRD_1 571 573 PF00675 0.577
CLV_NRD_NRD_1 574 576 PF00675 0.546
CLV_PCSK_FUR_1 303 307 PF00082 0.566
CLV_PCSK_FUR_1 572 576 PF00082 0.641
CLV_PCSK_KEX2_1 152 154 PF00082 0.531
CLV_PCSK_KEX2_1 224 226 PF00082 0.601
CLV_PCSK_KEX2_1 305 307 PF00082 0.571
CLV_PCSK_KEX2_1 411 413 PF00082 0.548
CLV_PCSK_KEX2_1 573 575 PF00082 0.565
CLV_PCSK_PC1ET2_1 573 575 PF00082 0.648
CLV_PCSK_SKI1_1 153 157 PF00082 0.535
CLV_PCSK_SKI1_1 323 327 PF00082 0.578
CLV_PCSK_SKI1_1 433 437 PF00082 0.541
CLV_PCSK_SKI1_1 519 523 PF00082 0.640
CLV_PCSK_SKI1_1 664 668 PF00082 0.594
CLV_PCSK_SKI1_1 752 756 PF00082 0.577
CLV_PCSK_SKI1_1 762 766 PF00082 0.475
CLV_PCSK_SKI1_1 770 774 PF00082 0.510
CLV_PCSK_SKI1_1 89 93 PF00082 0.630
DEG_APCC_DBOX_1 376 384 PF00400 0.778
DEG_APCC_DBOX_1 432 440 PF00400 0.742
DEG_SCF_FBW7_1 699 705 PF00400 0.777
DEG_SCF_FBW7_2 666 671 PF00400 0.778
DEG_SPOP_SBC_1 609 613 PF00917 0.798
DOC_CDC14_PxL_1 13 21 PF14671 0.415
DOC_CKS1_1 554 559 PF01111 0.758
DOC_CKS1_1 590 595 PF01111 0.652
DOC_CKS1_1 699 704 PF01111 0.775
DOC_MAPK_gen_1 224 232 PF00069 0.789
DOC_PP2B_LxvP_1 490 493 PF13499 0.758
DOC_PP2B_LxvP_1 510 513 PF13499 0.614
DOC_PP2B_LxvP_1 607 610 PF13499 0.837
DOC_USP7_MATH_1 107 111 PF00917 0.415
DOC_USP7_MATH_1 142 146 PF00917 0.719
DOC_USP7_MATH_1 148 152 PF00917 0.677
DOC_USP7_MATH_1 176 180 PF00917 0.836
DOC_USP7_MATH_1 2 6 PF00917 0.415
DOC_USP7_MATH_1 217 221 PF00917 0.776
DOC_USP7_MATH_1 260 264 PF00917 0.768
DOC_USP7_MATH_1 370 374 PF00917 0.829
DOC_USP7_MATH_1 50 54 PF00917 0.543
DOC_USP7_MATH_1 610 614 PF00917 0.723
DOC_USP7_MATH_1 64 68 PF00917 0.470
DOC_USP7_MATH_1 686 690 PF00917 0.801
DOC_USP7_MATH_1 691 695 PF00917 0.743
DOC_USP7_MATH_1 73 77 PF00917 0.464
DOC_USP7_MATH_2 493 499 PF00917 0.774
DOC_WW_Pin1_4 252 257 PF00397 0.786
DOC_WW_Pin1_4 333 338 PF00397 0.839
DOC_WW_Pin1_4 37 42 PF00397 0.558
DOC_WW_Pin1_4 396 401 PF00397 0.800
DOC_WW_Pin1_4 500 505 PF00397 0.777
DOC_WW_Pin1_4 513 518 PF00397 0.656
DOC_WW_Pin1_4 553 558 PF00397 0.760
DOC_WW_Pin1_4 589 594 PF00397 0.652
DOC_WW_Pin1_4 605 610 PF00397 0.735
DOC_WW_Pin1_4 664 669 PF00397 0.773
DOC_WW_Pin1_4 676 681 PF00397 0.678
DOC_WW_Pin1_4 698 703 PF00397 0.818
DOC_WW_Pin1_4 711 716 PF00397 0.715
DOC_WW_Pin1_4 742 747 PF00397 0.767
LIG_14-3-3_CanoR_1 261 267 PF00244 0.856
LIG_14-3-3_CanoR_1 411 420 PF00244 0.740
LIG_14-3-3_CanoR_1 572 582 PF00244 0.749
LIG_14-3-3_CanoR_1 72 78 PF00244 0.488
LIG_14-3-3_CanoR_1 89 95 PF00244 0.316
LIG_BIR_III_4 390 394 PF00653 0.692
LIG_BRCT_BRCA1_1 651 655 PF00533 0.757
LIG_BRCT_BRCA1_1 87 91 PF00533 0.357
LIG_CtBP_PxDLS_1 568 572 PF00389 0.671
LIG_FHA_1 119 125 PF00498 0.659
LIG_FHA_1 20 26 PF00498 0.467
LIG_FHA_1 344 350 PF00498 0.745
LIG_FHA_1 516 522 PF00498 0.727
LIG_FHA_1 523 529 PF00498 0.744
LIG_FHA_1 554 560 PF00498 0.836
LIG_FHA_1 590 596 PF00498 0.748
LIG_FHA_1 622 628 PF00498 0.682
LIG_FHA_1 677 683 PF00498 0.721
LIG_FHA_1 699 705 PF00498 0.850
LIG_FHA_1 761 767 PF00498 0.744
LIG_FHA_1 777 783 PF00498 0.631
LIG_FHA_2 283 289 PF00498 0.829
LIG_FHA_2 385 391 PF00498 0.779
LIG_Integrin_RGD_1 341 343 PF01839 0.554
LIG_LIR_Apic_2 486 492 PF02991 0.661
LIG_LIR_Apic_2 576 582 PF02991 0.834
LIG_LIR_Apic_2 768 774 PF02991 0.796
LIG_LIR_Apic_2 93 97 PF02991 0.280
LIG_LIR_Gen_1 138 148 PF02991 0.622
LIG_LIR_Gen_1 76 86 PF02991 0.484
LIG_LIR_Nem_3 138 143 PF02991 0.653
LIG_LIR_Nem_3 581 586 PF02991 0.828
LIG_LIR_Nem_3 76 81 PF02991 0.555
LIG_LIR_Nem_3 88 94 PF02991 0.292
LIG_MYND_1 585 589 PF01753 0.829
LIG_Pex14_2 351 355 PF04695 0.826
LIG_SH2_CRK 140 144 PF00017 0.626
LIG_SH2_CRK 590 594 PF00017 0.651
LIG_SH2_CRK 94 98 PF00017 0.280
LIG_SH2_STAP1 87 91 PF00017 0.497
LIG_SH2_STAT5 483 486 PF00017 0.752
LIG_SH2_STAT5 489 492 PF00017 0.715
LIG_SH2_STAT5 579 582 PF00017 0.754
LIG_SH3_1 579 585 PF00018 0.831
LIG_SH3_3 318 324 PF00018 0.840
LIG_SH3_3 397 403 PF00018 0.779
LIG_SH3_3 431 437 PF00018 0.818
LIG_SH3_3 465 471 PF00018 0.828
LIG_SH3_3 511 517 PF00018 0.733
LIG_SH3_3 551 557 PF00018 0.766
LIG_SH3_3 579 585 PF00018 0.831
LIG_SH3_3 696 702 PF00018 0.842
LIG_SH3_3 703 709 PF00018 0.791
LIG_SH3_3 745 751 PF00018 0.752
LIG_SH3_5 41 45 PF00018 0.551
LIG_SH3_CIN85_PxpxPR_1 256 261 PF14604 0.785
LIG_SUMO_SIM_par_1 104 110 PF11976 0.415
LIG_SUMO_SIM_par_1 16 22 PF11976 0.512
LIG_SUMO_SIM_par_1 760 768 PF11976 0.696
LIG_TRAF2_1 539 542 PF00917 0.768
LIG_TRAF2_1 672 675 PF00917 0.773
LIG_TRAF2_1 758 761 PF00917 0.792
LIG_UBA3_1 210 216 PF00899 0.676
LIG_WRC_WIRS_1 4 9 PF05994 0.523
MOD_CDC14_SPxK_1 516 519 PF00782 0.661
MOD_CDK_SPK_2 256 261 PF00069 0.785
MOD_CDK_SPxK_1 513 519 PF00069 0.661
MOD_CDK_SPxxK_3 553 560 PF00069 0.761
MOD_CDK_SPxxK_3 676 683 PF00069 0.673
MOD_CK1_1 24 30 PF00069 0.551
MOD_CK1_1 282 288 PF00069 0.846
MOD_CK1_1 297 303 PF00069 0.657
MOD_CK1_1 308 314 PF00069 0.768
MOD_CK1_1 386 392 PF00069 0.788
MOD_CK1_1 396 402 PF00069 0.741
MOD_CK1_1 407 413 PF00069 0.710
MOD_CK1_1 48 54 PF00069 0.572
MOD_CK1_1 482 488 PF00069 0.779
MOD_CK1_1 59 65 PF00069 0.521
MOD_CK1_1 605 611 PF00069 0.841
MOD_CK1_1 642 648 PF00069 0.831
MOD_CK1_1 649 655 PF00069 0.766
MOD_CK1_1 656 662 PF00069 0.682
MOD_CK1_1 68 74 PF00069 0.396
MOD_CK2_1 132 138 PF00069 0.764
MOD_CK2_1 217 223 PF00069 0.759
MOD_CK2_1 293 299 PF00069 0.774
MOD_CK2_1 361 367 PF00069 0.742
MOD_CK2_1 482 488 PF00069 0.791
MOD_CK2_1 491 497 PF00069 0.706
MOD_CK2_1 536 542 PF00069 0.715
MOD_CK2_1 669 675 PF00069 0.778
MOD_CK2_1 755 761 PF00069 0.800
MOD_DYRK1A_RPxSP_1 664 668 PF00069 0.770
MOD_GlcNHglycan 140 143 PF01048 0.564
MOD_GlcNHglycan 144 147 PF01048 0.522
MOD_GlcNHglycan 156 159 PF01048 0.498
MOD_GlcNHglycan 178 181 PF01048 0.511
MOD_GlcNHglycan 256 259 PF01048 0.638
MOD_GlcNHglycan 262 265 PF01048 0.612
MOD_GlcNHglycan 390 394 PF01048 0.492
MOD_GlcNHglycan 413 416 PF01048 0.616
MOD_GlcNHglycan 50 53 PF01048 0.784
MOD_GlcNHglycan 59 62 PF01048 0.677
MOD_GlcNHglycan 641 644 PF01048 0.570
MOD_GlcNHglycan 655 658 PF01048 0.445
MOD_GlcNHglycan 757 760 PF01048 0.419
MOD_GSK3_1 107 114 PF00069 0.306
MOD_GSK3_1 138 145 PF00069 0.654
MOD_GSK3_1 211 218 PF00069 0.772
MOD_GSK3_1 242 249 PF00069 0.862
MOD_GSK3_1 252 259 PF00069 0.748
MOD_GSK3_1 260 267 PF00069 0.648
MOD_GSK3_1 293 300 PF00069 0.780
MOD_GSK3_1 30 37 PF00069 0.617
MOD_GSK3_1 389 396 PF00069 0.804
MOD_GSK3_1 407 414 PF00069 0.619
MOD_GSK3_1 466 473 PF00069 0.827
MOD_GSK3_1 475 482 PF00069 0.730
MOD_GSK3_1 48 55 PF00069 0.442
MOD_GSK3_1 491 498 PF00069 0.686
MOD_GSK3_1 513 520 PF00069 0.758
MOD_GSK3_1 522 529 PF00069 0.695
MOD_GSK3_1 549 556 PF00069 0.713
MOD_GSK3_1 56 63 PF00069 0.529
MOD_GSK3_1 605 612 PF00069 0.756
MOD_GSK3_1 64 71 PF00069 0.433
MOD_GSK3_1 642 649 PF00069 0.811
MOD_GSK3_1 655 662 PF00069 0.681
MOD_GSK3_1 698 705 PF00069 0.762
MOD_GSK3_1 81 88 PF00069 0.409
MOD_N-GLC_1 138 143 PF02516 0.516
MOD_N-GLC_1 246 251 PF02516 0.668
MOD_N-GLC_1 351 356 PF02516 0.549
MOD_N-GLC_1 649 654 PF02516 0.601
MOD_N-GLC_1 691 696 PF02516 0.458
MOD_N-GLC_1 755 760 PF02516 0.603
MOD_NEK2_1 183 188 PF00069 0.644
MOD_NEK2_1 19 24 PF00069 0.605
MOD_NEK2_1 211 216 PF00069 0.846
MOD_NEK2_1 426 431 PF00069 0.653
MOD_NEK2_1 476 481 PF00069 0.742
MOD_NEK2_1 549 554 PF00069 0.677
MOD_NEK2_1 655 660 PF00069 0.804
MOD_NEK2_1 681 686 PF00069 0.783
MOD_NEK2_1 765 770 PF00069 0.782
MOD_NEK2_1 81 86 PF00069 0.449
MOD_NEK2_2 610 615 PF00069 0.673
MOD_PIKK_1 160 166 PF00454 0.758
MOD_PIKK_1 370 376 PF00454 0.845
MOD_PIKK_1 466 472 PF00454 0.653
MOD_PK_1 226 232 PF00069 0.787
MOD_PKA_1 305 311 PF00069 0.773
MOD_PKA_1 411 417 PF00069 0.742
MOD_PKA_1 573 579 PF00069 0.843
MOD_PKA_2 242 248 PF00069 0.775
MOD_PKA_2 260 266 PF00069 0.651
MOD_PKA_2 274 280 PF00069 0.684
MOD_PKA_2 305 311 PF00069 0.839
MOD_PKA_2 384 390 PF00069 0.778
MOD_PKA_2 410 416 PF00069 0.820
MOD_PKA_2 573 579 PF00069 0.843
MOD_PKB_1 224 232 PF00069 0.789
MOD_PKB_1 303 311 PF00069 0.770
MOD_Plk_1 138 144 PF00069 0.719
MOD_Plk_1 183 189 PF00069 0.643
MOD_Plk_1 351 357 PF00069 0.747
MOD_Plk_1 452 458 PF00069 0.835
MOD_Plk_1 536 542 PF00069 0.735
MOD_Plk_1 691 697 PF00069 0.699
MOD_Plk_1 760 766 PF00069 0.711
MOD_Plk_2-3 132 138 PF00069 0.691
MOD_Plk_2-3 21 27 PF00069 0.622
MOD_Plk_2-3 536 542 PF00069 0.715
MOD_Plk_4 3 9 PF00069 0.415
MOD_Plk_4 479 485 PF00069 0.748
MOD_Plk_4 517 523 PF00069 0.663
MOD_Plk_4 53 59 PF00069 0.501
MOD_Plk_4 602 608 PF00069 0.731
MOD_Plk_4 656 662 PF00069 0.832
MOD_Plk_4 726 732 PF00069 0.749
MOD_Plk_4 73 79 PF00069 0.455
MOD_ProDKin_1 252 258 PF00069 0.786
MOD_ProDKin_1 333 339 PF00069 0.839
MOD_ProDKin_1 37 43 PF00069 0.557
MOD_ProDKin_1 396 402 PF00069 0.799
MOD_ProDKin_1 500 506 PF00069 0.775
MOD_ProDKin_1 513 519 PF00069 0.657
MOD_ProDKin_1 553 559 PF00069 0.760
MOD_ProDKin_1 589 595 PF00069 0.652
MOD_ProDKin_1 605 611 PF00069 0.736
MOD_ProDKin_1 664 670 PF00069 0.773
MOD_ProDKin_1 676 682 PF00069 0.678
MOD_ProDKin_1 698 704 PF00069 0.822
MOD_ProDKin_1 711 717 PF00069 0.718
MOD_ProDKin_1 742 748 PF00069 0.765
MOD_SUMO_rev_2 530 540 PF00179 0.764
MOD_SUMO_rev_2 694 702 PF00179 0.754
TRG_DiLeu_BaEn_1 760 765 PF01217 0.781
TRG_DiLeu_BaLyEn_6 771 776 PF01217 0.804
TRG_ENDOCYTIC_2 140 143 PF00928 0.621
TRG_ER_diArg_1 224 226 PF00400 0.793
TRG_ER_diArg_1 571 574 PF00400 0.778
TRG_ER_diArg_1 614 617 PF00400 0.681
TRG_NLS_MonoCore_2 571 576 PF00514 0.768
TRG_NLS_MonoExtC_3 571 577 PF00514 0.766
TRG_Pf-PMV_PEXEL_1 246 251 PF00026 0.591
TRG_Pf-PMV_PEXEL_1 454 458 PF00026 0.461

Homologs

Protein Taxonomy Sequence identity Coverage
A4HMR7 Leishmania braziliensis 55% 100%
E9AF67 Leishmania major 86% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2024 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS