CS domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S7X9A9_LEIDO

TriTrypDb:

LdBPK_352570.1 , LdCL_350030600 , LDHU3_35.3320

Length:

338

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S7X9A9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7X9A9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	240	244	PF00656	0.508
CLV_NRD_NRD_1	120	122	PF00675	0.702
CLV_NRD_NRD_1	253	255	PF00675	0.515
CLV_NRD_NRD_1	296	298	PF00675	0.617
CLV_NRD_NRD_1	299	301	PF00675	0.643
CLV_NRD_NRD_1	314	316	PF00675	0.583
CLV_NRD_NRD_1	327	329	PF00675	0.440
CLV_NRD_NRD_1	331	333	PF00675	0.411
CLV_PCSK_FUR_1	297	301	PF00082	0.579
CLV_PCSK_KEX2_1	120	122	PF00082	0.739
CLV_PCSK_KEX2_1	253	255	PF00082	0.535
CLV_PCSK_KEX2_1	298	300	PF00082	0.589
CLV_PCSK_KEX2_1	326	328	PF00082	0.466
CLV_PCSK_KEX2_1	333	335	PF00082	0.491
CLV_PCSK_PC1ET2_1	298	300	PF00082	0.589
CLV_PCSK_PC1ET2_1	333	335	PF00082	0.544
CLV_PCSK_SKI1_1	175	179	PF00082	0.534
DEG_APCC_DBOX_1	252	260	PF00400	0.411
DEG_SPOP_SBC_1	185	189	PF00917	0.520
DOC_CYCLIN_yCln2_LP_2	205	208	PF00134	0.515
DOC_MAPK_FxFP_2	231	234	PF00069	0.427
DOC_MAPK_gen_1	253	263	PF00069	0.413
DOC_MAPK_MEF2A_6	253	260	PF00069	0.407
DOC_MAPK_MEF2A_6	265	272	PF00069	0.413
DOC_MAPK_NFAT4_5	253	261	PF00069	0.519
DOC_PP2B_LxvP_1	205	208	PF13499	0.417
DOC_PP4_FxxP_1	166	169	PF00568	0.425
DOC_PP4_FxxP_1	231	234	PF00568	0.427
DOC_PP4_FxxP_1	264	267	PF00568	0.512
DOC_USP7_MATH_1	218	222	PF00917	0.596
DOC_USP7_MATH_1	64	68	PF00917	0.701
DOC_USP7_MATH_2	169	175	PF00917	0.356
DOC_WW_Pin1_4	301	306	PF00397	0.675
DOC_WW_Pin1_4	35	40	PF00397	0.555
DOC_WW_Pin1_4	66	71	PF00397	0.635
DOC_WW_Pin1_4	95	100	PF00397	0.583
LIG_14-3-3_CanoR_1	186	191	PF00244	0.553
LIG_14-3-3_CanoR_1	278	288	PF00244	0.477
LIG_14-3-3_CanoR_1	49	53	PF00244	0.565
LIG_APCC_ABBA_1	261	266	PF00400	0.462
LIG_deltaCOP1_diTrp_1	243	250	PF00928	0.548
LIG_FHA_1	159	165	PF00498	0.406
LIG_FHA_1	201	207	PF00498	0.492
LIG_FHA_1	282	288	PF00498	0.462
LIG_FHA_1	289	295	PF00498	0.466
LIG_FHA_2	128	134	PF00498	0.649
LIG_FHA_2	154	160	PF00498	0.493
LIG_FHA_2	187	193	PF00498	0.652
LIG_FHA_2	40	46	PF00498	0.648
LIG_LIR_Apic_2	163	169	PF02991	0.416
LIG_LIR_Gen_1	136	143	PF02991	0.554
LIG_LIR_Nem_3	136	142	PF02991	0.505
LIG_LIR_Nem_3	178	183	PF02991	0.563
LIG_LIR_Nem_3	312	317	PF02991	0.479
LIG_LIR_Nem_3	7	12	PF02991	0.567
LIG_Pex14_1	246	250	PF04695	0.539
LIG_Pex14_1	276	280	PF04695	0.383
LIG_Pex14_2	166	170	PF04695	0.531
LIG_Pex14_2	314	318	PF04695	0.517
LIG_SH2_STAP1	139	143	PF00017	0.584
LIG_SH3_5	2	6	PF00018	0.631
LIG_SUMO_SIM_anti_2	201	206	PF11976	0.459
LIG_SUMO_SIM_par_1	158	165	PF11976	0.493
LIG_TRAF2_1	321	324	PF00917	0.477
LIG_TYR_ITIM	137	142	PF00017	0.591
MOD_CDK_SPxxK_3	301	308	PF00069	0.667
MOD_CK1_1	111	117	PF00069	0.772
MOD_CK1_1	15	21	PF00069	0.630
MOD_CK1_1	35	41	PF00069	0.655
MOD_CK1_1	48	54	PF00069	0.519
MOD_CK2_1	153	159	PF00069	0.528
MOD_CK2_1	16	22	PF00069	0.666
MOD_CK2_1	173	179	PF00069	0.544
MOD_CK2_1	186	192	PF00069	0.604
MOD_CK2_1	39	45	PF00069	0.676
MOD_CK2_1	95	101	PF00069	0.793
MOD_Cter_Amidation	118	121	PF01082	0.696
MOD_GlcNHglycan	14	17	PF01048	0.659
MOD_GlcNHglycan	144	147	PF01048	0.286
MOD_GlcNHglycan	18	21	PF01048	0.657
MOD_GlcNHglycan	212	215	PF01048	0.666
MOD_GlcNHglycan	218	221	PF01048	0.647
MOD_GlcNHglycan	66	69	PF01048	0.731
MOD_GSK3_1	10	17	PF00069	0.688
MOD_GSK3_1	107	114	PF00069	0.679
MOD_GSK3_1	138	145	PF00069	0.376
MOD_GSK3_1	158	165	PF00069	0.469
MOD_GSK3_1	169	176	PF00069	0.533
MOD_GSK3_1	186	193	PF00069	0.590
MOD_GSK3_1	212	219	PF00069	0.617
MOD_GSK3_1	279	286	PF00069	0.417
MOD_GSK3_1	35	42	PF00069	0.683
MOD_GSK3_1	78	85	PF00069	0.676
MOD_N-GLC_1	111	116	PF02516	0.770
MOD_N-GLC_1	82	87	PF02516	0.680
MOD_NEK2_1	12	17	PF00069	0.691
MOD_NEK2_1	138	143	PF00069	0.507
MOD_NEK2_1	200	205	PF00069	0.476
MOD_NEK2_1	212	217	PF00069	0.424
MOD_NEK2_1	270	275	PF00069	0.504
MOD_PIKK_1	153	159	PF00454	0.419
MOD_PIKK_1	288	294	PF00454	0.584
MOD_PK_1	173	179	PF00069	0.565
MOD_PKA_2	185	191	PF00069	0.535
MOD_PKA_2	48	54	PF00069	0.587
MOD_Plk_1	158	164	PF00069	0.533
MOD_Plk_1	200	206	PF00069	0.478
MOD_Plk_1	282	288	PF00069	0.442
MOD_Plk_4	162	168	PF00069	0.409
MOD_Plk_4	270	276	PF00069	0.452
MOD_Plk_4	283	289	PF00069	0.500
MOD_ProDKin_1	301	307	PF00069	0.667
MOD_ProDKin_1	35	41	PF00069	0.556
MOD_ProDKin_1	66	72	PF00069	0.636
MOD_ProDKin_1	95	101	PF00069	0.584
MOD_SUMO_for_1	93	96	PF00179	0.710
MOD_SUMO_rev_2	165	174	PF00179	0.343
TRG_DiLeu_BaEn_1	201	206	PF01217	0.459
TRG_DiLeu_BaLyEn_6	254	259	PF01217	0.408
TRG_ENDOCYTIC_2	139	142	PF00928	0.480
TRG_ER_diArg_1	252	254	PF00400	0.440
TRG_ER_diArg_1	297	300	PF00400	0.579
TRG_ER_diArg_1	325	328	PF00400	0.508
TRG_Pf-PMV_PEXEL_1	257	262	PF00026	0.379
TRG_Pf-PMV_PEXEL_1	334	338	PF00026	0.606

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PE56	Leptomonas seymouri	51%	100%
A0A0S4KNN3	Bodo saltans	31%	100%
A0A1X0P6G0	Trypanosomatidae	40%	100%
A0A3R7NBC1	Trypanosoma rangeli	42%	100%
A4HMS4	Leishmania braziliensis	73%	100%
A4IBG2	Leishmania infantum	99%	100%
C9ZZA2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	40%	100%
E9AF76	Leishmania major	89%	100%
E9B6D2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	100%
V5BJ90	Trypanosoma cruzi	37%	100%