DUF4205 domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Domain of unknown function (DUF4205), putative

Species:

Leishmania donovani

UniProt:

A0A3S7X9A6_LEIDO

TriTrypDb:

LdBPK_352060.1 , LdCL_350025800 , LDHU3_35.2670

Length:

704

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S7X9A6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7X9A6

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	7
GO:0004843	cysteine-type deubiquitinase activity	5	7
GO:0008233	peptidase activity	3	7
GO:0008234	cysteine-type peptidase activity	4	7
GO:0016787	hydrolase activity	2	7
GO:0019783	ubiquitin-like protein peptidase activity	4	7
GO:0101005	deubiquitinase activity	5	7
GO:0140096	catalytic activity, acting on a protein	2	7
GO:1990380	K48-linked deubiquitinase activity	6	7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	201	205	PF00656	0.755
CLV_C14_Caspase3-7	227	231	PF00656	0.679
CLV_C14_Caspase3-7	511	515	PF00656	0.521
CLV_NRD_NRD_1	138	140	PF00675	0.655
CLV_NRD_NRD_1	37	39	PF00675	0.515
CLV_NRD_NRD_1	97	99	PF00675	0.560
CLV_PCSK_KEX2_1	175	177	PF00082	0.738
CLV_PCSK_KEX2_1	37	39	PF00082	0.515
CLV_PCSK_KEX2_1	399	401	PF00082	0.436
CLV_PCSK_KEX2_1	97	99	PF00082	0.560
CLV_PCSK_PC1ET2_1	175	177	PF00082	0.705
CLV_PCSK_PC1ET2_1	399	401	PF00082	0.436
CLV_PCSK_SKI1_1	148	152	PF00082	0.706
CLV_PCSK_SKI1_1	180	184	PF00082	0.673
CLV_PCSK_SKI1_1	348	352	PF00082	0.580
CLV_PCSK_SKI1_1	38	42	PF00082	0.624
CLV_PCSK_SKI1_1	4	8	PF00082	0.675
CLV_PCSK_SKI1_1	422	426	PF00082	0.411
CLV_PCSK_SKI1_1	478	482	PF00082	0.472
CLV_PCSK_SKI1_1	540	544	PF00082	0.436
CLV_PCSK_SKI1_1	622	626	PF00082	0.411
CLV_PCSK_SKI1_1	673	677	PF00082	0.348
CLV_Separin_Metazoa	467	471	PF03568	0.389
DEG_APCC_DBOX_1	37	45	PF00400	0.621
DEG_APCC_DBOX_1	526	534	PF00400	0.513
DEG_SCF_TRCP1_1	514	519	PF00400	0.397
DEG_SPOP_SBC_1	242	246	PF00917	0.635
DEG_SPOP_SBC_1	585	589	PF00917	0.416
DOC_ANK_TNKS_1	76	83	PF00023	0.564
DOC_CDC14_PxL_1	9	17	PF14671	0.674
DOC_MAPK_MEF2A_6	517	524	PF00069	0.436
DOC_PP1_RVXF_1	538	545	PF00149	0.389
DOC_PP1_RVXF_1	656	663	PF00149	0.436
DOC_PP2B_LxvP_1	520	523	PF13499	0.513
DOC_PP2B_LxvP_1	615	618	PF13499	0.474
DOC_USP7_MATH_1	242	246	PF00917	0.795
DOC_USP7_MATH_1	303	307	PF00917	0.732
DOC_USP7_MATH_1	581	585	PF00917	0.349
DOC_USP7_MATH_1	62	66	PF00917	0.633
DOC_USP7_MATH_1	682	686	PF00917	0.381
DOC_USP7_MATH_1	688	692	PF00917	0.343
DOC_USP7_UBL2_3	140	144	PF12436	0.733
DOC_WW_Pin1_4	181	186	PF00397	0.708
DOC_WW_Pin1_4	257	262	PF00397	0.809
DOC_WW_Pin1_4	586	591	PF00397	0.513
LIG_14-3-3_CanoR_1	139	147	PF00244	0.692
LIG_14-3-3_CanoR_1	180	185	PF00244	0.840
LIG_14-3-3_CanoR_1	527	531	PF00244	0.478
LIG_14-3-3_CanoR_1	61	70	PF00244	0.641
LIG_14-3-3_CanoR_1	673	679	PF00244	0.411
LIG_Actin_WH2_2	2	18	PF00022	0.641
LIG_Actin_WH2_2	455	472	PF00022	0.436
LIG_BRCT_BRCA1_1	488	492	PF00533	0.513
LIG_BRCT_BRCA1_1	658	662	PF00533	0.513
LIG_FHA_1	464	470	PF00498	0.513
LIG_FHA_1	527	533	PF00498	0.387
LIG_FHA_1	619	625	PF00498	0.411
LIG_FHA_1	652	658	PF00498	0.459
LIG_FHA_1	99	105	PF00498	0.594
LIG_FHA_2	196	202	PF00498	0.705
LIG_FHA_2	354	360	PF00498	0.389
LIG_FHA_2	409	415	PF00498	0.411
LIG_FHA_2	644	650	PF00498	0.411
LIG_FHA_2	83	89	PF00498	0.503
LIG_GBD_Chelix_1	405	413	PF00786	0.513
LIG_GBD_Chelix_1	487	495	PF00786	0.474
LIG_LIR_Apic_2	476	482	PF02991	0.411
LIG_LIR_Gen_1	453	462	PF02991	0.393
LIG_LIR_Gen_1	489	500	PF02991	0.513
LIG_LIR_Gen_1	610	618	PF02991	0.513
LIG_LIR_Nem_3	489	495	PF02991	0.513
LIG_LIR_Nem_3	610	615	PF02991	0.513
LIG_NRBOX	490	496	PF00104	0.513
LIG_REV1ctd_RIR_1	541	549	PF16727	0.513
LIG_SH2_GRB2like	593	596	PF00017	0.513
LIG_SH2_NCK_1	593	597	PF00017	0.513
LIG_SH2_STAP1	389	393	PF00017	0.411
LIG_SH2_STAP1	557	561	PF00017	0.411
LIG_SH2_STAT5	394	397	PF00017	0.411
LIG_SH2_STAT5	439	442	PF00017	0.436
LIG_SH2_STAT5	593	596	PF00017	0.411
LIG_SH3_3	110	116	PF00018	0.658
LIG_SH3_3	179	185	PF00018	0.630
LIG_SH3_3	373	379	PF00018	0.411
LIG_SH3_3	46	52	PF00018	0.419
LIG_SH3_3	596	602	PF00018	0.396
LIG_SUMO_SIM_anti_2	636	641	PF11976	0.513
LIG_SUMO_SIM_par_1	422	428	PF11976	0.416
LIG_SUMO_SIM_par_1	646	656	PF11976	0.424
LIG_TRAF2_1	18	21	PF00917	0.487
LIG_TRAF2_1	461	464	PF00917	0.389
LIG_WRC_WIRS_1	487	492	PF05994	0.513
MOD_CK1_1	171	177	PF00069	0.728
MOD_CK1_1	181	187	PF00069	0.775
MOD_CK1_1	206	212	PF00069	0.732
MOD_CK1_1	228	234	PF00069	0.742
MOD_CK1_1	241	247	PF00069	0.823
MOD_CK1_1	276	282	PF00069	0.769
MOD_CK1_1	437	443	PF00069	0.443
MOD_CK1_1	584	590	PF00069	0.434
MOD_CK2_1	252	258	PF00069	0.681
MOD_CK2_1	290	296	PF00069	0.769
MOD_CK2_1	408	414	PF00069	0.362
MOD_CK2_1	458	464	PF00069	0.389
MOD_CK2_1	643	649	PF00069	0.436
MOD_CK2_1	82	88	PF00069	0.517
MOD_CMANNOS	604	607	PF00535	0.513
MOD_GlcNHglycan	151	154	PF01048	0.757
MOD_GlcNHglycan	185	188	PF01048	0.821
MOD_GlcNHglycan	240	243	PF01048	0.845
MOD_GlcNHglycan	514	517	PF01048	0.410
MOD_GlcNHglycan	524	527	PF01048	0.303
MOD_GlcNHglycan	569	572	PF01048	0.388
MOD_GlcNHglycan	583	586	PF01048	0.306
MOD_GlcNHglycan	665	668	PF01048	0.364
MOD_GlcNHglycan	690	693	PF01048	0.384
MOD_GSK3_1	202	209	PF00069	0.730
MOD_GSK3_1	224	231	PF00069	0.722
MOD_GSK3_1	238	245	PF00069	0.831
MOD_GSK3_1	425	432	PF00069	0.436
MOD_GSK3_1	486	493	PF00069	0.515
MOD_GSK3_1	505	512	PF00069	0.279
MOD_GSK3_1	522	529	PF00069	0.478
MOD_GSK3_1	581	588	PF00069	0.437
MOD_GSK3_1	674	681	PF00069	0.411
MOD_N-GLC_1	168	173	PF02516	0.671
MOD_N-GLC_1	594	599	PF02516	0.513
MOD_N-GLC_1	633	638	PF02516	0.455
MOD_NEK2_1	202	207	PF00069	0.703
MOD_NEK2_1	252	257	PF00069	0.826
MOD_NEK2_1	342	347	PF00069	0.509
MOD_NEK2_1	40	45	PF00069	0.521
MOD_NEK2_1	425	430	PF00069	0.485
MOD_NEK2_1	469	474	PF00069	0.389
MOD_NEK2_1	490	495	PF00069	0.393
MOD_NEK2_1	535	540	PF00069	0.411
MOD_NEK2_1	591	596	PF00069	0.513
MOD_NEK2_1	653	658	PF00069	0.408
MOD_NEK2_1	678	683	PF00069	0.404
MOD_PIKK_1	260	266	PF00454	0.691
MOD_PKA_1	139	145	PF00069	0.679
MOD_PKA_2	171	177	PF00069	0.780
MOD_PKA_2	290	296	PF00069	0.769
MOD_PKA_2	437	443	PF00069	0.383
MOD_PKA_2	469	475	PF00069	0.411
MOD_PKA_2	516	522	PF00069	0.363
MOD_PKA_2	526	532	PF00069	0.461
MOD_PKA_2	608	614	PF00069	0.513
MOD_Plk_1	633	639	PF00069	0.455
MOD_Plk_2-3	309	315	PF00069	0.681
MOD_Plk_2-3	643	649	PF00069	0.411
MOD_Plk_4	273	279	PF00069	0.593
MOD_Plk_4	425	431	PF00069	0.500
MOD_Plk_4	469	475	PF00069	0.411
MOD_Plk_4	486	492	PF00069	0.411
MOD_Plk_4	516	522	PF00069	0.416
MOD_Plk_4	600	606	PF00069	0.411
MOD_Plk_4	674	680	PF00069	0.411
MOD_Plk_4	82	88	PF00069	0.502
MOD_ProDKin_1	181	187	PF00069	0.709
MOD_ProDKin_1	257	263	PF00069	0.808
MOD_ProDKin_1	586	592	PF00069	0.513
MOD_SUMO_for_1	78	81	PF00179	0.567
TRG_DiLeu_BaEn_1	100	105	PF01217	0.593
TRG_DiLeu_BaEn_1	21	26	PF01217	0.514
TRG_DiLeu_LyEn_5	100	105	PF01217	0.554
TRG_ENDOCYTIC_2	119	122	PF00928	0.619
TRG_ER_diArg_1	451	454	PF00400	0.443
TRG_ER_diArg_1	97	99	PF00400	0.560
TRG_NES_CRM1_1	84	96	PF08389	0.514
TRG_NLS_MonoCore_2	144	149	PF00514	0.688
TRG_NLS_MonoExtC_3	143	148	PF00514	0.680
TRG_NLS_MonoExtN_4	144	149	PF00514	0.692
TRG_Pf-PMV_PEXEL_1	103	107	PF00026	0.580
TRG_Pf-PMV_PEXEL_1	61	66	PF00026	0.633
TRG_Pf-PMV_PEXEL_1	622	626	PF00026	0.513
TRG_Pf-PMV_PEXEL_1	97	102	PF00026	0.561

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1ILT4	Leptomonas seymouri	54%	100%
A4HMM7	Leishmania braziliensis	78%	100%
A4IBA5	Leishmania infantum	99%	100%
E9AF29	Leishmania major	92%	100%
E9B685	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	100%