DUF3421 domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S7X999_LEIDO

TriTrypDb:

LdBPK_352330.1 , LdCL_350028200 , LDHU3_35.2970

Length:

465

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S7X999

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7X999

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	252	256	PF00656	0.402
CLV_NRD_NRD_1	442	444	PF00675	0.386
CLV_PCSK_KEX2_1	130	132	PF00082	0.567
CLV_PCSK_PC1ET2_1	130	132	PF00082	0.567
CLV_PCSK_SKI1_1	264	268	PF00082	0.459
CLV_PCSK_SKI1_1	444	448	PF00082	0.449
CLV_PCSK_SKI1_1	49	53	PF00082	0.715
DEG_Nend_Nbox_1	1	3	PF02207	0.762
DEG_SPOP_SBC_1	27	31	PF00917	0.801
DOC_CKS1_1	55	60	PF01111	0.612
DOC_CYCLIN_RxL_1	441	451	PF00134	0.337
DOC_CYCLIN_yClb5_NLxxxL_5	117	125	PF00134	0.511
DOC_CYCLIN_yCln2_LP_2	298	304	PF00134	0.507
DOC_CYCLIN_yCln2_LP_2	446	452	PF00134	0.438
DOC_MAPK_gen_1	272	281	PF00069	0.363
DOC_MAPK_gen_1	296	302	PF00069	0.440
DOC_MAPK_gen_1	453	461	PF00069	0.488
DOC_MAPK_MEF2A_6	272	281	PF00069	0.391
DOC_MAPK_MEF2A_6	327	334	PF00069	0.443
DOC_MAPK_MEF2A_6	342	349	PF00069	0.368
DOC_PP1_RVXF_1	184	191	PF00149	0.442
DOC_PP2B_LxvP_1	182	185	PF13499	0.477
DOC_PP2B_LxvP_1	298	301	PF13499	0.549
DOC_PP4_FxxP_1	375	378	PF00568	0.374
DOC_PP4_FxxP_1	55	58	PF00568	0.597
DOC_PP4_FxxP_1	85	88	PF00568	0.449
DOC_USP7_MATH_1	18	22	PF00917	0.787
DOC_USP7_MATH_1	26	30	PF00917	0.762
DOC_USP7_MATH_1	448	452	PF00917	0.515
DOC_WW_Pin1_4	54	59	PF00397	0.619
LIG_APCC_ABBA_1	347	352	PF00400	0.432
LIG_BIR_III_4	25	29	PF00653	0.811
LIG_BRCT_BRCA1_1	215	219	PF00533	0.509
LIG_deltaCOP1_diTrp_1	220	227	PF00928	0.397
LIG_deltaCOP1_diTrp_1	388	393	PF00928	0.452
LIG_FHA_1	104	110	PF00498	0.533
LIG_FHA_1	248	254	PF00498	0.394
LIG_FHA_1	293	299	PF00498	0.426
LIG_FHA_1	358	364	PF00498	0.402
LIG_FHA_1	398	404	PF00498	0.456
LIG_FHA_1	437	443	PF00498	0.435
LIG_FHA_1	82	88	PF00498	0.444
LIG_FHA_2	216	222	PF00498	0.416
LIG_FHA_2	64	70	PF00498	0.641
LIG_IBAR_NPY_1	312	314	PF08397	0.426
LIG_LIR_Apic_2	54	58	PF02991	0.659
LIG_LIR_Apic_2	84	88	PF02991	0.454
LIG_LIR_Gen_1	116	125	PF02991	0.567
LIG_LIR_Gen_1	159	168	PF02991	0.404
LIG_LIR_Gen_1	220	230	PF02991	0.377
LIG_LIR_Gen_1	235	244	PF02991	0.351
LIG_LIR_Gen_1	371	378	PF02991	0.371
LIG_LIR_Gen_1	71	80	PF02991	0.522
LIG_LIR_Gen_1	99	109	PF02991	0.429
LIG_LIR_Nem_3	116	121	PF02991	0.571
LIG_LIR_Nem_3	159	163	PF02991	0.400
LIG_LIR_Nem_3	220	226	PF02991	0.369
LIG_LIR_Nem_3	285	291	PF02991	0.414
LIG_LIR_Nem_3	371	377	PF02991	0.367
LIG_LIR_Nem_3	388	393	PF02991	0.338
LIG_LIR_Nem_3	409	414	PF02991	0.408
LIG_LIR_Nem_3	71	77	PF02991	0.544
LIG_LIR_Nem_3	99	105	PF02991	0.430
LIG_PCNA_yPIPBox_3	364	373	PF02747	0.473
LIG_PCNA_yPIPBox_3	435	444	PF02747	0.389
LIG_Pex14_1	222	226	PF04695	0.388
LIG_PTB_Apo_2	107	114	PF02174	0.482
LIG_SH2_CRK	74	78	PF00017	0.592
LIG_SH2_NCK_1	160	164	PF00017	0.416
LIG_SH2_NCK_1	74	78	PF00017	0.551
LIG_SH2_SRC	160	163	PF00017	0.396
LIG_SH2_SRC	343	346	PF00017	0.368
LIG_SH2_STAP1	144	148	PF00017	0.366
LIG_SH2_STAP1	175	179	PF00017	0.376
LIG_SH2_STAP1	249	253	PF00017	0.484
LIG_SH2_STAP1	83	87	PF00017	0.469
LIG_SH2_STAT5	223	226	PF00017	0.396
LIG_SH2_STAT5	238	241	PF00017	0.441
LIG_SH2_STAT5	249	252	PF00017	0.419
LIG_SH2_STAT5	260	263	PF00017	0.311
LIG_SH2_STAT5	314	317	PF00017	0.432
LIG_SH2_STAT5	372	375	PF00017	0.355
LIG_SH2_STAT5	381	384	PF00017	0.383
LIG_SH2_STAT5	392	395	PF00017	0.259
LIG_SH2_STAT5	65	68	PF00017	0.689
LIG_SH2_STAT5	83	86	PF00017	0.295
LIG_SH3_3	411	417	PF00018	0.454
LIG_SH3_3	442	448	PF00018	0.397
LIG_TRAF2_1	218	221	PF00917	0.400
LIG_TRAF2_1	66	69	PF00917	0.562
LIG_TYR_ITIM	158	163	PF00017	0.412
LIG_UBA3_1	315	322	PF00899	0.444
LIG_WRC_WIRS_1	175	180	PF05994	0.234
MOD_CK1_1	29	35	PF00069	0.726
MOD_CK2_1	193	199	PF00069	0.574
MOD_CK2_1	215	221	PF00069	0.379
MOD_CK2_1	253	259	PF00069	0.269
MOD_CK2_1	365	371	PF00069	0.408
MOD_CK2_1	377	383	PF00069	0.370
MOD_CK2_1	44	50	PF00069	0.771
MOD_CK2_1	63	69	PF00069	0.514
MOD_CMANNOS	387	390	PF00535	0.370
MOD_GlcNHglycan	22	25	PF01048	0.756
MOD_GlcNHglycan	274	277	PF01048	0.396
MOD_GlcNHglycan	45	49	PF01048	0.591
MOD_GSK3_1	1	8	PF00069	0.733
MOD_GSK3_1	174	181	PF00069	0.450
MOD_GSK3_1	243	250	PF00069	0.417
MOD_GSK3_1	64	71	PF00069	0.693
MOD_GSK3_1	72	79	PF00069	0.675
MOD_N-GLC_1	292	297	PF02516	0.402
MOD_NEK2_1	113	118	PF00069	0.531
MOD_NEK2_1	178	183	PF00069	0.528
MOD_NEK2_1	253	258	PF00069	0.392
MOD_NEK2_1	292	297	PF00069	0.456
MOD_NEK2_2	448	453	PF00069	0.341
MOD_PIKK_1	100	106	PF00454	0.564
MOD_PKA_2	397	403	PF00069	0.568
MOD_PKA_2	43	49	PF00069	0.778
MOD_PKB_1	42	50	PF00069	0.719
MOD_Plk_1	113	119	PF00069	0.613
MOD_Plk_1	199	205	PF00069	0.473
MOD_Plk_1	213	219	PF00069	0.367
MOD_Plk_4	174	180	PF00069	0.490
MOD_Plk_4	243	249	PF00069	0.394
MOD_Plk_4	343	349	PF00069	0.412
MOD_Plk_4	56	62	PF00069	0.650
MOD_ProDKin_1	54	60	PF00069	0.616
MOD_SUMO_for_1	111	114	PF00179	0.560
MOD_SUMO_rev_2	45	54	PF00179	0.569
MOD_SUMO_rev_2	95	103	PF00179	0.434
TRG_DiLeu_BaEn_1	263	268	PF01217	0.510
TRG_DiLeu_BaLyEn_6	442	447	PF01217	0.500
TRG_ENDOCYTIC_2	144	147	PF00928	0.404
TRG_ENDOCYTIC_2	160	163	PF00928	0.346
TRG_ENDOCYTIC_2	175	178	PF00928	0.365
TRG_ENDOCYTIC_2	223	226	PF00928	0.376
TRG_ENDOCYTIC_2	230	233	PF00928	0.374
TRG_ENDOCYTIC_2	238	241	PF00928	0.359
TRG_ENDOCYTIC_2	314	317	PF00928	0.432
TRG_ENDOCYTIC_2	372	375	PF00928	0.366
TRG_ENDOCYTIC_2	74	77	PF00928	0.546
TRG_Pf-PMV_PEXEL_1	251	255	PF00026	0.343

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P8S2	Leptomonas seymouri	86%	100%
A0A0S4JF65	Bodo saltans	57%	100%
A0A1X0P745	Trypanosomatidae	71%	100%
A0A3R7NH73	Trypanosoma rangeli	70%	100%
A4HMQ2	Leishmania braziliensis	88%	100%
A4IBC0	Leishmania infantum	100%	100%
C9ZZC8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	70%	100%
E9AF52	Leishmania major	95%	100%
E9B6A8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	94%	100%
V5BNX6	Trypanosoma cruzi	70%	100%