Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S7X993_LEIDO

TriTrypDb:

LdBPK_352280.1 , LdCL_350027700 , LDHU3_35.2910

Length:

291

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	yes	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S7X993

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7X993

PDB structure(s): 7ane_ao

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	140	144	PF00656	0.354
CLV_C14_Caspase3-7	262	266	PF00656	0.519
CLV_NRD_NRD_1	259	261	PF00675	0.376
CLV_NRD_NRD_1	29	31	PF00675	0.382
CLV_PCSK_KEX2_1	191	193	PF00082	0.558
CLV_PCSK_KEX2_1	259	261	PF00082	0.376
CLV_PCSK_KEX2_1	29	31	PF00082	0.365
CLV_PCSK_PC1ET2_1	191	193	PF00082	0.405
CLV_PCSK_PC7_1	255	261	PF00082	0.359
CLV_PCSK_SKI1_1	213	217	PF00082	0.349
CLV_PCSK_SKI1_1	62	66	PF00082	0.521
DEG_Nend_Nbox_1	1	3	PF02207	0.521
DOC_CYCLIN_yCln2_LP_2	38	44	PF00134	0.456
DOC_MAPK_gen_1	11	19	PF00069	0.423
DOC_MAPK_gen_1	26	34	PF00069	0.384
DOC_MAPK_MEF2A_6	110	118	PF00069	0.434
DOC_PP4_FxxP_1	131	134	PF00568	0.317
DOC_PP4_FxxP_1	286	289	PF00568	0.384
DOC_USP7_MATH_1	175	179	PF00917	0.558
DOC_USP7_MATH_1	269	273	PF00917	0.415
DOC_WW_Pin1_4	199	204	PF00397	0.351
DOC_WW_Pin1_4	273	278	PF00397	0.374
DOC_WW_Pin1_4	83	88	PF00397	0.640
LIG_14-3-3_CanoR_1	241	249	PF00244	0.333
LIG_BRCT_BRCA1_1	4	8	PF00533	0.504
LIG_FHA_1	2	8	PF00498	0.446
LIG_FHA_1	225	231	PF00498	0.357
LIG_FHA_1	43	49	PF00498	0.347
LIG_FHA_1	59	65	PF00498	0.360
LIG_FHA_1	84	90	PF00498	0.726
LIG_FHA_2	138	144	PF00498	0.449
LIG_LIR_Apic_2	283	289	PF02991	0.403
LIG_LIR_Apic_2	71	77	PF02991	0.379
LIG_LIR_Gen_1	159	169	PF02991	0.355
LIG_LIR_Nem_3	159	164	PF02991	0.347
LIG_LIR_Nem_3	16	21	PF02991	0.320
LIG_LIR_Nem_3	227	232	PF02991	0.510
LIG_LRP6_Inhibitor_1	104	110	PF00058	0.401
LIG_PTB_Apo_2	125	132	PF02174	0.301
LIG_SH2_CRK	171	175	PF00017	0.377
LIG_SH2_CRK	74	78	PF00017	0.450
LIG_SH2_NCK_1	74	78	PF00017	0.459
LIG_SH2_STAP1	79	83	PF00017	0.389
LIG_SH2_STAT5	117	120	PF00017	0.316
LIG_SH2_STAT5	18	21	PF00017	0.327
LIG_SH2_STAT5	248	251	PF00017	0.346
LIG_SH3_3	123	129	PF00018	0.314
LIG_SH3_3	200	206	PF00018	0.348
LIG_SH3_3	38	44	PF00018	0.512
LIG_TYR_ITIM	169	174	PF00017	0.358
MOD_CK1_1	243	249	PF00069	0.362
MOD_CK2_1	139	145	PF00069	0.491
MOD_CK2_1	175	181	PF00069	0.466
MOD_GlcNHglycan	235	238	PF01048	0.368
MOD_GSK3_1	269	276	PF00069	0.360
MOD_GSK3_1	58	65	PF00069	0.432
MOD_GSK3_1	77	84	PF00069	0.589
MOD_N-GLC_1	77	82	PF02516	0.402
MOD_NEK2_1	1	6	PF00069	0.508
MOD_NEK2_1	116	121	PF00069	0.320
MOD_NEK2_1	169	174	PF00069	0.417
MOD_NEK2_2	254	259	PF00069	0.350
MOD_PIKK_1	137	143	PF00454	0.514
MOD_PIKK_1	235	241	PF00454	0.362
MOD_PKA_2	2	8	PF00069	0.427
MOD_PKA_2	240	246	PF00069	0.337
MOD_PKA_2	254	260	PF00069	0.353
MOD_PKA_2	28	34	PF00069	0.372
MOD_PKA_2	81	87	PF00069	0.610
MOD_Plk_1	282	288	PF00069	0.486
MOD_Plk_4	13	19	PF00069	0.492
MOD_Plk_4	156	162	PF00069	0.354
MOD_Plk_4	43	49	PF00069	0.347
MOD_ProDKin_1	199	205	PF00069	0.349
MOD_ProDKin_1	273	279	PF00069	0.370
MOD_ProDKin_1	83	89	PF00069	0.642
MOD_SUMO_rev_2	16	24	PF00179	0.323
TRG_DiLeu_BaLyEn_6	38	43	PF01217	0.494
TRG_DiLeu_BaLyEn_6	59	64	PF01217	0.509
TRG_ENDOCYTIC_2	161	164	PF00928	0.389
TRG_ENDOCYTIC_2	171	174	PF00928	0.324
TRG_ENDOCYTIC_2	21	24	PF00928	0.348
TRG_ENDOCYTIC_2	214	217	PF00928	0.370
TRG_ER_diArg_1	211	214	PF00400	0.374
TRG_ER_diArg_1	258	260	PF00400	0.364

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P378	Leptomonas seymouri	81%	100%
A0A0S4JD50	Bodo saltans	57%	100%
A0A1X0P6P5	Trypanosomatidae	71%	100%
A0A422MYC0	Trypanosoma rangeli	67%	100%
A4HMP6	Leishmania braziliensis	92%	100%
A4IBB5	Leishmania infantum	99%	100%
C9ZZD8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	65%	99%
E9AF47	Leishmania major	96%	100%
E9B6A3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	97%	100%
V5BTH8	Trypanosoma cruzi	69%	100%