Short_chain_dehydrogenase_putative/Pfam:PF00106

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

short chain dehydrogenase, putative

Species:

Leishmania donovani

UniProt:

A0A3S7X986_LEIDO

TriTrypDb:

LdBPK_352210.1 , LdCL_350027000 , LDHU3_35.2820

Length:

484

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 27
NetGPI	no	yes: 0, no: 27

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	11
GO:0110165	cellular anatomical entity	1	12
GO:0005737	cytoplasm	2	1
GO:0005739	mitochondrion	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1

Expansion

Sequence features

A0A3S7X986

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7X986

Function

Biological processes
Term	Name	Level	Count
GO:0006082	organic acid metabolic process	3	1
GO:0006629	lipid metabolic process	3	1
GO:0006631	fatty acid metabolic process	4	1
GO:0006633	fatty acid biosynthetic process	5	1
GO:0008152	metabolic process	1	1
GO:0008610	lipid biosynthetic process	4	1
GO:0009058	biosynthetic process	2	1
GO:0009987	cellular process	1	1
GO:0016053	organic acid biosynthetic process	4	1
GO:0019752	carboxylic acid metabolic process	5	1
GO:0030497	fatty acid elongation	6	1
GO:0032787	monocarboxylic acid metabolic process	6	1
GO:0043436	oxoacid metabolic process	4	1
GO:0044237	cellular metabolic process	2	1
GO:0044238	primary metabolic process	2	1
GO:0044249	cellular biosynthetic process	3	1
GO:0044255	cellular lipid metabolic process	3	1
GO:0044281	small molecule metabolic process	2	1
GO:0044283	small molecule biosynthetic process	3	1
GO:0046394	carboxylic acid biosynthetic process	5	1
GO:0071704	organic substance metabolic process	2	1
GO:0072330	monocarboxylic acid biosynthetic process	6	1
GO:1901576	organic substance biosynthetic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	3
GO:0004312	fatty acid synthase activity	5	2
GO:0004316	3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity	5	2
GO:0016491	oxidoreductase activity	2	3
GO:0016614	oxidoreductase activity, acting on CH-OH group of donors	3	2
GO:0016616	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor	4	2
GO:0016740	transferase activity	2	2
GO:0016746	acyltransferase activity	3	2
GO:0016747	acyltransferase activity, transferring groups other than amino-acyl groups	4	2
GO:0008667	2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase activity	5	1
GO:0016627	oxidoreductase activity, acting on the CH-CH group of donors	3	1
GO:0016628	oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor	4	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	343	347	PF00656	0.789
CLV_NRD_NRD_1	335	337	PF00675	0.567
CLV_PCSK_SKI1_1	107	111	PF00082	0.329
CLV_PCSK_SKI1_1	381	385	PF00082	0.327
CLV_PCSK_SKI1_1	72	76	PF00082	0.253
DEG_Nend_Nbox_1	1	3	PF02207	0.525
DOC_CDC14_PxL_1	392	400	PF14671	0.265
DOC_CYCLIN_RxL_1	167	177	PF00134	0.505
DOC_MAPK_FxFP_2	393	396	PF00069	0.399
DOC_MAPK_MEF2A_6	153	162	PF00069	0.435
DOC_MAPK_MEF2A_6	359	367	PF00069	0.624
DOC_PP1_RVXF_1	105	111	PF00149	0.418
DOC_PP1_RVXF_1	168	175	PF00149	0.497
DOC_PP2B_LxvP_1	215	218	PF13499	0.455
DOC_PP4_FxxP_1	243	246	PF00568	0.479
DOC_PP4_FxxP_1	393	396	PF00568	0.364
DOC_USP7_MATH_1	11	15	PF00917	0.319
DOC_USP7_MATH_1	124	128	PF00917	0.430
DOC_USP7_MATH_1	189	193	PF00917	0.418
DOC_USP7_MATH_1	194	198	PF00917	0.402
DOC_USP7_UBL2_3	121	125	PF12436	0.523
DOC_USP7_UBL2_3	327	331	PF12436	0.705
DOC_USP7_UBL2_3	337	341	PF12436	0.559
DOC_WW_Pin1_4	329	334	PF00397	0.738
DOC_WW_Pin1_4	351	356	PF00397	0.712
DOC_WW_Pin1_4	461	466	PF00397	0.387
LIG_14-3-3_CanoR_1	103	110	PF00244	0.438
LIG_14-3-3_CanoR_1	193	199	PF00244	0.583
LIG_14-3-3_CanoR_1	317	323	PF00244	0.537
LIG_Actin_WH2_2	168	184	PF00022	0.543
LIG_BRCT_BRCA1_1	396	400	PF00533	0.441
LIG_BRCT_BRCA1_1	46	50	PF00533	0.330
LIG_BRCT_BRCA1_2	396	402	PF00533	0.455
LIG_DCNL_PONY_1	1	4	PF03556	0.528
LIG_deltaCOP1_diTrp_1	291	297	PF00928	0.607
LIG_eIF4E_1	210	216	PF01652	0.418
LIG_FHA_1	103	109	PF00498	0.555
LIG_FHA_1	131	137	PF00498	0.458
LIG_FHA_1	228	234	PF00498	0.543
LIG_FHA_1	310	316	PF00498	0.449
LIG_FHA_1	330	336	PF00498	0.548
LIG_FHA_1	346	352	PF00498	0.627
LIG_FHA_1	374	380	PF00498	0.509
LIG_FHA_1	417	423	PF00498	0.369
LIG_FHA_1	462	468	PF00498	0.406
LIG_FHA_1	68	74	PF00498	0.550
LIG_FHA_1	78	84	PF00498	0.540
LIG_FHA_1	95	101	PF00498	0.480
LIG_FHA_2	341	347	PF00498	0.616
LIG_FHA_2	401	407	PF00498	0.345
LIG_LIR_Apic_2	242	246	PF02991	0.482
LIG_LIR_Apic_2	390	396	PF02991	0.432
LIG_LIR_Gen_1	291	301	PF02991	0.509
LIG_LIR_Gen_1	93	102	PF02991	0.569
LIG_LIR_Nem_3	291	297	PF02991	0.527
LIG_LIR_Nem_3	377	383	PF02991	0.533
LIG_LIR_Nem_3	390	395	PF02991	0.368
LIG_LIR_Nem_3	93	99	PF02991	0.492
LIG_LYPXL_yS_3	395	398	PF13949	0.260
LIG_PCNA_yPIPBox_3	34	42	PF02747	0.190
LIG_Pex14_1	387	391	PF04695	0.243
LIG_Pex14_2	400	404	PF04695	0.324
LIG_SH2_STAP1	85	89	PF00017	0.446
LIG_SH2_STAT5	145	148	PF00017	0.543
LIG_SH2_STAT5	210	213	PF00017	0.522
LIG_SH2_STAT5	26	29	PF00017	0.381
LIG_SH2_STAT5	288	291	PF00017	0.606
LIG_SH2_STAT5	378	381	PF00017	0.604
LIG_SH2_STAT5	391	394	PF00017	0.323
LIG_SH2_STAT5	427	430	PF00017	0.331
LIG_SH2_STAT5	69	72	PF00017	0.627
LIG_SH3_4	337	344	PF00018	0.589
LIG_SUMO_SIM_par_1	132	139	PF11976	0.418
LIG_TYR_ITIM	298	303	PF00017	0.288
MOD_CDK_SPxxK_3	329	336	PF00069	0.694
MOD_CDK_SPxxK_3	461	468	PF00069	0.314
MOD_CK1_1	111	117	PF00069	0.306
MOD_CK1_1	138	144	PF00069	0.369
MOD_CK1_1	228	234	PF00069	0.304
MOD_CK1_1	239	245	PF00069	0.349
MOD_CK1_1	347	353	PF00069	0.691
MOD_CK1_1	407	413	PF00069	0.448
MOD_CK2_1	400	406	PF00069	0.399
MOD_GlcNHglycan	184	187	PF01048	0.382
MOD_GlcNHglycan	406	409	PF01048	0.413
MOD_GlcNHglycan	429	432	PF01048	0.423
MOD_GlcNHglycan	436	439	PF01048	0.440
MOD_GlcNHglycan	442	445	PF01048	0.334
MOD_GlcNHglycan	64	67	PF01048	0.435
MOD_GlcNHglycan	80	83	PF01048	0.317
MOD_GSK3_1	180	187	PF00069	0.346
MOD_GSK3_1	220	227	PF00069	0.320
MOD_GSK3_1	235	242	PF00069	0.330
MOD_GSK3_1	325	332	PF00069	0.626
MOD_GSK3_1	340	347	PF00069	0.680
MOD_GSK3_1	400	407	PF00069	0.454
MOD_N-GLC_1	28	33	PF02516	0.443
MOD_NEK2_1	108	113	PF00069	0.340
MOD_NEK2_1	28	33	PF00069	0.316
MOD_NEK2_1	309	314	PF00069	0.512
MOD_NEK2_1	400	405	PF00069	0.496
MOD_NEK2_1	44	49	PF00069	0.373
MOD_NEK2_2	124	129	PF00069	0.243
MOD_NEK2_2	408	413	PF00069	0.419
MOD_PIKK_1	210	216	PF00454	0.316
MOD_PIKK_1	345	351	PF00454	0.718
MOD_PKA_2	102	108	PF00069	0.340
MOD_Plk_1	138	144	PF00069	0.321
MOD_Plk_1	224	230	PF00069	0.374
MOD_Plk_1	28	34	PF00069	0.384
MOD_Plk_1	290	296	PF00069	0.388
MOD_Plk_4	11	17	PF00069	0.309
MOD_Plk_4	239	245	PF00069	0.421
MOD_Plk_4	374	380	PF00069	0.469
MOD_Plk_4	394	400	PF00069	0.322
MOD_ProDKin_1	329	335	PF00069	0.695
MOD_ProDKin_1	351	357	PF00069	0.650
MOD_ProDKin_1	461	467	PF00069	0.481
MOD_SUMO_for_1	467	470	PF00179	0.579
MOD_SUMO_rev_2	177	183	PF00179	0.399
MOD_SUMO_rev_2	276	283	PF00179	0.701
TRG_DiLeu_BaLyEn_6	104	109	PF01217	0.305
TRG_DiLeu_BaLyEn_6	215	220	PF01217	0.259
TRG_DiLeu_BaLyEn_6	310	315	PF01217	0.440
TRG_ENDOCYTIC_2	22	25	PF00928	0.374
TRG_ENDOCYTIC_2	252	255	PF00928	0.504
TRG_ENDOCYTIC_2	300	303	PF00928	0.282
TRG_ENDOCYTIC_2	380	383	PF00928	0.373
TRG_ENDOCYTIC_2	395	398	PF00928	0.282
TRG_Pf-PMV_PEXEL_1	259	263	PF00026	0.528
TRG_Pf-PMV_PEXEL_1	313	318	PF00026	0.467

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I1M5	Leptomonas seymouri	63%	98%
A0A0S4IZG2	Bodo saltans	23%	100%
A0A0S4J1I6	Bodo saltans	25%	100%
A0A0S4J9U3	Bodo saltans	29%	100%
A0A1X0P5Q9	Trypanosomatidae	25%	100%
A0A1X0P5W3	Trypanosomatidae	45%	100%
A0A3Q8IM89	Leishmania donovani	27%	100%
A0A3R7K8J6	Trypanosoma rangeli	26%	100%
A0A3R7N7S2	Trypanosoma rangeli	43%	100%
A0A3S5H7D5	Leishmania donovani	24%	100%
A4HDP2	Leishmania braziliensis	23%	100%
A4HMN7	Leishmania braziliensis	25%	100%
A4HMN9	Leishmania braziliensis	85%	100%
C9ZWC1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	24%	97%
C9ZZF1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	42%	100%
E9AF39	Leishmania major	27%	100%
E9AF41	Leishmania major	95%	100%
E9AH88	Leishmania infantum	24%	100%
E9AHV6	Leishmania infantum	27%	100%
E9AHV8	Leishmania infantum	100%	100%
E9AX26	Leishmania mexicana (strain MHOM/GT/2001/U1103)	24%	96%
E9B694	Leishmania mexicana (strain MHOM/GT/2001/U1103)	27%	100%
E9B696	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%
Q4QAF0	Leishmania major	24%	100%
V5BJC7	Trypanosoma cruzi	27%	100%
V5BNY6	Trypanosoma cruzi	43%	100%