Hypothetical_protein_conserved

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S7X984_LEIDO

TriTrypDb:

LdBPK_352180.1 , LdCL_350026700 , LDHU3_35.2790

Length:

545

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S7X984

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7X984

Function

Biological processes
Term	Name	Level	Count
GO:0006629	lipid metabolic process	3	7
GO:0008152	metabolic process	1	7
GO:0044238	primary metabolic process	2	7
GO:0071704	organic substance metabolic process	2	7

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	244	248	PF00656	0.570
CLV_MEL_PAP_1	217	223	PF00089	0.447
CLV_MEL_PAP_1	37	43	PF00089	0.517
CLV_NRD_NRD_1	39	41	PF00675	0.430
CLV_NRD_NRD_1	522	524	PF00675	0.614
CLV_NRD_NRD_1	536	538	PF00675	0.676
CLV_NRD_NRD_1	61	63	PF00675	0.618
CLV_NRD_NRD_1	71	73	PF00675	0.538
CLV_PCSK_KEX2_1	39	41	PF00082	0.425
CLV_PCSK_KEX2_1	522	524	PF00082	0.571
CLV_PCSK_KEX2_1	536	538	PF00082	0.579
CLV_PCSK_KEX2_1	61	63	PF00082	0.626
CLV_PCSK_KEX2_1	70	72	PF00082	0.578
CLV_PCSK_PC1ET2_1	522	524	PF00082	0.630
CLV_PCSK_PC1ET2_1	70	72	PF00082	0.687
CLV_PCSK_PC7_1	57	63	PF00082	0.496
CLV_PCSK_SKI1_1	165	169	PF00082	0.493
CLV_PCSK_SKI1_1	177	181	PF00082	0.304
CLV_PCSK_SKI1_1	273	277	PF00082	0.491
CLV_PCSK_SKI1_1	356	360	PF00082	0.350
CLV_PCSK_SKI1_1	495	499	PF00082	0.527
CLV_Separin_Metazoa	475	479	PF03568	0.580
DEG_APCC_DBOX_1	164	172	PF00400	0.530
DEG_SPOP_SBC_1	389	393	PF00917	0.645
DOC_CKS1_1	197	202	PF01111	0.522
DOC_CYCLIN_RxL_1	174	184	PF00134	0.479
DOC_MAPK_DCC_7	347	357	PF00069	0.369
DOC_MAPK_gen_1	220	230	PF00069	0.493
DOC_MAPK_gen_1	495	504	PF00069	0.411
DOC_MAPK_MEF2A_6	223	230	PF00069	0.354
DOC_MAPK_MEF2A_6	495	504	PF00069	0.488
DOC_PP2B_LxvP_1	335	338	PF13499	0.439
DOC_USP7_MATH_1	18	22	PF00917	0.487
DOC_USP7_MATH_1	299	303	PF00917	0.408
DOC_USP7_MATH_1	388	392	PF00917	0.655
DOC_USP7_MATH_1	399	403	PF00917	0.734
DOC_USP7_MATH_1	439	443	PF00917	0.782
DOC_USP7_MATH_1	450	454	PF00917	0.661
DOC_USP7_MATH_1	530	534	PF00917	0.580
DOC_WW_Pin1_4	196	201	PF00397	0.532
DOC_WW_Pin1_4	292	297	PF00397	0.421
DOC_WW_Pin1_4	384	389	PF00397	0.478
DOC_WW_Pin1_4	414	419	PF00397	0.780
LIG_14-3-3_CanoR_1	191	196	PF00244	0.576
LIG_14-3-3_CanoR_1	211	221	PF00244	0.400
LIG_14-3-3_CanoR_1	301	305	PF00244	0.361
LIG_14-3-3_CanoR_1	523	530	PF00244	0.699
LIG_14-3-3_CanoR_1	89	94	PF00244	0.534
LIG_APCC_ABBA_1	171	176	PF00400	0.351
LIG_APCC_ABBA_1	8	13	PF00400	0.443
LIG_BIR_II_1	1	5	PF00653	0.476
LIG_BIR_III_2	413	417	PF00653	0.638
LIG_BRCT_BRCA1_1	37	41	PF00533	0.510
LIG_BRCT_BRCA1_1	452	456	PF00533	0.656
LIG_BRCT_BRCA1_2	452	458	PF00533	0.656
LIG_CaM_IQ_9	81	96	PF13499	0.420
LIG_DLG_GKlike_1	191	198	PF00625	0.569
LIG_eIF4E_1	174	180	PF01652	0.366
LIG_eIF4E_1	28	34	PF01652	0.510
LIG_eIF4E_1	484	490	PF01652	0.472
LIG_FHA_1	113	119	PF00498	0.309
LIG_FHA_1	202	208	PF00498	0.379
LIG_FHA_1	301	307	PF00498	0.374
LIG_FHA_1	330	336	PF00498	0.489
LIG_FHA_1	96	102	PF00498	0.448
LIG_FHA_2	242	248	PF00498	0.552
LIG_FHA_2	368	374	PF00498	0.405
LIG_FHA_2	503	509	PF00498	0.487
LIG_LIR_Apic_2	194	200	PF02991	0.539
LIG_LIR_Gen_1	129	138	PF02991	0.547
LIG_LIR_Gen_1	278	287	PF02991	0.400
LIG_LIR_Gen_1	515	526	PF02991	0.573
LIG_LIR_LC3C_4	224	228	PF02991	0.464
LIG_LIR_Nem_3	515	521	PF02991	0.668
LIG_LRP6_Inhibitor_1	350	356	PF00058	0.405
LIG_NRBOX	317	323	PF00104	0.324
LIG_PCNA_yPIPBox_3	339	349	PF02747	0.359
LIG_PTB_Apo_2	124	131	PF02174	0.382
LIG_PTB_Phospho_1	124	130	PF10480	0.388
LIG_SH2_CRK	106	110	PF00017	0.529
LIG_SH2_SRC	506	509	PF00017	0.516
LIG_SH2_STAP1	174	178	PF00017	0.469
LIG_SH2_STAT3	234	237	PF00017	0.393
LIG_SH2_STAT5	197	200	PF00017	0.517
LIG_SH2_STAT5	240	243	PF00017	0.350
LIG_SH2_STAT5	280	283	PF00017	0.393
LIG_SH2_STAT5	348	351	PF00017	0.360
LIG_SH2_STAT5	36	39	PF00017	0.404
LIG_SH2_STAT5	493	496	PF00017	0.389
LIG_SH2_STAT5	90	93	PF00017	0.445
LIG_SH3_2	296	301	PF14604	0.516
LIG_SH3_3	293	299	PF00018	0.538
LIG_SH3_3	362	368	PF00018	0.455
LIG_SH3_3	412	418	PF00018	0.793
LIG_SUMO_SIM_anti_2	176	182	PF11976	0.430
LIG_SUMO_SIM_anti_2	382	387	PF11976	0.384
LIG_SUMO_SIM_anti_2	426	432	PF11976	0.588
LIG_SUMO_SIM_par_1	226	233	PF11976	0.378
LIG_SUMO_SIM_par_1	382	387	PF11976	0.510
LIG_TRAF2_1	464	467	PF00917	0.741
LIG_TRAF2_1	532	535	PF00917	0.689
LIG_UBA3_1	138	147	PF00899	0.531
LIG_WRC_WIRS_1	138	143	PF05994	0.524
MOD_CDK_SPK_2	414	419	PF00069	0.662
MOD_CK1_1	137	143	PF00069	0.523
MOD_CK1_1	193	199	PF00069	0.475
MOD_CK1_1	212	218	PF00069	0.419
MOD_CK1_1	392	398	PF00069	0.691
MOD_CK2_1	137	143	PF00069	0.499
MOD_CK2_1	147	153	PF00069	0.547
MOD_CK2_1	18	24	PF00069	0.505
MOD_CK2_1	263	269	PF00069	0.480
MOD_CK2_1	367	373	PF00069	0.396
MOD_CK2_1	399	405	PF00069	0.738
MOD_CK2_1	502	508	PF00069	0.479
MOD_CK2_1	522	528	PF00069	0.450
MOD_CK2_1	529	535	PF00069	0.667
MOD_GlcNHglycan	121	124	PF01048	0.434
MOD_GlcNHglycan	20	23	PF01048	0.534
MOD_GlcNHglycan	211	214	PF01048	0.407
MOD_GlcNHglycan	250	253	PF01048	0.566
MOD_GlcNHglycan	30	33	PF01048	0.497
MOD_GlcNHglycan	441	444	PF01048	0.752
MOD_GlcNHglycan	446	451	PF01048	0.773
MOD_GlcNHglycan	524	527	PF01048	0.624
MOD_GSK3_1	133	140	PF00069	0.508
MOD_GSK3_1	203	210	PF00069	0.432
MOD_GSK3_1	23	30	PF00069	0.498
MOD_GSK3_1	271	278	PF00069	0.500
MOD_GSK3_1	316	323	PF00069	0.491
MOD_GSK3_1	327	334	PF00069	0.501
MOD_GSK3_1	337	344	PF00069	0.456
MOD_GSK3_1	384	391	PF00069	0.563
MOD_GSK3_1	399	406	PF00069	0.758
MOD_GSK3_1	446	453	PF00069	0.717
MOD_GSK3_1	498	505	PF00069	0.507
MOD_GSK3_1	61	68	PF00069	0.655
MOD_LATS_1	496	502	PF00433	0.486
MOD_N-GLC_1	126	131	PF02516	0.582
MOD_N-GLC_1	28	33	PF02516	0.516
MOD_N-GLC_1	389	394	PF02516	0.658
MOD_N-GLC_1	421	426	PF02516	0.609
MOD_NEK2_1	133	138	PF00069	0.495
MOD_NEK2_1	27	32	PF00069	0.520
MOD_NEK2_1	275	280	PF00069	0.491
MOD_NEK2_1	282	287	PF00069	0.457
MOD_NEK2_1	316	321	PF00069	0.448
MOD_NEK2_1	327	332	PF00069	0.500
MOD_PIKK_1	275	281	PF00454	0.466
MOD_PIKK_1	320	326	PF00454	0.530
MOD_PK_1	4	10	PF00069	0.519
MOD_PK_1	498	504	PF00069	0.508
MOD_PKA_1	147	153	PF00069	0.599
MOD_PKA_1	522	528	PF00069	0.690
MOD_PKA_1	61	67	PF00069	0.558
MOD_PKA_2	190	196	PF00069	0.581
MOD_PKA_2	300	306	PF00069	0.367
MOD_PKA_2	522	528	PF00069	0.647
MOD_PKA_2	61	67	PF00069	0.648
MOD_Plk_1	126	132	PF00069	0.546
MOD_Plk_1	134	140	PF00069	0.464
MOD_Plk_1	23	29	PF00069	0.423
MOD_Plk_1	230	236	PF00069	0.380
MOD_Plk_2-3	250	256	PF00069	0.555
MOD_Plk_2-3	403	409	PF00069	0.650
MOD_Plk_2-3	466	472	PF00069	0.644
MOD_Plk_4	113	119	PF00069	0.372
MOD_Plk_4	134	140	PF00069	0.489
MOD_Plk_4	193	199	PF00069	0.538
MOD_Plk_4	203	209	PF00069	0.482
MOD_Plk_4	23	29	PF00069	0.423
MOD_Plk_4	271	277	PF00069	0.374
MOD_Plk_4	300	306	PF00069	0.360
MOD_Plk_4	316	322	PF00069	0.322
MOD_Plk_4	426	432	PF00069	0.588
MOD_Plk_4	498	504	PF00069	0.540
MOD_ProDKin_1	196	202	PF00069	0.530
MOD_ProDKin_1	292	298	PF00069	0.421
MOD_ProDKin_1	384	390	PF00069	0.497
MOD_ProDKin_1	414	420	PF00069	0.776
MOD_SUMO_rev_2	140	149	PF00179	0.460
TRG_DiLeu_BaEn_1	176	181	PF01217	0.477
TRG_DiLeu_BaEn_2	372	378	PF01217	0.410
TRG_DiLeu_BaLyEn_6	174	179	PF01217	0.364
TRG_ENDOCYTIC_2	11	14	PF00928	0.386
TRG_ENDOCYTIC_2	130	133	PF00928	0.550
TRG_ENDOCYTIC_2	280	283	PF00928	0.369
TRG_ENDOCYTIC_2	518	521	PF00928	0.569
TRG_ENDOCYTIC_2	90	93	PF00928	0.424
TRG_ER_diArg_1	39	41	PF00400	0.441
TRG_ER_diArg_1	536	539	PF00400	0.726
TRG_NLS_MonoCore_2	68	73	PF00514	0.649
TRG_NLS_MonoExtN_4	69	74	PF00514	0.690
TRG_Pf-PMV_PEXEL_1	495	499	PF00026	0.449
TRG_Pf-PMV_PEXEL_1	536	540	PF00026	0.680

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1P9E6	Leptomonas seymouri	64%	99%
A0A1X0P5Q0	Trypanosomatidae	43%	100%
A0A3R7RFL4	Trypanosoma rangeli	46%	100%
A4HMN6	Leishmania braziliensis	87%	100%
C9ZZF2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	45%	100%
E9AF38	Leishmania major	95%	100%
E9AHV5	Leishmania infantum	100%	100%
E9B693	Leishmania mexicana (strain MHOM/GT/2001/U1103)	93%	100%
V5BTI6	Trypanosoma cruzi	46%	100%