Hypothetical_protein_conserved

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S7X983_LEIDO

TriTrypDb:

LdBPK_351930.1 , LdCL_350024500 , LDHU3_35.2530

Length:

619

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S7X983

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7X983

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	152	154	PF00675	0.634
CLV_NRD_NRD_1	302	304	PF00675	0.489
CLV_NRD_NRD_1	361	363	PF00675	0.576
CLV_NRD_NRD_1	371	373	PF00675	0.531
CLV_NRD_NRD_1	395	397	PF00675	0.565
CLV_NRD_NRD_1	439	441	PF00675	0.758
CLV_NRD_NRD_1	471	473	PF00675	0.674
CLV_NRD_NRD_1	496	498	PF00675	0.697
CLV_NRD_NRD_1	501	503	PF00675	0.644
CLV_NRD_NRD_1	530	532	PF00675	0.691
CLV_NRD_NRD_1	535	537	PF00675	0.670
CLV_NRD_NRD_1	556	558	PF00675	0.721
CLV_NRD_NRD_1	614	616	PF00675	0.657
CLV_NRD_NRD_1	91	93	PF00675	0.408
CLV_PCSK_FUR_1	499	503	PF00082	0.566
CLV_PCSK_KEX2_1	151	153	PF00082	0.632
CLV_PCSK_KEX2_1	302	304	PF00082	0.485
CLV_PCSK_KEX2_1	361	363	PF00082	0.576
CLV_PCSK_KEX2_1	371	373	PF00082	0.531
CLV_PCSK_KEX2_1	395	397	PF00082	0.565
CLV_PCSK_KEX2_1	439	441	PF00082	0.758
CLV_PCSK_KEX2_1	470	472	PF00082	0.681
CLV_PCSK_KEX2_1	495	497	PF00082	0.612
CLV_PCSK_KEX2_1	501	503	PF00082	0.585
CLV_PCSK_KEX2_1	535	537	PF00082	0.689
CLV_PCSK_KEX2_1	556	558	PF00082	0.618
CLV_PCSK_KEX2_1	614	616	PF00082	0.657
CLV_PCSK_PC7_1	497	503	PF00082	0.649
CLV_PCSK_PC7_1	531	537	PF00082	0.644
CLV_PCSK_SKI1_1	133	137	PF00082	0.506
CLV_PCSK_SKI1_1	206	210	PF00082	0.331
CLV_PCSK_SKI1_1	218	222	PF00082	0.359
CLV_PCSK_SKI1_1	290	294	PF00082	0.351
CLV_PCSK_SKI1_1	36	40	PF00082	0.505
CLV_PCSK_SKI1_1	590	594	PF00082	0.668
CLV_PCSK_SKI1_1	615	619	PF00082	0.656
DEG_APCC_DBOX_1	287	295	PF00400	0.473
DEG_SCF_TRCP1_1	47	53	PF00400	0.473
DEG_SPOP_SBC_1	462	466	PF00917	0.677
DEG_SPOP_SBC_1	61	65	PF00917	0.613
DEG_SPOP_SBC_1	84	88	PF00917	0.444
DOC_CKS1_1	476	481	PF01111	0.601
DOC_CYCLIN_yCln2_LP_2	444	450	PF00134	0.624
DOC_MAPK_gen_1	151	159	PF00069	0.617
DOC_MAPK_gen_1	286	293	PF00069	0.353
DOC_MAPK_gen_1	340	348	PF00069	0.497
DOC_MAPK_MEF2A_6	342	350	PF00069	0.494
DOC_MIT_MIM_1	201	210	PF04212	0.433
DOC_PP2B_LxvP_1	552	555	PF13499	0.527
DOC_PP4_FxxP_1	221	224	PF00568	0.365
DOC_PP4_FxxP_1	268	271	PF00568	0.459
DOC_PP4_FxxP_1	373	376	PF00568	0.618
DOC_PP4_FxxP_1	476	479	PF00568	0.608
DOC_USP7_MATH_1	135	139	PF00917	0.594
DOC_USP7_MATH_1	163	167	PF00917	0.600
DOC_USP7_MATH_1	353	357	PF00917	0.495
DOC_USP7_MATH_1	387	391	PF00917	0.595
DOC_USP7_MATH_1	414	418	PF00917	0.734
DOC_USP7_MATH_1	45	49	PF00917	0.608
DOC_USP7_MATH_1	463	467	PF00917	0.754
DOC_USP7_MATH_1	485	489	PF00917	0.639
DOC_USP7_MATH_1	571	575	PF00917	0.670
DOC_USP7_MATH_1	592	596	PF00917	0.664
DOC_USP7_MATH_1	606	610	PF00917	0.660
DOC_USP7_MATH_1	61	65	PF00917	0.594
DOC_USP7_UBL2_3	93	97	PF12436	0.387
DOC_WW_Pin1_4	107	112	PF00397	0.436
DOC_WW_Pin1_4	133	138	PF00397	0.595
DOC_WW_Pin1_4	249	254	PF00397	0.620
DOC_WW_Pin1_4	443	448	PF00397	0.671
DOC_WW_Pin1_4	475	480	PF00397	0.609
DOC_WW_Pin1_4	5	10	PF00397	0.369
DOC_WW_Pin1_4	513	518	PF00397	0.609
DOC_WW_Pin1_4	567	572	PF00397	0.634
DOC_WW_Pin1_4	598	603	PF00397	0.603
LIG_14-3-3_CanoR_1	16	25	PF00244	0.457
LIG_14-3-3_CanoR_1	182	191	PF00244	0.445
LIG_14-3-3_CanoR_1	206	211	PF00244	0.329
LIG_14-3-3_CanoR_1	361	365	PF00244	0.567
LIG_14-3-3_CanoR_1	366	373	PF00244	0.540
LIG_14-3-3_CanoR_1	395	402	PF00244	0.593
LIG_14-3-3_CanoR_1	439	445	PF00244	0.632
LIG_14-3-3_CanoR_1	470	479	PF00244	0.681
LIG_14-3-3_CanoR_1	547	553	PF00244	0.782
LIG_14-3-3_CanoR_1	556	562	PF00244	0.719
LIG_14-3-3_CanoR_1	579	588	PF00244	0.588
LIG_14-3-3_CanoR_1	590	598	PF00244	0.691
LIG_14-3-3_CanoR_1	72	78	PF00244	0.439
LIG_14-3-3_CanoR_1	92	96	PF00244	0.468
LIG_BIR_II_1	1	5	PF00653	0.450
LIG_BRCT_BRCA1_1	472	476	PF00533	0.684
LIG_CaM_IQ_9	316	331	PF13499	0.382
LIG_FHA_1	152	158	PF00498	0.594
LIG_FHA_1	215	221	PF00498	0.378
LIG_FHA_1	549	555	PF00498	0.613
LIG_FHA_1	57	63	PF00498	0.551
LIG_FHA_1	599	605	PF00498	0.583
LIG_FHA_1	78	84	PF00498	0.396
LIG_FHA_2	117	123	PF00498	0.366
LIG_FHA_2	168	174	PF00498	0.705
LIG_FHA_2	188	194	PF00498	0.610
LIG_FHA_2	472	478	PF00498	0.679
LIG_FHA_2	76	82	PF00498	0.490
LIG_IBAR_NPY_1	399	401	PF08397	0.604
LIG_Integrin_RGD_1	502	504	PF01839	0.686
LIG_LIR_Apic_2	267	271	PF02991	0.461
LIG_LIR_Apic_2	473	479	PF02991	0.618
LIG_LIR_Gen_1	204	214	PF02991	0.423
LIG_LIR_Gen_1	94	103	PF02991	0.394
LIG_LIR_Nem_3	204	210	PF02991	0.364
LIG_LIR_Nem_3	410	416	PF02991	0.594
LIG_LIR_Nem_3	94	98	PF02991	0.397
LIG_Pex14_2	264	268	PF04695	0.466
LIG_Rb_pABgroove_1	97	105	PF01858	0.330
LIG_SH2_CRK	103	107	PF00017	0.402
LIG_SH2_CRK	413	417	PF00017	0.588
LIG_SH2_STAP1	103	107	PF00017	0.408
LIG_SH2_STAP1	212	216	PF00017	0.382
LIG_SH2_STAT3	422	425	PF00017	0.625
LIG_SH2_STAT5	13	16	PF00017	0.338
LIG_SH2_STAT5	401	404	PF00017	0.597
LIG_SH3_3	3	9	PF00018	0.367
LIG_SH3_3	444	450	PF00018	0.668
LIG_SH3_3	476	482	PF00018	0.648
LIG_SH3_3	527	533	PF00018	0.656
LIG_SUMO_SIM_anti_2	289	297	PF11976	0.354
LIG_SUMO_SIM_par_1	189	197	PF11976	0.507
LIG_SUMO_SIM_par_1	78	88	PF11976	0.383
LIG_WRC_WIRS_1	265	270	PF05994	0.458
MOD_CDK_SPK_2	598	603	PF00069	0.636
MOD_CDK_SPxK_1	133	139	PF00069	0.531
MOD_CDK_SPxxK_3	5	12	PF00069	0.370
MOD_CK1_1	2	8	PF00069	0.432
MOD_CK1_1	269	275	PF00069	0.683
MOD_CK1_1	356	362	PF00069	0.465
MOD_CK1_1	378	384	PF00069	0.621
MOD_CK1_1	406	412	PF00069	0.644
MOD_CK1_1	427	433	PF00069	0.695
MOD_CK1_1	464	470	PF00069	0.649
MOD_CK1_1	506	512	PF00069	0.676
MOD_CK1_1	538	544	PF00069	0.758
MOD_CK1_1	546	552	PF00069	0.659
MOD_CK1_1	574	580	PF00069	0.599
MOD_CK1_1	581	587	PF00069	0.595
MOD_CK2_1	116	122	PF00069	0.365
MOD_CK2_1	16	22	PF00069	0.494
MOD_CK2_1	167	173	PF00069	0.687
MOD_CK2_1	187	193	PF00069	0.513
MOD_CK2_1	505	511	PF00069	0.562
MOD_CK2_1	73	79	PF00069	0.427
MOD_GlcNHglycan	160	163	PF01048	0.723
MOD_GlcNHglycan	233	236	PF01048	0.641
MOD_GlcNHglycan	249	252	PF01048	0.641
MOD_GlcNHglycan	377	380	PF01048	0.538
MOD_GlcNHglycan	385	388	PF01048	0.651
MOD_GlcNHglycan	389	392	PF01048	0.648
MOD_GlcNHglycan	41	45	PF01048	0.615
MOD_GlcNHglycan	426	429	PF01048	0.664
MOD_GlcNHglycan	435	438	PF01048	0.612
MOD_GlcNHglycan	46	50	PF01048	0.560
MOD_GlcNHglycan	538	541	PF01048	0.641
MOD_GlcNHglycan	564	568	PF01048	0.767
MOD_GlcNHglycan	581	584	PF01048	0.495
MOD_GlcNHglycan	608	611	PF01048	0.664
MOD_GlcNHglycan	65	68	PF01048	0.625
MOD_GlcNHglycan	87	90	PF01048	0.412
MOD_GSK3_1	147	154	PF00069	0.703
MOD_GSK3_1	163	170	PF00069	0.670
MOD_GSK3_1	227	234	PF00069	0.642
MOD_GSK3_1	243	250	PF00069	0.697
MOD_GSK3_1	272	279	PF00069	0.656
MOD_GSK3_1	28	35	PF00069	0.437
MOD_GSK3_1	356	363	PF00069	0.576
MOD_GSK3_1	371	378	PF00069	0.475
MOD_GSK3_1	383	390	PF00069	0.704
MOD_GSK3_1	461	468	PF00069	0.709
MOD_GSK3_1	471	478	PF00069	0.585
MOD_GSK3_1	536	543	PF00069	0.637
MOD_GSK3_1	546	553	PF00069	0.669
MOD_GSK3_1	56	63	PF00069	0.621
MOD_GSK3_1	563	570	PF00069	0.645
MOD_GSK3_1	571	578	PF00069	0.580
MOD_GSK3_1	588	595	PF00069	0.551
MOD_GSK3_1	73	80	PF00069	0.471
MOD_N-GLC_1	32	37	PF02516	0.524
MOD_NEK2_1	116	121	PF00069	0.427
MOD_NEK2_1	167	172	PF00069	0.697
MOD_NEK2_1	26	31	PF00069	0.474
MOD_NEK2_1	264	269	PF00069	0.526
MOD_NEK2_1	588	593	PF00069	0.655
MOD_NEK2_1	62	67	PF00069	0.647
MOD_NEK2_1	73	78	PF00069	0.341
MOD_NEK2_1	83	88	PF00069	0.337
MOD_PIKK_1	353	359	PF00454	0.576
MOD_PIKK_1	366	372	PF00454	0.461
MOD_PKA_1	151	157	PF00069	0.486
MOD_PKA_1	371	377	PF00069	0.547
MOD_PKA_1	470	476	PF00069	0.685
MOD_PKA_1	495	501	PF00069	0.587
MOD_PKA_1	535	541	PF00069	0.690
MOD_PKA_2	151	157	PF00069	0.536
MOD_PKA_2	360	366	PF00069	0.482
MOD_PKA_2	371	377	PF00069	0.584
MOD_PKA_2	394	400	PF00069	0.559
MOD_PKA_2	433	439	PF00069	0.682
MOD_PKA_2	470	476	PF00069	0.625
MOD_PKA_2	495	501	PF00069	0.755
MOD_PKA_2	535	541	PF00069	0.642
MOD_PKA_2	546	552	PF00069	0.654
MOD_PKA_2	578	584	PF00069	0.622
MOD_PKA_2	91	97	PF00069	0.408
MOD_PKB_1	243	251	PF00069	0.559
MOD_PKB_1	495	503	PF00069	0.609
MOD_Plk_1	2	8	PF00069	0.426
MOD_Plk_1	257	263	PF00069	0.550
MOD_Plk_4	187	193	PF00069	0.527
MOD_Plk_4	2	8	PF00069	0.426
MOD_Plk_4	50	56	PF00069	0.561
MOD_ProDKin_1	107	113	PF00069	0.428
MOD_ProDKin_1	133	139	PF00069	0.605
MOD_ProDKin_1	249	255	PF00069	0.620
MOD_ProDKin_1	443	449	PF00069	0.670
MOD_ProDKin_1	475	481	PF00069	0.605
MOD_ProDKin_1	5	11	PF00069	0.367
MOD_ProDKin_1	513	519	PF00069	0.608
MOD_ProDKin_1	567	573	PF00069	0.635
MOD_ProDKin_1	598	604	PF00069	0.604
TRG_DiLeu_BaEn_1	304	309	PF01217	0.488
TRG_ENDOCYTIC_2	103	106	PF00928	0.441
TRG_ENDOCYTIC_2	413	416	PF00928	0.610
TRG_ER_diArg_1	151	153	PF00400	0.591
TRG_ER_diArg_1	242	245	PF00400	0.567
TRG_ER_diArg_1	285	288	PF00400	0.474
TRG_ER_diArg_1	301	303	PF00400	0.339
TRG_ER_diArg_1	339	342	PF00400	0.502
TRG_ER_diArg_1	371	373	PF00400	0.579
TRG_ER_diArg_1	470	472	PF00400	0.663
TRG_ER_diArg_1	494	497	PF00400	0.602
TRG_ER_diArg_1	499	502	PF00400	0.696
TRG_ER_diArg_1	555	557	PF00400	0.697
TRG_ER_diArg_1	613	615	PF00400	0.636
TRG_NES_CRM1_1	320	335	PF08389	0.601
TRG_Pf-PMV_PEXEL_1	206	211	PF00026	0.389
TRG_Pf-PMV_PEXEL_1	403	408	PF00026	0.617
TRG_Pf-PMV_PEXEL_1	559	564	PF00026	0.592

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PBH3	Leptomonas seymouri	46%	94%
A0A1X0P5W2	Trypanosomatidae	34%	100%
A4HML5	Leishmania braziliensis	76%	100%
A4IB92	Leishmania infantum	100%	100%
E9AF16	Leishmania major	90%	100%
E9B672	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	100%