Iron-sulfur assembly protein 2, putative

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Iron-sulfur assembly protein 2, putative

Species:

Leishmania donovani

UniProt:

A0A3S7X981_LEIDO

TriTrypDb:

LdBPK_351350.1 , LdCL_350018400 , LDHU3_35.1780

Length:

220

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 1, no: 9
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005739	mitochondrion	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A0A3S7X981

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7X981

Function

Biological processes
Term	Name	Level	Count
GO:0006790	sulfur compound metabolic process	3	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	1
GO:0009987	cellular process	1	1
GO:0016043	cellular component organization	3	1
GO:0016226	iron-sulfur cluster assembly	4	1
GO:0019538	protein metabolic process	3	1
GO:0022607	cellular component assembly	4	1
GO:0031163	metallo-sulfur cluster assembly	5	1
GO:0043170	macromolecule metabolic process	3	1
GO:0044237	cellular metabolic process	2	1
GO:0044238	primary metabolic process	2	1
GO:0051604	protein maturation	4	1
GO:0071704	organic substance metabolic process	2	1
GO:0071840	cellular component organization or biogenesis	2	1
GO:0097428	protein maturation by iron-sulfur cluster transfer	5	1
GO:0106035	protein maturation by [4Fe-4S] cluster transfer	6	1
GO:1901564	organonitrogen compound metabolic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	1
GO:0005506	iron ion binding	6	1
GO:0043167	ion binding	2	1
GO:0043169	cation binding	3	1
GO:0046872	metal ion binding	4	1
GO:0046914	transition metal ion binding	5	1
GO:0051536	iron-sulfur cluster binding	3	1
GO:0051537	2 iron, 2 sulfur cluster binding	4	1
GO:0051539	4 iron, 4 sulfur cluster binding	4	1
GO:0051540	metal cluster binding	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	165	167	PF00675	0.623
CLV_NRD_NRD_1	212	214	PF00675	0.749
CLV_NRD_NRD_1	50	52	PF00675	0.689
CLV_NRD_NRD_1	7	9	PF00675	0.592
CLV_PCSK_KEX2_1	212	214	PF00082	0.749
CLV_PCSK_KEX2_1	7	9	PF00082	0.592
CLV_PCSK_PC7_1	208	214	PF00082	0.747
CLV_PCSK_PC7_1	3	9	PF00082	0.627
CLV_PCSK_SKI1_1	213	217	PF00082	0.766
DEG_Nend_Nbox_1	1	3	PF02207	0.551
DEG_SPOP_SBC_1	173	177	PF00917	0.761
DOC_USP7_MATH_1	12	16	PF00917	0.713
DOC_USP7_MATH_1	173	177	PF00917	0.737
DOC_USP7_MATH_1	198	202	PF00917	0.714
DOC_USP7_MATH_1	68	72	PF00917	0.553
DOC_WW_Pin1_4	101	106	PF00397	0.722
DOC_WW_Pin1_4	113	118	PF00397	0.699
DOC_WW_Pin1_4	22	27	PF00397	0.735
DOC_WW_Pin1_4	39	44	PF00397	0.684
LIG_14-3-3_CanoR_1	3	7	PF00244	0.559
LIG_14-3-3_CanoR_1	51	58	PF00244	0.713
LIG_14-3-3_CterR_2	217	220	PF00244	0.738
LIG_DCNL_PONY_1	1	4	PF03556	0.677
LIG_LIR_Gen_1	143	153	PF02991	0.596
LIG_LIR_Gen_1	61	69	PF02991	0.557
LIG_LIR_Nem_3	143	148	PF02991	0.599
LIG_LIR_Nem_3	61	67	PF02991	0.568
LIG_SH2_STAT5	64	67	PF00017	0.624
LIG_SH2_STAT5	77	80	PF00017	0.694
LIG_SH3_3	99	105	PF00018	0.661
LIG_SUMO_SIM_anti_2	99	104	PF11976	0.757
MOD_CDK_SPK_2	113	118	PF00069	0.699
MOD_CDK_SPK_2	39	44	PF00069	0.693
MOD_CK1_1	15	21	PF00069	0.712
MOD_CK1_1	172	178	PF00069	0.773
MOD_CK1_1	211	217	PF00069	0.703
MOD_CK2_1	124	130	PF00069	0.689
MOD_GlcNHglycan	124	127	PF01048	0.729
MOD_GlcNHglycan	14	17	PF01048	0.748
MOD_GlcNHglycan	142	145	PF01048	0.591
MOD_GlcNHglycan	171	174	PF01048	0.752
MOD_GlcNHglycan	176	179	PF01048	0.738
MOD_GlcNHglycan	182	185	PF01048	0.658
MOD_GlcNHglycan	191	194	PF01048	0.633
MOD_GlcNHglycan	213	216	PF01048	0.709
MOD_GlcNHglycan	70	73	PF01048	0.546
MOD_GSK3_1	12	19	PF00069	0.735
MOD_GSK3_1	120	127	PF00069	0.642
MOD_GSK3_1	169	176	PF00069	0.722
MOD_GSK3_1	213	220	PF00069	0.759
MOD_GSK3_1	22	29	PF00069	0.691
MOD_GSK3_1	35	42	PF00069	0.697
MOD_GSK3_1	47	54	PF00069	0.695
MOD_N-GLC_1	130	135	PF02516	0.675
MOD_NEK2_1	124	129	PF00069	0.683
MOD_NEK2_1	140	145	PF00069	0.589
MOD_NEK2_1	161	166	PF00069	0.585
MOD_NEK2_1	2	7	PF00069	0.559
MOD_PK_1	37	43	PF00069	0.694
MOD_PKA_1	166	172	PF00069	0.670
MOD_PKA_1	51	57	PF00069	0.704
MOD_PKA_2	169	175	PF00069	0.736
MOD_PKA_2	2	8	PF00069	0.560
MOD_PKA_2	211	217	PF00069	0.698
MOD_Plk_1	130	136	PF00069	0.670
MOD_Plk_2-3	130	136	PF00069	0.671
MOD_Plk_4	26	32	PF00069	0.669
MOD_ProDKin_1	101	107	PF00069	0.725
MOD_ProDKin_1	113	119	PF00069	0.695
MOD_ProDKin_1	22	28	PF00069	0.729
MOD_ProDKin_1	39	45	PF00069	0.680
MOD_SUMO_rev_2	135	143	PF00179	0.573
TRG_ENDOCYTIC_2	64	67	PF00928	0.624
TRG_ER_diArg_1	6	8	PF00400	0.584
TRG_NLS_MonoExtC_3	165	170	PF00514	0.700
TRG_NLS_MonoExtN_4	166	171	PF00514	0.652

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PD94	Leptomonas seymouri	65%	98%
A0A0S4JDK9	Bodo saltans	42%	100%
A0A1X0NHC3	Trypanosomatidae	52%	100%
A0A3R7LRU0	Trypanosoma rangeli	57%	100%
A4HMF6	Leishmania braziliensis	78%	100%
A4IB28	Leishmania infantum	100%	100%
C9ZNM4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	51%	100%
E9B613	Leishmania mexicana (strain MHOM/GT/2001/U1103)	86%	100%
Q9GRP9	Leishmania major	93%	100%