Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S7X976_LEIDO

TriTrypDb:

LdBPK_352110.1 , LdCL_350026300 , LDHU3_35.2730

Length:

482

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S7X976

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7X976

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	182	186	PF00656	0.639
CLV_NRD_NRD_1	159	161	PF00675	0.602
CLV_NRD_NRD_1	179	181	PF00675	0.834
CLV_NRD_NRD_1	204	206	PF00675	0.658
CLV_PCSK_KEX2_1	178	180	PF00082	0.649
CLV_PCSK_KEX2_1	204	206	PF00082	0.658
CLV_PCSK_KEX2_1	238	240	PF00082	0.640
CLV_PCSK_PC1ET2_1	238	240	PF00082	0.640
CLV_PCSK_SKI1_1	321	325	PF00082	0.620
CLV_PCSK_SKI1_1	361	365	PF00082	0.495
DEG_SPOP_SBC_1	106	110	PF00917	0.630
DEG_SPOP_SBC_1	198	202	PF00917	0.602
DOC_CYCLIN_RxL_1	374	383	PF00134	0.441
DOC_MAPK_gen_1	306	313	PF00069	0.425
DOC_PP1_RVXF_1	109	116	PF00149	0.639
DOC_PP1_SILK_1	302	307	PF00149	0.352
DOC_PP4_FxxP_1	275	278	PF00568	0.598
DOC_SPAK_OSR1_1	464	468	PF12202	0.523
DOC_USP7_MATH_1	106	110	PF00917	0.578
DOC_USP7_MATH_1	198	202	PF00917	0.620
DOC_USP7_MATH_1	219	223	PF00917	0.572
DOC_USP7_MATH_1	233	237	PF00917	0.498
DOC_USP7_MATH_1	33	37	PF00917	0.526
DOC_USP7_MATH_1	412	416	PF00917	0.565
DOC_USP7_MATH_1	470	474	PF00917	0.569
DOC_USP7_MATH_1	476	480	PF00917	0.561
DOC_USP7_MATH_1	98	102	PF00917	0.573
DOC_WW_Pin1_4	248	253	PF00397	0.637
DOC_WW_Pin1_4	257	262	PF00397	0.554
DOC_WW_Pin1_4	280	285	PF00397	0.485
DOC_WW_Pin1_4	387	392	PF00397	0.535
DOC_WW_Pin1_4	400	405	PF00397	0.499
DOC_WW_Pin1_4	62	67	PF00397	0.486
LIG_14-3-3_CanoR_1	188	198	PF00244	0.637
LIG_14-3-3_CanoR_1	199	204	PF00244	0.574
LIG_14-3-3_CanoR_1	239	243	PF00244	0.626
LIG_14-3-3_CanoR_1	345	354	PF00244	0.428
LIG_14-3-3_CanoR_1	464	472	PF00244	0.588
LIG_14-3-3_CanoR_1	477	481	PF00244	0.508
LIG_Actin_WH2_2	223	240	PF00022	0.543
LIG_Actin_WH2_2	364	382	PF00022	0.426
LIG_APCC_ABBA_1	253	258	PF00400	0.549
LIG_BRCT_BRCA1_1	35	39	PF00533	0.520
LIG_BRCT_BRCA1_1	87	91	PF00533	0.415
LIG_Clathr_ClatBox_1	436	440	PF01394	0.463
LIG_DLG_GKlike_1	160	167	PF00625	0.592
LIG_FHA_1	108	114	PF00498	0.640
LIG_FHA_1	272	278	PF00498	0.596
LIG_FHA_1	32	38	PF00498	0.554
LIG_FHA_1	70	76	PF00498	0.437
LIG_FHA_2	126	132	PF00498	0.633
LIG_FHA_2	241	247	PF00498	0.592
LIG_FHA_2	261	267	PF00498	0.496
LIG_FHA_2	347	353	PF00498	0.427
LIG_FHA_2	364	370	PF00498	0.291
LIG_IRF3_LxIS_1	4	10	PF10401	0.440
LIG_LIR_Apic_2	272	278	PF02991	0.596
LIG_LIR_Apic_2	415	421	PF02991	0.544
LIG_LIR_Gen_1	18	29	PF02991	0.510
LIG_LIR_Nem_3	18	24	PF02991	0.557
LIG_LIR_Nem_3	301	305	PF02991	0.439
LIG_LIR_Nem_3	42	47	PF02991	0.539
LIG_LIR_Nem_3	88	94	PF02991	0.421
LIG_LYPXL_yS_3	44	47	PF13949	0.506
LIG_NRBOX	3	9	PF00104	0.485
LIG_Rb_pABgroove_1	162	170	PF01858	0.595
LIG_SH2_NCK_1	418	422	PF00017	0.533
LIG_SH2_NCK_1	455	459	PF00017	0.596
LIG_SH2_SRC	418	421	PF00017	0.565
LIG_SH2_STAP1	455	459	PF00017	0.596
LIG_SH2_STAT5	68	71	PF00017	0.441
LIG_SH2_STAT5	89	92	PF00017	0.463
LIG_SH3_1	418	424	PF00018	0.516
LIG_SH3_3	10	16	PF00018	0.492
LIG_SH3_3	418	424	PF00018	0.516
LIG_SH3_3	43	49	PF00018	0.691
LIG_SH3_3	80	86	PF00018	0.433
LIG_SUMO_SIM_anti_2	425	431	PF11976	0.475
LIG_SUMO_SIM_anti_2	53	60	PF11976	0.509
LIG_SUMO_SIM_par_1	258	266	PF11976	0.591
LIG_TRAF2_1	349	352	PF00917	0.453
LIG_TRAF2_1	353	356	PF00917	0.409
LIG_UBA3_1	74	82	PF00899	0.443
MOD_CDC14_SPxK_1	251	254	PF00782	0.609
MOD_CDK_SPxK_1	248	254	PF00069	0.611
MOD_CK1_1	105	111	PF00069	0.632
MOD_CK1_1	126	132	PF00069	0.633
MOD_CK1_1	163	169	PF00069	0.593
MOD_CK1_1	181	187	PF00069	0.517
MOD_CK1_1	192	198	PF00069	0.568
MOD_CK1_1	214	220	PF00069	0.569
MOD_CK1_1	260	266	PF00069	0.609
MOD_CK1_1	269	275	PF00069	0.550
MOD_CK1_1	283	289	PF00069	0.439
MOD_CK1_1	403	409	PF00069	0.553
MOD_CK2_1	125	131	PF00069	0.637
MOD_CK2_1	240	246	PF00069	0.594
MOD_CK2_1	25	31	PF00069	0.533
MOD_CK2_1	346	352	PF00069	0.576
MOD_GlcNHglycan	100	103	PF01048	0.590
MOD_GlcNHglycan	104	107	PF01048	0.600
MOD_GlcNHglycan	205	208	PF01048	0.630
MOD_GlcNHglycan	216	220	PF01048	0.549
MOD_GlcNHglycan	39	42	PF01048	0.545
MOD_GlcNHglycan	393	396	PF01048	0.596
MOD_GlcNHglycan	405	408	PF01048	0.513
MOD_GlcNHglycan	467	470	PF01048	0.597
MOD_GlcNHglycan	472	475	PF01048	0.554
MOD_GlcNHglycan	9	12	PF01048	0.464
MOD_GSK3_1	102	109	PF00069	0.560
MOD_GSK3_1	145	152	PF00069	0.619
MOD_GSK3_1	199	206	PF00069	0.629
MOD_GSK3_1	211	218	PF00069	0.564
MOD_GSK3_1	256	263	PF00069	0.601
MOD_GSK3_1	267	274	PF00069	0.523
MOD_GSK3_1	276	283	PF00069	0.490
MOD_GSK3_1	33	40	PF00069	0.540
MOD_GSK3_1	387	394	PF00069	0.643
MOD_GSK3_1	459	466	PF00069	0.555
MOD_GSK3_1	93	100	PF00069	0.518
MOD_N-GLC_1	336	341	PF02516	0.494
MOD_NEK2_1	191	196	PF00069	0.650
MOD_NEK2_1	203	208	PF00069	0.565
MOD_NEK2_1	256	261	PF00069	0.564
MOD_NEK2_1	363	368	PF00069	0.504
MOD_NEK2_1	386	391	PF00069	0.487
MOD_NEK2_1	465	470	PF00069	0.538
MOD_NEK2_1	7	12	PF00069	0.476
MOD_NEK2_2	233	238	PF00069	0.535
MOD_PIKK_1	189	195	PF00454	0.653
MOD_PIKK_1	240	246	PF00454	0.594
MOD_PIKK_1	363	369	PF00454	0.344
MOD_PIKK_1	380	386	PF00454	0.503
MOD_PIKK_1	50	56	PF00454	0.510
MOD_PK_1	238	244	PF00069	0.621
MOD_PK_1	443	449	PF00069	0.478
MOD_PKA_1	160	166	PF00069	0.592
MOD_PKA_1	178	184	PF00069	0.512
MOD_PKA_1	238	244	PF00069	0.639
MOD_PKA_2	178	184	PF00069	0.652
MOD_PKA_2	189	195	PF00069	0.576
MOD_PKA_2	198	204	PF00069	0.508
MOD_PKA_2	211	217	PF00069	0.566
MOD_PKA_2	238	244	PF00069	0.639
MOD_PKA_2	463	469	PF00069	0.561
MOD_PKA_2	476	482	PF00069	0.538
MOD_PKA_2	98	104	PF00069	0.588
MOD_Plk_1	412	418	PF00069	0.520
MOD_Plk_2-3	25	31	PF00069	0.533
MOD_Plk_4	163	169	PF00069	0.583
MOD_Plk_4	33	39	PF00069	0.523
MOD_Plk_4	412	418	PF00069	0.564
MOD_Plk_4	53	59	PF00069	0.497
MOD_ProDKin_1	248	254	PF00069	0.637
MOD_ProDKin_1	257	263	PF00069	0.556
MOD_ProDKin_1	280	286	PF00069	0.479
MOD_ProDKin_1	387	393	PF00069	0.542
MOD_ProDKin_1	400	406	PF00069	0.500
MOD_ProDKin_1	62	68	PF00069	0.477
MOD_SUMO_rev_2	241	249	PF00179	0.609
TRG_DiLeu_BaLyEn_6	377	382	PF01217	0.420
TRG_DiLeu_BaLyEn_6	73	78	PF01217	0.433
TRG_ENDOCYTIC_2	360	363	PF00928	0.619
TRG_ENDOCYTIC_2	44	47	PF00928	0.506
TRG_ER_diArg_1	178	180	PF00400	0.831
TRG_ER_diArg_1	188	191	PF00400	0.679
TRG_ER_diArg_1	203	205	PF00400	0.538
TRG_ER_diArg_1	305	308	PF00400	0.516
TRG_NES_CRM1_1	426	440	PF08389	0.470
TRG_Pf-PMV_PEXEL_1	130	134	PF00026	0.579
TRG_Pf-PMV_PEXEL_1	321	326	PF00026	0.438
TRG_Pf-PMV_PEXEL_1	380	384	PF00026	0.515

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A4HMN2	Leishmania braziliensis	76%	100%
A4IBA9	Leishmania infantum	100%	100%
E9AF34	Leishmania major	89%	95%
E9B689	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	100%