LeishMANIAdb
  • Home
  • Browse
  • Manual
  • FAQ
  • Download

40S ribosomal protein S6

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
40S ribosomal protein S6
Gene product:
40S ribosomal protein S6, putative
Species:
Leishmania donovani
UniProt:
A0A3S7X972_LEIDO
TriTrypDb:
LdCL_350025200 , LDHU3_21.2560 , LDHU3_35.2610
Length:
249

Annotations

Annotations by Jardim et al.

Ribosomal Protein, 40S ribosomal S6 RPS6

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) yes yes: 4
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. yes yes: 28
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 18
NetGPI no yes: 0, no: 18
Cellular components
Term Name Level Count
GO:0005840 ribosome 5 19
GO:0032991 protein-containing complex 1 19
GO:0043226 organelle 2 19
GO:0043228 non-membrane-bounded organelle 3 19
GO:0043229 intracellular organelle 3 19
GO:0043232 intracellular non-membrane-bounded organelle 4 19
GO:0110165 cellular anatomical entity 1 19
GO:1990904 ribonucleoprotein complex 2 19
GO:0005730 nucleolus 5 1
GO:0005737 cytoplasm 2 1

Expansion

Sequence features

A0A3S7X972
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7X972

PDB structure(s): 5osg_P

Function

Biological processes
Term Name Level Count
GO:0006412 translation 4 19
GO:0006518 peptide metabolic process 4 19
GO:0006807 nitrogen compound metabolic process 2 19
GO:0008152 metabolic process 1 19
GO:0009058 biosynthetic process 2 19
GO:0009059 macromolecule biosynthetic process 4 19
GO:0009987 cellular process 1 19
GO:0019538 protein metabolic process 3 19
GO:0034641 cellular nitrogen compound metabolic process 3 19
GO:0034645 obsolete cellular macromolecule biosynthetic process 4 19
GO:0043043 peptide biosynthetic process 5 19
GO:0043170 macromolecule metabolic process 3 19
GO:0043603 amide metabolic process 3 19
GO:0043604 amide biosynthetic process 4 19
GO:0044237 cellular metabolic process 2 19
GO:0044238 primary metabolic process 2 19
GO:0044249 cellular biosynthetic process 3 19
GO:0044260 obsolete cellular macromolecule metabolic process 3 19
GO:0044271 cellular nitrogen compound biosynthetic process 4 19
GO:0071704 organic substance metabolic process 2 19
GO:1901564 organonitrogen compound metabolic process 3 19
GO:1901566 organonitrogen compound biosynthetic process 4 19
GO:1901576 organic substance biosynthetic process 3 19
Molecular functions
Term Name Level Count
GO:0003735 structural constituent of ribosome 2 19
GO:0005198 structural molecule activity 1 19

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 57 61 PF00656 0.401
CLV_NRD_NRD_1 134 136 PF00675 0.528
CLV_NRD_NRD_1 144 146 PF00675 0.442
CLV_NRD_NRD_1 156 158 PF00675 0.441
CLV_NRD_NRD_1 163 165 PF00675 0.464
CLV_NRD_NRD_1 190 192 PF00675 0.476
CLV_NRD_NRD_1 209 211 PF00675 0.461
CLV_NRD_NRD_1 220 222 PF00675 0.578
CLV_NRD_NRD_1 24 26 PF00675 0.340
CLV_NRD_NRD_1 96 98 PF00675 0.340
CLV_PCSK_KEX2_1 134 136 PF00082 0.528
CLV_PCSK_KEX2_1 139 141 PF00082 0.441
CLV_PCSK_KEX2_1 162 164 PF00082 0.507
CLV_PCSK_KEX2_1 190 192 PF00082 0.476
CLV_PCSK_KEX2_1 209 211 PF00082 0.461
CLV_PCSK_KEX2_1 220 222 PF00082 0.507
CLV_PCSK_KEX2_1 24 26 PF00082 0.340
CLV_PCSK_KEX2_1 79 81 PF00082 0.343
CLV_PCSK_KEX2_1 95 97 PF00082 0.340
CLV_PCSK_PC1ET2_1 139 141 PF00082 0.441
CLV_PCSK_PC1ET2_1 79 81 PF00082 0.340
CLV_PCSK_PC7_1 135 141 PF00082 0.471
CLV_PCSK_PC7_1 186 192 PF00082 0.500
CLV_PCSK_SKI1_1 145 149 PF00082 0.465
CLV_PCSK_SKI1_1 164 168 PF00082 0.509
CLV_PCSK_SKI1_1 181 185 PF00082 0.388
CLV_PCSK_SKI1_1 190 194 PF00082 0.496
CLV_PCSK_SKI1_1 220 224 PF00082 0.669
CLV_Separin_Metazoa 21 25 PF03568 0.384
DEG_APCC_DBOX_1 209 217 PF00400 0.470
DEG_Nend_UBRbox_1 1 4 PF02207 0.360
DOC_CKS1_1 182 187 PF01111 0.601
DOC_CYCLIN_RxL_1 139 151 PF00134 0.550
DOC_MAPK_gen_1 209 215 PF00069 0.547
DOC_MAPK_gen_1 79 85 PF00069 0.363
DOC_MAPK_RevD_3 177 191 PF00069 0.475
DOC_PP2B_LxvP_1 174 177 PF13499 0.563
DOC_USP7_UBL2_3 139 143 PF12436 0.511
DOC_USP7_UBL2_3 167 171 PF12436 0.498
DOC_USP7_UBL2_3 231 235 PF12436 0.675
DOC_WW_Pin1_4 181 186 PF00397 0.584
LIG_14-3-3_CanoR_1 73 77 PF00244 0.393
LIG_FHA_1 151 157 PF00498 0.576
LIG_FHA_1 182 188 PF00498 0.494
LIG_FHA_1 231 237 PF00498 0.631
LIG_LIR_Gen_1 211 217 PF02991 0.479
LIG_LIR_Nem_3 211 215 PF02991 0.492
LIG_LIR_Nem_3 44 49 PF02991 0.346
LIG_LIR_Nem_3 60 65 PF02991 0.319
LIG_LIR_Nem_3 87 91 PF02991 0.371
LIG_PCNA_APIM_2 156 162 PF02747 0.446
LIG_Pex14_2 42 46 PF04695 0.340
LIG_SH2_STAT5 159 162 PF00017 0.469
LIG_SH2_STAT5 212 215 PF00017 0.499
LIG_SH2_STAT5 49 52 PF00017 0.373
LIG_SH3_3 60 66 PF00018 0.371
LIG_SUMO_SIM_anti_2 107 113 PF11976 0.342
LIG_SUMO_SIM_anti_2 71 78 PF11976 0.363
LIG_WRC_WIRS_1 85 90 PF05994 0.371
MOD_CDK_SPK_2 181 186 PF00069 0.647
MOD_CDK_SPxxK_3 181 188 PF00069 0.606
MOD_CK1_1 72 78 PF00069 0.360
MOD_CK2_1 148 154 PF00069 0.542
MOD_CK2_1 202 208 PF00069 0.472
MOD_Cter_Amidation 168 171 PF01082 0.502
MOD_GlcNHglycan 167 170 PF01048 0.701
MOD_GlcNHglycan 204 207 PF01048 0.471
MOD_GSK3_1 226 233 PF00069 0.727
MOD_GSK3_1 68 75 PF00069 0.488
MOD_LATS_1 228 234 PF00433 0.695
MOD_N-GLC_1 112 117 PF02516 0.442
MOD_N-GLC_1 148 153 PF02516 0.489
MOD_N-GLC_1 9 14 PF02516 0.340
MOD_NEK2_1 148 153 PF00069 0.608
MOD_NEK2_1 215 220 PF00069 0.531
MOD_NEK2_1 69 74 PF00069 0.465
MOD_NEK2_2 84 89 PF00069 0.371
MOD_PIKK_1 230 236 PF00454 0.516
MOD_PKA_1 139 145 PF00069 0.609
MOD_PKA_1 230 236 PF00069 0.662
MOD_PKA_2 139 145 PF00069 0.609
MOD_PKA_2 202 208 PF00069 0.468
MOD_PKA_2 72 78 PF00069 0.388
MOD_PKB_1 224 232 PF00069 0.690
MOD_PKB_1 52 60 PF00069 0.507
MOD_Plk_1 112 118 PF00069 0.442
MOD_Plk_4 72 78 PF00069 0.360
MOD_ProDKin_1 181 187 PF00069 0.578
TRG_DiLeu_BaEn_1 211 216 PF01217 0.489
TRG_DiLeu_BaLyEn_6 178 183 PF01217 0.446
TRG_DiLeu_LyEn_5 211 216 PF01217 0.548
TRG_ENDOCYTIC_2 212 215 PF00928 0.508
TRG_ER_diArg_1 133 135 PF00400 0.532
TRG_ER_diArg_1 161 164 PF00400 0.472
TRG_ER_diArg_1 223 226 PF00400 0.548
TRG_ER_diArg_1 23 25 PF00400 0.340
TRG_ER_diArg_1 51 54 PF00400 0.507
TRG_ER_diArg_1 95 97 PF00400 0.340
TRG_NES_CRM1_1 17 30 PF08389 0.471
TRG_Pf-PMV_PEXEL_1 221 225 PF00026 0.666

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1I6J8 Leptomonas seymouri 91% 100%
A0A0S4IXL4 Bodo saltans 74% 100%
A0A0S4JEL0 Bodo saltans 71% 94%
A0A1D8PL99 Candida albicans (strain SC5314 / ATCC MYA-2876) 52% 100%
A0A1X0NHJ4 Trypanosomatidae 74% 100%
A0A1X0P5W5 Trypanosomatidae 72% 100%
A0A3R7K8Y0 Trypanosoma rangeli 75% 100%
A0A3S7WWY7 Leishmania donovani 100% 100%
A0A422NNU2 Trypanosoma rangeli 75% 100%
A4HLC0 Leishmania braziliensis 96% 100%
A4HMM1 Leishmania braziliensis 96% 100%
A4HZI4 Leishmania infantum 100% 100%
C9ZZM7 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 75% 100%
D0A0Y7 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 75% 91%
E9AF23 Leishmania major 100% 100%
E9AVH4 Leishmania mexicana (strain MHOM/GT/2001/U1103) 100% 100%
O01727 Branchiostoma floridae 46% 100%
O44012 Leishmania infantum 100% 100%
O48549 Arabidopsis thaliana 44% 100%
P05752 Schizosaccharomyces pombe (strain 972 / ATCC 24843) 48% 100%
P0CX37 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 53% 100%
P0CX38 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 53% 100%
P29327 Drosophila melanogaster 49% 100%
P29345 Nicotiana tabacum 43% 100%
P39017 Xenopus laevis 47% 100%
P41798 Kluyveromyces marxianus 55% 100%
P47838 Gallus gallus 50% 100%
P51430 Arabidopsis thaliana 47% 100%
P62753 Homo sapiens 50% 100%
P62754 Mus musculus 50% 100%
P62755 Rattus norvegicus 50% 100%
Q2PQM1 Glossina morsitans morsitans 48% 100%
Q4R4K6 Macaca fascicularis 50% 100%
Q54UU3 Dictyostelium discoideum 49% 100%
Q5E995 Bos taurus 50% 100%
Q6BXH8 Debaryomyces hansenii (strain ATCC 36239 / CBS 767 / BCRC 21394 / JCM 1990 / NBRC 0083 / IGC 2968) 50% 100%
Q6C169 Yarrowia lipolytica (strain CLIB 122 / E 150) 49% 100%
Q6CM04 Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37) 49% 100%
Q6FJH3 Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65) 53% 100%
Q74ZK3 Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056) 52% 100%
Q8SRY0 Encephalitozoon cuniculi (strain GB-M1) 39% 100%
Q90YR8 Ictalurus punctatus 47% 100%
Q94624 Manduca sexta 45% 98%
Q95V32 Spodoptera frugiperda 46% 98%
Q9BMX5 Aplysia californica 47% 100%
Q9C0Z7 Schizosaccharomyces pombe (strain 972 / ATCC 24843) 54% 100%
Q9M3V8 Asparagus officinalis 48% 99%
Q9NE83 Leishmania major 100% 100%
Q9NEN6 Caenorhabditis elegans 47% 100%
Q9U761 Aedes aegypti 46% 72%
Q9U762 Aedes albopictus 46% 71%
Q9YGF2 Oncorhynchus mykiss 47% 100%
V5B8X2 Trypanosoma cruzi 75% 100%

Download

Download
LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2024 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS