Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S7X958_LEIDO

TriTrypDb:

LdBPK_351590.1 , LdCL_350020800 , LDHU3_35.2120

Length:

578

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	10
GO:0110165	cellular anatomical entity	1	10

Expansion

Sequence features

A0A3S7X958

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7X958

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	190	194	PF00656	0.527
CLV_C14_Caspase3-7	247	251	PF00656	0.417
CLV_NRD_NRD_1	123	125	PF00675	0.714
CLV_NRD_NRD_1	431	433	PF00675	0.693
CLV_NRD_NRD_1	459	461	PF00675	0.654
CLV_PCSK_KEX2_1	110	112	PF00082	0.737
CLV_PCSK_KEX2_1	122	124	PF00082	0.653
CLV_PCSK_KEX2_1	143	145	PF00082	0.662
CLV_PCSK_KEX2_1	459	461	PF00082	0.649
CLV_PCSK_PC1ET2_1	110	112	PF00082	0.737
CLV_PCSK_PC1ET2_1	143	145	PF00082	0.703
CLV_PCSK_SKI1_1	10	14	PF00082	0.494
CLV_PCSK_SKI1_1	408	412	PF00082	0.548
CLV_PCSK_SKI1_1	513	517	PF00082	0.610
CLV_PCSK_SKI1_1	557	561	PF00082	0.577
CLV_PCSK_SKI1_1	59	63	PF00082	0.711
DEG_APCC_DBOX_1	496	504	PF00400	0.425
DEG_APCC_DBOX_1	9	17	PF00400	0.680
DEG_Nend_UBRbox_1	1	4	PF02207	0.714
DOC_CYCLIN_RxL_1	510	521	PF00134	0.402
DOC_MAPK_DCC_7	10	18	PF00069	0.704
DOC_MAPK_gen_1	143	151	PF00069	0.499
DOC_MAPK_gen_1	155	164	PF00069	0.530
DOC_MAPK_gen_1	330	337	PF00069	0.329
DOC_MAPK_gen_1	4	13	PF00069	0.665
DOC_MAPK_gen_1	407	413	PF00069	0.383
DOC_MAPK_MEF2A_6	144	153	PF00069	0.486
DOC_MAPK_MEF2A_6	158	166	PF00069	0.453
DOC_MAPK_MEF2A_6	460	469	PF00069	0.379
DOC_PP2B_LxvP_1	515	518	PF13499	0.414
DOC_SPAK_OSR1_1	347	351	PF12202	0.439
DOC_USP7_MATH_1	128	132	PF00917	0.392
DOC_USP7_MATH_1	276	280	PF00917	0.363
DOC_USP7_MATH_1	381	385	PF00917	0.342
DOC_USP7_MATH_1	388	392	PF00917	0.355
DOC_USP7_MATH_1	5	9	PF00917	0.768
DOC_USP7_MATH_1	53	57	PF00917	0.459
DOC_WW_Pin1_4	182	187	PF00397	0.517
DOC_WW_Pin1_4	340	345	PF00397	0.304
DOC_WW_Pin1_4	386	391	PF00397	0.426
DOC_WW_Pin1_4	461	466	PF00397	0.352
DOC_WW_Pin1_4	526	531	PF00397	0.422
DOC_WW_Pin1_4	547	552	PF00397	0.279
LIG_14-3-3_CanoR_1	173	178	PF00244	0.450
LIG_14-3-3_CanoR_1	230	239	PF00244	0.529
LIG_14-3-3_CanoR_1	284	292	PF00244	0.412
LIG_14-3-3_CanoR_1	38	46	PF00244	0.487
LIG_14-3-3_CanoR_1	478	484	PF00244	0.395
LIG_14-3-3_CanoR_1	497	501	PF00244	0.447
LIG_14-3-3_CanoR_1	543	551	PF00244	0.388
LIG_14-3-3_CanoR_1	557	565	PF00244	0.379
LIG_14-3-3_CanoR_1	6	13	PF00244	0.709
LIG_14-3-3_CanoR_1	63	73	PF00244	0.475
LIG_Actin_WH2_2	44	61	PF00022	0.514
LIG_BRCT_BRCA1_1	481	485	PF00533	0.315
LIG_Clathr_ClatBox_1	134	138	PF01394	0.533
LIG_Clathr_ClatBox_1	535	539	PF01394	0.387
LIG_deltaCOP1_diTrp_1	573	578	PF00928	0.371
LIG_FHA_1	113	119	PF00498	0.462
LIG_FHA_1	234	240	PF00498	0.453
LIG_FHA_1	531	537	PF00498	0.378
LIG_FHA_1	543	549	PF00498	0.295
LIG_FHA_1	67	73	PF00498	0.515
LIG_FHA_2	155	161	PF00498	0.472
LIG_FHA_2	202	208	PF00498	0.522
LIG_FHA_2	242	248	PF00498	0.424
LIG_FHA_2	251	257	PF00498	0.468
LIG_FHA_2	285	291	PF00498	0.382
LIG_FHA_2	519	525	PF00498	0.465
LIG_HCF-1_HBM_1	486	489	PF13415	0.419
LIG_LIR_Apic_2	264	269	PF02991	0.424
LIG_LIR_Gen_1	286	297	PF02991	0.354
LIG_LIR_Gen_1	482	493	PF02991	0.320
LIG_LIR_Gen_1	529	540	PF02991	0.389
LIG_LIR_Nem_3	101	107	PF02991	0.471
LIG_LIR_Nem_3	228	232	PF02991	0.464
LIG_LIR_Nem_3	286	292	PF02991	0.354
LIG_LIR_Nem_3	311	316	PF02991	0.345
LIG_LIR_Nem_3	394	400	PF02991	0.435
LIG_LIR_Nem_3	482	488	PF02991	0.313
LIG_LIR_Nem_3	529	535	PF02991	0.398
LIG_LYPXL_yS_3	445	448	PF13949	0.465
LIG_MYND_1	514	518	PF01753	0.445
LIG_NRBOX	499	505	PF00104	0.455
LIG_PCNA_yPIPBox_3	77	87	PF02747	0.541
LIG_Pex14_1	357	361	PF04695	0.452
LIG_Pex14_2	177	181	PF04695	0.448
LIG_Pex14_2	309	313	PF04695	0.351
LIG_PTB_Apo_2	223	230	PF02174	0.535
LIG_PTB_Apo_2	301	308	PF02174	0.411
LIG_Rb_LxCxE_1	422	431	PF01857	0.333
LIG_REV1ctd_RIR_1	258	267	PF16727	0.434
LIG_SH2_CRK	266	270	PF00017	0.364
LIG_SH2_CRK	438	442	PF00017	0.414
LIG_SH2_GRB2like	178	181	PF00017	0.444
LIG_SH2_GRB2like	520	523	PF00017	0.442
LIG_SH2_NCK_1	520	524	PF00017	0.447
LIG_SH2_STAT5	178	181	PF00017	0.490
LIG_SH2_STAT5	315	318	PF00017	0.423
LIG_SH2_STAT5	336	339	PF00017	0.430
LIG_SH2_STAT5	440	443	PF00017	0.348
LIG_SH2_STAT5	473	476	PF00017	0.405
LIG_SH2_STAT5	483	486	PF00017	0.326
LIG_SH2_STAT5	489	492	PF00017	0.311
LIG_SH2_STAT5	520	523	PF00017	0.466
LIG_SH2_STAT5	558	561	PF00017	0.308
LIG_SH3_3	237	243	PF00018	0.445
LIG_SH3_3	338	344	PF00018	0.321
LIG_SUMO_SIM_anti_2	130	136	PF11976	0.471
LIG_SUMO_SIM_par_1	163	168	PF11976	0.472
LIG_SUMO_SIM_par_1	501	508	PF11976	0.425
LIG_SUMO_SIM_par_1	533	539	PF11976	0.327
LIG_TRAF2_1	321	324	PF00917	0.472
LIG_TRAF2_1	95	98	PF00917	0.499
LIG_TYR_ITIM	436	441	PF00017	0.405
LIG_WRC_WIRS_1	174	179	PF05994	0.444
MOD_CDK_SPxxK_3	340	347	PF00069	0.414
MOD_CDK_SPxxK_3	386	393	PF00069	0.368
MOD_CK1_1	176	182	PF00069	0.475
MOD_CK1_1	233	239	PF00069	0.456
MOD_CK1_1	502	508	PF00069	0.427
MOD_CK2_1	154	160	PF00069	0.474
MOD_CK2_1	201	207	PF00069	0.407
MOD_CK2_1	241	247	PF00069	0.402
MOD_CK2_1	250	256	PF00069	0.453
MOD_CK2_1	284	290	PF00069	0.357
MOD_CK2_1	388	394	PF00069	0.348
MOD_CK2_1	488	494	PF00069	0.398
MOD_CK2_1	495	501	PF00069	0.385
MOD_CK2_1	518	524	PF00069	0.441
MOD_GlcNHglycan	193	196	PF01048	0.493
MOD_GlcNHglycan	232	235	PF01048	0.709
MOD_GlcNHglycan	353	356	PF01048	0.667
MOD_GSK3_1	176	183	PF00069	0.479
MOD_GSK3_1	230	237	PF00069	0.461
MOD_GSK3_1	369	376	PF00069	0.428
MOD_GSK3_1	495	502	PF00069	0.419
MOD_GSK3_1	526	533	PF00069	0.454
MOD_GSK3_1	547	554	PF00069	0.333
MOD_N-GLC_1	112	117	PF02516	0.728
MOD_N-GLC_1	128	133	PF02516	0.556
MOD_N-GLC_1	201	206	PF02516	0.673
MOD_N-GLC_1	225	230	PF02516	0.745
MOD_N-GLC_1	261	266	PF02516	0.661
MOD_N-GLC_1	305	310	PF02516	0.550
MOD_N-GLC_1	446	451	PF02516	0.635
MOD_N-GLC_2	180	182	PF02516	0.644
MOD_NEK2_1	149	154	PF00069	0.440
MOD_NEK2_1	191	196	PF00069	0.338
MOD_NEK2_1	261	266	PF00069	0.387
MOD_NEK2_1	283	288	PF00069	0.404
MOD_NEK2_1	316	321	PF00069	0.429
MOD_NEK2_1	552	557	PF00069	0.328
MOD_NEK2_2	225	230	PF00069	0.418
MOD_PIKK_1	165	171	PF00454	0.505
MOD_PIKK_1	507	513	PF00454	0.454
MOD_PIKK_1	66	72	PF00454	0.532
MOD_PKA_2	283	289	PF00069	0.402
MOD_PKA_2	290	296	PF00069	0.419
MOD_PKA_2	37	43	PF00069	0.510
MOD_PKA_2	496	502	PF00069	0.449
MOD_PKA_2	5	11	PF00069	0.715
MOD_PKA_2	542	548	PF00069	0.357
MOD_PKB_1	367	375	PF00069	0.412
MOD_Plk_1	128	134	PF00069	0.526
MOD_Plk_1	225	231	PF00069	0.557
MOD_Plk_1	261	267	PF00069	0.462
MOD_Plk_1	305	311	PF00069	0.346
MOD_Plk_1	507	513	PF00069	0.473
MOD_Plk_2-3	250	256	PF00069	0.505
MOD_Plk_2-3	96	102	PF00069	0.520
MOD_Plk_4	128	134	PF00069	0.481
MOD_Plk_4	17	23	PF00069	0.330
MOD_Plk_4	276	282	PF00069	0.412
MOD_Plk_4	479	485	PF00069	0.396
MOD_Plk_4	499	505	PF00069	0.434
MOD_ProDKin_1	182	188	PF00069	0.515
MOD_ProDKin_1	340	346	PF00069	0.305
MOD_ProDKin_1	386	392	PF00069	0.423
MOD_ProDKin_1	461	467	PF00069	0.348
MOD_ProDKin_1	526	532	PF00069	0.418
MOD_ProDKin_1	547	553	PF00069	0.280
MOD_SUMO_for_1	109	112	PF00179	0.538
MOD_SUMO_rev_2	311	316	PF00179	0.385
MOD_SUMO_rev_2	55	61	PF00179	0.514
TRG_DiLeu_BaEn_1	130	135	PF01217	0.528
TRG_DiLeu_BaEn_1	68	73	PF01217	0.534
TRG_DiLeu_BaEn_4	247	253	PF01217	0.485
TRG_DiLeu_BaLyEn_6	341	346	PF01217	0.358
TRG_DiLeu_BaLyEn_6	511	516	PF01217	0.453
TRG_ENDOCYTIC_2	104	107	PF00928	0.521
TRG_ENDOCYTIC_2	438	441	PF00928	0.376
TRG_ENDOCYTIC_2	445	448	PF00928	0.414
TRG_ENDOCYTIC_2	489	492	PF00928	0.316
TRG_ER_diArg_1	121	124	PF00400	0.490
TRG_NES_CRM1_1	140	154	PF08389	0.496
TRG_Pf-PMV_PEXEL_1	230	235	PF00026	0.679
TRG_Pf-PMV_PEXEL_1	263	267	PF00026	0.654
TRG_Pf-PMV_PEXEL_1	314	318	PF00026	0.572
TRG_Pf-PMV_PEXEL_1	383	387	PF00026	0.612
TRG_Pf-PMV_PEXEL_1	52	57	PF00026	0.670

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IJZ6	Leptomonas seymouri	43%	100%
A0A0S4J8J1	Bodo saltans	24%	100%
A0A1X0P5Y1	Trypanosomatidae	29%	100%
A0A3R7KJC8	Trypanosoma rangeli	29%	100%
A4HMI0	Leishmania braziliensis	71%	99%
A4IB60	Leishmania infantum	99%	100%
E9AEY1	Leishmania major	90%	100%
E9B637	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	100%
V5BJE1	Trypanosoma cruzi	29%	100%