Emp24/gp25L/p24 family/GOLD protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

COP-coated vesicle membrane protein gp25L precursor, putative

Species:

Leishmania donovani

UniProt:

A0A3S7X951_LEIDO

TriTrypDb:

LdBPK_351840.1 , LdCL_350023300 , LDHU3_35.2410

Length:

214

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	yes	yes: 8, no: 2
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	11
GO:0110165	cellular anatomical entity	1	11
GO:0005783	endoplasmic reticulum	5	1
GO:0005793	endoplasmic reticulum-Golgi intermediate compartment	5	1
GO:0005794	Golgi apparatus	5	1
GO:0030134	COPII-coated ER to Golgi transport vesicle	8	1
GO:0030135	coated vesicle	7	1
GO:0031410	cytoplasmic vesicle	6	1
GO:0031982	vesicle	4	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0097708	intracellular vesicle	5	1

Expansion

Sequence features

A0A3S7X951

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7X951

Function

Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	1
GO:0006886	intracellular protein transport	4	1
GO:0006888	endoplasmic reticulum to Golgi vesicle-mediated transport	4	1
GO:0006996	organelle organization	4	1
GO:0007030	Golgi organization	5	1
GO:0008104	protein localization	4	1
GO:0009987	cellular process	1	1
GO:0015031	protein transport	4	1
GO:0016043	cellular component organization	3	1
GO:0016192	vesicle-mediated transport	4	1
GO:0033036	macromolecule localization	2	1
GO:0045184	establishment of protein localization	3	1
GO:0046907	intracellular transport	3	1
GO:0048193	Golgi vesicle transport	5	1
GO:0051179	localization	1	1
GO:0051234	establishment of localization	2	1
GO:0051641	cellular localization	2	1
GO:0051649	establishment of localization in cell	3	1
GO:0070727	cellular macromolecule localization	3	1
GO:0071702	organic substance transport	4	1
GO:0071705	nitrogen compound transport	4	1
GO:0071840	cellular component organization or biogenesis	2	1

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	3	5	PF00675	0.725
CLV_PCSK_KEX2_1	204	206	PF00082	0.271
CLV_PCSK_KEX2_1	210	212	PF00082	0.402
CLV_PCSK_KEX2_1	3	5	PF00082	0.714
CLV_PCSK_PC1ET2_1	204	206	PF00082	0.273
CLV_PCSK_PC1ET2_1	210	212	PF00082	0.401
CLV_PCSK_SKI1_1	115	119	PF00082	0.524
CLV_PCSK_SKI1_1	201	205	PF00082	0.274
CLV_PCSK_SKI1_1	39	43	PF00082	0.536
DEG_APCC_DBOX_1	114	122	PF00400	0.340
DEG_APCC_DBOX_1	38	46	PF00400	0.281
DEG_SPOP_SBC_1	21	25	PF00917	0.511
DOC_MAPK_gen_1	112	120	PF00069	0.268
DOC_MAPK_gen_1	136	144	PF00069	0.274
DOC_MAPK_MEF2A_6	112	121	PF00069	0.279
DOC_MAPK_MEF2A_6	138	146	PF00069	0.262
DOC_MAPK_MEF2A_6	180	188	PF00069	0.425
DOC_PP1_RVXF_1	178	184	PF00149	0.313
DOC_USP7_MATH_1	10	14	PF00917	0.439
DOC_USP7_UBL2_3	204	208	PF12436	0.540
LIG_14-3-3_CanoR_1	4	10	PF00244	0.633
LIG_Actin_WH2_2	38	54	PF00022	0.331
LIG_BIR_II_1	1	5	PF00653	0.468
LIG_BRCT_BRCA1_1	37	41	PF00533	0.340
LIG_BRCT_BRCA1_1	84	88	PF00533	0.308
LIG_BRCT_BRCA1_1	98	102	PF00533	0.146
LIG_FHA_1	112	118	PF00498	0.298
LIG_FHA_1	12	18	PF00498	0.578
LIG_FHA_1	176	182	PF00498	0.271
LIG_FHA_2	150	156	PF00498	0.313
LIG_FHA_2	58	64	PF00498	0.343
LIG_LIR_Gen_1	129	134	PF02991	0.274
LIG_LIR_Gen_1	159	168	PF02991	0.292
LIG_LIR_Gen_1	63	72	PF02991	0.337
LIG_LIR_Nem_3	159	163	PF02991	0.272
LIG_LIR_Nem_3	58	64	PF02991	0.299
LIG_LIR_Nem_3	76	81	PF02991	0.298
LIG_Pex14_2	192	196	PF04695	0.428
LIG_SH2_STAP1	130	134	PF00017	0.291
LIG_SH2_STAT5	162	165	PF00017	0.279
LIG_SH2_STAT5	197	200	PF00017	0.425
LIG_SH2_STAT5	206	209	PF00017	0.449
LIG_SUMO_SIM_anti_2	116	122	PF11976	0.308
LIG_SUMO_SIM_anti_2	63	70	PF11976	0.369
LIG_SUMO_SIM_par_1	17	25	PF11976	0.409
LIG_TRAF2_1	152	155	PF00917	0.364
MOD_CK1_1	35	41	PF00069	0.364
MOD_CK2_1	149	155	PF00069	0.337
MOD_GlcNHglycan	109	112	PF01048	0.554
MOD_GlcNHglycan	34	37	PF01048	0.545
MOD_GlcNHglycan	46	49	PF01048	0.482
MOD_GlcNHglycan	84	87	PF01048	0.541
MOD_GSK3_1	107	114	PF00069	0.278
MOD_GSK3_1	96	103	PF00069	0.296
MOD_NEK2_1	100	105	PF00069	0.367
MOD_NEK2_1	113	118	PF00069	0.128
MOD_NEK2_1	149	154	PF00069	0.294
MOD_NEK2_1	182	187	PF00069	0.361
MOD_NEK2_1	20	25	PF00069	0.540
MOD_NEK2_1	81	86	PF00069	0.311
MOD_PKA_1	3	9	PF00069	0.651
MOD_PKA_2	170	176	PF00069	0.313
MOD_PKA_2	3	9	PF00069	0.638
MOD_PKA_2	90	96	PF00069	0.340
MOD_Plk_1	149	155	PF00069	0.313
MOD_Plk_1	57	63	PF00069	0.327
MOD_Plk_1	96	102	PF00069	0.255
MOD_Plk_4	73	79	PF00069	0.292
TRG_ENDOCYTIC_2	130	133	PF00928	0.261
TRG_ENDOCYTIC_2	197	200	PF00928	0.425
TRG_ENDOCYTIC_2	61	64	PF00928	0.273
TRG_ENDOCYTIC_2	78	81	PF00928	0.281
TRG_ER_diArg_1	163	166	PF00400	0.364
TRG_NES_CRM1_1	137	151	PF08389	0.274
TRG_NLS_MonoCore_2	207	212	PF00514	0.619
TRG_NLS_MonoExtC_3	208	214	PF00514	0.612
TRG_NLS_MonoExtN_4	205	212	PF00514	0.600

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PBE2	Leptomonas seymouri	61%	100%
A0A0S4IQL9	Bodo saltans	41%	100%
A0A0S4J7E6	Bodo saltans	23%	97%
A0A0S4JYK0	Bodo saltans	23%	100%
A0A1X0NVX2	Trypanosomatidae	21%	94%
A0A1X0P6V5	Trypanosomatidae	43%	100%
A0A3R7NST9	Trypanosoma rangeli	44%	100%
A0A422NB76	Trypanosoma rangeli	22%	97%
A0AQ71	Drosophila simulans	25%	100%
A4HMK6	Leishmania braziliensis	85%	100%
A4IB85	Leishmania infantum	99%	100%
A7SXK3	Nematostella vectensis	22%	100%
B3LVB0	Drosophila ananassae	25%	100%
B3MTS8	Drosophila ananassae	26%	99%
B3NZM5	Drosophila erecta	26%	99%
B3P6T8	Drosophila erecta	25%	100%
B4GE47	Drosophila persimilis	25%	100%
B4GMC3	Drosophila persimilis	26%	99%
B4HJV5	Drosophila sechellia	27%	99%
B4JG34	Drosophila grimshawi	27%	99%
B4JYU5	Drosophila grimshawi	25%	100%
B4K4G5	Drosophila mojavensis	25%	100%
B4KB41	Drosophila mojavensis	26%	99%
B4LYB8	Drosophila virilis	26%	99%
B4MGF8	Drosophila virilis	25%	100%
B4NIY1	Drosophila willistoni	26%	100%
B4NKL0	Drosophila willistoni	27%	99%
B4PUZ3	Drosophila yakuba	25%	100%
B4PVC6	Drosophila yakuba	27%	99%
B4QWH9	Drosophila simulans	27%	99%
C9ZZL0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	45%	98%
D0AA90	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	24%	94%
D3ZTX0	Rattus norvegicus	23%	95%
E9AF06	Leishmania major	96%	100%
E9B662	Leishmania mexicana (strain MHOM/GT/2001/U1103)	94%	100%
F4J4Y0	Arabidopsis thaliana	30%	99%
O13946	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	30%	99%
O14324	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	24%	100%
O17528	Caenorhabditis elegans	24%	100%
O35587	Mesocricetus auratus	28%	98%
O81045	Arabidopsis thaliana	26%	100%
P27869	Canis lupus familiaris	22%	100%
P38819	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	24%	100%
P49020	Cricetulus griseus	23%	100%
P49755	Homo sapiens	28%	98%
P53198	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	24%	99%
Q05359	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	24%	98%
Q13445	Homo sapiens	24%	94%
Q15363	Homo sapiens	23%	100%
Q28735	Oryctolagus cuniculus	28%	98%
Q295B2	Drosophila pseudoobscura pseudoobscura	26%	99%
Q2TBK5	Bos taurus	26%	94%
Q3T133	Bos taurus	27%	91%
Q3V009	Mus musculus	26%	94%
Q4HY20	Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)	31%	100%
Q54BN0	Dictyostelium discoideum	25%	100%
Q5A302	Candida albicans (strain SC5314 / ATCC MYA-2876)	29%	100%
Q5B5L5	Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)	29%	99%
Q5E971	Bos taurus	28%	98%
Q5I0E7	Rattus norvegicus	27%	91%
Q5R7E6	Pongo abelii	24%	94%
Q5RE32	Pongo abelii	28%	98%
Q63524	Rattus norvegicus	23%	100%
Q63584	Rattus norvegicus	28%	98%
Q6AY25	Rattus norvegicus	25%	97%
Q6BTC2	Debaryomyces hansenii (strain ATCC 36239 / CBS 767 / BCRC 21394 / JCM 1990 / NBRC 0083 / IGC 2968)	30%	100%
Q6C503	Yarrowia lipolytica (strain CLIB 122 / E 150)	28%	100%
Q6CWW7	Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)	27%	100%
Q6FRZ3	Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65)	30%	100%
Q6IDL4	Arabidopsis thaliana	27%	99%
Q759T8	Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)	28%	100%
Q769F9	Dictyostelium discoideum	27%	100%
Q78IS1	Mus musculus	25%	97%
Q7Z7H5	Homo sapiens	28%	94%
Q8GYG1	Arabidopsis thaliana	27%	100%
Q8R1V4	Mus musculus	29%	94%
Q8RWM6	Arabidopsis thaliana	29%	99%
Q8SXY6	Drosophila melanogaster	24%	100%
Q8VY92	Arabidopsis thaliana	27%	100%
Q90515	Takifugu rubripes	28%	100%
Q99KF1	Mus musculus	27%	91%
Q9BVK6	Homo sapiens	27%	91%
Q9D1D4	Mus musculus	29%	98%
Q9D2R4	Mus musculus	25%	100%
Q9FVU0	Arabidopsis thaliana	28%	100%
Q9HEK4	Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)	31%	99%
Q9I7K5	Drosophila melanogaster	27%	99%
Q9LIL4	Arabidopsis thaliana	24%	100%
Q9LJV9	Arabidopsis thaliana	23%	95%
Q9LQY3	Arabidopsis thaliana	27%	100%
Q9P7I9	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	23%	100%
Q9R0Q3	Mus musculus	23%	100%
Q9Y3B3	Homo sapiens	24%	96%
Q9Y3Q3	Homo sapiens	26%	99%
V5BG96	Trypanosoma cruzi	22%	97%