DNA polymerase II subunit 2

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

DNA polymerase epsilon subunit B, putative

Species:

Leishmania donovani

UniProt:

A0A3S7X944_LEIDO

TriTrypDb:

LdBPK_351780.1 , LdCL_350022700 , LDHU3_35.2340

Length:

552

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0008622	epsilon DNA polymerase complex	3	12
GO:0032991	protein-containing complex	1	12
GO:0042575	DNA polymerase complex	3	12
GO:0061695	transferase complex, transferring phosphorus-containing groups	4	12
GO:0140513	nuclear protein-containing complex	2	12
GO:0140535	intracellular protein-containing complex	2	12
GO:1902494	catalytic complex	2	12
GO:1990234	transferase complex	3	12

Expansion

Sequence features

A0A3S7X944

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7X944

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	12
GO:0006259	DNA metabolic process	4	12
GO:0006260	DNA replication	5	12
GO:0006261	DNA-templated DNA replication	6	12
GO:0006725	cellular aromatic compound metabolic process	3	12
GO:0006807	nitrogen compound metabolic process	2	12
GO:0008152	metabolic process	1	12
GO:0009987	cellular process	1	12
GO:0034641	cellular nitrogen compound metabolic process	3	12
GO:0043170	macromolecule metabolic process	3	12
GO:0044237	cellular metabolic process	2	12
GO:0044238	primary metabolic process	2	12
GO:0044260	obsolete cellular macromolecule metabolic process	3	12
GO:0046483	heterocycle metabolic process	3	12
GO:0071704	organic substance metabolic process	2	12
GO:0090304	nucleic acid metabolic process	4	12
GO:1901360	organic cyclic compound metabolic process	3	12
GO:0000731	DNA synthesis involved in DNA repair	6	1
GO:0006281	DNA repair	5	1
GO:0006301	postreplication repair	6	1
GO:0006950	response to stress	2	1
GO:0006974	DNA damage response	4	1
GO:0009058	biosynthetic process	2	1
GO:0009059	macromolecule biosynthetic process	4	1
GO:0018130	heterocycle biosynthetic process	4	1
GO:0019438	aromatic compound biosynthetic process	4	1
GO:0019985	translesion synthesis	7	1
GO:0033554	cellular response to stress	3	1
GO:0034654	nucleobase-containing compound biosynthetic process	4	1
GO:0042276	error-prone translesion synthesis	8	1
GO:0044249	cellular biosynthetic process	3	1
GO:0044271	cellular nitrogen compound biosynthetic process	4	1
GO:0050896	response to stimulus	1	1
GO:0051716	cellular response to stimulus	2	1
GO:0071897	DNA biosynthetic process	5	1
GO:1901362	organic cyclic compound biosynthetic process	4	1
GO:1901576	organic substance biosynthetic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	12
GO:0003677	DNA binding	4	12
GO:0003824	catalytic activity	1	8
GO:0005488	binding	1	12
GO:0016740	transferase activity	2	8
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	8
GO:0016779	nucleotidyltransferase activity	4	8
GO:0097159	organic cyclic compound binding	2	12
GO:1901363	heterocyclic compound binding	2	12

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	244	248	PF00656	0.370
CLV_C14_Caspase3-7	446	450	PF00656	0.409
CLV_NRD_NRD_1	134	136	PF00675	0.279
CLV_NRD_NRD_1	240	242	PF00675	0.377
CLV_NRD_NRD_1	41	43	PF00675	0.360
CLV_NRD_NRD_1	423	425	PF00675	0.244
CLV_NRD_NRD_1	8	10	PF00675	0.516
CLV_PCSK_KEX2_1	133	135	PF00082	0.301
CLV_PCSK_KEX2_1	240	242	PF00082	0.368
CLV_PCSK_KEX2_1	271	273	PF00082	0.551
CLV_PCSK_KEX2_1	41	43	PF00082	0.371
CLV_PCSK_KEX2_1	423	425	PF00082	0.262
CLV_PCSK_PC1ET2_1	271	273	PF00082	0.382
CLV_PCSK_PC7_1	267	273	PF00082	0.381
CLV_PCSK_SKI1_1	128	132	PF00082	0.268
CLV_PCSK_SKI1_1	241	245	PF00082	0.494
CLV_PCSK_SKI1_1	310	314	PF00082	0.389
CLV_PCSK_SKI1_1	401	405	PF00082	0.296
CLV_PCSK_SKI1_1	42	46	PF00082	0.322
CLV_PCSK_SKI1_1	424	428	PF00082	0.278
CLV_PCSK_SKI1_1	473	477	PF00082	0.293
DEG_APCC_DBOX_1	41	49	PF00400	0.321
DEG_APCC_DBOX_1	423	431	PF00400	0.265
DEG_Nend_UBRbox_1	1	4	PF02207	0.500
DEG_SCF_FBW7_1	384	390	PF00400	0.265
DEG_SPOP_SBC_1	112	116	PF00917	0.452
DEG_SPOP_SBC_1	462	466	PF00917	0.262
DOC_CKS1_1	384	389	PF01111	0.389
DOC_CKS1_1	538	543	PF01111	0.296
DOC_CYCLIN_RxL_1	470	478	PF00134	0.265
DOC_CYCLIN_yClb1_LxF_4	409	414	PF00134	0.244
DOC_CYCLIN_yCln2_LP_2	497	503	PF00134	0.338
DOC_MAPK_DCC_7	16	24	PF00069	0.381
DOC_MAPK_gen_1	270	279	PF00069	0.461
DOC_MAPK_HePTP_8	489	501	PF00069	0.308
DOC_MAPK_MEF2A_6	192	199	PF00069	0.427
DOC_MAPK_MEF2A_6	271	280	PF00069	0.450
DOC_MAPK_MEF2A_6	492	501	PF00069	0.282
DOC_MAPK_NFAT4_5	192	200	PF00069	0.446
DOC_PIKK_1	183	191	PF02985	0.419
DOC_PIKK_1	58	65	PF02985	0.412
DOC_PP1_RVXF_1	194	200	PF00149	0.373
DOC_PP1_RVXF_1	308	315	PF00149	0.363
DOC_PP1_RVXF_1	409	415	PF00149	0.268
DOC_PP2B_LxvP_1	257	260	PF13499	0.435
DOC_PP2B_LxvP_1	497	500	PF13499	0.264
DOC_SPAK_OSR1_1	342	346	PF12202	0.188
DOC_USP7_MATH_1	248	252	PF00917	0.525
DOC_USP7_MATH_1	362	366	PF00917	0.380
DOC_USP7_MATH_1	371	375	PF00917	0.316
DOC_USP7_MATH_1	460	464	PF00917	0.257
DOC_USP7_UBL2_3	16	20	PF12436	0.388
DOC_WW_Pin1_4	203	208	PF00397	0.255
DOC_WW_Pin1_4	383	388	PF00397	0.389
DOC_WW_Pin1_4	479	484	PF00397	0.389
DOC_WW_Pin1_4	537	542	PF00397	0.283
LIG_14-3-3_CanoR_1	111	119	PF00244	0.500
LIG_14-3-3_CanoR_1	26	31	PF00244	0.454
LIG_14-3-3_CanoR_1	272	277	PF00244	0.522
LIG_14-3-3_CanoR_1	413	421	PF00244	0.263
LIG_14-3-3_CanoR_1	470	476	PF00244	0.423
LIG_Actin_WH2_2	184	200	PF00022	0.376
LIG_Actin_WH2_2	294	312	PF00022	0.389
LIG_BRCT_BRCA1_1	339	343	PF00533	0.188
LIG_FHA_1	225	231	PF00498	0.253
LIG_FHA_1	398	404	PF00498	0.326
LIG_FHA_1	414	420	PF00498	0.201
LIG_FHA_1	470	476	PF00498	0.399
LIG_FHA_1	503	509	PF00498	0.377
LIG_FHA_2	229	235	PF00498	0.386
LIG_FHA_2	242	248	PF00498	0.347
LIG_FHA_2	34	40	PF00498	0.423
LIG_FHA_2	464	470	PF00498	0.270
LIG_FHA_2	472	478	PF00498	0.216
LIG_FHA_2	538	544	PF00498	0.297
LIG_IRF3_LxIS_1	156	162	PF10401	0.371
LIG_LIR_Apic_2	535	541	PF02991	0.291
LIG_LIR_Gen_1	25	34	PF02991	0.351
LIG_LIR_Gen_1	317	327	PF02991	0.351
LIG_LIR_Gen_1	340	350	PF02991	0.188
LIG_LIR_Gen_1	365	373	PF02991	0.340
LIG_LIR_Gen_1	465	476	PF02991	0.264
LIG_LIR_Gen_1	47	54	PF02991	0.307
LIG_LIR_Nem_3	25	30	PF02991	0.337
LIG_LIR_Nem_3	317	323	PF02991	0.324
LIG_LIR_Nem_3	340	346	PF02991	0.236
LIG_LIR_Nem_3	365	370	PF02991	0.340
LIG_LIR_Nem_3	465	471	PF02991	0.264
LIG_LIR_Nem_3	47	52	PF02991	0.293
LIG_LIR_Nem_3	516	522	PF02991	0.353
LIG_LIR_Nem_3	535	539	PF02991	0.185
LIG_PCNA_PIPBox_1	291	300	PF02747	0.389
LIG_Pex14_1	515	519	PF04695	0.312
LIG_Pex14_2	316	320	PF04695	0.386
LIG_Pex14_2	323	327	PF04695	0.389
LIG_REV1ctd_RIR_1	295	304	PF16727	0.244
LIG_SH2_CRK	519	523	PF00017	0.349
LIG_SH2_NCK_1	539	543	PF00017	0.326
LIG_SH2_STAT5	539	542	PF00017	0.277
LIG_SH3_3	230	236	PF00018	0.453
LIG_SH3_3	256	262	PF00018	0.510
LIG_SH3_3	365	371	PF00018	0.243
LIG_SH3_3	381	387	PF00018	0.222
LIG_SH3_3	497	503	PF00018	0.303
LIG_SH3_3	521	527	PF00018	0.346
LIG_SUMO_SIM_anti_2	155	160	PF11976	0.446
LIG_SUMO_SIM_anti_2	275	281	PF11976	0.303
LIG_SUMO_SIM_par_1	177	185	PF11976	0.371
LIG_SUMO_SIM_par_1	20	25	PF11976	0.377
LIG_SUMO_SIM_par_1	68	75	PF11976	0.467
LIG_TRAF2_1	36	39	PF00917	0.408
LIG_TRAF2_1	72	75	PF00917	0.389
LIG_TRFH_1	17	21	PF08558	0.338
LIG_TRFH_1	255	259	PF08558	0.426
LIG_TRFH_1	367	371	PF08558	0.338
LIG_WRC_WIRS_1	27	32	PF05994	0.446
MOD_CK1_1	113	119	PF00069	0.549
MOD_CK1_1	200	206	PF00069	0.455
MOD_CK1_1	374	380	PF00069	0.433
MOD_CK1_1	463	469	PF00069	0.179
MOD_CK2_1	159	165	PF00069	0.438
MOD_CK2_1	302	308	PF00069	0.251
MOD_CK2_1	33	39	PF00069	0.470
MOD_CK2_1	463	469	PF00069	0.294
MOD_CK2_1	481	487	PF00069	0.312
MOD_CK2_1	69	75	PF00069	0.462
MOD_GlcNHglycan	161	164	PF01048	0.468
MOD_GlcNHglycan	219	222	PF01048	0.430
MOD_GlcNHglycan	457	460	PF01048	0.371
MOD_GSK3_1	22	29	PF00069	0.388
MOD_GSK3_1	224	231	PF00069	0.251
MOD_GSK3_1	310	317	PF00069	0.328
MOD_GSK3_1	383	390	PF00069	0.433
MOD_GSK3_1	397	404	PF00069	0.368
MOD_GSK3_1	441	448	PF00069	0.350
MOD_GSK3_1	460	467	PF00069	0.195
MOD_GSK3_1	81	88	PF00069	0.507
MOD_N-GLC_1	224	229	PF02516	0.445
MOD_N-GLC_1	532	537	PF02516	0.318
MOD_NEK2_1	110	115	PF00069	0.522
MOD_NEK2_1	22	27	PF00069	0.425
MOD_NEK2_1	228	233	PF00069	0.457
MOD_PIKK_1	387	393	PF00454	0.265
MOD_PK_1	272	278	PF00069	0.372
MOD_PKA_1	401	407	PF00069	0.389
MOD_PKA_2	110	116	PF00069	0.449
MOD_PKA_2	442	448	PF00069	0.188
MOD_PKA_2	469	475	PF00069	0.351
MOD_PKB_1	411	419	PF00069	0.244
MOD_Plk_1	200	206	PF00069	0.425
MOD_Plk_1	241	247	PF00069	0.370
MOD_Plk_1	310	316	PF00069	0.266
MOD_Plk_1	318	324	PF00069	0.248
MOD_Plk_1	328	334	PF00069	0.214
MOD_Plk_1	374	380	PF00069	0.389
MOD_Plk_4	214	220	PF00069	0.422
MOD_Plk_4	26	32	PF00069	0.331
MOD_Plk_4	272	278	PF00069	0.367
MOD_Plk_4	310	316	PF00069	0.278
MOD_Plk_4	471	477	PF00069	0.259
MOD_Plk_4	502	508	PF00069	0.320
MOD_Plk_4	532	538	PF00069	0.300
MOD_ProDKin_1	203	209	PF00069	0.250
MOD_ProDKin_1	383	389	PF00069	0.389
MOD_ProDKin_1	479	485	PF00069	0.389
MOD_ProDKin_1	537	543	PF00069	0.292
MOD_SUMO_for_1	4	7	PF00179	0.391
MOD_SUMO_for_1	65	68	PF00179	0.390
MOD_SUMO_rev_2	264	273	PF00179	0.503
MOD_SUMO_rev_2	58	67	PF00179	0.435
MOD_SUMO_rev_2	72	78	PF00179	0.420
TRG_ENDOCYTIC_2	519	522	PF00928	0.355
TRG_ER_diArg_1	133	135	PF00400	0.332
TRG_ER_diArg_1	40	42	PF00400	0.394
TRG_ER_diArg_1	411	414	PF00400	0.244
TRG_Pf-PMV_PEXEL_1	42	47	PF00026	0.533

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P4D7	Leptomonas seymouri	70%	100%
A0A0S4IQS3	Bodo saltans	39%	100%
A0A1X0P6P7	Trypanosomatidae	48%	100%
A0A3R7LHF8	Trypanosoma rangeli	45%	100%
A4HMK0	Leishmania braziliensis	86%	100%
A4IB79	Leishmania infantum	99%	100%
A7YWS7	Bos taurus	24%	100%
C9ZZK4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	45%	100%
E9AF00	Leishmania major	95%	100%
E9B656	Leishmania mexicana (strain MHOM/GT/2001/U1103)	94%	100%
O54956	Mus musculus	24%	100%
O94263	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	28%	93%
P0CN24	Cryptococcus neoformans var. neoformans serotype D (strain JEC21 / ATCC MYA-565)	26%	100%
P0CN25	Cryptococcus neoformans var. neoformans serotype D (strain B-3501A)	26%	100%
P24482	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	26%	80%
P56282	Homo sapiens	23%	100%
Q19196	Caenorhabditis elegans	23%	100%
Q500V9	Arabidopsis thaliana	26%	100%
Q54Y85	Dictyostelium discoideum	25%	82%
Q5ZKQ6	Gallus gallus	22%	100%
Q6BQR8	Debaryomyces hansenii (strain ATCC 36239 / CBS 767 / BCRC 21394 / JCM 1990 / NBRC 0083 / IGC 2968)	23%	83%
Q6CPH8	Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)	25%	78%
Q6FSK8	Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65)	27%	77%
Q758V1	Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)	24%	82%
Q9VRQ7	Drosophila melanogaster	26%	100%
V5BHX7	Trypanosoma cruzi	45%	100%