Hypothetical_protein_conserved

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S7X940_LEIDO

TriTrypDb:

LdBPK_350960.1 , LdCL_350014400 , LDHU3_35.1170

Length:

249

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	4
GO:0110165	cellular anatomical entity	1	4

Expansion

Sequence features

A0A3S7X940

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7X940

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	217	219	PF00675	0.361
CLV_NRD_NRD_1	82	84	PF00675	0.512
CLV_PCSK_KEX2_1	216	218	PF00082	0.388
CLV_PCSK_KEX2_1	28	30	PF00082	0.511
CLV_PCSK_KEX2_1	82	84	PF00082	0.512
CLV_PCSK_PC1ET2_1	216	218	PF00082	0.437
CLV_PCSK_PC1ET2_1	28	30	PF00082	0.449
CLV_PCSK_SKI1_1	194	198	PF00082	0.455
DEG_Nend_Nbox_1	1	3	PF02207	0.740
DEG_SPOP_SBC_1	17	21	PF00917	0.715
DEG_SPOP_SBC_1	67	71	PF00917	0.702
DOC_USP7_MATH_1	17	21	PF00917	0.715
DOC_USP7_MATH_1	47	51	PF00917	0.699
DOC_USP7_MATH_1	65	69	PF00917	0.747
DOC_USP7_MATH_2	91	97	PF00917	0.712
DOC_USP7_UBL2_3	105	109	PF12436	0.683
DOC_USP7_UBL2_3	194	198	PF12436	0.655
DOC_WW_Pin1_4	167	172	PF00397	0.665
DOC_WW_Pin1_4	175	180	PF00397	0.667
LIG_14-3-3_CanoR_1	158	164	PF00244	0.654
LIG_14-3-3_CanoR_1	29	38	PF00244	0.705
LIG_14-3-3_CanoR_1	48	53	PF00244	0.661
LIG_BRCT_BRCA1_1	95	99	PF00533	0.656
LIG_DCNL_PONY_1	1	4	PF03556	0.674
LIG_FHA_1	105	111	PF00498	0.679
LIG_FHA_1	19	25	PF00498	0.753
LIG_FHA_1	33	39	PF00498	0.599
LIG_FHA_1	67	73	PF00498	0.754
LIG_FHA_2	197	203	PF00498	0.645
LIG_FHA_2	210	216	PF00498	0.593
LIG_LIR_Gen_1	100	110	PF02991	0.611
LIG_LIR_Nem_3	100	106	PF02991	0.616
LIG_LIR_Nem_3	7	11	PF02991	0.734
LIG_LYPXL_yS_3	208	211	PF13949	0.683
LIG_MAD2	195	203	PF02301	0.705
LIG_Pex14_2	99	103	PF04695	0.644
LIG_SH2_NCK_1	127	131	PF00017	0.688
LIG_SH2_STAP1	192	196	PF00017	0.681
LIG_SH2_STAT5	163	166	PF00017	0.659
LIG_SH3_3	173	179	PF00018	0.688
LIG_SH3_3	61	67	PF00018	0.631
LIG_SUMO_SIM_par_1	18	27	PF11976	0.689
LIG_SUMO_SIM_par_1	209	215	PF11976	0.635
LIG_TRAF2_1	212	215	PF00917	0.682
LIG_ULM_U2AF65_1	216	222	PF00076	0.515
MOD_CDK_SPxxK_3	175	182	PF00069	0.589
MOD_CK1_1	162	168	PF00069	0.564
MOD_CK1_1	18	24	PF00069	0.722
MOD_CK1_1	27	33	PF00069	0.539
MOD_CK1_1	34	40	PF00069	0.737
MOD_CK1_1	68	74	PF00069	0.624
MOD_CK1_1	9	15	PF00069	0.717
MOD_CK2_1	196	202	PF00069	0.564
MOD_CK2_1	209	215	PF00069	0.500
MOD_GlcNHglycan	227	230	PF01048	0.485
MOD_GlcNHglycan	29	32	PF01048	0.708
MOD_GlcNHglycan	56	59	PF01048	0.650
MOD_GlcNHglycan	8	11	PF01048	0.653
MOD_GlcNHglycan	95	98	PF01048	0.573
MOD_GSK3_1	27	34	PF00069	0.755
MOD_NEK2_1	16	21	PF00069	0.634
MOD_NEK2_1	233	238	PF00069	0.397
MOD_NEK2_1	24	29	PF00069	0.553
MOD_NEK2_1	4	9	PF00069	0.698
MOD_PKA_2	47	53	PF00069	0.734
MOD_PKA_2	75	81	PF00069	0.662
MOD_Plk_1	99	105	PF00069	0.551
MOD_ProDKin_1	167	173	PF00069	0.585
MOD_ProDKin_1	175	181	PF00069	0.590
TRG_DiLeu_BaLyEn_6	76	81	PF01217	0.652
TRG_ENDOCYTIC_2	207	210	PF00928	0.570
TRG_ER_diArg_1	217	219	PF00400	0.463
TRG_ER_diArg_1	81	83	PF00400	0.611
TRG_Pf-PMV_PEXEL_1	239	243	PF00026	0.635

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IIS0	Leptomonas seymouri	63%	100%
A0A1X0NKL7	Trypanosomatidae	52%	100%
A4HMC5	Leishmania braziliensis	80%	100%
A4IAZ1	Leishmania infantum	99%	100%
C9ZNI9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	51%	100%
E9B5X4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	87%	94%