LeishMANIAdb
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Mitochondrial_processing_peptidase_beta_subunit_p utative/GeneDB:LmjF.35.1380

Quick info Annotations Function or PPIs Localization Abundance Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Mitochondrial_processing_peptidase_beta_subunit_p utative/GeneDB:LmjF.35.1380
Gene product:
mitochondrial processing peptidase, beta subunit, putative
Species:
Leishmania donovani
UniProt:
A0A3S7X938_LEIDO
TriTrypDb:
LdBPK_351390.1 , LdCL_350018800 , LDHU3_35.1820
Length:
490

Annotations

Annotations by Jardim et al.

Electron Transport Chain (see tricarboxylic acid section for Complex II), mitochondrial processing peptidase, beta subunit

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. yes yes: 25
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 7
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. yes yes: 14
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 11
NetGPI no yes: 0, no: 11
Cellular components
Term Name Level Count
GO:0005737 cytoplasm 2 1
GO:0005739 mitochondrion 5 1
GO:0043226 organelle 2 1
GO:0043227 membrane-bounded organelle 3 1
GO:0043229 intracellular organelle 3 1
GO:0043231 intracellular membrane-bounded organelle 4 1
GO:0110165 cellular anatomical entity 1 1

Abundance

Amastigote (protein)
Source Evidence on protein Close homologs
Pescher et al. (upgregulation) no yes: 0
Promastigote and amastigote
Source Evidence on protein Close homologs
Lahav et al.
- mRNA
- Protein

Expansion

Sequence features

A0A3S7X938
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7X938

Function

Could not find GO biological_process term for this entry.
Molecular functions
Term Name Level Count
GO:0003824 catalytic activity 1 7
GO:0004175 endopeptidase activity 4 2
GO:0004222 metalloendopeptidase activity 5 2
GO:0005488 binding 1 12
GO:0008233 peptidase activity 3 2
GO:0008237 metallopeptidase activity 4 2
GO:0016787 hydrolase activity 2 2
GO:0043167 ion binding 2 12
GO:0043169 cation binding 3 12
GO:0046872 metal ion binding 4 12
GO:0140096 catalytic activity, acting on a protein 2 2
GO:0016491 oxidoreductase activity 2 5

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_NRD_NRD_1 432 434 PF00675 0.404
CLV_NRD_NRD_1 461 463 PF00675 0.426
CLV_PCSK_KEX2_1 432 434 PF00082 0.404
CLV_PCSK_SKI1_1 176 180 PF00082 0.338
CLV_PCSK_SKI1_1 198 202 PF00082 0.442
CLV_PCSK_SKI1_1 233 237 PF00082 0.407
CLV_PCSK_SKI1_1 248 252 PF00082 0.327
CLV_PCSK_SKI1_1 25 29 PF00082 0.561
CLV_PCSK_SKI1_1 316 320 PF00082 0.338
CLV_PCSK_SKI1_1 425 429 PF00082 0.412
CLV_PCSK_SKI1_1 54 58 PF00082 0.395
DEG_APCC_DBOX_1 24 32 PF00400 0.562
DEG_APCC_DBOX_1 432 440 PF00400 0.414
DEG_APCC_KENBOX_2 123 127 PF00400 0.458
DOC_CKS1_1 186 191 PF01111 0.426
DOC_MAPK_JIP1_4 165 171 PF00069 0.407
DOC_MAPK_MEF2A_6 54 62 PF00069 0.395
DOC_PIKK_1 167 174 PF02985 0.354
DOC_USP7_MATH_1 178 182 PF00917 0.338
DOC_USP7_MATH_1 234 238 PF00917 0.345
DOC_USP7_UBL2_3 402 406 PF12436 0.418
DOC_WW_Pin1_4 179 184 PF00397 0.381
DOC_WW_Pin1_4 185 190 PF00397 0.391
DOC_WW_Pin1_4 325 330 PF00397 0.326
LIG_14-3-3_CanoR_1 209 214 PF00244 0.407
LIG_14-3-3_CanoR_1 269 274 PF00244 0.338
LIG_14-3-3_CanoR_1 316 322 PF00244 0.327
LIG_14-3-3_CanoR_1 433 443 PF00244 0.495
LIG_APCC_ABBAyCdc20_2 152 158 PF00400 0.446
LIG_BIR_II_1 1 5 PF00653 0.557
LIG_BRCT_BRCA1_1 1 5 PF00533 0.557
LIG_BRCT_BRCA1_1 20 24 PF00533 0.518
LIG_Clathr_ClatBox_1 410 414 PF01394 0.456
LIG_deltaCOP1_diTrp_1 479 484 PF00928 0.411
LIG_EH_1 342 346 PF12763 0.354
LIG_FHA_1 270 276 PF00498 0.338
LIG_FHA_1 55 61 PF00498 0.344
LIG_FHA_1 74 80 PF00498 0.372
LIG_FHA_2 227 233 PF00498 0.338
LIG_FHA_2 379 385 PF00498 0.354
LIG_LIR_Gen_1 114 122 PF02991 0.369
LIG_LIR_Gen_1 2 12 PF02991 0.557
LIG_LIR_Gen_1 320 329 PF02991 0.338
LIG_LIR_Gen_1 384 393 PF02991 0.331
LIG_LIR_Gen_1 437 448 PF02991 0.435
LIG_LIR_Nem_3 116 122 PF02991 0.369
LIG_LIR_Nem_3 2 8 PF02991 0.541
LIG_LIR_Nem_3 21 27 PF02991 0.514
LIG_LIR_Nem_3 237 242 PF02991 0.356
LIG_LIR_Nem_3 320 324 PF02991 0.338
LIG_LIR_Nem_3 348 352 PF02991 0.454
LIG_LIR_Nem_3 384 388 PF02991 0.331
LIG_LIR_Nem_3 437 443 PF02991 0.422
LIG_LIR_Nem_3 467 471 PF02991 0.364
LIG_LIR_Nem_3 66 71 PF02991 0.459
LIG_PCNA_PIPBox_1 452 461 PF02747 0.402
LIG_PCNA_yPIPBox_3 304 318 PF02747 0.338
LIG_PCNA_yPIPBox_3 452 463 PF02747 0.405
LIG_Pex14_1 266 270 PF04695 0.354
LIG_Pex14_1 484 488 PF04695 0.424
LIG_PTB_Apo_2 264 271 PF02174 0.354
LIG_PTB_Phospho_1 264 270 PF10480 0.354
LIG_Rb_pABgroove_1 434 442 PF01858 0.541
LIG_SH2_CRK 119 123 PF00017 0.395
LIG_SH2_CRK 270 274 PF00017 0.354
LIG_SH2_CRK 466 470 PF00017 0.370
LIG_SH2_NCK_1 380 384 PF00017 0.354
LIG_SH2_NCK_1 440 444 PF00017 0.429
LIG_SH2_NCK_1 68 72 PF00017 0.458
LIG_SH2_SRC 68 71 PF00017 0.458
LIG_SH2_STAT5 117 120 PF00017 0.423
LIG_SH2_STAT5 238 241 PF00017 0.373
LIG_SH2_STAT5 258 261 PF00017 0.372
LIG_SH2_STAT5 358 361 PF00017 0.346
LIG_SH2_STAT5 380 383 PF00017 0.352
LIG_SH2_STAT5 458 461 PF00017 0.412
LIG_SH2_STAT5 468 471 PF00017 0.358
LIG_SH3_2 243 248 PF14604 0.407
LIG_SH3_3 183 189 PF00018 0.507
LIG_SH3_3 240 246 PF00018 0.411
LIG_SUMO_SIM_par_1 217 223 PF11976 0.355
LIG_TRAF2_1 46 49 PF00917 0.372
LIG_TRAF2_1 99 102 PF00917 0.446
LIG_TYR_ITIM 268 273 PF00017 0.354
LIG_WRC_WIRS_1 318 323 PF05994 0.338
MOD_CK1_1 327 333 PF00069 0.341
MOD_CK1_1 338 344 PF00069 0.321
MOD_CK1_1 4 10 PF00069 0.534
MOD_CK1_1 416 422 PF00069 0.399
MOD_CK2_1 226 232 PF00069 0.338
MOD_CK2_1 302 308 PF00069 0.325
MOD_CK2_1 378 384 PF00069 0.338
MOD_CK2_1 63 69 PF00069 0.352
MOD_Cter_Amidation 430 433 PF01082 0.428
MOD_Cter_Amidation 460 463 PF01082 0.484
MOD_GlcNHglycan 20 23 PF01048 0.621
MOD_GlcNHglycan 222 225 PF01048 0.383
MOD_GlcNHglycan 414 418 PF01048 0.446
MOD_GSK3_1 120 127 PF00069 0.458
MOD_GSK3_1 13 20 PF00069 0.576
MOD_GSK3_1 298 305 PF00069 0.458
MOD_GSK3_1 31 38 PF00069 0.446
MOD_GSK3_1 320 327 PF00069 0.345
MOD_GSK3_1 478 485 PF00069 0.396
MOD_GSK3_1 50 57 PF00069 0.426
MOD_GSK3_1 85 92 PF00069 0.363
MOD_N-GLC_1 34 39 PF02516 0.490
MOD_N-GLC_1 89 94 PF02516 0.372
MOD_NEK2_1 1 6 PF00069 0.538
MOD_NEK2_1 107 112 PF00069 0.430
MOD_NEK2_1 302 307 PF00069 0.330
MOD_NEK2_1 324 329 PF00069 0.349
MOD_NEK2_1 345 350 PF00069 0.447
MOD_NEK2_1 378 383 PF00069 0.338
MOD_NEK2_1 413 418 PF00069 0.436
MOD_NEK2_1 85 90 PF00069 0.372
MOD_PIKK_1 302 308 PF00454 0.345
MOD_PIKK_1 478 484 PF00454 0.421
MOD_PKA_1 198 204 PF00069 0.442
MOD_PKA_2 208 214 PF00069 0.363
MOD_PKB_1 11 19 PF00069 0.604
MOD_Plk_1 107 113 PF00069 0.374
MOD_Plk_1 226 232 PF00069 0.348
MOD_Plk_1 335 341 PF00069 0.423
MOD_Plk_1 34 40 PF00069 0.499
MOD_Plk_4 113 119 PF00069 0.403
MOD_Plk_4 226 232 PF00069 0.452
MOD_Plk_4 234 240 PF00069 0.461
MOD_Plk_4 248 254 PF00069 0.458
MOD_Plk_4 4 10 PF00069 0.534
MOD_Plk_4 464 470 PF00069 0.369
MOD_ProDKin_1 179 185 PF00069 0.381
MOD_ProDKin_1 325 331 PF00069 0.326
TRG_DiLeu_BaEn_2 80 86 PF01217 0.423
TRG_ENDOCYTIC_2 117 120 PF00928 0.377
TRG_ENDOCYTIC_2 270 273 PF00928 0.354
TRG_ENDOCYTIC_2 349 352 PF00928 0.452
TRG_ENDOCYTIC_2 440 443 PF00928 0.418
TRG_ENDOCYTIC_2 466 469 PF00928 0.368
TRG_ENDOCYTIC_2 68 71 PF00928 0.464
TRG_ER_diArg_1 11 14 PF00400 0.621
TRG_ER_diArg_1 432 434 PF00400 0.404

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N0P575 Leptomonas seymouri 28% 99%
A0A0N1PEB5 Leptomonas seymouri 90% 100%
A0A0S4IUJ1 Bodo saltans 31% 95%
A0A0S4KFV6 Bodo saltans 65% 98%
A0A1X0NHX2 Trypanosomatidae 68% 95%
A0A1X0P2L6 Trypanosomatidae 28% 96%
A0A422N9N5 Trypanosoma rangeli 75% 100%
A0A422NGW3 Trypanosoma rangeli 29% 100%
A0A451EJB9 Leishmania donovani 30% 99%
A4HMG0 Leishmania braziliensis 93% 100%
A4HRI8 Leishmania infantum 30% 100%
A4IB31 Leishmania infantum 100% 100%
C9ZNM7 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 73% 100%
C9ZXM0 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 30% 100%
E9AC56 Leishmania major 30% 100%
E9AEW1 Leishmania major 99% 100%
E9AJF2 Leishmania mexicana (strain MHOM/GT/2001/U1103) 30% 100%
E9B617 Leishmania mexicana (strain MHOM/GT/2001/U1103) 97% 100%
O04308 Arabidopsis thaliana 25% 98%
O25656 Helicobacter pylori (strain ATCC 700392 / 26695) 22% 100%
O32965 Mycobacterium leprae (strain TN) 26% 100%
O60044 Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987) 25% 100%
O75439 Homo sapiens 31% 100%
O86835 Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145) 24% 100%
O94745 Schizosaccharomyces pombe (strain 972 / ATCC 24843) 25% 98%
P07256 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 26% 100%
P0A5S9 Mycobacterium bovis (strain ATCC BAA-935 / AF2122/97) 26% 100%
P10507 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 28% 100%
P11913 Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987) 29% 100%
P11914 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 23% 100%
P20069 Rattus norvegicus 26% 94%
P22695 Homo sapiens 25% 100%
P23004 Bos taurus 25% 100%
P29677 Solanum tuberosum 27% 97%
P31800 Bos taurus 31% 100%
P31930 Homo sapiens 29% 100%
P32551 Rattus norvegicus 26% 100%
P43264 Euglena gracilis 31% 99%
P55679 Sinorhizobium fredii (strain NBRC 101917 / NGR234) 24% 96%
P97997 Blastocladiella emersonii 25% 100%
P98080 Caenorhabditis elegans 28% 100%
P9WHT4 Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh) 25% 100%
P9WHT5 Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) 26% 100%
Q00302 Blastocladiella emersonii 29% 100%
Q03346 Rattus norvegicus 31% 100%
Q0P5M8 Bos taurus 27% 93%
Q10713 Homo sapiens 26% 93%
Q1RJ61 Rickettsia bellii (strain RML369-C) 22% 100%
Q23295 Caenorhabditis elegans 29% 100%
Q3SZ71 Bos taurus 31% 100%
Q42290 Arabidopsis thaliana 32% 92%
Q4UML9 Rickettsia felis (strain ATCC VR-1525 / URRWXCal2) 23% 100%
Q4W6B5 Dictyostelium discoideum 28% 100%
Q5R513 Pongo abelii 26% 93%
Q5REK3 Pongo abelii 31% 100%
Q68FY0 Rattus norvegicus 30% 100%
Q6C2E3 Yarrowia lipolytica (strain CLIB 122 / E 150) 22% 100%
Q95XN2 Caenorhabditis elegans 24% 95%
Q9CXT8 Mus musculus 31% 100%
Q9CZ13 Mus musculus 30% 100%
Q9DB77 Mus musculus 26% 100%
Q9DC61 Mus musculus 27% 94%
Q9P7X1 Schizosaccharomyces pombe (strain 972 / ATCC 24843) 29% 100%
Q9Y8B5 Lentinula edodes 30% 100%
Q9ZU25 Arabidopsis thaliana 24% 97%
V5BGV2 Trypanosoma cruzi 77% 100%
V5BH27 Trypanosoma cruzi 30% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2024 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS